AiPD: Autoinhibited Protein Database

Q70IA8

Gene name	MOB3C (MOBKL2C)
Protein name	MOB kinase activator 3C
Names	Mob1 homolog 2C , Mps one binder kinase activator-like 2C
Species	Homo sapiens (Human)
KEGG Pathway	hsa:148932
EC number
Protein Class

Descriptions

MOB1A is a multifunctional protein involved in key signaling pathways like Hippo and NDR pathway signaling in metazoans and the Mitotic Exit Network in yeast. It regulates protein interactions by binding to upstream kinases MST1 and MST2 and downstream AGC group kinases LATS1, LATS2, NDR1, and NDR2. The autoinhibition of MOB1A occurs when its nonphosphorylated N-terminal extension binds to the core domain, blocking the kinase-binding site. This inhibitory interaction is relieved upon phosphorylation at specific sites (T12 and T35), which induces a conformational change that exposes the kinase-binding surface. Phosphorylation of MOB1A at T12 and T35 is crucial for regulating its interactions with both upstream and downstream kinases. The phosphorylation status dictates the binding affinity of MOB1A, enabling or inhibiting interactions with other proteins. The phosphorylation-dependent conformational changes in MOB1A are essential for the proper functioning of the Hippo signaling pathway, which is critical for cell proliferation and tissue growth regulation.

Autoinhibitory domains (AIDs)

26-40 (N-terminal extension) SS

Target domain	55-216 (MOB1A core domain)
Relief mechanism	PTM
Assay

AID

26-40 (N-terminal extension)

Target domain

55-216 (MOB1A core domain)

Relief mechanism

PTM (Phosphorylation of Thr12 and Thr35)

Assay

Accessory elements

No accessory elements

References

Xiong S et al. (2017) "Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation", Molecular & cellular proteomics : MCP, 16, 1111-1125

