AiPD: Autoinhibited Protein Database

Q7LBR1

Gene name	CHMP1B (C18orf2)
Protein name	Charged multivesicular body protein 1b
Names	CHMP1.5, Chromatin-modifying protein 1b, CHMP1b, Vacuolar protein sorting-associated protein 46-2, Vps46-2, hVps46-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:57132
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-199 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-199 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

9 structures for Q7LBR1

Entry ID	Method	Resolution	Chain	Position	Source
3EAB	X-ray	250 A	G/H/I/J/K/L	148-197	PDB
3JC1	EM	400 A	Ab/Ad/Af/Ah/Aj/Al/An/Ap/Ar/At/Av/Ax/Az/Bb/Bd/Bf/Bh/Bj/Bl/Bn/Bp/Br/Bt/Bv/Bx/Bz/Cb/Cd/Cf/Ch	4-163	PDB
4TXQ	X-ray	221 A	C/D	176-199	PDB
4TXR	X-ray	100 A	B	176-199	PDB
6E8G	EM	290 A	AA/AB/B/CA/CB/D/EA/EB/F/GA/GB/H/IA/IB/J/KA/KB/L/MA/MB/N/OA/OB/P/QA/QB/R/SA/SB/T	1-199	PDB
6TZ4	EM	320 A	02/A/BA/BB/C/DA/DB/E/FA/FB/G/HA/HB/I/JA/JB/K/LA/LB/M/NA/NB/O/PA/PB/Q/RA/RB/S/TA	1-199	PDB
6TZ5	EM	310 A	AA/AB/B/CA/CB/D/EA/EB/F/GA/GB/H/IA/IB/J/KA/KB/L/MA/MB/N/OA/OB/P/QA/QB/R/SA/T/UA	1-199	PDB
6TZ9	EM	620 A	A/AA/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T/V/W/X/Y/Z	1-199	PDB
AF-Q7LBR1-F1	Predicted				AlphaFoldDB

