Q764M6

SS
Gene name
IRF3
Protein name
Interferon regulatory factor 3
Names
IRF-3
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:396656
EC number
Protein Class

Descriptions

IRF3 is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses and is present in an inactive cytoplasmic form. Human IRF3 (Q14653) contains a C-terminal region containing phosphorylation sites. Phosphorylation of the sites converts IRF3 into a constitutively active form. The C-terminal autoinhibitory region intramolecularly interact with N-terminal region overlapping with an atypical transactivation domain.

Autoinhibitory domains (AIDs)

378-419 (C-terminal autoinhibitory region) SS

Target domain

199-378 (IFN association domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q764M6

Entry ID Method Resolution Chain Position Source
AF-Q764M6-F1 Predicted AlphaFoldDB

No variants for Q764M6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q764M6

No associated diseases with Q764M6

6 regional properties for Q764M6

Type Name Position InterPro Accession
domain Dbl homology (DH) domain 1158 - 1342 IPR000219
conserved_site Guanine-nucleotide dissociation stimulator, CDC24, conserved site 1290 - 1315 IPR001331
domain SH3 domain 1494 - 1555 IPR001452
domain Pleckstrin homology domain 1375 - 1488 IPR001849
domain Rho guanine nucleotide exchange factor 5/35, N-terminal 1 - 477 IPR029212
domain Ephexin-like, PH domain 1362 - 1488 IPR047270

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Mitochondrion
  • Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect
  • When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm
  • Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

10 GO annotations of biological process

Name Definition
cellular response to virus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
positive regulation of interferon-alpha production Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.
positive regulation of interferon-beta production Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
positive regulation of type I interferon production Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
regulation of apoptotic process Any process that modulates the occurrence or rate of cell death by apoptotic process.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
TRIF-dependent toll-like receptor signaling pathway The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q4JF28 IRF3 Interferon regulatory factor 3 Bos taurus (Bovine) SS
Q14653 IRF3 Interferon regulatory factor 3 Homo sapiens (Human) EV
P70671 Irf3 Interferon regulatory factor 3 Mus musculus (Mouse) SS
10 20 30 40 50 60
MGTQKPRILP WLISQLNQGQ LEGVAWLDEG HTRFRIPWKH GLRQDAQQED FGIFQAWAEA
70 80 90 100 110 120
SGAYTPGKDK PDLPTWKRNF RSALNRKEAL RLAEDHSKDP HDPHKIYEFV TSGVGDFPEP
130 140 150 160 170 180
DTSLDLSGRY STSDTHEDSL DKLLSGMDLA SDAGPQSLTL ALEQPPQLSL SPSVDAPASC
190 200 210 220 230 240
PNLGVRENPL KQLLANDDEW EFQVTVFYRG CQVFQQTVCS PGGLRLVGSE AEDGTLAGQP
250 260 270 280 290 300
VRLPDPAASL TDRGVADYVR RVLSCLGGGL ALWRAGQWLW AQRLGHCHVY WAMGEELIPD
310 320 330 340 350 360
SGHKPDGEVP KDREGGVFDL GPFIEDLIAF IEGSRRSPRY TLWFCMGQSW PQDEPWVKRL
370 380 390 400 410
VMVKVVPMCL RALVDMARDG GASSLENTVD LHISNSHPLS LTSDQYKACL RDLVEDMDF