Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for Q75LX7

Entry ID Method Resolution Chain Position Source
AF-Q75LX7-F1 Predicted AlphaFoldDB

No variants for Q75LX7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q75LX7

1 associated diseases with Q75LX7

Without disease ID

10 regional properties for Q75LX7

Type Name Position InterPro Accession
repeat Leucine-rich repeat 594 - 652 IPR001611-1
repeat Leucine-rich repeat 664 - 708 IPR001611-2
repeat Leucine-rich repeat 710 - 766 IPR001611-3
repeat Leucine-rich repeat, typical subtype 614 - 637 IPR003591-1
repeat Leucine-rich repeat, typical subtype 639 - 661 IPR003591-2
repeat Leucine-rich repeat, typical subtype 662 - 685 IPR003591-3
repeat Leucine-rich repeat, typical subtype 687 - 706 IPR003591-4
repeat Leucine-rich repeat, typical subtype 708 - 731 IPR003591-5
repeat Leucine-rich repeat, typical subtype 754 - 777 IPR003591-6
domain LRRC8, pannexin-like TM region 1 - 341 IPR021040

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q8MIB7 TGIF2LX Homeobox protein TGIF2LX Pan troglodytes (Chimpanzee) PR
Q8IUE1 TGIF2LX Homeobox protein TGIF2LX Homo sapiens (Human) PR
A8K0S8 MEIS3P2 Putative homeobox protein Meis3-like 2 Homo sapiens (Human) PR
A6NDR6 MEIS3P1 Putative homeobox protein Meis3-like 1 Homo sapiens (Human) PR
Q99687 MEIS3 Homeobox protein Meis3 Homo sapiens (Human) SS
O00470 MEIS1 Homeobox protein Meis1 Homo sapiens (Human) SS
O14770 MEIS2 Homeobox protein Meis2 Homo sapiens (Human) EV
P40425 PBX2 Pre-B-cell leukemia transcription factor 2 Homo sapiens (Human) PR
P40424 PBX1 Pre-B-cell leukemia transcription factor 1 Homo sapiens (Human) PR
Q8IUE0 TGIF2LY Homeobox protein TGIF2LY Homo sapiens (Human) PR
P97368 Meis3 Homeobox protein Meis3 Mus musculus (Mouse) PR
P97367 Meis2 Homeobox protein Meis2 Mus musculus (Mouse) SS
O35984 Pbx2 Pre-B-cell leukemia transcription factor 2 Mus musculus (Mouse) PR
Q75LX9 Os03g0673500 Putative homeobox protein knotted-1-like 5 Oryza sativa subsp japonica (Rice) PR
Q19503 ceh-40 Homeobox protein ceh-40 Caenorhabditis elegans PR
Q1PFD1 BLH11 BEL1-like homeodomain protein 11 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIW1 BLH7 BEL1-like homeodomain protein 7 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEQQLPLLAP DSKAATSSPL CLTLDNPTST STSPAVPSSA PPPAAALEPS RQSFHERETD
70 80 90 100 110 120
AIKAKIMSHP LYPALLRAFI DCQKVGAPPE VVGRLSALAG ELDSRAEDRY LQGQSSDPEL
130 140 150 160 170 180
DEFMETYIDM LVSYRQELTR PIQEADQFFR NMEAQIDSFT LDDNGSEGGN SSEDEQEAGG
190 200 210 220 230 240
GDMASAGLPE ITSPCAEDKE LKSHLLNKYS GYLSSLWREL SKKKKKGKLP RDARQKLLHW
250 260 270 280 290 300
WQLHYRWPYP SELEKAALAE STGLDAKQIN NWFINQRKRH WKPTPPAMEY RSLQPAGAAS
310 320 330
YGGASAGAST SGGGSAVVRG MEGQHFTGGG AYPRGDP