177 variants for Q7LBR1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA296055540 rs980878125	3	N>D		No	ClinGen TOPMed gnomAD
CA401928491 rs749979805	4	M>L		No	ClinGen ExAC gnomAD
CA8893988 rs749979805	4	M>V		No	ClinGen ExAC gnomAD
rs760445799 CA8893989	6	K>N		No	ClinGen ExAC TOPMed gnomAD
CA8893991 CA296055553 rs376388065	7	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA8893990 rs766642864	7	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1237603863 CA401928520	8	L>V		No	ClinGen TOPMed gnomAD
rs755446778 CA8893992	9	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1360455718 CA401928527	9	F>S		No	ClinGen TOPMed
CA8893993 rs779354092	13	F>I		No	ClinGen ExAC TOPMed gnomAD
CA8893995 rs753226487	14	A>E		No	ClinGen ExAC TOPMed gnomAD
rs1397382348 CA401928559	14	A>T		No	ClinGen gnomAD
CA8893994 rs753226487	14	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1419644692 CA401928570	16	K>E		No	ClinGen TOPMed
CA401928572 rs777911714	16	K>I		No	ClinGen ExAC TOPMed gnomAD
rs1259545003 CA401928575	16	K>N		No	ClinGen TOPMed
rs777911714 CA8893996	16	K>R		No	ClinGen ExAC TOPMed gnomAD
rs747190624 CA8893997	17	E>K		No	ClinGen ExAC gnomAD
CA401928585 rs1188161321	18	L>R		No	ClinGen TOPMed
CA401928590 rs1486157193	19	S>C		No	ClinGen TOPMed
rs771241756 CA8893998	19	S>N		No	ClinGen ExAC TOPMed gnomAD
rs1211964016 CA401928604	21	S>G		No	ClinGen TOPMed
TCGA novel	24	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs756274240	25	C>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs749131244 CA8894001	25	C>W		No	ClinGen ExAC gnomAD
rs1232508978 CA401928635	25	C>Y		No	ClinGen gnomAD
CA8894002 rs768600593	26	D>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	26	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401928647 rs1216651201	27	K>E		No	ClinGen gnomAD
CA401928649 rs1257524312	27	K>T		No	ClinGen gnomAD
CA401928660 rs1567892083	28	E>D		No	ClinGen Ensembl
rs368781162 CA8894004	28	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA401928674 rs1298225930	30	K>N		No	ClinGen TOPMed
CA296055580 rs1053039371	30	K>R		No	ClinGen gnomAD
CA8894007 rs555902532	31	A>P		No	ClinGen 1000Genomes ExAC gnomAD
CA401928680 rs1189119978	31	A>V		No	ClinGen gnomAD
CA296055587 rs779086835	32	E>G		No	ClinGen Ensembl
CA296055605 rs933590082	34	A>V		No	ClinGen Ensembl
rs760223704 CA8894009	35	K>N		No	ClinGen ExAC gnomAD
TCGA novel	36	I>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401928729 rs1374126927	38	K>N		No	ClinGen gnomAD
rs1462108140 CA401928731	39	A>T		No	ClinGen gnomAD
rs1264189524 CA401928736	39	A>V		No	ClinGen gnomAD
CA401928738 rs1383199965	40	I>V		No	ClinGen TOPMed
rs1567892135 CA401928762	43	G>S		No	ClinGen Ensembl
COSM1732947 CA8894012 rs759848382	44	N>S	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA401928769 rs759848382	44	N>T		No	ClinGen ExAC TOPMed gnomAD
CA8894013 rs577828370	45	M>L		No	ClinGen 1000Genomes ExAC gnomAD
CA8894014 rs577828370	45	M>V		No	ClinGen 1000Genomes ExAC gnomAD
rs758967526 CA8894015	48	A>G		No	ClinGen ExAC TOPMed gnomAD
rs758967526 CA401928797	48	A>V		No	ClinGen ExAC TOPMed gnomAD
CA8894016 rs372758165	49	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs372758165 CA296055625	49	R>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1461190700 CA401928812	51	H>D		No	ClinGen TOPMed
CA401928817 rs1371062795	51	H>Q		No	ClinGen TOPMed
rs1294858936 CA401928837	54	N>S		No	ClinGen gnomAD
CA8894019 rs757390250	57	R>G		No	ClinGen ExAC gnomAD
CA296055641 rs1050860397	57	R>L		No	ClinGen TOPMed gnomAD
