Q76II0

SS
Gene name
KIT
Protein name
Mast/stem cell growth factor receptor Kit
Names
Species
Callithrix jacchus (White-tufted-ear marmoset)
KEGG Pathway
cjc:100411615
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The c-Kit receptor protein-tyrosine kinase is tightly regulated in normal cells, whereas deregulated c-Kit kinase activity is implicated in the pathogenesis of human cancers. Crystal structures of c-Kit kinase reveal a manner in which the small juxtamembrane domain functions to maintain the kinase in an autoinhibited state. Insertion of this autoinhibitory domain into the cleft between the kinase N- and C-lobes flips the DFG motif into its off state, thereby inducing the activation loop to fold back over from its extended conformation in the active kinase where it binds as a pseudosubstrate at the kinase-active center.

Autoinhibitory domains (AIDs)

540-579 (Juxtamembrane region) SS

Target domain

585-933 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

805-830 (Activation loop from InterPro)

Target domain

585-933 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q76II0

Entry ID Method Resolution Chain Position Source
AF-Q76II0-F1 Predicted AlphaFoldDB

No variants for Q76II0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q76II0

No associated diseases with Q76II0

11 regional properties for Q76II0

Type Name Position InterPro Accession
domain Protein kinase domain 585 - 933 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 585 - 919 IPR001245
conserved_site Tyrosine-protein kinase, receptor class III, conserved site 644 - 657 IPR001824
domain Immunoglobulin subtype 43 - 112 IPR003599-1
domain Immunoglobulin subtype 218 - 308 IPR003599-2
domain Immunoglobulin subtype 320 - 410 IPR003599-3
domain Immunoglobulin-like domain 212 - 308 IPR007110
active_site Tyrosine-protein kinase, active site 784 - 796 IPR008266
domain Immunoglobulin 217 - 304 IPR013151
binding_site Protein kinase, ATP binding site 591 - 619 IPR017441
domain Tyrosine-protein kinase, catalytic domain 585 - 920 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cytokine binding Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
metal ion binding Binding to a metal ion.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

27 GO annotations of biological process

Name Definition
actin cytoskeleton reorganization A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
cell chemotaxis The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
detection of mechanical stimulus involved in sensory perception of sound The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.
digestive tract development The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
embryonic hemopoiesis The stages of blood cell formation that take place within the embryo.
erythrocyte differentiation The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
erythropoietin-mediated signaling pathway The series of molecular signals initiated by erythropoietin (EPO) binding to the erythropoietin receptor (EPO-R) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Fc receptor signaling pathway The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
immature B cell differentiation The process in which a precursor cell type acquires the specialized features of an immature B cell.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
Kit signaling pathway The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.
lamellipodium assembly Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
mast cell degranulation The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.
mast cell differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a mast cell. A mast cell is a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.
megakaryocyte development The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.
melanocyte adhesion The attachment of a melanocyte to another cell via adhesion molecules.
melanocyte differentiation The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.
melanocyte migration The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.
ovarian follicle development The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.
pigmentation The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells.
positive regulation of dendritic cell cytokine production Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production.
positive regulation of mast cell cytokine production Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production.
regulation of cell shape Any process that modulates the surface configuration of a cell.
spermatogenesis The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.
stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
T cell differentiation The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRGARGAWDF LCVLLLLLRV QTGSSQPSVS PEEASPPFID PAKSELIVSV GDEIRLFCND
70 80 90 100 110 120
PGFVKWTFEV LDQMNENKQK EWIMQKAEAT NTGKYTCTNK HGLSSSIYVF VRDPDKLFLV
130 140 150 160 170 180
DRSLYGKEDN DTLVRCPLTD PEVTNYSLKG CQGKPIPKDL RFVPDPKAGI TIKNVKRAYH
190 200 210 220 230 240
RLCLHCSADR KGQSKLSEKF ILKVRPAFKA VPVVSVSKAS YLLREGEEFT VTCTIKDVSS
250 260 270 280 290 300
SVYSSWKKEN SPTKLQEKYN SWHQGDFNYE RQATLTISSV RVNDSGVFMC YASNTFGSAN
310 320 330 340 350 360
VTTTLEVVDK GFINIFPMIN TTVFVNDGEN VDLIVEYEAF PRPEHQQWIY MNRTFTDKWE
370 380 390 400 410 420
DYPKSENESN IRYVSELHLT RLKDTEGGTY TFLVSNSDVS SSIAFTVYVN TKPEILTYDR
430 440 450 460 470 480
LMNGMLQCVA AGFPEPTIDW YFCPGTEQRC SAPVLPVDVQ IQNTSGPPFG KLVVQSSIDS
490 500 510 520 530 540
SAFKHNGTVE CKAYNDVGKT SAYFNFAFKE QIQPHTLFTP LLIGFVVVAG MMCIIVMILT
550 560 570 580 590 600
YKYLQKPMYE VQWKVVEEIN GNNYVYIDPT QLPYDHKWEF PRNRLSFGKT LGAGAFGKVV
610 620 630 640 650 660
EATAYGLIKS DTAMTVAVKM LKPSAHLTER EALMSELKVL SYLGNHMNIV NLLGACTIGG
670 680 690 700 710 720
PTLVITEYCC YGDLLNFLRR KRDSFICSKQ EDHAEAALYK NLLHSKESSC SDSTNEYMDM
730 740 750 760 770 780
KPGVSYVVPT KAEKRRSARV GSYIERDVTP AIMEDDELAL DLEDLLSFSY QVAKGMAFLA
790 800 810 820 830 840
SKNCIHRDLA ARNILLTHGR ITKICDFGLA RDIKNDSNYV VKGNARLPVK WMAPESIFNC
850 860 870 880 890 900
VYTFESDVWS YGIFLWELFS LGSSPYPGMP VDSKFYKMIK EGFRMLSPEH APAEMYDIMK
910 920 930 940 950 960
TCWDADPLKR PTFKQIVQLI EKQISESTNH IYSNLTNCSP SQQKPVVDHS VRINSVGSTA
970
SSSQPLLVRD DV