Q6ZPL9
PR
Gene name |
Ddx55 (Kiaa1595) |
Protein name |
ATP-dependent RNA helicase DDX55 |
Names |
DEAD box protein 55 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67848 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6ZPL9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6ZPL9-F1 | Predicted | AlphaFoldDB |
23 variants for Q6ZPL9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388782219 | 12 | L>M | No | EVA | |
| rs3388784652 | 21 | L>I | No | EVA | |
| rs3388764149 | 32 | M>I | No | EVA | |
| rs3388764091 | 87 | V>G | No | EVA | |
| rs3388790715 | 88 | I>N | No | EVA | |
| rs3388792931 | 89 | T>I | No | EVA | |
| rs3388778237 | 125 | E>G | No | EVA | |
| rs3388790752 | 156 | L>V | No | EVA | |
| rs3412844621 | 216 | G>* | No | EVA | |
| rs3388774445 | 233 | S>I | No | EVA | |
| rs3388792952 | 235 | T>I | No | EVA | |
| rs260726812 | 291 | L>V | No | EVA | |
| rs3388786865 | 302 | K>N | No | EVA | |
| rs3413151110 | 325 | T>S | No | EVA | |
| rs250593275 | 402 | D>N | No | EVA | |
| rs3388790793 | 411 | A>D | No | EVA | |
| rs3388784624 | 425 | F>L | No | EVA | |
| rs3388792951 | 465 | E>V | No | EVA | |
| rs3388790756 | 469 | K>M | No | EVA | |
| rs3388764177 | 480 | D>Y | No | EVA | |
| rs3388791096 | 481 | T>P | No | EVA | |
| rs33637949 | 482 | D>H | No | EVA | |
| rs229934083 | 572 | E>K | No | EVA |
No associated diseases with Q6ZPL9
6 regional properties for Q6ZPL9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 493 - 681 | IPR001650 |
| domain | B30.2/SPRY domain | 70 - 247 | IPR001870 |
| domain | SPRY domain | 130 - 246 | IPR003877 |
| domain | DEAD/DEAH box helicase domain | 26 - 418 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 21 - 444 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 2 - 30 | IPR014014 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q2NL08 | DDX55 | ATP-dependent RNA helicase DDX55 | Bos taurus (Bovine) | PR |
| Q5ZLN8 | DDX55 | ATP-dependent RNA helicase DDX55 | Gallus gallus (Chicken) | PR |
| P17844 | DDX5 | Probable ATP-dependent RNA helicase DDX5 | Homo sapiens (Human) | PR |
| Q8NHQ9 | DDX55 | ATP-dependent RNA helicase DDX55 | Homo sapiens (Human) | PR |
| Q99MJ9 | Ddx50 | ATP-dependent RNA helicase DDX50 | Mus musculus (Mouse) | PR |
| Q61656 | Ddx5 | Probable ATP-dependent RNA helicase DDX5 | Mus musculus (Mouse) | PR |
| Q501J6 | Ddx17 | Probable ATP-dependent RNA helicase DDX17 | Mus musculus (Mouse) | PR |
| Q8K363 | Ddx18 | ATP-dependent RNA helicase DDX18 | Mus musculus (Mouse) | PR |
| Q4FZF3 | Ddx49 | Probable ATP-dependent RNA helicase DDX49 | Mus musculus (Mouse) | PR |
| Q8K4L0 | Ddx54 | ATP-dependent RNA helicase DDX54 | Mus musculus (Mouse) | PR |
| Q9CWX9 | Ddx47 | Probable ATP-dependent RNA helicase DDX47 | Mus musculus (Mouse) | PR |
| Q9CWT6 | Ddx28 | Probable ATP-dependent RNA helicase DDX28 | Mus musculus (Mouse) | PR |
| Q91VR5 | Ddx1 | ATP-dependent RNA helicase DDX1 | Mus musculus (Mouse) | PR |
| Q9ESV0 | Ddx24 | ATP-dependent RNA helicase DDX24 | Mus musculus (Mouse) | PR |
| P60843 | Eif4a1 | Eukaryotic initiation factor 4A-I | Mus musculus (Mouse) | PR |
| P10630 | Eif4a2 | Eukaryotic initiation factor 4A-II | Mus musculus (Mouse) | PR |
| Q569Z5 | Ddx46 | Probable ATP-dependent RNA helicase DDX46 | Mus musculus (Mouse) | PR |
| Q5QMN3 | Os01g0197200 | DEAD-box ATP-dependent RNA helicase 20 | Oryza sativa subsp japonica (Rice) | PR |
| Q5N7W4 | Os01g0911100 | DEAD-box ATP-dependent RNA helicase 30 | Oryza sativa subsp japonica (Rice) | PR |
| Q0E2Z7 | Os02g0201900 | DEAD-box ATP-dependent RNA helicase 41 | Oryza sativa subsp japonica (Rice) | PR |
| P34640 | ZK512.2 | Probable ATP-dependent RNA helicase DDX55 homolog | Caenorhabditis elegans | PR |
| Q9C718 | RH20 | DEAD-box ATP-dependent RNA helicase 20 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8H136 | RH14 | DEAD-box ATP-dependent RNA helicase 14 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q56X76 | RH39 | DEAD-box ATP-dependent RNA helicase 39 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8W4R3 | RH30 | DEAD-box ATP-dependent RNA helicase 30 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FVV4 | RH55 | DEAD-box ATP-dependent RNA helicase 55 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8JHJ2 | ddx55 | ATP-dependent RNA helicase DDX55 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEHVTEGAWE | SLQVPLHPRV | LGALRELGFP | HMTPVQSATI | PLFMKNKDVA | AEAVTGSGKT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LAFVIPILEI | LLRREEKLKK | NQVGAIVITP | TRELAIQIDE | VLSHFTKHFP | QFSQILWIGG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RNPGEDVERF | KQHGGNIIVA | TPGRLEDMFR | RKAEGLDLAS | CVKSLDVLVL | DEADRLLDMG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FEASINTILE | FLPKQRRTGL | FSATQTQEVE | NLVRAGLRNP | VRISVKEKGV | AASSTQKTPS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RLENHYMICK | ADEKFNQLVH | FLRSRQQEKH | LVFFSTCACV | EYYGKALEAL | LKKVKILCIH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GKMKYKRNKI | FMEFRKLQSG | ILVCTDVMAR | GIDIPEVNWV | LQYDPPSNAS | AFVHRCGRTA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RIGHGGSALV | FLLPMEEAYI | NFLAINQKCP | LQEMSLQRNT | IDLLPKLRAM | ALADRAVFEK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GMKAFVSFVQ | AYAKHECSLI | FRLKDLDFAG | LARGFALLRM | PRMPELRGKQ | FPDFVPVDID |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TDTIPFKDKI | REKQRQKLLE | QKRKERSENE | GRKKFIKNKA | WSKQKAKKER | KKKMNAKRKK |
| 550 | 560 | 570 | 580 | 590 | |
| DEGSDIDDED | MEELLNDTRL | LKKFKKGKIT | EEEFEKGLLT | SAKRTVQLTD | LGVSDLEEDS |