rs1260068235 CA401928862	58	Q>R		No	ClinGen gnomAD
CA8894021 rs200810906	59	K>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768510996 CA8894022	60	N>K		No	ClinGen ExAC TOPMed gnomAD
CA401928876 rs1193387832	60	N>T		No	ClinGen gnomAD
rs1007245929 CA296055647	61	Q>*		No	ClinGen TOPMed
CA8894023 rs201261255	62	A>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs201261255 CA401928890	62	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA401928896 rs1598428156	63	V>G		No	ClinGen Ensembl
rs1171945498 CA401928906	65	F>I		No	ClinGen gnomAD
CA401928940 rs1253384854	69	S>N		No	ClinGen TOPMed
rs1376895764 CA401928945	70	A>T		No	ClinGen gnomAD
CA8894026 rs772566478	71	R>P		No	ClinGen ExAC gnomAD
TCGA novel	72	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1266710923 CA401928966	73	D>V		No	ClinGen gnomAD
rs760196342 CA8894028	77	A>G		No	ClinGen ExAC gnomAD
CA8894031 rs776210771	78	R>G		No	ClinGen ExAC gnomAD
rs765579637 CA8894032	79	V>G		No	ClinGen ExAC gnomAD
rs1301933761 CA401929010	80	Q>H		No	ClinGen TOPMed
rs993999075 CA296055672	83	V>M		No	ClinGen TOPMed gnomAD
CA8894033 rs775888398	84	T>M		No	ClinGen ExAC gnomAD
CA8894034 rs763343480	86	G>S		No	ClinGen ExAC TOPMed gnomAD
CA401929051 rs372085953	87	K>M		No	ClinGen ESP ExAC gnomAD
rs372085953 CA8894035	87	K>R		No	ClinGen ESP ExAC gnomAD
rs529426406 CA8894036	88	V>M		No	ClinGen 1000Genomes ExAC gnomAD
rs1422738305 CA401929070	90	K>T		No	ClinGen TOPMed gnomAD
CA8894037 rs757310923	92	M>I		No	ClinGen ExAC gnomAD
CA401929092 rs952579364	93	A>G		No	ClinGen TOPMed gnomAD
rs952579364 CA296055698	93	A>V		No	ClinGen TOPMed gnomAD
rs767506161 CA8894038	94	G>V		No	ClinGen ExAC gnomAD
CA401929122 rs1193683005	98	S>W		No	ClinGen gnomAD
CA8894041 rs188014726	102	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA401929149 rs1158139986	102	T>S		No	ClinGen gnomAD
rs747997562 CA8894042	106	M>I		No	ClinGen ExAC gnomAD
rs1291773728 CA401929174	106	M>V		No	ClinGen gnomAD
TCGA novel	109	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8894044 rs777720728	111	I>L		No	ClinGen ExAC gnomAD
rs1378206044 CA401929227	113	A>V		No	ClinGen TOPMed
TCGA novel	114	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1374997744 CA401929241	115	M>I		No	ClinGen gnomAD
rs1567892310 CA401929235	115	M>V		No	ClinGen Ensembl
CA401929249 rs1223367435	116	D>G		No	ClinGen gnomAD
rs770409909 CA8894046	117	K>Q		No	ClinGen ExAC gnomAD
CA401929281 rs776188158	119	E>K		No	ClinGen ExAC gnomAD
CA8894047 rs776188158	119	E>Q		No	ClinGen ExAC gnomAD
rs1436274813 CA401929312	121	Q>H		No	ClinGen TOPMed
CA401929317 rs1273156911	122	F>L		No	ClinGen gnomAD
rs1469289774 CA401929372	127	V>A		No	ClinGen gnomAD
rs1456992668 CA401929386	128	Q>H		No	ClinGen TOPMed gnomAD
rs1485576961 CA401929409	130	Q>L		No	ClinGen TOPMed
rs745503644 CA8894048	131	Q>E		No	ClinGen ExAC gnomAD
rs769482223 CA8894049	131	Q>R		No	ClinGen ExAC gnomAD
CA296055752 rs981760833	132	M>I		No	ClinGen TOPMed gnomAD
CA8894050 rs775796754	132	M>L		No	ClinGen ExAC gnomAD
CA8894051 rs763336856	135	T>A		No	ClinGen ExAC gnomAD
CA8894052 rs764387927	135	T>R		No	ClinGen ExAC gnomAD
rs562746140 CA8894054	138	S>R		No	ClinGen 1000Genomes ExAC gnomAD
CA401929517 rs1328011169	139	T>A		No	ClinGen gnomAD
rs377323477 CA401929546	142	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA8894056 rs377323477	142	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1366864125 CA401929558	143	T>S		No	ClinGen gnomAD
CA8894059 rs754140300	144	T>A		No	ClinGen ExAC gnomAD
