Q710E8

PR
Gene name
ORC1A
Protein name
Origin of replication complex subunit 1A
Names
AtORC1a, Origin recognition complex subunit 1a
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT4G14700
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-265 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q710E8

Entry ID Method Resolution Chain Position Source
AF-Q710E8-F1 Predicted AlphaFoldDB

194 variants for Q710E8

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_4_8422242_T_G 3 S>A No 1000Genomes
ENSVATH00504666 5 L>P No 1000Genomes
ENSVATH06665541 7 S>A No 1000Genomes
tmp_4_8422266_A_G 11 T>A No 1000Genomes
tmp_4_8422275_T_G 14 S>A No 1000Genomes
ENSVATH06665542 14 S>F No 1000Genomes
tmp_4_8422288_C_A 18 T>N No 1000Genomes
ENSVATH11738232 21 K>N No 1000Genomes
ENSVATH14192944 26 S>* No 1000Genomes
tmp_4_8422317_C_A 28 L>I No 1000Genomes
tmp_4_8422335_T_A 34 S>T No 1000Genomes
ENSVATH02833654 37 P>H No 1000Genomes
ENSVATH11738235 40 T>P No 1000Genomes
tmp_4_8422368_A_G 45 T>A No 1000Genomes
ENSVATH06665544 46 P>S No 1000Genomes
ENSVATH02833656 61 G>E No 1000Genomes
ENSVATH02833656 61 G>V No 1000Genomes
tmp_4_8422429_T_A 65 I>N No 1000Genomes
tmp_4_8422432_A_T 66 D>V No 1000Genomes
ENSVATH02833657 67 L>F No 1000Genomes
ENSVATH02833658 69 G>E No 1000Genomes
ENSVATH02833659 70 K>R No 1000Genomes
ENSVATH00504668 73 V>I No 1000Genomes
tmp_4_8422460_A_T 75 E>D No 1000Genomes
ENSVATH11738236 77 N>K No 1000Genomes
ENSVATH06665549 82 P>A No 1000Genomes
ENSVATH06665550 82 P>R No 1000Genomes
ENSVATH06665553 91 V>I No 1000Genomes
ENSVATH06665554 95 S>L No 1000Genomes
tmp_4_8422518_T_C 95 S>P No 1000Genomes
ENSVATH11738237 103 E>Q No 1000Genomes
ENSVATH06665555 105 S>F No 1000Genomes
tmp_4_8422572_C_T 113 R>* No 1000Genomes
tmp_4_8422597_A_C,G 121 K>R No 1000Genomes
tmp_4_8422597_A_C,G 121 K>T No 1000Genomes
ENSVATH06665556 129 K>N No 1000Genomes
ENSVATH11738275 135 T>A No 1000Genomes
ENSVATH06665559 151 A>P No 1000Genomes
ENSVATH11738278 157 E>D No 1000Genomes
tmp_4_8422704_G_A 157 E>K No 1000Genomes
ENSVATH06665560 161 P>L No 1000Genomes
ENSVATH11738280 166 C>Y No 1000Genomes
ENSVATH14192967 169 C>S No 1000Genomes
tmp_4_8422745_C_G 170 F>L No 1000Genomes
ENSVATH06665561 171 K>R No 1000Genomes
ENSVATH06665562 173 H>D No 1000Genomes
tmp_4_8422755_A_G 174 T>A No 1000Genomes
ENSVATH11738281 176 T>A No 1000Genomes
tmp_4_8422789_T_C 185 L>S No 1000Genomes
ENSVATH06665563 190 L>M No 1000Genomes
ENSVATH02833660 190 L>S No 1000Genomes
ENSVATH11738282 194 K>E No 1000Genomes
ENSVATH06665566 212 V>I No 1000Genomes
tmp_4_8422878_T_C 215 S>P No 1000Genomes
ENSVATH02833663 223 P>S No 1000Genomes
tmp_4_8422933_G_A 233 R>K No 1000Genomes
ENSVATH14192968 234 T>P No 1000Genomes
tmp_4_8422942_A_G 236 K>R No 1000Genomes
