Q71DI3
PR
Gene name |
H3C13 |
Protein name |
Histone H3.2 |
Names |
H3-clustered histone 13, H3-clustered histone 14, H3-clustered histone 15, Histone H3/m, Histone H3/o |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:653604 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
78 structures for Q71DI3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 2IIJ | NMR | - | B | 121-136 | PDB |
| 2X4W | X-ray | 150 A | B | 23-43 | PDB |
| 2X4X | X-ray | 185 A | B/D/F/H | 23-43 | PDB |
| 2X4Y | X-ray | 170 A | B/D/F/H/J/L/N/P | 23-43 | PDB |
| 3AV1 | X-ray | 250 A | A/E | 1-136 | PDB |
| 3DB3 | X-ray | 240 A | B | 7-12 | PDB |
| 3MO8 | X-ray | 169 A | B | 31-42 | PDB |
| 3QO2 | X-ray | 249 A | P/Q/R/S | 2-16 | PDB |
| 3R93 | X-ray | 206 A | E/F/G/H | 2-16 | PDB |
| 4MZF | X-ray | 210 A | A | 2-8 | PDB |
| 4MZG | X-ray | 170 A | A/C | 2-21 | PDB |
| 4MZH | X-ray | 220 A | B | 2-10 | PDB |
| 4OUC | X-ray | 190 A | B | 2-12 | PDB |
| 5B0Y | X-ray | 256 A | A/E | 1-136 | PDB |
| 5B0Z | X-ray | 199 A | A/E | 1-136 | PDB |
| 5B40 | X-ray | 333 A | A/E | 1-136 | PDB |
| 5BO0 | X-ray | 291 A | A | 57-136 | PDB |
| 5CIU | X-ray | 224 A | C/D | 29-43 | PDB |
| 5VAC | X-ray | 195 A | C | 19-37 | PDB |
| 6ACE | X-ray | 198 A | B | 119-126 | PDB |
| 6FML | EM | 434 A | M/Q | 2-136 | PDB |
| 6T79 | EM | 320 A | A/E | 1-136 | PDB |
| 6T7A | EM | 370 A | A/E | 1-136 | PDB |
| 6T7B | EM | 510 A | A/E | 1-136 | PDB |
| 6T7C | EM | 400 A | A/E | 1-136 | PDB |
| 6T7D | EM | 440 A | A/E | 1-136 | PDB |
| 6X59 | EM | 298 A | A/E | 2-136 | PDB |
| 6X5A | EM | 436 A | A/E | 2-136 | PDB |
| 6XJD | EM | 680 A | A/E | 2-136 | PDB |
| 6Y5D | EM | 410 A | A/E/M/Q | 39-136 | PDB |
| 6Y5E | EM | 315 A | A/E | 39-134 | PDB |
| 7BQZ | X-ray | 310 A | B/D/F/H | 2-16 | PDB |
| 7BU9 | X-ray | 350 A | B/D/F/H | 2-16 | PDB |
| 7JO9 | EM | 330 A | A/E | 1-136 | PDB |
| 7JOA | EM | 330 A | A/E | 1-136 | PDB |
| 7JZV | EM | 390 A | P/p | 2-136 | PDB |
| 7PET | EM | 950 A | A/E/K/O/a/e/k/o | 1-136 | PDB |
| 7PEU | EM | 720 A | A/E/K/O/a/e | 1-136 | PDB |
| 7PEV | EM | 600 A | A/E/K/O | 1-136 | PDB |
| 7PEW | EM | 460 A | A/E | 1-136 | PDB |
| 7PEX | EM | 510 A | a/e | 1-136 | PDB |
| 7PEY | EM | 450 A | K/O | 1-136 | PDB |
| 7PEZ | EM | 790 A | k/o | 1-136 | PDB |
| 7PF0 | EM | 1100 A | A/E/K/O/a/e | 1-136 | PDB |
| 7PF2 | EM | 510 A | A/E/K/O | 1-136 | PDB |
| 7PF3 | EM | 400 A | k/o | 1-136 | PDB |
| 7PF4 | EM | 400 A | K/O | 1-136 | PDB |
| 7PF5 | EM | 380 A | a/e | 1-136 | PDB |
| 7PF6 | EM | 400 A | A/E | 1-136 | PDB |
| 7PFA | EM | 970 A | A/E/K/O/a/e | 1-136 | PDB |
| 7PFC | EM | 640 A | A/E/K/O | 1-136 | PDB |
| 7PFD | EM | 440 A | A/E | 1-136 | PDB |
| 7PFE | EM | 440 A | a/e | 1-136 | PDB |
| 7PFF | EM | 430 A | K/O | 1-136 | PDB |
| 7PFT | EM | 980 A | A/E/K/O/a/e | 1-136 | PDB |
| 7PFU | EM | 500 A | A/E/K/O | 1-136 | PDB |
| 7PFV | EM | 440 A | A/E | 1-136 | PDB |
| 7PFW | EM | 520 A | a/e | 1-136 | PDB |
| 7PFX | EM | 430 A | K/O | 1-136 | PDB |
| 7TAN | EM | 300 A | A/E | 2-136 | PDB |
| 7U50 | EM | 340 A | A/E | 2-136 | PDB |
| 7U51 | EM | 310 A | A/E | 2-136 | PDB |
| 7U52 | EM | 340 A | A/E | 2-136 | PDB |
| 7U53 | EM | 400 A | A/E | 2-136 | PDB |
| 7UV9 | EM | 320 A | A/E | 2-136 | PDB |
| 7UVA | X-ray | 198 A | C/F | 30-42 | PDB |
| 7XCR | EM | 257 A | A/E | 38-136 | PDB |
| 7XCT | EM | 272 A | A/E | 38-136 | PDB |
| 7XD0 | EM | 348 A | A/E | 38-136 | PDB |
| 7YRD | EM | 320 A | A/E | 34-136 | PDB |
| 8AAG | EM | 1000 A | A/E | 1-136 | PDB |
| 8ATF | EM | 345 A | M/Q | 2-136 | PDB |
| 8AV6 | EM | 468 A | M/Q | 2-136 | PDB |
| 8GRQ | EM | 387 A | A/E | 38-135 | PDB |
| 8JLB | EM | 236 A | A/E | 2-136 | PDB |
| 8JLD | EM | 248 A | A/E | 2-136 | PDB |
| 8OL1 | EM | 350 A | A/E | 38-135 | PDB |
| AF-Q71DI3-F1 | Predicted | AlphaFoldDB |
168 variants for Q71DI3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA29973950 rs782432282 |
2 | A>T | No |
ClinGen gnomAD |
|
|
CA342249165 rs1490919028 |
