Q7TPM3
PR
Gene name |
Trim17 |
Protein name |
E3 ubiquitin-protein ligase TRIM17 |
Names |
RING-type E3 ubiquitin transferase TRIM17, Tripartite motif-containing protein 17 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:56631 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7TPM3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7TPM3-F1 | Predicted | AlphaFoldDB |
18 variants for Q7TPM3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs240745771 | 61 | P>L | No | EVA | |
| rs3389169033 | 81 | T>I | No | EVA | |
| rs3389124421 | 121 | C>S | No | EVA | |
| rs26971762 | 129 | M>I | No | EVA | |
| rs3389160649 | 195 | F>S | No | EVA | |
| rs247613857 | 245 | Q>R | No | EVA | |
| rs3389152990 | 252 | Q>R | No | EVA | |
| rs26971738 | 259 | N>S | No | EVA | |
| rs225521517 | 264 | F>L | No | EVA | |
| rs49657417 | 280 | L>M | No | EVA | |
| rs3389155655 | 305 | Y>* | No | EVA | |
| rs3389165756 | 305 | Y>N | No | EVA | |
| rs3389172789 | 318 | Y>N | No | EVA | |
| rs3389124431 | 341 | V>M | No | EVA | |
| rs3389159307 | 347 | S>F | No | EVA | |
| rs3389147554 | 360 | T>I | No | EVA | |
| rs3402284785 | 401 | S>P | No | EVA | |
| rs3389159705 | 437 | G>R | No | EVA |
No associated diseases with Q7TPM3
13 regional properties for Q7TPM3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | B-box-type zinc finger | 94 - 135 | IPR000315 |
| domain | Zinc finger, RING-type | 16 - 66 | IPR001841 |
| domain | B30.2/SPRY domain | 276 - 475 | IPR001870 |
| domain | SPRY domain | 348 - 472 | IPR003877 |
| domain | Butyrophylin-like, SPRY domain | 293 - 310 | IPR003879-1 |
| domain | Butyrophylin-like, SPRY domain | 333 - 357 | IPR003879-2 |
| domain | Butyrophylin-like, SPRY domain | 365 - 378 | IPR003879-3 |
| domain | Butyrophylin-like, SPRY domain | 409 - 433 | IPR003879-4 |
| domain | Butyrophylin-like, SPRY domain | 440 - 458 | IPR003879-5 |
| domain | SPRY-associated | 294 - 347 | IPR006574 |
| conserved_site | Zinc finger, RING-type, conserved site | 31 - 40 | IPR017907 |
| domain | Zinc finger, RING-type, eukaryotic | 16 - 63 | IPR027370 |
| domain | TRIM17, PRY/SPRY domain | 296 - 472 | IPR035687 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein-macromolecule adaptor activity | The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| zinc ion binding | Binding to a zinc ion (Zn). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| protein autoubiquitination | The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| regulation of protein localization | Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location. |
46 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9G4 | TRIM10 | Tripartite motif-containing protein 10 | Bos taurus (Bovine) | PR |
| E1BJS7 | TRIM71 | E3 ubiquitin-protein ligase TRIM71 | Bos taurus (Bovine) | PR |
| Q7YRV4 | TRIM21 | E3 ubiquitin-protein ligase TRIM21 | Bos taurus (Bovine) | PR |
| Q2T9Z0 | TRIM17 | E3 ubiquitin-protein ligase TRIM17 | Bos taurus (Bovine) | PR |
| Q1PRL4 | TRIM71 | E3 ubiquitin-protein ligase TRIM71 | Gallus gallus (Chicken) | PR |
| Q7YR32 | TRIM10 | Tripartite motif-containing protein 10 | Pan troglodytes (Chimpanzee) | PR |
| O15553 | MEFV | Pyrin | Homo sapiens (Human) | SS |
| Q9BTV5 | FSD1 | Fibronectin type III and SPRY domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q9H2S5 | RNF39 | RING finger protein 39 | Homo sapiens (Human) | PR |
| P19474 | TRIM21 | E3 ubiquitin-protein ligase TRIM21 | Homo sapiens (Human) | PR |
| Q9UJV3 | MID2 | Probable E3 ubiquitin-protein ligase MID2 | Homo sapiens (Human) | PR |
| P29590 | PML | Protein PML | Homo sapiens (Human) | PR |
| Q9C029 | TRIM7 | E3 ubiquitin-protein ligase TRIM7 | Homo sapiens (Human) | PR |