tmp_4_8422959_A_G 242 S>G No 1000Genomes
ENSVATH06665570 259 G>D No 1000Genomes
tmp_4_8423038_A_G 268 Y>C No 1000Genomes
ENSVATH00504670 275 V>I No 1000Genomes
tmp_4_8423064_G_A 277 G>R No 1000Genomes
ENSVATH06665571 278 R>I No 1000Genomes
ENSVATH06665571 278 R>T No 1000Genomes
tmp_4_8423073_C_T 280 R>C No 1000Genomes
tmp_4_8423108_T_A 291 N>K No 1000Genomes
tmp_4_8423126_G_T 297 E>D No 1000Genomes
ENSVATH08340362 301 V>F No 1000Genomes
ENSVATH06665576 302 L>V No 1000Genomes
ENSVATH06665577 309 C>S No 1000Genomes
ENSVATH11738306 314 S>* No 1000Genomes
ENSVATH06665580 317 S>I No 1000Genomes
ENSVATH14192969 336 S>R No 1000Genomes
ENSVATH06665583 338 K>R No 1000Genomes
ENSVATH06665585 340 V>E No 1000Genomes
ENSVATH06665584 340 V>L No 1000Genomes
ENSVATH06665586 342 E>G No 1000Genomes
ENSVATH06665587 347 D>E No 1000Genomes
ENSVATH02833668 347 D>G No 1000Genomes
ENSVATH06665589 352 Q>L No 1000Genomes
tmp_4_8423297_G_A 354 W>* No 1000Genomes
tmp_4_8423301_G_T 356 G>C No 1000Genomes
tmp_4_8423314_A_G 360 E>G No 1000Genomes
ENSVATH06665590 362 I>T No 1000Genomes
ENSVATH06665591 364 Y>D No 1000Genomes
tmp_4_8423334_G_C 367 E>Q No 1000Genomes
ENSVATH06665592 369 I>F No 1000Genomes
ENSVATH06665593 369 I>M No 1000Genomes
ENSVATH06665592 369 I>V No 1000Genomes
ENSVATH06665594 372 D>G No 1000Genomes
tmp_4_8423392_G_A 386 G>D No 1000Genomes
ENSVATH14192971 390 S>F No 1000Genomes
tmp_4_8423407_G_T 391 R>L No 1000Genomes
ENSVATH11738308 394 R>C No 1000Genomes
ENSVATH06665595 397 G>R No 1000Genomes
ENSVATH06665597 401 V>M No 1000Genomes
tmp_4_8423439_G_C 402 G>R No 1000Genomes
tmp_4_8423462_T_A 409 H>Q No 1000Genomes
tmp_4_8423487_T_A 418 L>I No 1000Genomes
ENSVATH11738309 422 K>T No 1000Genomes
tmp_4_8423521_C_T 429 T>I No 1000Genomes
tmp_4_8423541_TGTA_T 436 C>* No 1000Genomes
tmp_4_8423554_A_G 440 E>G No 1000Genomes
ENSVATH11738310 455 D>Y No 1000Genomes
ENSVATH11738311 456 Q>* No 1000Genomes
ENSVATH02833672 456 Q>H No 1000Genomes
ENSVATH06665600 457 C>F No 1000Genomes
ENSVATH06665600 457 C>Y No 1000Genomes
tmp_4_8423610_G_A 459 G>S No 1000Genomes
tmp_4_8423621_G_A 462 M>I No 1000Genomes
ENSVATH06665601 464 I>M No 1000Genomes
tmp_4_8423626_T_A 464 I>N No 1000Genomes
ENSVATH06665602 465 H>Y No 1000Genomes
ENSVATH14192973 469 G>D No 1000Genomes
ENSVATH11738312 470 T>P No 1000Genomes
ENSVATH06665603 474 I>N No 1000Genomes
tmp_4_8423688_G_A 485 A>T No 1000Genomes
ENSVATH11738313 485 A>V No 1000Genomes
ENSVATH14192974 506 A>V No 1000Genomes
tmp_4_8423765_C_A 510 N>K No 1000Genomes
tmp_4_8423775_G_A 514 V>I No 1000Genomes
ENSVATH02833676 516 Y>C No 1000Genomes
ENSVATH02833676 516 Y>F No 1000Genomes
ENSVATH06665605 523 R>C No 1000Genomes
tmp_4_8423809_G_A 525 G>D No 1000Genomes