3 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA342249166 rs1490919028 |
3 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs1197534607 CA342249162 |
3 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1197534607 CA342249164 |
3 | R>P | No |
ClinGen TOPMed gnomAD |
|
|
CA342249148 COSM3399678 rs1553755015 |
4 | T>S | Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA1070111 rs782443691 |
5 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA1070110 rs781806302 |
5 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA342249122 rs1553755012 |
6 | Q>* | No |
ClinGen gnomAD |
|
|
rs1429145694 CA342249110 |
7 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
CA342249103 rs782549707 |
7 | T>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA1070108 rs782549707 |
7 | T>N | No |
ClinGen ExAC gnomAD |
|
|
CA342249108 rs1429145694 |
7 | T>S | No |
ClinGen TOPMed gnomAD |
|
|
CA1070107 rs587655126 |
8 | A>G | No |
ClinGen 1000Genomes ExAC |
|
|
CA1070105 rs782100924 |
9 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA342249080 rs782100924 |
9 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs1460289026 CA526258899 |
10 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs1553755006 CA342249045 COSM423737 |
11 | S>L | Variant assessed as Somatic; 0.0 impact. urinary_tract breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
CA1070100 rs782381961 |
13 | G>C | No |
ClinGen ExAC gnomAD |
|
|
CA342249029 rs782381961 |
13 | G>S | No |
ClinGen ExAC gnomAD |
|
|
CA1070099 rs782270425 |
14 | G>A | No |
ClinGen ExAC gnomAD |
|
|
rs1553755002 CA342249020 |
14 | G>S | No |
ClinGen gnomAD |
|
|
rs1366321261 CA342248994 |
16 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1366321261 CA342248997 |
16 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA342248989 rs1382261269 |
16 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
COSM3930374 rs782170985 CA1070096 |
17 | P>R | urinary_tract [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA342248960 rs1362002007 |
19 | K>E | No |
ClinGen TOPMed |
|
|
rs782525932 CA1070090 |
19 | K>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1265041360 CA342248932 |
21 | L>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs1553754994 CA342248916 |
23 | T>A | No |
ClinGen gnomAD |
|
|
rs1447650068 CA342248911 |
23 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA1070085 rs782703372 |
25 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA342248883 rs1553754985 |
26 | A>G | No |
ClinGen gnomAD |
|
|
rs782459540 CA342248876 |
27 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782459540 CA1070084 |
27 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782820282 CA342248855 |
28 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs587630029 CA1070082 |
28 | K>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs782119561 CA1070080 |
29 | S>C | No |
ClinGen ExAC gnomAD |
|
|
CA342248840 rs1553754976 |
29 | S>R | No |
ClinGen gnomAD |
|
|
CA342248829 rs1435064824 |
30 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA1070078 rs782724873 |
31 | P>L | No |
ClinGen ExAC |
|
|
rs1553754969 CA342248808 |
32 | A>G | No |
ClinGen gnomAD |
|
|
rs782094182 CA1070077 |
32 | A>P | No |
ClinGen ExAC gnomAD |
|
|
CA342248812 rs782094182 |
32 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs782321169 CA1070075 |
33 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs1553754964 CA342248795 |
33 | T>M | No |
ClinGen gnomAD |
|
|
rs1553754964 CA342248796 |
33 | T>R | No |
ClinGen gnomAD |
|
|
CA1070076 rs782321169 |
33 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA1070073 rs782028060 |
38 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs1553754959 CA342248715 |
39 | P>L | No |
ClinGen gnomAD |
|
|
CA342248694 rs782255373 |
41 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1259077708 CA342248692 |
41 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
CA1070071 rs782255373 |
41 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs113528548 CA29973625 |