Autoinhibited structure

Activated structure

0 structures for Q70IA8

Entry ID	Method	Resolution	Chain	Position	Source
No available structures

273 variants for Q70IA8

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs529251316	2	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	1000Genomes ExAC NCI-TCGA gnomAD
rs1277336810	3	L>M		No	gnomAD
rs1441040164	3	L>P		No	gnomAD
rs1174265171	4	C>Y		No	TOPMed gnomAD
rs768567480	6	K>Q		No	ExAC gnomAD
rs568493531	7	Q>L		No	1000Genomes TOPMed gnomAD
rs568493531	7	Q>R		No	1000Genomes TOPMed gnomAD
rs749258127	8	V>L		No	ExAC TOPMed gnomAD
rs1675506014	9	F>L		No	gnomAD
rs201224467	10	A>P		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1675505882	11	K>R		No	TOPMed
rs1416515112	12	D>E		No	TOPMed gnomAD
rs766445532	14	T>M		No	Ensembl
rs745644252	15	F>S		No	ExAC gnomAD
rs1675505390	16	R>P		No	TOPMed
TCGA novel	16	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs904953441	17	P>L		No	TOPMed gnomAD
rs756939338	18	R>Q		No	ExAC TOPMed
rs1242445973	19	K>M		No	gnomAD
rs777449352	20	R>C		No	ExAC gnomAD
rs777449352	20	R>G		No	ExAC gnomAD
rs1675504997	20	R>L		No	Ensembl
rs777449352	20	R>S		No	ExAC gnomAD
rs1675504940	21	F>S		No	TOPMed
rs1266868825	22	E>D		No	TOPMed gnomAD
rs1026421185	22	E>K		No	Ensembl
rs757789714	23	P>L		No	ExAC TOPMed gnomAD
rs757789714	23	P>Q		No	ExAC TOPMed gnomAD
rs1313672481	23	P>T		No	gnomAD
rs1353937715	24	G>A		No	gnomAD
rs754376722	24	G>C		No	ExAC TOPMed gnomAD
rs754376722	24	G>S		No	ExAC TOPMed gnomAD
rs1311066634	25	T>I		No	TOPMed gnomAD
rs1311066634	25	T>R		No	TOPMed gnomAD
rs1449823871	26	Q>E		No	gnomAD
rs1557916694	26	Q>H		No	TOPMed
rs1381489183	26	Q>P		No	TOPMed gnomAD
rs766793952	27	R>C		No	ExAC gnomAD
rs538105910	27	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed gnomAD
rs756563654	30	L>P		No	ExAC
rs1675503778	31	Y>C		No	TOPMed
rs115135917	31	Y>H		No	1000Genomes ESP ExAC TOPMed gnomAD
rs1675503778	31	Y>S		No	TOPMed
rs767825672	32	K>R		No	ExAC TOPMed gnomAD
rs1351552566	37	S>T		No	Ensembl
rs762041431	38	L>F		No	ExAC TOPMed gnomAD
rs1161974150	39	K>E		No	gnomAD
rs774496217	39	K>R		No	ExAC TOPMed gnomAD
rs762935989	40	S>P		No	ExAC TOPMed gnomAD
rs775553966	40	S>W		No	ExAC gnomAD
rs769596245	41	G>D		No	ExAC gnomAD
rs1570381452	43	D>A		No	Ensembl
rs1675503142	45	R>C		No	Ensembl
COSM3419283 COSM3419284	45	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs776600787	51	P>S		No	ExAC TOPMed gnomAD
rs770800766	52	P>A		No	ExAC gnomAD
rs1476437643	52	P>R		No	TOPMed
rs1312840476 COSM1215329	53	G>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs746675262	54	E>D		No	ExAC TOPMed gnomAD
TCGA novel	54	E>R	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1360463792	55	N>I		No	gnomAD
rs1288853970	57	D>E		No	gnomAD
rs1675502582	57	D>H		No	Ensembl
rs1675502582	57	D>Y		No	Ensembl
rs771683063 COSM4870004 COSM910345	58	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs771683063	58	D>Y		No	ExAC gnomAD
rs1362846676	59	W>*		No	gnomAD
rs1301459575	60	I>V		No	gnomAD
rs371678179	61	A>D		No	ESP ExAC TOPMed gnomAD
rs375302001	61	A>T		No	ESP ExAC TOPMed gnomAD
rs750876270	62	V>G		No	ExAC gnomAD
rs756586971	62	V>M		No	ExAC TOPMed gnomAD
rs756353510	63	H>Y		No	ExAC TOPMed gnomAD
rs1424325915	64	V>G		No	Ensembl
rs757549206	64	V>M		No	ExAC TOPMed gnomAD
rs751844185	65	V>M		No	ExAC TOPMed gnomAD
rs764208170	68	F>C		No	ExAC TOPMed gnomAD
COSM3790094 COSM3790093	68	F>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs763141334	69	N>K		No	ExAC TOPMed gnomAD
rs1675501525	69	N>S		No	Ensembl
rs61753780	69	N>Y		No	Ensembl
rs752687868	70	R>C		No	ExAC TOPMed gnomAD
rs765320718	71	I>V		No	ExAC gnomAD
rs1557916583	72	N>S		No	TOPMed
rs1675501264	72	N>Y		No	Ensembl
rs759569065	74	I>L		No	ExAC gnomAD
rs776654062	74	I>M		No	ExAC TOPMed gnomAD
rs759569065	74	I>V		No	ExAC gnomAD
TCGA novel	76	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1404763879	78	M>R		No	gnomAD
rs1404763879	78	M>T		No	gnomAD