CA401929566 rs1407372558	144	T>N		No	ClinGen gnomAD
CA8894060 rs758158028 CA401929617	148	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1340313610 CA401929636	150	D>G		No	ClinGen TOPMed gnomAD
rs551779348 CA8894062 CA8894063	151	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1374586589 CA401929644	151	M>V		No	ClinGen TOPMed
CA401929660 rs1310853841	152	L>R		No	ClinGen TOPMed
CA401929655 rs1435626999	152	L>V		No	ClinGen gnomAD
rs915372954 CA296055794	155	E>D		No	ClinGen TOPMed gnomAD
rs779631894 CA8894067	155	E>G		No	ClinGen ExAC gnomAD
CA401929728 rs1308250707	158	D>E		No	ClinGen gnomAD
TCGA novel	159	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401929744 rs1221080522	160	A>T		No	ClinGen gnomAD
rs1256462232 CA401929758	161	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs748904850 CA8894068	162	L>F		No	ClinGen ExAC gnomAD
rs1598428477 CA401929777	163	D>A		No	ClinGen Ensembl
TCGA novel	163	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401929783 rs1289732853	164	L>F		No	ClinGen TOPMed gnomAD
CA8894070 rs774638280	165	N>I		No	ClinGen ExAC gnomAD
CA8894071 rs774638280	165	N>S		No	ClinGen ExAC gnomAD
CA8894072 rs772746987	166	M>L		No	ClinGen ExAC TOPMed gnomAD
CA401929810 rs1598428505	166	M>R		No	ClinGen Ensembl
CA401929805 rs772746987	166	M>V		No	ClinGen ExAC TOPMed gnomAD
rs773886733 CA8894073	167	E>*		No	ClinGen ExAC
rs760793456 CA296055805	167	E>A		No	ClinGen ExAC
CA8894074 rs760793456	167	E>V		No	ClinGen ExAC
CA401929836 rs1356518735	169	P>S		No	ClinGen gnomAD
CA8894077 rs534105520	171	G>D		No	ClinGen 1000Genomes ExAC gnomAD
CA401929857 rs1312654764	171	G>S		No	ClinGen gnomAD
CA8894079 rs759746944 CA401929874	172	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs763933033 CA8894080	173	T>P		No	ClinGen ExAC gnomAD
CA401929891 rs1262011494	174	G>A		No	ClinGen TOPMed
CA401929887 rs1213528655	174	G>R		No	ClinGen gnomAD
CA8894082 rs757150985	175	S>F		No	ClinGen ExAC gnomAD
CA8894084 rs549187606	176	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs549187606 CA8894085	176	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA401929920 rs1485915465	177	G>D		No	ClinGen gnomAD
CA401929916 rs1262309666	177	G>R		No	ClinGen gnomAD
rs1267206062 CA401929927	178	T>K		No	ClinGen Ensembl
CA401929942 rs1240339384	180	V>M		No	ClinGen TOPMed gnomAD
rs1161280273 CA401929958	181	A>G		No	ClinGen TOPMed gnomAD
rs145696105 CA8894089	181	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs748422423 CA8894090	182	S>L		No	ClinGen ExAC TOPMed gnomAD
rs772587665 CA401929974	183	A>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs772587665 CA401929975	183	A>G		No	ClinGen ExAC TOPMed gnomAD
rs772587665 CA8894091	183	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1376283177 CA401929981	184	E>K		No	ClinGen gnomAD
CA8894093 rs761272544	186	D>A		No	ClinGen ExAC TOPMed gnomAD
CA401930007 rs761272544	186	D>V		No	ClinGen ExAC TOPMed gnomAD
rs1296713863 CA401930028	188	L>V		No	ClinGen gnomAD
CA401930040 rs1270286694	189	S>F		No	ClinGen TOPMed gnomAD
CA8894095 rs771133779	189	S>P		No	ClinGen ExAC gnomAD
TCGA novel	191	R>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759779413 CA8894097	194	R>C		No	ClinGen ExAC gnomAD
rs765415090 CA8894098	195	L>F		No	ClinGen ExAC gnomAD
TCGA novel	196	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA401930112 rs1473358823	196	R>L		No	ClinGen TOPMed
rs1191620408 CA401930125	198	Q>K		No	ClinGen TOPMed
rs761542966 CA8894100	199	V>M		No	ClinGen ExAC gnomAD

