Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q7G8Y3

Entry ID Method Resolution Chain Position Source
AF-Q7G8Y3-F1 Predicted AlphaFoldDB

No variants for Q7G8Y3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q7G8Y3

No associated diseases with Q7G8Y3

9 regional properties for Q7G8Y3

Type Name Position InterPro Accession
domain SNF2, N-terminal 244 - 511 IPR000330
domain SANT/Myb domain 878 - 927 IPR001005-1
domain SANT/Myb domain 979 - 1041 IPR001005-2
domain Helicase, C-terminal 534 - 687 IPR001650
domain Helicase superfamily 1/2, ATP-binding domain 227 - 419 IPR014001
domain ISWI, HAND domain 795 - 874 IPR015194
domain SLIDE domain 935 - 1045 IPR015195
domain SANT domain 877 - 929 IPR017884
domain Isw1/2, N-terminal 228 - 448 IPR044754

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent activity, acting on DNA Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.
ATP-dependent chromatin remodeler activity An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
nucleosome binding Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

14 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38144 ISW1 ISWI chromatin-remodeling complex ATPase ISW1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3B7N1 CHD1L Chromodomain-helicase-DNA-binding protein 1-like Bos taurus (Bovine) SS
Q24368 Iswi Chromatin-remodeling complex ATPase chain Iswi Drosophila melanogaster (Fruit fly) SS
Q86WJ1 CHD1L Chromodomain-helicase-DNA-binding protein 1-like Homo sapiens (Human) EV
Q9NRZ9 HELLS Lymphoid-specific helicase Homo sapiens (Human) PR
O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Homo sapiens (Human) EV
P28370 SMARCA1 Probable global transcription activator SNF2L1 Homo sapiens (Human) SS
Q60848 Hells Lymphocyte-specific helicase Mus musculus (Mouse) PR
Q9CXF7 Chd1l Chromodomain-helicase-DNA-binding protein 1-like Mus musculus (Mouse) SS
Q91ZW3 Smarca5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 Mus musculus (Mouse) SS
Q6PGB8 Smarca1 Probable global transcription activator SNF2L1 Mus musculus (Mouse) SS
P41877 isw-1 Chromatin-remodeling complex ATPase chain isw-1 Caenorhabditis elegans SS
Q9XFH4 DDM1 ATP-dependent DNA helicase DDM1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RWY3 CHR11 ISWI chromatin-remodeling complex ATPase CHR11 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAKPVKYDEE EEEVSSSGEE EEEQSDGAGS GSGEEEDEEE EEAPAAAAGE AAGGEEEEVD
70 80 90 100 110 120
EEEIEAVTTG AGADEEEEES GAAAAAPGEG DEESQSTEDD EAVVGEDDDA DEAEGGAVVG
130 140 150 160 170 180
KREKARLKEM QKLKKQKIQE ILDTQNAAVD ADMNNKGKGR LKYLLQQTEI FAHFAKGNQS
190 200 210 220 230 240
KEKKPRGRGR HASKMTEEEE DEEYLKEEED ALAGSGGTRL LSQPSCIKGK MRDYQLAGLN
250 260 270 280 290 300
WLIRLYENGI NGILADEMGL GKTLQTISLL GYLHEFRGIT GPHMVVAPKS TLGNWIKEIQ
310 320 330 340 350 360
RFCPILRAVK FLGNPEERNH IRENLLQPGK FDVCVTSFEM AIKEKTTLKR FSWRYIIIDE
370 380 390 400 410 420
AHRIKNENSL LSKTMRIYNT NYRLLITGTP LQNNLHELWS LLNFLLPEIF SSAETFDEWF
430 440 450 460 470 480
QISGENDQQE VVQQLHKVLR PFLLRRLKSD VEKGLPPKKE TILKVGMSQM QKQYYRALLQ
490 500 510 520 530 540
KDLEVINAGG ERKRLLNIAM QLRKCCNHPY LFQGAEPGPP YTTGEHLVEN AGKMVLLDKL
550 560 570 580 590 600
LPKLKDRDSR VLIFSQMTRL LDILEDYLMY RGYQYCRIDG NTGGEDRDAS IEAFNKPGSE
610 620 630 640 650 660
KFVFLLSTRA GGLGINLATA DVVVLYDSDW NPQADLQAQD RAHRIGQKKE VQVFRFCTEY
670 680 690 700 710 720
TIEEKVIERA YKKLALDALV IQQGRLAEQK TVNKDDLLQM VRFGAEMVFS SKDSTITDED
730 740 750 760 770 780
IDRIIAKGEE TTAELDAKMK KFTEDAIKFK MDDTAELYDF DDDKEENKLD FKKLVSDNWI
790 800 810 820 830 840
EPPRRERKRN YSESEYFKQA LRQGAPAKPR EPRIPRMPHL HDFQFFNNQR LNELYEKEVR
850 860 870 880 890 900
YLMQANQKKD TIDGEDEDQL EPLTAEEQEE KEQLLEEGFA TWTRRDFNTF IRACEKYGRN
910 920 930 940 950 960
DIRSIAAEME GKTEEEVQRY AKVFKERYKE LSDYDRIIKN IERGEARISR KDEIMRAIGK
970 980 990 1000 1010 1020
KLDRYKNPWL ELKIQYGQNK GKFYNEECDR FMLCMVHKLG YGNWDELKAA FRMSPLFRFD
1030 1040 1050 1060 1070 1080
WFVKSRTTQE LARRCDTLIR LVEKENQEYD EQERQARKDK RMAKNMTPTK RSALRVSEGE
1090 1100
TTPSNSFKRR RQSLMDDYVG SGRRKRG