Q7SIG6
SS
Gene name |
Asap2 (Ddef2, Gm1523, Gm592) |
Protein name |
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 |
Names |
Development and differentiation-enhancing factor 2 , Paxillin-associated protein with ARF GAP activity 3 , PAG3 , Pyk2 C-terminus-associated protein , PAP |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:211914 |
EC number |
|
Protein Class |
|
Descriptions
ASAP1 is an Arf GTPase-activating protein (GAP) that functions on membrane surfaces to catalyze the hydrolysis of GTP bound to Arf. ASAP1 has a BAR domain which functions as membrane curvature sensors or as inducers of membrane curvature. The BAR domain influences GAP activity by binding to the PH domain and/or Arf GAP domain. The deletion of the entire BAR domain or the N-terminal extension increased GAP activity.
Autoinhibitory domains (AIDs)
Target domain |
310-397 (PH domain);424-548 (Arf GAP domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for Q7SIG6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1DCQ | X-ray | 210 A | A | 421-697 | PDB |
| AF-Q7SIG6-F1 | Predicted | AlphaFoldDB |
48 variants for Q7SIG6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3549142603 | 17 | D>G | No | EVA | |
| rs1132739064 | 24 | S>F | No | EVA | |
| rs3389248364 | 91 | D>E | No | EVA | |
| rs3389229615 | 141 | D>V | No | EVA | |
| rs3389232511 | 161 | E>G | No | EVA | |
| rs3389229590 | 162 | K>R | No | EVA | |
| rs3389235648 | 186 | E>* | No | EVA | |
| rs3389248274 | 191 | R>K | No | EVA | |
| rs3389229541 | 224 | F>V | No | EVA | |
| rs3389194197 | 250 | T>P | No | EVA | |
| rs3389220591 | 251 | D>N | No | EVA | |
| rs3389226267 | 264 | R>* | No | EVA | |
| rs3389201453 | 275 | S>* | No | EVA | |
| rs3389226266 | 302 | Q>H | No | EVA | |
| rs3389248330 | 359 | V>G | No | EVA | |
| rs3389230476 | 368 | C>Y | No | EVA | |
| rs3389206991 | 397 | N>D | No | EVA | |
| rs3389201504 | 424 | K>N | No | EVA | |
| rs3389229616 | 449 | W>* | No | EVA | |
| rs3389232460 | 449 | W>S | No | EVA | |
| rs3389229547 | 467 | R>P | No | EVA | |
| rs3389229577 | 469 | L>M | No | EVA | |
| rs3412747484 | 474 | S>F | No | EVA | |
| rs3389230490 | 491 | L>F | No | EVA | |
| rs3389235712 | 542 | K>R | No | EVA | |
| rs3549130557 | 547 | A>S | No | EVA | |
| rs3389230431 | 550 | L>F | No | EVA | |
| rs218646073 | 551 | H>Q | No | EVA | |
| rs3389235623 | 554 | C>G | No | EVA | |
| rs3389201495 | 566 | L>V | No | EVA | |
| rs3389234991 | 670 | E>D | No | EVA | |
| rs3389206933 | 670 | E>K | No | EVA | |
| rs3389166729 | 685 | N>K | No | EVA | |
| rs3389235619 | 726 | F>S | No | EVA | |
| rs3389226327 | 734 | F>Y | No | EVA | |
| rs3389235039 | 745 | T>S | No | EVA | |
| rs3389235681 | 774 | P>S | No | EVA | |
| rs243277419 | 811 | T>I | No | EVA | |
| rs3403180995 | 827 | P>A | No | EVA | |
| rs3403112309 | 827 | P>L | No | EVA | |
| rs3403112322 | 829 | T>N | No | EVA | |
| rs48963502 | 861 | T>I | No | EVA | |
| rs3389243100 | 863 | K>N | No | EVA | |
| rs3389240204 | 877 | N>D | No | EVA | |
| rs1132386928 | 877 | N>K | No | EVA | |
| rs3389166717 | 907 | C>W | No | EVA | |
| rs3389235013 | 950 | V>I | No | EVA | |
| rs3389220649 | 958 | D>E | No | EVA |
No associated diseases with Q7SIG6
7 regional properties for Q7SIG6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Arf GTPase activating protein | 424 - 546 | IPR001164 |
| domain | SH3 domain | 896 - 958 | IPR001452 |
| domain | Pleckstrin homology domain | 308 - 402 | IPR001849 |
| repeat | Ankyrin repeat | 587 - 686 | IPR002110 |
| domain | BAR domain | 33 - 266 | IPR004148 |