42 | Y>C | No |
ClinGen gnomAD |
|
|
rs113528548 CA342248681 |
42 | Y>S | No |
ClinGen gnomAD |
|
|
CA1070070 rs782618771 |
43 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs782312452 CA1070069 |
43 | R>P | No |
ClinGen ExAC gnomAD |
|
|
rs1553754953 CA342248662 |
44 | P>S | No |
ClinGen gnomAD |
|
|
CA342248649 rs1553754951 |
45 | G>D | No |
ClinGen gnomAD |
|
|
CA342248633 rs1462493133 |
47 | V>M | No |
ClinGen TOPMed |
|
|
rs1412789208 CA342248592 |
50 | R>L | No |
ClinGen TOPMed |
|
|
rs1553754948 CA342248588 |
51 | E>Q | No |
ClinGen gnomAD |
|
|
CA1070063 rs782487709 |
52 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs782693435 CA1070062 |
53 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA1070061 rs782693435 |
53 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs200122276 CA29973567 |
53 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
rs781886522 CA1070059 |
54 | R>C | No |
ClinGen ExAC gnomAD |
|
|
rs782807753 CA1070058 |
54 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs781886522 CA1070060 |
54 | R>S | No |
ClinGen ExAC gnomAD |
|
|
rs1553754941 CA342248544 |
55 | Y>C | No |
ClinGen gnomAD |
|
|
CA1070056 COSM895376 rs782001208 |
56 | Q>* | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
| TCGA novel | 57 | K>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs781941031 CA342248476 |
61 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782410284 CA1070052 |
61 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
rs781941031 CA1070053 |
61 | L>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1070048 rs782213478 |
64 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782213478 CA1070049 |
64 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1224131064 CA342248428 |
65 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
CA1070047 rs782619472 |
66 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
CA1070044 rs782663267 |
67 | P>L | No |
ClinGen ExAC |
|
|
rs781801867 CA1070045 |
67 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1559759476 CA342248400 |
68 | F>I | No |
ClinGen Ensembl |
|
|
CA342248394 rs1553754925 |
68 | F>S | No |
ClinGen gnomAD |
|
|
rs1178600921 CA342248379 |
69 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
rs782770271 CA1070040 |
70 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA342248354 rs1553754921 |
71 | L>V | No |
ClinGen gnomAD |
|
|
rs781791863 CA1070038 |
72 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs1553754919 CA342248346 |
72 | V>I | No |
ClinGen gnomAD |
|
|
CA342248334 rs1553754915 |
73 | R>G | No |
ClinGen gnomAD |
|
|
rs782148277 CA1070036 |
73 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA1070034 rs782381109 |
74 | E>* | No |
ClinGen ExAC gnomAD |
|
|
CA1070035 rs782381109 |
74 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs587652244 CA1070033 |
75 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1553754911 CA342248301 |
76 | A>V | No |
ClinGen gnomAD |
|
|
rs782171276 CA1070030 |
77 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA1070029 rs781928587 |
77 | Q>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1070025 rs782518558 |
78 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782290994 CA1070027 |
78 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1355500465 CA342248273 |
79 | F>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1355500465 CA342248272 |
79 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1444761737 CA342248256 |
80 | K>* | No |
ClinGen TOPMed |
|
| rs1553754909 | 80 | K>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1306412030 CA342248250 |
80 | K>M | No |
ClinGen TOPMed |
|
|
rs1405770242 CA342248248 |
80 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs782212332 CA1070024 |
81 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA342248240 rs1553754903 |
81 | T>R | No |
ClinGen gnomAD |
|
|
rs781891248 CA1070021 |
82 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs781875918 CA1070019 |
84 | R>H | No |