rs112472629	78	M>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs771605084	79	A>P		No	ExAC TOPMed gnomAD
rs771605084	79	A>S		No	ExAC TOPMed gnomAD
rs771605084	79	A>T		No	ExAC TOPMed gnomAD
rs867445391	79	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA TOPMed
rs1460528618	80	E>G		No	gnomAD
COSM4833556 COSM4833557	80	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
COSM4818488 COSM4818489 rs1675499821	80	E>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic TOPMed
rs112622804	81	R>C		No	ExAC TOPMed gnomAD
COSM1343156 rs1169802084 COSM4785935	81	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs1169802084	81	R>P		No	TOPMed gnomAD
rs112622804	81	R>S		No	ExAC TOPMed gnomAD
rs768093778	82	C>R		No	ExAC TOPMed gnomAD
rs1252493969	84	E>G		No	TOPMed
rs757674170	88	P>L		No	ExAC TOPMed gnomAD
rs757674170	88	P>Q		No	ExAC TOPMed gnomAD
rs757674170	88	P>R		No	ExAC TOPMed gnomAD
rs781660781	88	P>T		No	ExAC TOPMed gnomAD
rs1479336368	89	V>I		No	gnomAD
rs377232112	90	M>R		No	ESP ExAC TOPMed gnomAD
rs377232112	90	M>T		No	ESP ExAC TOPMed gnomAD
rs778095678	90	M>V		No	ExAC gnomAD
rs1033804000	92	G>S		No	TOPMed gnomAD
rs765420980	93	G>E		No	ExAC TOPMed gnomAD
rs541497333	94	P>S		No	1000Genomes ExAC TOPMed gnomAD
COSM5564222 COSM5564223 rs766409369	95	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA TOPMed gnomAD
rs766409369	95	R>G		No	ExAC TOPMed gnomAD
rs574352913	95	R>H		No	1000Genomes ExAC
rs766409369	95	R>S		No	ExAC TOPMed gnomAD
rs772855014	96	Y>C		No	ExAC gnomAD
rs141351633	97	E>*		No	ESP ExAC TOPMed gnomAD
rs141351633	97	E>K		No	ESP ExAC TOPMed gnomAD
rs141351633	97	E>Q		No	ESP ExAC TOPMed gnomAD
rs1477237033	98	Y>H		No	gnomAD
rs1006451264	99	R>C		No	TOPMed gnomAD
rs111448646	99	R>H		No	ExAC TOPMed gnomAD
rs111448646	99	R>L		No	ExAC TOPMed gnomAD
rs111448646	99	R>P		No	ExAC TOPMed gnomAD
rs1006451264	99	R>S		No	TOPMed gnomAD
rs777170203	100	W>*		No	ExAC gnomAD
rs748781587	100	W>R		No	ExAC gnomAD
rs1178688455	101	Q>*		No	gnomAD
rs771395935	101	Q>R		No	ExAC TOPMed gnomAD
rs748481466	102	D>E		No	ExAC TOPMed gnomAD
rs1034535136	102	D>Y		No	TOPMed
rs1353431397	103	E>G		No	TOPMed
rs778021599	103	E>K		No	ExAC TOPMed gnomAD
COSM83903 rs1557916438 COSM3805456	104	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed
rs1237108689	104	R>H		No	TOPMed gnomAD
rs1675496989	105	Q>R		No	TOPMed
rs1310335570	106	Y>C		No	gnomAD
rs1310335570	106	Y>S		No	gnomAD
rs755169615	107	R>L		No	ExAC TOPMed gnomAD
rs755169615	107	R>Q		No	ExAC TOPMed gnomAD
rs779275572	107	R>W		No	ExAC TOPMed gnomAD
rs753948020	108	R>W		No	ExAC TOPMed gnomAD
rs2148803946	109	P>A		No	Ensembl
rs1402594280	109	P>L		No	TOPMed gnomAD
rs750312246	110	A>T		No	ExAC gnomAD
rs1243336818	111	K>M		No	Ensembl
rs767217807	112	L>R		No	ExAC gnomAD
rs71638014	113	S>F		No	Ensembl
rs1440931271	113	S>P		No	TOPMed gnomAD
rs1187402837	114	A>G		No	TOPMed gnomAD
rs138258229	114	A>S		No	ESP ExAC TOPMed gnomAD
rs1187402837	114	A>V		No	TOPMed gnomAD
COSM4008600 COSM4008599	115	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs1258929543	116	R>C		No	TOPMed gnomAD
rs763711743	116	R>H		No	ExAC TOPMed gnomAD
rs763711743	116	R>L		No	ExAC TOPMed gnomAD
rs1286922576	117	Y>C		No	TOPMed gnomAD
rs1675494998	117	Y>H		No	TOPMed
rs1675494737	118	M>I		No	gnomAD
rs1557916371	118	M>T		No	Ensembl
rs775011378	118	M>V		No	ExAC gnomAD
rs1314497169	119	A>V		No	TOPMed gnomAD
rs1340967017	121	L>F		No	TOPMed gnomAD
rs1314835828	121	L>H		No	TOPMed gnomAD
rs1340967017	121	L>I		No	TOPMed gnomAD
rs539615481	122	M>I		No	1000Genomes ExAC TOPMed gnomAD
rs1380308825 COSM3400848 COSM3400849	122	M>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs566258784	123	D>G		No	1000Genomes ExAC gnomAD
rs1363126357	126	E>*		No	gnomAD
rs1162098305	126	E>G		No	TOPMed gnomAD
rs1363126357	126	E>K		No	gnomAD
rs1675493948	127	G>A		No	TOPMed
rs1675493998	127	G>R		No	TOPMed gnomAD
rs1675493847	128	L>F		No	TOPMed gnomAD
rs1675493770	129	I>V		No	TOPMed
rs1675493727	130	N>S		No	gnomAD
