Q7TNZ6
Gene name |
Strada |
Protein name |
STE20-related kinase adapter protein alpha |
Names |
STRAD alpha, STE20-related adapter protein |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:303605 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q7TNZ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q7TNZ6-F1 | Predicted | AlphaFoldDB |
No variants for Q7TNZ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q7TNZ6 | |||||
No associated diseases with Q7TNZ6
6 regional properties for Q7TNZ6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | 5'-3' exonuclease | 29 - 299 | IPR002421 |
| domain | XPG, N-terminal | 1 - 108 | IPR006085 |
| domain | XPG-I domain | 147 - 234 | IPR006086 |
| conserved_site | Helix-hairpin-helix motif, class 2 | 221 - 254 | IPR008918 |
| conserved_site | XPG conserved site | 80 - 94 | IPR019974-1 |
| conserved_site | XPG conserved site | 150 - 164 | IPR019974-2 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| intracellular protein-containing complex | A protein-containing complex located intracellularly. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| serine/threonine protein kinase complex | A protein complex which is capable of protein serine/threonine kinase activity. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| protein kinase activator activity | Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. |
| protein serine/threonine kinase activator activity | Binds to and increases the activity of a protein serine/threonine kinase. |
| protein-containing complex binding | Binding to a macromolecular complex. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| activation of protein kinase activity | Any process that initiates the activity of an inactive protein kinase. |
| G1 to G0 transition | A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters a specialized resting state known as G0 or quiescence. |
| protein export from nucleus | The directed movement of a protein from the nucleus into the cytoplasm. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9C0K7 | STRADB | STE20-related kinase adapter protein beta | Homo sapiens (Human) | PR |
| O95747 | OXSR1 | Serine/threonine-protein kinase OSR1 | Homo sapiens (Human) | PR |
| Q9UEW8 | STK39 | STE20/SPS1-related proline-alanine-rich protein kinase | Homo sapiens (Human) | PR |
| Q7RTN6 | STRADA | STE20-related kinase adapter protein alpha | Homo sapiens (Human) | PR |
| Q8K4T3 | Stradb | STE20-related kinase adapter protein beta | Mus musculus (Mouse) | PR |
| Q6P9R2 | Oxsr1 | Serine/threonine-protein kinase OSR1 | Mus musculus (Mouse) | PR |
| Q9Z1W9 | Stk39 | STE20/SPS1-related proline-alanine-rich protein kinase | Mus musculus (Mouse) | PR |
| Q3UUJ4 | Strada | STE20-related kinase adapter protein alpha | Mus musculus (Mouse) | PR |
| Q863I2 | OXSR1 | Serine/threonine-protein kinase OSR1 | Sus scrofa (Pig) | PR |
| O88506 | Stk39 | STE20/SPS1-related proline-alanine-rich protein kinase | Rattus norvegicus (Rat) | PR |
| O23304 | BLUS1 | Serine/threonine-protein kinase BLUS1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFLANEASS | ESIASFSKPE | IMSSFLPEGG | CYELLSVIGK | GFEDLMTVNS | RYKPTGEYVT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VRRINLEACS | NEMVTFLQGE | LHVSKLFSHP | NIVPYRATFI | ADNELWAVTS | FMAYGSAKDL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IGTHFMDGMS | ELAIAYILQG | VLKALDYIHH | MGYVHRSVKA | SHILISTDGK | VYLSGLRSNL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SMISHGQRQR | AVHDFPKYSI | KVLPWLSPEV | LQQNLQGYDA | KSDIYSVGIT | ACELANGHVP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FKDMPATQML | LEKLNGTVPC | LLDTSTIPAE | ELTMSPSRSI | ANPGLNDSLA | AGSLRPANGD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SPSHPYHRTF | SPHFHNFVEQ | CLQRNPDARP | NASTLLNHSF | FKQIKRRASE | ALPELLRPVT |
| 370 | 380 | 390 | |||
| PITSFEGSQS | QDHSGILGLV | TNLEDLEVDD | WEF |