Q6ZPF4

SS
Gene name
Fmnl3 (Frl2, Kiaa2014)
Protein name
Formin-like protein 3
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:22379
EC number
Protein Class

Descriptions

(Annotation from UniProt)
The DAD domain may regulate activation via by an autoinhibitory interaction with the N-terminus. This autoinhibition may be released upon competitive binding of an activated GTPase. The release of DAD may allow the FH2 domain to nucleate and elongate nonbranched actin filaments.

Autoinhibitory domains (AIDs)

986-1018 (DAD domain) SS

Target domain

26-472 (GBD/FH3 domain)

Relief mechanism

Partner binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q6ZPF4

Entry ID Method Resolution Chain Position Source
4EAH X-ray 340 A A/B/C/E 555-954 PDB
AF-Q6ZPF4-F1 Predicted AlphaFoldDB

5 variants for Q6ZPF4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs864300674 330 V>A No Ensembl
rs1133487529 362 T>M No Ensembl
rs234830390 507 A>T No Ensembl
rs864307832 547 A>P No Ensembl
rs46803720 869 V>I No Ensembl

No associated diseases with Q6ZPF4

3 regional properties for Q6ZPF4

Type Name Position InterPro Accession
domain Formin, FH3 domain 281 - 472 IPR010472
domain Formin, GTPase-binding domain 26 - 278 IPR010473
domain Formin, FH2 domain 561 - 995 IPR015425

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane ; Lipid-anchor
  • Enriched in lamellipodia
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
GTPase activating protein binding Binding to a GTPase activating protein.
small GTPase binding Binding to a small monomeric GTPase.

5 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
regulation of cell shape Any process that modulates the surface configuration of a cell.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9VUC6 Frl Formin-like protein Drosophila melanogaster (Fruit fly) EV
O95466 FMNL1 Formin-like protein 1 Homo sapiens (Human) SS
Q96PY5 FMNL2 Formin-like protein 2 Homo sapiens (Human) SS
Q8IVF7 FMNL3 Formin-like protein 3 Homo sapiens (Human) SS
Q9JL26 Fmnl1 Formin-like protein 1 Mus musculus (Mouse) SS
A2APV2 Fmnl2 Formin-like protein 2 Mus musculus (Mouse) SS
10 20 30 40 50 60
MGNLESTDGG PGEPPSVPLL LPPGKTPMPE PCELEERFAL VLSSMNLPPD KARLLRQYDN
70 80 90 100 110 120
EKKWDLICDQ ERFQVKNPPH TYIQKLQSFL DPNVTRKKFR RRVQESTKVL RELEISLRTN
130 140 150 160 170 180
HIGWVREFLN DENKGLDVLV DYLSFAQCSV MFDFEGLESG DDGAFDKLRS WSRSIEDLQP
190 200 210 220 230 240
PNALSAPFTN SLARSARQSV LRYSTLPGRR ALKNSRLVSQ KDDVHVCILC LRAIMNYQYG
250 260 270 280 290 300
FNLVMSHPHA VNEIALSLNN KNPRTKALVL ELLAAVCLVR GGHEIILAAF DNFKEVCKEL
310 320 330 340 350 360
HRFEKLMEYF RNEDSNIDFM VACMQFINIV VHSVEDMNFR VHLQYEFTKL GLEEFLQKSR
370 380 390 400 410 420
HTESEKLQVQ IQAYLDNVFD VGGLLEDAET KNVALEKVEE LEEHVSHLTE KLLDLENENM
430 440 450 460 470 480
MRVAELEKQL LQREKELESI KETYENTSNQ VHTLRRLIKE KEEAFQRRCH LEPSARGLES
490 500 510 520 530 540
MGGEALARVG PTELTEGIPP SDLDLLAPAP PTEETLPLPP PPAPPLPPPP PPLPDKCPPA
550 560 570 580 590 600
PPLPGAAPSV VLTVGLSAIR IKKPIKTKFR LPVFNWTALK PNQINGTVFS ELDDEKILED
610 620 630 640 650 660
LDLDRFEELF KTKAQGPALD LICSKNKTAQ KAASKVTLLE ANRAKNLAIT LRKAGRSAEE
670 680 690 700 710 720
ICRAIHTFDL QTLPVDFVEC LMRFLPTEAE VKLLRQYERE RQPLEELAAE DRFMLLFSKV
730 740 750 760 770 780
ERLTQRMAGM AFLGNFQDNL QMLTPQLNAI IAASASVKSS QKLKQMLEII LALGNYMNSS
790 800 810 820 830 840
KRGAVYGFKL QSLDLLLDTK STDRKMTLLH FIALTVKEKY PELANFWQEL HFVEKAAAVS
850 860 870 880 890 900
LENVLLDVKE LGRGMELIRR ECSIHDNSVL RNFLSTNEGK LDKLQRDAKT AEEAYNAVVR
910 920 930 940 950 960
YFGESPKTTP PSVFFPVFVR FIRSYKEAEQ ENEARKKQEE VMREKQLAQE AKKLDAKTPS
970 980 990 1000 1010 1020
QRNKWQQQEL IAELRRRQAK EHRPVYEGKD GTIEDIITVL KSVPFTARTA KRGSRFFCDA
AHHDESNC