Q7T2E3

PR
Gene name
csnk1da (csnk1dl, si:ch211-234h8.6)
Protein name
Casein kinase I isoform delta-A
Names
CKI-delta-A, CKId-A, Casein kinase I isoform delta-like
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:322106
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

(Annotation based on sequence homology with P49674)
Casein kinase I epsilon (CSNK1E) is a member of CKI family and is involved in signaling, circadian clock, DNA repair, and metabolism. The tail of autophosphorylated CKIε interacts with the kinase domain and blocks the active site. Proteolytic lysis of the C-terminal region relieves autoinhibition.

Autoinhibitory domains (AIDs)

277-403 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

148-178 (Activation loop from InterPro)

Target domain

9-287 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q7T2E3

Entry ID Method Resolution Chain Position Source
AF-Q7T2E3-F1 Predicted AlphaFoldDB

No variants for Q7T2E3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7T2E3

No associated diseases with Q7T2E3

3 regional properties for Q7T2E3

Type Name Position InterPro Accession
domain Protein kinase domain 9 - 287 IPR000719
active_site Serine/threonine-protein kinase, active site 124 - 136 IPR008271
binding_site Protein kinase, ATP binding site 15 - 38 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

8 GO annotations of biological process

Name Definition
non-motile cilium assembly The aggregation, arrangement and bonding together of a set of components to form a non-motile cilium.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of canonical Wnt signaling pathway Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
regulation of circadian rhythm Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
spindle assembly The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P29295 HRR25 Casein kinase I homolog HRR25 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P35508 CSNK1D Casein kinase I isoform delta Bos taurus (Bovine) SS
Q5ZLL1 CSNK1E Casein kinase I isoform epsilon Gallus gallus (Chicken) SS
P48730 CSNK1D Casein kinase I isoform delta Homo sapiens (Human) SS
P49674 CSNK1E Casein kinase I isoform epsilon Homo sapiens (Human) EV
Q86Y07 VRK2 Serine/threonine-protein kinase VRK2 Homo sapiens (Human) PR
Q9DC28 Csnk1d Casein kinase I isoform delta Mus musculus (Mouse) PR
Q8BN21 Vrk2 Serine/threonine-protein kinase VRK2 Mus musculus (Mouse) PR
Q9JMK2 Csnk1e Casein kinase I isoform epsilon Mus musculus (Mouse) SS
Q06486 Csnk1d Casein kinase I isoform delta Rattus norvegicus (Rat) PR
P42169 C03C10.2 Putative casein kinase I C03C10.2 Caenorhabditis elegans PR
P34516 K06H7.8 Putative serine/threonine-protein kinase K06H7.1 Caenorhabditis elegans PR
Q6P647 csnk1d Casein kinase I isoform delta Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q6P3K7 csnk1db Casein kinase I isoform delta-B Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q7ZUS1 vrk1 Serine/threonine-protein kinase VRK1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MELRVGNRYR LGRKIGSGSF GDIYLGTDIT TGEEVAIKLE CVKTKHPQLH IESKIYKMMQ
70 80 90 100 110 120
GGVGIPTIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH
130 140 150 160 170 180
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA
190 200 210 220 230 240
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL
250 260 270 280 290 300
CKGYPSEFAT YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGGARE
310 320 330 340 350 360
DPERDRRDRE ERIRQGRIPL PRVMLPTSSG RPRGTQEVAP APPLTPDSHT GMERERKVSM
370 380 390 400
RLHRGAPVNV SSSDLTGRQD CSRISTSQAH SRVPSGLQSA VPR