ENSVATH06665607 527 K>N No 1000Genomes
ENSVATH06665606 527 K>T No 1000Genomes
ENSVATH15004522 532 S>F No 1000Genomes
ENSVATH06665608 537 F>S No 1000Genomes
tmp_4_8423859_A_G 542 K>E No 1000Genomes
tmp_4_8423860_A_G 542 K>R No 1000Genomes
tmp_4_8423884_C_T 550 P>L No 1000Genomes
ENSVATH02833677 552 I>L No 1000Genomes
ENSVATH06665610 552 I>M No 1000Genomes
ENSVATH11738314 555 I>T No 1000Genomes
ENSVATH14192976 556 D>N No 1000Genomes
ENSVATH08340370 568 V>L No 1000Genomes
ENSVATH00504674 571 N>K No 1000Genomes
ENSVATH11738395 583 L>F No 1000Genomes
ENSVATH00504675 585 V>A No 1000Genomes
tmp_4_8423988_G_C 585 V>L No 1000Genomes
ENSVATH11738396 601 R>Q No 1000Genomes
tmp_4_8424059_A_G 608 I>M No 1000Genomes
ENSVATH06665612 614 G>S No 1000Genomes
tmp_4_8424082_A_G 616 Y>C No 1000Genomes
ENSVATH06665614 627 T>I No 1000Genomes
ENSVATH14192978 629 L>F No 1000Genomes
ENSVATH14192977 629 L>W No 1000Genomes
ENSVATH00504676 630 E>K No 1000Genomes
tmp_4_8424130_T_C 632 I>T No 1000Genomes
ENSVATH14192979 638 T>A No 1000Genomes
tmp_4_8424156_G_A 641 E>K No 1000Genomes
tmp_4_8424173_A_T 646 K>N No 1000Genomes
tmp_4_8424196_CA_GA,C 654 A>G No 1000Genomes
tmp_4_8424202_G_A 656 R>H No 1000Genomes
ENSVATH02833681 657 A>T No 1000Genomes
tmp_4_8424220_G_A 662 R>K No 1000Genomes
tmp_4_8424223_G_T,A 663 R>H No 1000Genomes
tmp_4_8424223_G_T,A 663 R>L No 1000Genomes
ENSVATH06665617 675 S>I No 1000Genomes
ENSVATH02833682 682 Q>* No 1000Genomes
ENSVATH06665618 692 A>G No 1000Genomes
tmp_4_8424313_T_A 693 I>N No 1000Genomes
ENSVATH06665619 701 H>Y No 1000Genomes
tmp_4_8424345_G_A 704 V>I No 1000Genomes
tmp_4_8424351_A_G 706 K>E No 1000Genomes
ENSVATH00504678 712 S>N No 1000Genomes
tmp_4_8424379_T_A 715 F>Y No 1000Genomes
tmp_4_8424390_A_G 719 M>V No 1000Genomes
ENSVATH06665620 721 H>Y No 1000Genomes
tmp_4_8424415_G_C 727 G>A No 1000Genomes
tmp_4_8424424_A_C 730 E>A No 1000Genomes
tmp_4_8424423_G_A 730 E>K No 1000Genomes
ENSVATH08340375 736 V>I No 1000Genomes
ENSVATH06665624 741 S>L No 1000Genomes
ENSVATH11738397 745 L>* No 1000Genomes
ENSVATH11738398 750 A>T No 1000Genomes
ENSVATH11738399 758 L>P No 1000Genomes
tmp_4_8424520_G_A 762 C>Y No 1000Genomes
tmp_4_8424540_A_C 769 I>L No 1000Genomes
ENSVATH06665625 774 P>T No 1000Genomes
ENSVATH06665626 778 H>Y No 1000Genomes
tmp_4_8424575_G_T 780 L>F No 1000Genomes
ENSVATH06665627 786 N>D No 1000Genomes
tmp_4_8424598_C_G 788 P>R No 1000Genomes
tmp_4_8424622_T_A 796 L>* No 1000Genomes
tmp_4_8424629_C_A 798 D>E No 1000Genomes
tmp_4_8424639_CTTCCATGG_ATTCCATGG,C 802 L>I No 1000Genomes
tmp_4_8424646_G_A 804 W>* No 1000Genomes
tmp_4_8424652_C_G 806 A>G No 1000Genomes
ENSVATH11738400 807 N>S No 1000Genomes
ENSVATH00504679 809 L>F No 1000Genomes
ENSVATH04326403 810 L>Y No 1000Genomes

