Q7TSE6

SS
Gene name
Stk38l
Protein name
Serine/threonine-protein kinase 38-like
Names
NDR2 protein kinase, Nuclear Dbf2-related kinase 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:232533
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

STK38L, called nuclear Dbf2-related kinase 2 (NDR2 protein kinase), is a subclass of the AGC family of protein kinases that are involved in the regulation of cell division and cell morphology. NDR kinase activity is regulated by phosphorylation and by the Ca2+-binding protein, S100B. According to a study with human NDR (Q15208), the N-terminal domain (265-276) of NDR reduced NDR kinase activity. The binding of human MOB1 to the N-terminal domain of NDR induces the release of autoinhibition.

Autoinhibitory domains (AIDs)

265-277 (Autoinhibitory segment) SS

Target domain

90-383 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

230-242 (Activation loop from InterPro)

Target domain

90-383 (Protein kinase domain)

Relief mechanism

Assay

279-288 (Activation loop from InterPro)

Target domain

90-383 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q7TSE6

Entry ID Method Resolution Chain Position Source
AF-Q7TSE6-F1 Predicted AlphaFoldDB

2 variants for Q7TSE6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs235779635 214 V>I No Ensembl
rs1134985839 440 N>K No Ensembl

No associated diseases with Q7TSE6

5 regional properties for Q7TSE6

Type Name Position InterPro Accession
domain Protein kinase domain 90 - 383 IPR000719
domain AGC-kinase, C-terminal 384 - 453 IPR000961
active_site Serine/threonine-protein kinase, active site 209 - 221 IPR008271
binding_site Protein kinase, ATP binding site 96 - 119 IPR017441
domain Protein kinase, C-terminal 402 - 443 IPR017892

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytoskeleton
  • Membrane
  • Associated with the actin cytoskeleton
  • Co-localizes with STK24/MST3 in the membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
actin cytoskeleton The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

6 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

4 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of cellular component organization Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

26 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P53894 CBK1 Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
A2VDV2 STK38 Serine/threonine-protein kinase 38 Bos taurus (Bovine) SS
Q9NBK5 trc Serine/threonine-protein kinase tricornered Drosophila melanogaster (Fruit fly) SS
Q96LW2 RSKR Ribosomal protein S6 kinase-related protein Homo sapiens (Human) PR
Q15208 STK38 Serine/threonine-protein kinase 38 Homo sapiens (Human) EV
Q9Y2H1 STK38L Serine/threonine-protein kinase 38-like Homo sapiens (Human) EV
Q9Z2A0 Pdpk1 3-phosphoinositide-dependent protein kinase 1 Mus musculus (Mouse) SS
Q02956 Prkcz Protein kinase C zeta type Mus musculus (Mouse) SS
Q62074 Prkci Protein kinase C iota type Mus musculus (Mouse) SS
P70268 Pkn1 Serine/threonine-protein kinase N1 Mus musculus (Mouse) SS
Q8K045 Pkn3 Serine/threonine-protein kinase N3 Mus musculus (Mouse) SS
Q8BWW9 Pkn2 Serine/threonine-protein kinase N2 Mus musculus (Mouse) SS
P23298 Prkch Protein kinase C eta type Mus musculus (Mouse) PR
P16054 Prkce Protein kinase C epsilon type Mus musculus (Mouse) PR
Q02111 Prkcq Protein kinase C theta type Mus musculus (Mouse) PR
P28867 Prkcd Protein kinase C delta type Mus musculus (Mouse) PR
P20444 Prkca Protein kinase C alpha type Mus musculus (Mouse) SS
P63318 Prkcg Protein kinase C gamma type Mus musculus (Mouse) SS
P68404 Prkcb Protein kinase C beta type Mus musculus (Mouse) SS
Q60823 Akt2 RAC-beta serine/threonine-protein kinase Mus musculus (Mouse) PR
P31750 Akt1 RAC-alpha serine/threonine-protein kinase Mus musculus (Mouse) PR
Q9WUA6 Akt3 RAC-gamma serine/threonine-protein kinase Mus musculus (Mouse) PR
Q9ERE3 Sgk3 Serine/threonine-protein kinase Sgk3 Mus musculus (Mouse) PR
Q8QZV4 Stk32c Serine/threonine-protein kinase 32C Mus musculus (Mouse) PR
Q91VJ4 Stk38 Serine/threonine-protein kinase 38 Mus musculus (Mouse) SS
Q2L6W9 sax-1 Serine/threonine-protein kinase sax-1 Caenorhabditis elegans SS
10 20 30 40 50 60
MAMTAGATTT FPMSNHTRER VTVAKLTLEN FYSNLILQHE ERETRQKKLE VAMEEEGLAD
70 80 90 100 110 120
EEKKLRRSQH ARKETEFLRL KRTRLGLDDF ESLKVIGRGA FGEVRLVQKK DTGHIYAMKI
130 140 150 160 170 180
LRKADMLEKE QVAHIRAERD ILVEADGAWV VKMFYSFQDK RNLYLIMEFL PGGDMMTLLM
190 200 210 220 230 240
KKDTLTEEET QFYISETVLA IDAIHQLGFI HRDVKPDNLL LDAKGHVKLS DFGLCTGLKK
250 260 270 280 290 300
AHRTEFYRNL THNPPSDFSF QNMNSKRKAE TWKKNRRQLA YSTVGTPDYI APEVFMQTGY
310 320 330 340 350 360
NKLCDWWSLG VIMYEMLIGF PPFCSETPQE TYRKVMSWKE TLAFPPEVPV SEKAKDLILR
370 380 390 400 410 420
FCTDSENRIG NGGVEEIKGH PFFEGVDWGH IRERPAAIPI EIRSIDDTSN FDDFPESDIL
430 440 450 460
QPVPNTTEPD YKSKDWVFLN YTYKRFEGLT QRGSIPTYMK AGKL