No associated diseases with Q7LBR1

5 regional properties for Q7LBR1

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	13 - 268	IPR000719
domain	NAF domain	309 - 370	IPR004041
active_site	Serine/threonine-protein kinase, active site	132 - 144	IPR008271
binding_site	Protein kinase, ATP binding site	19 - 42	IPR017441
domain	NAF/FISL domain	307 - 331	IPR018451

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm, cytosol Endosome Late endosome membrane ; Peripheral membrane protein	Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5 Localized at the periphery of the Fleming body
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

16 GO annotations of cellular component

Name	Definition
amphisome membrane	Any membrane that is part of an amphisome.
autophagosome membrane	The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endosome membrane	The lipid bilayer surrounding an endosome.
ESCRT III complex	A complex with membrane scission activity that plays a major role in many processes where membranes are remodelled - including endosomal transport (vesicle budding), nuclear envelope organisation (membrane closure, mitotic bridge cleavage), and cytokinesis (abscission).
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
kinetochore	A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
kinetochore microtubule	Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
membrane coat	Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.
midbody	A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
multivesicular body	A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
multivesicular body membrane	The lipid bilayer surrounding a multivesicular body.
nuclear pore	A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
MIT domain binding	Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking.
protein domain specific binding	Binding to a specific domain of a protein.

25 GO annotations of biological process

Name	Definition
autophagosome maturation	Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.
autophagy	The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
endosome transport via multivesicular body sorting pathway	The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.
ESCRT III complex disassembly	The disaggregation of an ESCRT III complex into its constituent components.
establishment of protein localization	The directed movement of a protein to a specific location.
late endosome to lysosome transport	The directed movement of substances from late endosome to lysosome.
late endosome to vacuole transport	The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.
membrane fission	A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.
midbody abscission	The process by which the midbody, the cytoplasmic bridge that connects the two prospective daughter cells, is severed at the end of mitotic cytokinesis, resulting in two separate daughter cells.
mitotic metaphase plate congression	The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.
multivesicular body assembly	The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
multivesicular body sorting pathway	A vesicle-mediated transport process in which transmembrane proteins are ubiquitylated to facilitate their entry into luminal vesicles of multivesicular bodies (MVBs); upon subsequent fusion of MVBs with lysosomes or vacuoles, the cargo proteins are degraded.
multivesicular body-lysosome fusion	The organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle.
negative regulation of cell death	Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
nuclear membrane reassembly	The reformation of the nuclear membranes following their breakdown in the context of a normal process.
nucleus organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.
plasma membrane repair	The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
protein transport	The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
regulation of centrosome duplication	Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.
regulation of mitotic spindle assembly	Any process that modulates the frequency, rate or extent of mitotic spindle assembly.
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.
vesicle fusion with vacuole	The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the vacuole.
viral budding from plasma membrane	A viral budding that starts with formation of a membrane curvature in the host plasma membrane.
viral budding via host ESCRT complex	Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5E994	CHMP1B	Charged multivesicular body protein 1b	Bos taurus (Bovine)	PR
Q5ZKX1	CHMP1B	Charged multivesicular body protein 1b	Gallus gallus (Chicken)	PR
O43633	CHMP2A	Charged multivesicular body protein 2a	Homo sapiens (Human)	EV
Q9Y3E7	CHMP3	Charged multivesicular body protein 3	Homo sapiens (Human)	EV
Q9CQD4	Chmp1b2	Charged multivesicular body protein 1b-2	Mus musculus (Mouse)	PR
Q99LU0	Chmp1b1	Charged multivesicular body protein 1b-1	Mus musculus (Mouse)	PR
Q84VG1	CHMP1	ESCRT-related protein CHMP1	Oryza sativa subsp japonica (Rice)	PR
Q8LE58	CHMP1A	ESCRT-related protein CHMP1A	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SSM4	CHMP1B	ESCRT-related protein CHMP1B	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6DF27	chmp1b	Charged multivesicular body protein 1b	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q7ZVB1	chmp1b	Charged multivesicular body protein 1b	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSNMEKHLFN	LKFAAKELSR	SAKKCDKEEK	AEKAKIKKAI	QKGNMEVARI	HAENAIRQKN
70	80	90	100	110	120
QAVNFLRMSA	RVDAVAARVQ	TAVTMGKVTK	SMAGVVKSMD	ATLKTMNLEK	ISALMDKFEH
130	140	150	160	170	180
QFETLDVQTQ	QMEDTMSSTT	TLTTPQNQVD	MLLQEMADEA	GLDLNMELPQ	GQTGSVGTSV
190
ASAEQDELSQ	RLARLRDQV