| Q9NQ86 | TRIM36 | E3 ubiquitin-protein ligase TRIM36 | Homo sapiens (Human) | PR |
| Q86UV6 | TRIM74 | Tripartite motif-containing protein 74 | Homo sapiens (Human) | PR |
| Q9UPQ4 | TRIM35 | E3 ubiquitin-protein ligase TRIM35 | Homo sapiens (Human) | PR |
| Q6ZMU5 | TRIM72 | Tripartite motif-containing protein 72 | Homo sapiens (Human) | PR |
| Q86UV7 | TRIM73 | Tripartite motif-containing protein 73 | Homo sapiens (Human) | PR |
| Q8N9V2 | TRIML1 | Probable E3 ubiquitin-protein ligase TRIML1 | Homo sapiens (Human) | PR |
| Q86XT4 | TRIM50 | E3 ubiquitin-protein ligase TRIM50 | Homo sapiens (Human) | PR |
| Q5EBN2 | TRIM61 | Putative tripartite motif-containing protein 61 | Homo sapiens (Human) | PR |
| Q9BZY9 | TRIM31 | E3 ubiquitin-protein ligase TRIM31 | Homo sapiens (Human) | PR |
| Q2Q1W2 | TRIM71 | E3 ubiquitin-protein ligase TRIM71 | Homo sapiens (Human) | PR |
| Q9BXM9 | FSD1L | FSD1-like protein | Homo sapiens (Human) | PR |
| Q8BZT2 | Sh3rf2 | E3 ubiquitin-protein ligase SH3RF2 | Mus musculus (Mouse) | PR |
| Q60953 | Pml | Protein PML | Mus musculus (Mouse) | PR |
| Q99PQ1 | Trim12a | Tripartite motif-containing protein 12A | Mus musculus (Mouse) | PR |
| Q61510 | Trim25 | E3 ubiquitin/ISG15 ligase TRIM25 | Mus musculus (Mouse) | PR |
| Q1PSW8 | Trim71 | E3 ubiquitin-protein ligase TRIM71 | Mus musculus (Mouse) | PR |
| P86449 | Trim43c | Tripartite motif-containing protein 43C | Mus musculus (Mouse) | PR |
| Q1XH17 | Trim72 | Tripartite motif-containing protein 72 | Mus musculus (Mouse) | PR |
| Q3TL54 | Trim43a | Tripartite motif-containing protein 43A | Mus musculus (Mouse) | PR |
| Q810I2 | Trim50 | E3 ubiquitin-protein ligase TRIM50 | Mus musculus (Mouse) | PR |
| Q9JJ26 | Mefv | Pyrin | Mus musculus (Mouse) | SS |
| Q9WUH5 | Trim10 | Tripartite motif-containing protein 10 | Mus musculus (Mouse) | PR |
| O77666 | TRIM26 | Tripartite motif-containing protein 26 | Sus scrofa (Pig) | PR |
| O19085 | TRIM10 | Tripartite motif-containing protein 10 | Sus scrofa (Pig) | PR |
| Q865W2 | TRIM50 | E3 ubiquitin-protein ligase TRIM50 | Sus scrofa (Pig) | PR |
| Q920M2 | Rnf39 | RING finger protein 39 | Rattus norvegicus (Rat) | PR |
| Q9JJ25 | Mefv | Pyrin | Rattus norvegicus (Rat) | SS |
| A0JPQ4 | Trim72 | Tripartite motif-containing protein 72 | Rattus norvegicus (Rat) | PR |
| Q810I1 | Trim50 | E3 ubiquitin-protein ligase TRIM50 | Rattus norvegicus (Rat) | PR |
| D3ZVM4 | Trim71 | E3 ubiquitin-protein ligase TRIM71 | Rattus norvegicus (Rat) | PR |
| F6QEU4 | trim71 | E3 ubiquitin-protein ligase TRIM71 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q640S6 | trim72 | Tripartite motif-containing protein 72 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| E7FAM5 | trim71 | E3 ubiquitin-protein ligase TRIM71 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDAVELARRL | QEEATCSICL | DYFTDPVMTA | CGHNFCRECI | QMSWEKGKVK | KGKKKQKGSF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PCPECREMSP | QRNLRPNRLL | TKVAEMARQH | PGLQKRDLCQ | AHQEPLKLFC | QDDQSPICVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CREAQEHRMH | RVLPLDEAAR | EYKLKLEEDI | KYLREEMMKT | ETLQAKEEQT | LTEWQERVKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RRERILEEFQ | KVVLFLVEEE | RRILQVLKKE | EEDTLGKLQD | SKASLDHQSR | SLDLILLQLE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ERSQQEPLQM | LQDVKDTLNR | KESFSVQYPE | VVLPAAIKTL | CRVPGQIEVL | KSFQEDVMPD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PSSAYPYLLL | YESRQRRYLS | PPPEGSAPYS | KDRFVAYPCA | VGQKSFSSGR | HYWEVGMNLT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GDALWALGVC | RDNVSRKDRV | LKSPENGFWV | VQLSKGKKQL | SLLPNSTLVT | LTEPPSHMGI |
| 430 | 440 | 450 | 460 | 470 | |
| FLDFQAGEVS | FYSVNDGSHL | HSFSQAAFPG | PLLPFFCLGA | PKSGQMVIST | VTMWVKG |