ClinGen ExAC TOPMed |
|
|
rs781875918 CA1070018 |
84 | R>L | No |
ClinGen ExAC TOPMed |
|
|
rs782736198 CA1070017 |
85 | F>C | No |
ClinGen ExAC gnomAD |
|
|
CA342248179 rs1277772195 |
86 | Q>H | No |
ClinGen TOPMed |
|
|
CA342248170 rs1553754899 |
87 | S>N | No |
ClinGen gnomAD |
|
|
rs781912457 CA342248162 CA1070015 |
87 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 87 | S>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs587737208 CA1070013 |
88 | S>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs782720234 CA1070014 |
88 | S>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA1070011 rs782366854 |
91 | M>I | No |
ClinGen ExAC gnomAD |
|
|
VAR_059313 rs2664732 CA29973301 |
91 | M>T | No |
ClinGen UniProt Ensembl dbSNP |
|
|
rs1559759355 CA342248101 |
92 | A>V | No |
ClinGen Ensembl |
|
|
rs1553754889 CA342248091 |
93 | L>R | No |
ClinGen gnomAD |
|
|
rs1553754887 CA342248085 |
94 | Q>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1270471381 CA342248070 |
95 | E>Q | No |
ClinGen TOPMed |
|
|
CA1070009 rs781949525 |
97 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA342248008 rs1167168313 |
100 | Y>F | No |
ClinGen TOPMed |
|
|
CA1070007 rs782198130 |
100 | Y>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782566358 CA1070005 |
101 | L>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1553754878 CA342248001 |
102 | V>M | No |
ClinGen gnomAD |
|
| TCGA novel | 103 | G>E | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1305168156 CA342247995 |
103 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA1070000 rs201064709 |
105 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA342247982 rs1571429927 |
105 | F>V | No |
ClinGen Ensembl |
|
|
rs781845279 CA1069999 |
106 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA342247965 rs1274194122 |
107 | D>G | No |
ClinGen TOPMed |
|
|
CA1069997 rs782707194 |
108 | T>M | No |
ClinGen ExAC |
|
|
rs1571429866 CA342247945 |
110 | L>P | No |
ClinGen Ensembl |
|
|
rs782796894 CA1069994 |
111 | C>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA342247926 rs1222798261 |
112 | A>G | No |
ClinGen TOPMed |
|
|
rs377047288 CA1069992 |
112 | A>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA1069990 rs782100571 |
113 | I>T | No |
ClinGen ExAC gnomAD |
|
|
CA1069988 rs782407106 |
114 | H>P | No |
ClinGen ExAC gnomAD |
|
|
CA1069986 rs373018965 |
115 | A>T | No |
ClinGen ESP ExAC |
|
|
CA1069985 rs782390772 |
115 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA1069984 rs782216841 |
116 | K>Q | No |
ClinGen ExAC gnomAD |
|
|
CA342247878 rs1242181199 |
116 | K>R | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
rs782616504 CA1069983 |
117 | R>H | No |
ClinGen ExAC gnomAD |
|
|
COSM308573 CA1069981 rs782193306 |
119 | T>A | biliary_tract Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
CA342247848 rs782193306 |
119 | T>P | No |
ClinGen ExAC gnomAD |
|
|
CA342247828 rs782549284 |
120 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782659915 CA1069980 |
120 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1445568245 CA342247816 |
121 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
CA342247826 rs1187192600 |
121 | M>L | No |
ClinGen TOPMed gnomAD |
|
|
CA342247821 rs1390005019 |
121 | M>T | No |
ClinGen TOPMed |
|
|
CA342247809 rs1165743138 |
122 | P>S | No |
ClinGen TOPMed |
|
|
CA342247800 rs1388765546 |
123 | K>E | No |
ClinGen TOPMed |
|
|
rs587674278 COSM3801709 CA1069978 |
123 | K>N | breast [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA1069977 rs782655535 |
125 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA342247731 rs2664731 |
128 | A>G | No |
ClinGen Ensembl |
|
|
CA1069976 rs782462930 |
128 | A>T | No |
ClinGen ExAC gnomAD |
|
|
VAR_059314 CA29973091 rs2664731 |
128 | A>V | No |
ClinGen UniProt Ensembl dbSNP |
|
|
rs2788822 CA29973076 |
129 | R>S | No |
ClinGen Ensembl |
|
|
CA342247718 COSM3801707 rs1553754855 |
130 | R>C | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