rs1370696140	131	D>N		No	gnomAD
rs748534010	132	E>K		No	ExAC TOPMed gnomAD
rs779328921	133	E>K		No	ExAC TOPMed gnomAD
rs779328921	133	E>Q		No	ExAC TOPMed gnomAD
rs1570381006	137	T>K		No	Ensembl
rs1570381006	137	T>M		No	Ensembl
rs780307724 COSM4643858 COSM271395	138	R>H	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ExAC NCI-TCGA gnomAD
rs1489911773	138	R>S		No	gnomAD
rs950071042	140	G>A		No	TOPMed gnomAD
rs1210494116	140	G>R		No	gnomAD
rs1675442737	141	V>D		No	TOPMed gnomAD
rs1321151682	141	V>F		No	gnomAD
rs1436773883	142	P>S		No	gnomAD
rs759082566	145	K>E		No	ExAC TOPMed gnomAD
rs1410511798	147	F>Y		No	TOPMed gnomAD
rs1326243033	148	Q>*		No	gnomAD
rs1445463281	149	Q>E		No	gnomAD
rs1557915384	150	V>I		No	Ensembl
rs773652024	151	C>W		No	ExAC TOPMed gnomAD
rs1675442231	152	T>I		No	Ensembl
rs1675442093	153	K>N		No	gnomAD
rs79329978	156	T>P		No	Ensembl
rs145023386	157	R>C		No	1000Genomes ESP ExAC TOPMed gnomAD
rs762128331	157	R>H		No	ExAC TOPMed gnomAD
rs769097454	158	L>I		No	ExAC gnomAD
rs1675441129	159	F>S		No	Ensembl
rs749521623	160	R>*		No	ExAC gnomAD
rs147799654	160	R>P		No	ESP ExAC TOPMed gnomAD
COSM4702808 COSM4702809 rs147799654	160	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic ESP ExAC NCI-TCGA TOPMed gnomAD
rs1458321367	161	V>A		No	TOPMed gnomAD
rs781029830	164	H>L		No	ExAC gnomAD
rs1450271447	168	H>Q		No	TOPMed gnomAD
rs1440429191	169	H>D		No	gnomAD
rs751448989	169	H>L		No	ExAC gnomAD
rs1219625122	170	F>L		No	TOPMed gnomAD
rs1675440451	170	F>Y		No	Ensembl
rs777558044	171	D>H		No	ExAC TOPMed gnomAD
rs777558044	171	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ExAC NCI-TCGA TOPMed gnomAD
rs1675440176	172	S>N		No	TOPMed
rs1675440124	173	I>F		No	gnomAD
rs1675440037	174	L>H		No	Ensembl
rs1675439994	175	S>G		No	Ensembl
rs752414785	176	M>I		No	ExAC TOPMed gnomAD
rs41297853	176	M>V		No	1000Genomes ESP ExAC TOPMed gnomAD
rs149966116	180	A>V		No	ESP ExAC TOPMed gnomAD
COSM4867880 rs1406048385 COSM910342	182	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic NCI-TCGA TOPMed gnomAD
rs762437591	183	N>D		No	ExAC gnomAD
rs1675439079	183	N>S		No	TOPMed
rs774927153	184	T>P		No	ExAC gnomAD
rs769205622	185	C>R		No	ExAC gnomAD
rs1675438885	185	C>Y		No	TOPMed
rs1675438759	186	Y>*		No	TOPMed
rs1471749918	186	Y>H		No	gnomAD
rs1675438661	187	K>E		No	Ensembl
TCGA novel	187	K>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1188220906	187	K>R		No	TOPMed
rs763409816	188	H>D		No	ExAC gnomAD
rs1443990942	189	F>L		No	gnomAD
rs150228237	190	Y>C		No	1000Genomes ExAC gnomAD
rs150228237	190	Y>F		No	1000Genomes ExAC gnomAD
rs1557915303	191	Y>*		No	Ensembl
rs1675438399	191	Y>C		No	Ensembl
rs1675438294	192	F>S		No	Ensembl
rs141966856	193	I>S		No	ESP ExAC TOPMed gnomAD
rs1675438244	193	I>V		No	TOPMed
rs375774135	194	R>C		No	ESP ExAC TOPMed gnomAD
rs146098342	194	R>H		No	ESP ExAC TOPMed gnomAD
rs146098342	194	R>L		No	ESP ExAC TOPMed gnomAD
rs915737918	195	E>K		No	TOPMed gnomAD
rs1285367030	197	S>G		No	gnomAD
rs1450631634	197	S>I		No	gnomAD
rs1433436596	200	D>G		No	TOPMed
rs555090925	202	R>Q		No	1000Genomes ExAC TOPMed gnomAD
rs372064327	202	R>W		No	ESP ExAC TOPMed gnomAD
rs368921116	203	E>*		No	TOPMed gnomAD
rs368921116	203	E>Q		No	TOPMed gnomAD
rs752455940	204	L>P		No	ExAC gnomAD
rs752455940	204	L>R		No	ExAC gnomAD
rs1570379378	204	L>V		No	Ensembl
rs778477314	205	E>G		No	ExAC gnomAD
rs1329675639	208	R>S		No	gnomAD
rs1675428562	210	M>I		No	TOPMed
rs1025826126	210	M>V		No	TOPMed gnomAD
COSM3490334 COSM3490335	212	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA Cosmic
rs185862798	213	R>Q		No	1000Genomes ESP ExAC TOPMed gnomAD
rs200410364	213	R>W	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ESP ExAC NCI-TCGA TOPMed gnomAD
rs537146848	214	I>N		No	1000Genomes ExAC gnomAD
rs765179943	215	C>G		No	TOPMed
rs1246520751	215	C>W		No	TOPMed
rs759007613	216	H>R		No	ExAC gnomAD
rs977032461	217	H>L		No	TOPMed gnomAD
rs149444077	217	H>R		No	ESP ExAC TOPMed gnomAD

