Descriptions
Mosquitocidal toxin (MTX) from Bacillus sphaericus is a protein produced during the vegetative growth phase of the bacterium. It exhibits strong toxicity against mosquito larvae, and its ADP-ribosyltransferase activity is essential for its cytotoxicity. The autoinhibition of MTX is mediated by the putative binding and autoinhibiting domain that consists of four ricin-like domains (domain I-IV). Cleavages by trypsin occur after Lys262 and by chymotrypsin after Phe264 increase the enzymatic activity of MTX, thereby relieving the autoinhibition of MTX.
Autoinhibitory domains (AIDs)
Target domain |
30-264 (Enzyme domain) |
Relief mechanism |
Cleavage |
Assay |
Structural analysis, Split protein assay |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q75UG7
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q75UG7-F1 | Predicted | AlphaFoldDB |
No variants for Q75UG7
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q75UG7 | |||||
No associated diseases with Q75UG7
3 regional properties for Q75UG7
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ricin B, lectin domain | 298 - 579 | IPR000772-1 |
| domain | Ricin B, lectin domain | 591 - 720 | IPR000772-2 |
| domain | Ricin B, lectin domain | 729 - 862 | IPR000772-3 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAIKKVLKII | LAIIIIISCQ | LPLNQKTVYA | SPNSPKDNTW | IQAASLTWLM | DMSSLLYQLI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| STRIPSFASP | NGLYMREQTI | DSNTGQIQID | NEHRLLRWDR | RPPNDIFLNG | FIPRVTNQNL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPVEDTHLLN | YLRTNSPSIF | VSTTRARYNN | LGLEITPWTP | HSANNNIIYR | YEIFAPGGID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| INASLSRNHN | PFPNEDEITF | PGGIRPEFIR | STYEYHNGEI | VRIWINPNFI | NPSTLNDVSG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSNISKVFWH | ENHSEGNNMD | SKGFILDLDY | NQDFDMFAPN | GEIPNNNLLN | NNSLNVIQNS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EYQIKNKKDR | NIVVTLDSDY | GGSPVESYKN | FGFENQKWNI | KYDSKKNAYK | IYNRETPTLL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSWNSNSSNG | EQVIRGYTES | GSNNQYWTIE | KNVNGFYKFR | NLSDPSKILD | LKDGNTLNKT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PLVVSSENSS | SSQEWLIEKT | NYQTVKDGTY | QVSSKLNENK | VIEQISTNKI | HIFSNSDKEN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QVWNLIYNPI | LKAYKIKSLK | YPNYSLAWDS | NNTRTIVAAT | GDYNDQYWLI | ERNEDNTYII |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RNYENRKIVL | DLSNGSTTDG | NGLLGFEFHG | GINQRWIIKP | FSFNSIQDGI | YQFMTVINQD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LIADLTTNNY | TIATKTNNYS | SNQKWTVTYN | DKKRAYKIRN | LQHAHLSLAW | DSNHSDKIFG |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ATGDYDDQYW | IPILQTDGSF | IFRNYKNPNK | IFGTNGQPIN | DIPLKAQDVT | GQNNQKWYLR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HLNSSNNFTG | YFNISSKKNF | NKIITMNSNK | TQAVIFDNIG | INNQSWKLKY | NDNKNAYQIH |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ILDNFLYFQG | GHNIVATMQN | VTNDDLRSYW | YVEYNFNKDG | FIIRNAFDTS | YVLDVFQGNF |
| 850 | 860 | ||||
| ANNTPIITYQ | NYLNDNQLWN | FIPSLGVEPR |