| TCGA novel | 132 | R>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1318402070 CA342247675 |
133 | G>E | No |
ClinGen TOPMed |
|
|
CA342247649 rs1285610295 |
135 | R>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1559759179 CA342247643 |
136 | A>P | No |
ClinGen Ensembl |
|
|
rs782765811 CA342247635 |
137 | A>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs782765811 CA1069971 |
137 | A>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA342247626 rs1227380801 |
137 | A>Y | No |
ClinGen TOPMed |
No associated diseases with Q71DI3
1 regional properties for Q71DI3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Histone H2A/H2B/H3 | 1 - 132 | IPR007125 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular exosome | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleosome | A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| structural constituent of chromatin | The action of a molecule that contributes to the structural integrity of chromatin. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| nucleosome assembly | The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA. |
36 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P68428 | Histone H3.2 | Triticum aestivum (Wheat) | PR | |
| Q5E9F8 | H3-3B | Histone H3.3 | Bos taurus (Bovine) | PR |
| P68432 | Histone H3.1 | Bos taurus (Bovine) | PR | |
| P84227 | Histone H3.2 | Bos taurus (Bovine) | PR | |
| P84247 | H3-X | Histone H3.3 | Gallus gallus (Chicken) | PR |
| P84229 | H3-VIII | Histone H3.2 | Gallus gallus (Chicken) | PR |
| P02299 | His3 | Histone H3 | Drosophila melanogaster (Fruit fly) | PR |
| Q71H73 | Histone H3.3 | Vitis vinifera (Grape) | PR | |
| Q71DI3 | H3C13 | Histone H3.2 | Homo sapiens (Human) | PR |
| P68431 | H3C12 | Histone H3.1 | Homo sapiens (Human) | PR |
| P84243 | H3-3B | Histone H3.3 | Homo sapiens (Human) | PR |
| Q16695 | H3-4 | Histone H3.1t | Homo sapiens (Human) | PR |
| P69246 | H3C4 | Histone H3.2 | Zea mays (Maize) | PR |
| P68433 | H3c11 | Histone H3.1 | Mus musculus (Mouse) | PR |
| P84244 | H3-3b | Histone H3.3 | Mus musculus (Mouse) | PR |
| P84228 | H3c15 | Histone H3.2 | Mus musculus (Mouse) | PR |
| Q71LE2 | H3-3A | Histone H3.3 | Sus scrofa (Pig) | PR |
| P84245 | H3-3b | Histone H3.3 | Rattus norvegicus (Rat) | PR |
| O35799 | Hfe | Hereditary hemochromatosis protein homolog | Rattus norvegicus (Rat) | PR |
| Q6LED0 | Histone H3.1 | Rattus norvegicus (Rat) | PR | |
| Q0JCT1 | H3 | Histone H3.3 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAD9 | H3R-21 | Histone H3.2 | Oryza sativa subsp japonica (Rice) | PR |
| Q27490 | his-70 | Histone H3.3-like type 1 | Caenorhabditis elegans | PR |
| Q10453 | his-71 | Histone H3.3 type 1 | Caenorhabditis elegans | PR |
| Q27532 | his-74 | Histone H3.3-like type 2 | Caenorhabditis elegans | PR |
| P08898 | his-2 | Histone H3 | Caenorhabditis elegans | PR |
| Q9FX60 | At1g13370 | Histone H3-like 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXI7 | MGH3 | Histone H3-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKQ3 | At5g65350 | Histone H3-like 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P59226 | HTR2 | Histone H3.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LR02 | At1g75600 | Histone H3-like 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P59169 | HTR4 | Histone H3.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6P823 | TGas113e22.1 | Histone H3.3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q28D37 | TGas081o10.1 | Histone H3.2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q6PI20 | h3f3a | Histone H3.3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q4QRF4 | zgc:113984; | Histone H3.2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARTKQTARK | STGGKAPRKQ | LATKAARKSA | PATGGVKKPH | RYRPGTVALR | EIRRYQKSTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLIRKLPFQR | LVREIAQDFK | TDLRFQSSAV | MALQEASEAY | LVGLFEDTNL | CAIHAKRVTI |
| 130 | |||||
| MPKDIQLARR | IRGERA |