Q7TSS2
Gene name |
Ube2q1 (Ube2q) |
Protein name |
Ubiquitin-conjugating enzyme E2 Q1 |
Names |
E2 ubiquitin-conjugating enzyme Q1, Galactosyl transferase-associated protein, GTAP, Ubiquitin carrier protein Q1, Ubiquitin-protein ligase Q1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:70093 |
EC number |
2.3.2.23: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7TSS2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7TSS2-F1 | Predicted | AlphaFoldDB |
14 variants for Q7TSS2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3393114078 | 20 | V>G | No | EVA | |
| rs3388645348 | 148 | H>Y | No | EVA | |
| rs3388635253 | 161 | N>D | No | EVA | |
| rs3388630906 | 175 | L>F | No | EVA | |
| rs3412613788 | 177 | A>T | No | EVA | |
| rs3388637304 | 229 | I>T | No | EVA | |
| rs3388640728 | 290 | L>H | No | EVA | |
| rs3388637305 | 307 | K>M | No | EVA | |
| rs3388646109 | 318 | N>Y | No | EVA | |
| rs3388643259 | 342 | G>W | No | EVA | |
| rs3388624682 | 353 | E>K | No | EVA | |
| rs3388637245 | 385 | Q>H | No | EVA | |
| rs3412897224 | 417 | P>R | No | EVA | |
| rs3388640682 | 422 | G>A | No | EVA |
No associated diseases with Q7TSS2
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.23 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| filopodium | Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ubiquitin conjugating enzyme activity | Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| embryo implantation | Attachment of the blastocyst to the uterine lining. |
| fertilization | The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). |
| mating behavior | The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes. |
| prolactin secretion | The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary. |
| protein polyubiquitination | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. |
| reproductive system development | The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction. |
| suckling behavior | Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q32L27 | UBE2Q2 | Ubiquitin-conjugating enzyme E2 Q2 | Bos taurus (Bovine) | PR |
| A1L167 | UBE2QL1 | Ubiquitin-conjugating enzyme E2Q-like protein 1 | Homo sapiens (Human) | PR |
| Q7Z7E8 | UBE2Q1 | Ubiquitin-conjugating enzyme E2 Q1 | Homo sapiens (Human) | PR |
| Q64362 | Aktip | AKT-interacting protein | Mus musculus (Mouse) | PR |
| Q9JJZ4 | Ube2j1 | Ubiquitin-conjugating enzyme E2 J1 | Mus musculus (Mouse) | PR |
| P61087 | Ube2k | Ubiquitin-conjugating enzyme E2 K | Mus musculus (Mouse) | PR |
| Q9CQ37 | Ube2t | Ubiquitin-conjugating enzyme E2 T | Mus musculus (Mouse) | PR |
| Q9D1C1 | Ube2c | Ubiquitin-conjugating enzyme E2 C | Mus musculus (Mouse) | PR |
| P61079 | Ube2d3 | Ubiquitin-conjugating enzyme E2 D3 | Mus musculus (Mouse) | PR |
| P52483 | Ube2e3 | Ubiquitin-conjugating enzyme E2 E3 | Mus musculus (Mouse) | PR |
| A0PJN4 | Ube2ql1 | Ubiquitin-conjugating enzyme E2Q-like protein 1 | Mus musculus (Mouse) | PR |
| Q921J4 | Ube2s | Ubiquitin-conjugating enzyme E2 S | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MQQPQPQGQQ | QPGPGQQLGV | QGAAPGAGGG | PGGGPGPGPC | LRRELKLLES | IFHRGHERFR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IASACLDELS | CEFLLAGAGG | AGAGAAPGPH | LPSRGSVPGD | PVRIHCNITE | SYPAVPPIWS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VESDDPNLAA | VLERLVDIKK | GNTLLLQHLK | RIISDLCKLY | NLPQHPDVEM | LDQPLPAEQC |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TQEEVSSEDE | DEEMPEDTED | LDHYEMKEEE | PAEGKKSEDD | GIGKENLAIL | EKIKKNQRQD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YLNGAVSGSV | QATDRLMKEL | RDIYRSQSFK | GGNYAVELVN | DSLYDWNVKL | LKVDQDSALH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NDLQILKEKE | GADFILLNFS | FKDNFPFDPP | FVRVVSPVLS | GGYVLGGGAI | CMELLTKQGW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSAYSIESVI | MQISATLVKG | KARVQFGANK | SQYSLTRAQQ | SYKSLVQIHE | KNGWYTPPKE |
| DG |