AiPD: Autoinhibited Protein Database

Gene name	lrrc40 (zgc:63729)
Protein name	Leucine-rich repeat-containing protein 40
Names
Species	Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway	dre:334130
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-53 (Predicted disordered autoinhibitory region) PR

1-53 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q7SXW3-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for Q7SXW3

Type	Name	Position	InterPro Accession
repeat	Leucine-rich repeat	81 - 148	IPR001611-1
repeat	Leucine-rich repeat	150 - 172	IPR001611-2
repeat	Leucine-rich repeat	173 - 195	IPR001611-3
repeat	Leucine-rich repeat	196 - 263	IPR001611-4
repeat	Leucine-rich repeat	264 - 333	IPR001611-5
repeat	Leucine-rich repeat	449 - 506	IPR001611-6
repeat	Leucine-rich repeat	517 - 575	IPR001611-7
repeat	Leucine-rich repeat, typical subtype	80 - 101	IPR003591-1
repeat	Leucine-rich repeat, typical subtype	102 - 124	IPR003591-2
repeat	Leucine-rich repeat, typical subtype	125 - 147	IPR003591-3
repeat	Leucine-rich repeat, typical subtype	148 - 170	IPR003591-4
repeat	Leucine-rich repeat, typical subtype	171 - 193	IPR003591-5
repeat	Leucine-rich repeat, typical subtype	194 - 217	IPR003591-6
repeat	Leucine-rich repeat, typical subtype	240 - 262	IPR003591-7
repeat	Leucine-rich repeat, typical subtype	286 - 308	IPR003591-8
repeat	Leucine-rich repeat, typical subtype	309 - 330	IPR003591-9
repeat	Leucine-rich repeat, typical subtype	332 - 355	IPR003591-10
repeat	Leucine-rich repeat, typical subtype	449 - 469	IPR003591-11
repeat	Leucine-rich repeat, typical subtype	470 - 492	IPR003591-12
repeat	Leucine-rich repeat, typical subtype	493 - 516	IPR003591-13
repeat	Leucine-rich repeat, typical subtype	540 - 563	IPR003591-14

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

Name	Definition
protein serine/threonine phosphatase activity	Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.

Name	Definition
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A6H694	Lrrc63	Leucine-rich repeat-containing protein 63	Mus musculus (Mouse)	PR
Q4V8G0	Lrrc63	Leucine-rich repeat-containing protein 63	Rattus norvegicus (Rat)	PR