Q6ZQK5
PR
Gene name |
Acap2 (Centb2, Kiaa0041) |
Protein name |
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 |
Names |
Centaurin-beta-2, Cnt-b2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:78618 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6ZQK5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6ZQK5-F1 | Predicted | AlphaFoldDB |
31 variants for Q6ZQK5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389414977 | 2 | K>E | No | EVA | |
| rs3389402154 | 5 | V>* | No | EVA | |
| rs3389414945 | 5 | V>G | No | EVA | |
| rs3389403754 | 6 | D>E | No | EVA | |
| rs3389414942 | 8 | E>G | No | EVA | |
| rs1135008864 | 28 | V>E | No | EVA | |
| rs3405842737 | 121 | K>* | No | EVA | |
| rs3389415022 | 136 | N>T | No | EVA | |
| rs3389408788 | 141 | N>I | No | EVA | |
| rs3406469311 | 202 | F>C | No | EVA | |
| rs3406810490 | 203 | F>L | No | EVA | |
| rs3406469262 | 203 | F>V | No | EVA | |
| rs3405842713 | 205 | Q>E | No | EVA | |
| rs3389419926 | 217 | M>I | No | EVA | |
| rs3389419849 | 217 | M>V | No | EVA | |
| rs3389391678 | 245 | I>N | No | EVA | |
| rs3389427451 | 322 | E>D | No | EVA | |
| rs3389379259 | 329 | C>* | No | EVA | |
| rs3389327347 | 363 | A>V | No | EVA | |
| rs3406469200 | 415 | C>S | No | EVA | |
| rs3389402163 | 444 | L>V | No | EVA | |
| rs3389403785 | 451 | V>A | No | EVA | |
| rs3389327322 | 474 | V>G | No | EVA | |
| rs3389413608 | 495 | Q>K | No | EVA | |
| rs586959148 | 497 | Q>H | No | EVA | |
| rs3389404884 | 515 | K>N | No | EVA | |
| rs3389359505 | 524 | E>V | No | EVA | |
| rs3389419901 | 550 | V>F | No | EVA | |
| rs3389391583 | 689 | G>D | No | EVA | |
| rs3389413664 | 696 | D>G | No | EVA | |
| rs3389419856 | 759 | K>N | No | EVA |
No associated diseases with Q6ZQK5
5 regional properties for Q6ZQK5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Arf GTPase activating protein | 399 - 520 | IPR001164 |
| domain | Pleckstrin homology domain | 266 - 363 | IPR001849 |
| repeat | Ankyrin repeat | 602 - 697 | IPR002110-1 |
| repeat | Ankyrin repeat | 698 - 727 | IPR002110-2 |
| domain | BAR domain | 5 - 238 | IPR004148 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome membrane | The lipid bilayer surrounding an endosome. |
| ruffle | Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| metal ion binding | Binding to a metal ion. |
| phosphatidylinositol-3,5-bisphosphate binding | Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. |
| small GTPase binding | Binding to a small monomeric GTPase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| actin filament-based process | Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins. |
| cellular response to nerve growth factor stimulus | A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. |
| endocytic recycling | The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. |
15 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A5PK26 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
| O97902 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Bos taurus (Bovine) | SS |
| A1Z7A6 | Asap | ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein | Drosophila melanogaster (Fruit fly) | SS |
| O43150 | ASAP2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | SS |
| Q8TDY4 | ASAP3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Homo sapiens (Human) | SS |
| Q9ULH1 | ASAP1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q15027 | ACAP1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Homo sapiens (Human) | EV |
| Q15057 | ACAP2 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 | Homo sapiens (Human) | PR |
| Q5U464 | Asap3 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 | Mus musculus (Mouse) | SS |
| Q7SIG6 | Asap2 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 | Mus musculus (Mouse) | SS |
| Q9QWY8 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q8K2H4 | Acap1 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 | Mus musculus (Mouse) | SS |
| Q1AAU6 | Asap1 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 | Rattus norvegicus (Rat) | SS |
| Q9SMX5 | AGD4 | ADP-ribosylation factor GTPase-activating protein AGD4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9C6C3 | AGD2 | ADP-ribosylation factor GTPase-activating protein AGD2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKMTVDFEEC | LKDSPRFRAA | LEEVEGDVAE | LELKLDKLVK | LCIAMIDTGK | AFCVANKQFM |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NGIRDLAQYS | SNDAVVETSL | TKFSDSLQEM | INFHTILFDQ | TQRSIKAQLQ | NFVKEDLRKF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDAKKQFEKV | SEEKENALVK | NAQVQRNKQH | EVEEAANILT | ATRKCFRHIA | LDYVLQINVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QSKRRSEILK | SMLSFMYAHL | AFFHQGYDLF | SELGPYMKDL | GAQLDRLVVD | AAKEKREMEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KHSTIQQKDF | SSDDSKLEYN | VDAANGIVME | GYLFKRASNA | FKTWNRRWFS | IQNNQLVYQK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KFKDSPTVVV | EDLRLCTVKH | CEDIERRFCF | EVVSPTKSCM | LQADSEKLRQ | AWIKAVQTSI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ATAYREKGDE | SEKLDKKSSP | STGSLDSGNE | SKEKLLKGES | ALQRVQCIPG | NTSCCDCGLA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DPRWASINLG | ITLCIECSGI | HRSLGVHFSK | VRSLTLDTWE | PELLKLMCEL | GNDVINRVYE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| AKLEKMGVKK | PQPGQRQEKE | AYIRAKYVER | KFVDKYSALL | SPSEQEKRII | SKSCEDQRLS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| HARASVHTPV | KSNDSGIQQC | SEDGRESLPS | TVSANSLYEP | EGERQESSVF | LDSKHLNPGL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| QLYRASYEKN | LPKMAEALAH | GADVNWANSD | ENQATPLIQA | VLGGSLVTCE | FLLQNGANVN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| QRDVQGRGPL | HHATVLGHTG | QVCLFLKRGA | NQHATDEEGK | DPLSIAVEAA | NADIVTLLRL |
| 730 | 740 | 750 | 760 | ||
| ARMNEEMRES | EGLYGQPGDE | TYQDIFRDFS | QMASNNPEKL | NRFQQDSQKF |