Q76M68
SS
Gene name |
Iqsec3 (Sag) |
Protein name |
IQ motif and SEC7 domain-containing protein 3 |
Names |
Potential synaptic guanine nucleotide exchange factor for Arf , SynArfGEF-Po |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:404781 |
EC number |
|
Protein Class |
|
Descriptions
IQ motif and SEC7 domain-containing protein 2 (IQSEC2, also known as BRAG1) is a guanine nucleotide exchange factor (GEF) that is highly enriched in synapses. The autoinhibition of IQSEC2 is mediated by its IQ motif, which binds to apo-CaM and folds together with its Sec7-PH tandem, leading IQSEC2 to adopt a closed conformation in the absence of Ca2+. This autoinhibition is released by calcium binding, which triggers a conformational change that exposes the DH domain for activation.
Autoinhibitory domains (AIDs)
Target domain |
646-983 (Sec7-PH domains) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q76M68
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q76M68-F1 | Predicted | AlphaFoldDB |
No variants for Q76M68
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q76M68 | |||||
No associated diseases with Q76M68
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| GABA-ergic synapse | A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. |
| glycinergic synapse | A synapse that uses glycine as a neurotransmitter. |
| inhibitory synapse | A synapse in which an action potential in the presynaptic cell reduces the probability of an action potential occurring in the postsynaptic cell. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| postsynaptic specialization of symmetric synapse | A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. |
| activation of GTPase activity | Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP. |
| postsynapse organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. |
| regulation of ARF protein signal transduction | Any process that modulates the frequency, rate or extent of ARF protein signal transduction. |
| regulation of small GTPase mediated signal transduction | Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5JU85 | IQSEC2 | IQ motif and SEC7 domain-containing protein 2 | Homo sapiens (Human) | EV |
| Q6DN90 | IQSEC1 | IQ motif and SEC7 domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q9UPP2 | IQSEC3 | IQ motif and SEC7 domain-containing protein 3 | Homo sapiens (Human) | SS |
| Q5DU25 | Iqsec2 | IQ motif and SEC7 domain-containing protein 2 | Mus musculus (Mouse) | SS |
| Q8R0S2 | Iqsec1 | IQ motif and SEC7 domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q3TES0 | Iqsec3 | IQ motif and SEC7 domain-containing protein 3 | Mus musculus (Mouse) | SS |
| Q7TSU1 | Arfgef2 | Brefeldin A-inhibited guanine nucleotide-exchange protein 2 | Rattus norvegicus (Rat) | PR |
| D4A631 | Arfgef1 | Brefeldin A-inhibited guanine nucleotide-exchange protein 1 | Rattus norvegicus (Rat) | PR |
| A0A0G2JUG7 | Iqsec1 | IQ motif and SEC7 domain-containing protein 1 | Rattus norvegicus (Rat) | SS |
| P63035 | Cyth2 | Cytohesin-2 | Rattus norvegicus (Rat) | SS |
| P97696 | Cyth3 | Cytohesin-3 | Rattus norvegicus (Rat) | SS |
| P97694 | Cyth1 | Cytohesin-1 | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESLLENPVR | AVLYLKELTA | IVQNQQSLIH | TQRQRIDELE | RRLDELSAEN | RSLWEHQQLL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QAQPPPGLVP | PPSAPLPAPA | ATAPAATAAQ | EPLQDHGQLI | PATPEPPLQH | HGQLLAQPQP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| APSSRVQTPQ | SPHQHPVAPG | AVADKEKERP | SSCCAAAGAL | LQHASPAALG | KGVLSRRPKN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ETVLHQFCCP | ATDTEQKPAC | SDLASQSDGS | CAQAGGGMED | SVVAAVAAGR | PSAHAPKAQA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PELQQEEERP | GAVGSPRAGP | LRAASPGQQQ | PALATALCSH | TPAASEYELS | LDLKNKQIEM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LEHKYGGHLV | SRRAACTIQT | AFRQYQLSKN | FEKIRNSLLE | SRLPRRISLR | KVRAPTAESL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VAEKALLESC | GLLGLPLGRS | PSLPPTFAGS | LTELEDSFTE | QVQSLAKSID | DALSTWSLKT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| MCSLQESGAY | QLHQALHPSA | GQPGLETEAA | REPDSGPGSG | DEAGSLPQGH | SGTLMMAFRD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VTVQIANQNI | SVSSSTALSV | ANCLGAQTAQ | ATAEPAAVQT | EQGDAATQEV | SEVPASELMD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| PPVEDSEAAE | SGAQSAHEPT | VAEAVVEEAV | ATEAEEEEEG | AGQAGKGAEA | EVGDNSEQLS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SSSASTKSAK | SGSEVSAAAS | KEALQAVILS | LPRYHCENPA | SCRSPTLSTD | TLRKRLYRIG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LNLFNINPDK | GIQFLISRGF | IPDTPIGVAH | FLLQRKGLSR | QMIGEFLGNS | KKQFNRDVLD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| CVVDEMDFSN | MELDEALRKF | QAHIRVQGEA | QKVERLIEAF | SQRYCMCNPE | VVQQFHNPDT |
| 790 | 800 | 810 | 820 | 830 | 840 |
| IFILAFAIIL | LNTDMYSPNI | KPDRKMMLED | FIRNLRGVDD | GADIPRELVV | GIYERIQQKE |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LKSNEDHVTY | VTKVEKSIVG | MKTVLSMPHR | RLVCCSRLFE | VTDVNKLQKQ | AAHQREVFLF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NDLLVILKLC | PKKKSSFTYT | FCKAVGLLGM | RFHLFENEYY | SHGITLATPL | SGSEKKQVLH |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| FCALGSDEMQ | KFVEDLKESI | AEVTELEQIR | IEWELERQQG | TKTLSARSAG | AQGDPQSKQG |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SPTAKREAMA | GEKATESSGE | VSIHNRLQTF | QHSPKLGVER | GAPAPSPPTS | PPPPLPPDPQ |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| PSPLREQPPP | LPLPPPTPPG | TLVQCQQIVK | VIVLDKPCLA | RMEPLLSQAL | SCYASSSSDS |
| 1150 | 1160 | 1170 | 1180 | 1190 | |
| CGSTPLRGPG | SPVKVIHQPP | LPPPPPPYNH | PHQFCPPGSL | LLRRRYSSGS | RSLV |