| domain | ASAP2, SH3 domain | 900 - 955 | IPR035677 |
| domain | ASAP, PH domain | 300 - 406 | IPR037844 |
Functions
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| Golgi cisterna membrane | The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| metal ion binding | Binding to a metal ion. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A5PK26 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
| O97902 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
| A1Z7A6 | Asap | ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein | Drosophila melanogaster (Fruit fly) | SS |
| Q15027 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q15057 | ACAP2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | PR |
| Q8TDY4 | ASAP3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Homo sapiens (Human) | SS |
| Q9ULH1 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| O43150 | ASAP2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | SS |
| Q8K2H4 | Acap1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q6ZQK5 | Acap2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | PR |
| Q5U464 | Asap3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Mus musculus (Mouse) | SS |
| Q9QWY8 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q1AAU6 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Rattus norvegicus (Rat) | SS |
| Q9C6C3 | AGD2 | ADP-ribosylation factor GTPase-activating protein AGD2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SMX5 | AGD4 | ADP-ribosylation factor GTPase-activating protein AGD4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPDQISVSEF | VAETHEDYKA | PTASSFTTRT | AQCRNTVAAI | EEALDVDRMV | LYKMKKSVKA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| INISGLAHVE | NEEQYTQALE | KFGGNCVCRD | DPDLGSAFLK | FSVFTKELTA | LFKNLIQNMN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NIISFPLDSL | LKGDLKGVKG | DLKKPFDKAW | KDYETKITKI | EKEKKEHAKL | HGMIRTEISG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AEIAEEMEKE | RRFFQLQMCE | YLLKVNEIKV | KKGVDLLQNL | IKYFHAQCNF | FQDGLKAVES |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LKPSIETLST | DLHTIKQAQD | EERRQLIQLR | DILKSALQVE | QKESRRDSQL | RQSTAYSLHQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PQGNKEHGTE | RNGNLYKKSD | GIRKVWQKRK | CSVKNGFLTI | SHGTANRPPA | KLNLLTCQVK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TNPEEKKCFD | LISHDRTYHF | QAEDEQECQI | WMSVLQNSKE | EALNNAFKGD | DNTGENNIVQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ELTKEIISEV | QRMTGNDVCC | DCGAPDPTWL | STNLGILTCI | ECSGIHRELG | VHYSRMQSLT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LDVLGTSELL | LAKNIGNAGF | NEIMECCLPS | EDPVKPNPGS | DMIARKDYIT | AKYMERRYAR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KKHADTAAKL | HSLCEAVKTR | DIFGLLQAYA | DGVDLTEKIP | LANGHEPDET | ALHLAVRSVD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RTSLHIVDFL | VQNSGNLDKQ | TGKGSTALHY | CCLTDNAECL | KLLLRGKASI | EIANESGETP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LDIAKRLKHE | HCEELLTQAL | SGRFNSHVHV | EYEWRLLHED | LDESDDDVDE | KLQPSPNRRE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DRPVSFYQLG | SSQFQSNAVS | LARDTANLTK | DKQRGFGPSI | LQNETYGAIL | SGSPPSSQSI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PPSTTSAPPL | PPRNVGKDPL | TTTPPPPVAK | TSGTLEAMNQ | PSKSSQPGTS | QSKPPPLPPQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PPSRLPQKKP | ASGTDKPTPL | TNKGQPRGPE | ASGPLSNAMA | LQPPAPMPRK | SQATKSKPKR |
| 910 | 920 | 930 | 940 | 950 | |
| VKALYNCVAD | NPDELTFSEG | DVIIVDGEED | QEWWIGHIDG | EPSRKGAFPV | SFVHFIAD |