No associated diseases with Q710E8

1 regional properties for Q710E8

Type Name Position InterPro Accession
conserved_site TATA-box binding protein, conserved site 252 - 301 IPR030491

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nuclear origin of replication recognition complex A multisubunit complex that is located at the replication origins of a chromosome in the nucleus.
origin recognition complex A multisubunit complex that is located at the replication origins of a chromosome.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
chromatin binding Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
DNA replication origin binding Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.
double-stranded methylated DNA binding Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks.
metal ion binding Binding to a metal ion.

4 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
mitotic DNA replication checkpoint signaling A signal transduction process that contributes to a mitotic DNA replication checkpoint.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P54784 ORC1 Origin recognition complex subunit 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q58DC8 ORC1 Origin recognition complex subunit 1 Bos taurus (Bovine) PR
O16810 Orc1 Origin recognition complex subunit 1 Drosophila melanogaster (Fruit fly) EV
Q13415 ORC1 Origin recognition complex subunit 1 Homo sapiens (Human) PR
Q9Z1N2 Orc1 Origin recognition complex subunit 1 Mus musculus (Mouse) PR
Q80Z32 Orc1 Origin recognition complex subunit 1 Rattus norvegicus (Rat) PR
Q9SU24 ORC1B Origin of replication complex subunit 1B Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MASSLSSKAK TFKSPTKTPT KMYRKSYLSP SSTSLTPPQT PETLTPLRRS SRHVSRKINL
70 80 90 100 110 120
GNDPIDLPGK ESVEEINLIR KPRKRTNDIV VAEKSKKKKI DPEVSFSPVS PIRSETKKTK
130 140 150 160 170 180
KKKRVYYNKV EFDETEFEIG DDVYVKRTED ANPDEEEEED PEIEDCQICF KSHTNTIMIE
190 200 210 220 230 240
CDDCLGGFHL NCLKPPLKEV PEGDWICQFC EVKKSGQTLV VVPKPPEGKK LARTMKEKLL
250 260 270 280 290 300
SSDLWAARIE KLWKEVDDGV YWIRARWYMI PEETVLGRQR HNLKRELYLT NDFADIEMEC
310 320 330 340 350 360
VLRHCFVKCP KEFSKASNDG DDVFLCEYEY DVHWGSFKRV AELADGDEDS DQEWNGRKEE
370 380 390 400 410 420
EIDYSDEEIE FDDEESVRGV SKSKRGGANS RKGRFFGLEK VGMKRIPEHV RCHKQSELEK
430 440 450 460 470 480
AKATLLLATR PKSLPCRSKE MEEITAFIKG SISDDQCLGR CMYIHGVPGT GKTISVLSVM
490 500 510 520 530 540
KNLKAEVEAG SVSPYCFVEI NGLKLASPEN IYSVIYEGLS GHRVGWKKAL QSLNERFAEG
550 560 570 580 590 600
KKIGKENEKP CILLIDELDV LVTRNQSVLY NILDWPTKPN SKLVVLGIAN TMDLPEKLLP
610 620 630 640 650 660
RISSRMGIQR LCFGPYNHRQ LQEIISTRLE GINAFEKTAI EFASRKVAAI SGDARRALEI
670 680 690 700 710 720
CRRAAEVADY RLKKSNISAK SQLVIMADVE VAIQEMFQAP HIQVMKSVSK LSRIFLTAMV
730 740 750 760 770 780
HELYKTGMAE TSFDRVATTV SSICLTNGEA FPGWDILLKI GCDLGECRIV LCEPGEKHRL
790 800
QKLQLNFPSD DVAFALKDNK DLPWLANYL