No associated diseases with Q70IA8

No regional properties for Q70IA8

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q70IA8

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name	Definition
metal ion binding	Binding to a metal ion.
protein kinase activator activity	Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.

2 GO annotations of biological process

Name	Definition
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

11 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P43563	MOB2	CBK1 kinase activator protein MOB2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
P40484	MOB1	DBF2 kinase activator protein MOB1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
Q86TA1	MOB3B	MOB kinase activator 3B	Homo sapiens (Human)	SS
Q96BX8	MOB3A	MOB kinase activator 3A	Homo sapiens (Human)	SS
Q9H8S9	MOB1A	MOB kinase activator 1A	Homo sapiens (Human)	EV
Q7L9L4	MOB1B	MOB kinase activator 1B	Homo sapiens (Human)	SS
Q8BSU7	Mob3a	MOB kinase activator 3A	Mus musculus (Mouse)	SS
Q8VE04	Mob3b	MOB kinase activator 3B	Mus musculus (Mouse)	SS
Q8BJG4	Mob3c	MOB kinase activator 3C	Mus musculus (Mouse)	SS
Q8GYX0	MOB1B	MOB kinase activator-like 1B	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FHI1	MOB1A	MOB kinase activator-like 1A	Arabidopsis thaliana (Mouse-ear cress)	SS

10	20	30	40	50	60
MALCLKQVFA	KDKTFRPRKR	FEPGTQRFEL	YKKAQASLKS	GLDLRSVVRL	PPGENIDDWI
70	80	90	100	110	120
AVHVVDFFNR	INLIYGTMAE	RCSETSCPVM	AGGPRYEYRW	QDERQYRRPA	KLSAPRYMAL
130	140	150	160	170	180
LMDWIEGLIN	DEEVFPTRVG	VPFPKNFQQV	CTKILTRLFR	VFVHVYIHHF	DSILSMGAEA
190	200	210
HVNTCYKHFY	YFIREFSLVD	QRELEPLREM	TERICH