AiPD: Autoinhibited Protein Database

Q6ZNG9

Gene name	KRBA2
Protein name	KRAB-A domain-containing protein 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:124751
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

42-188 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

42-188 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for Q6ZNG9

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q6ZNG9-F1	Predicted				AlphaFoldDB

408 variants for Q6ZNG9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
TCGA novel	2	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1416989253 CA398010069	2	P>L		No	ClinGen gnomAD
CA8376022 rs749042261	4	F>I		No	ClinGen ExAC gnomAD
CA398010011 rs1296328908	5	L>P		No	ClinGen TOPMed
CA398009998 rs1278251313	6	V>L		No	ClinGen TOPMed gnomAD
rs1400313210 CA398009941	9	L>F		No	ClinGen TOPMed
CA398009922 rs1182003048	10	V>F		No	ClinGen gnomAD
rs777751622 CA8376021	11	S>F		No	ClinGen ExAC gnomAD
CA398009901 rs1274046579	11	S>T		No	ClinGen TOPMed
CA398009677 rs1315429164	23	G>A		No	ClinGen gnomAD
CA398009680 rs1315429164	23	G>D		No	ClinGen gnomAD
rs758082730 CA8376014	26	T>I		No	ClinGen ExAC gnomAD
CA8376013 rs541167034	27	I>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA287566615 rs541167034	27	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA8376012 rs765635078	28	W>*		No	ClinGen ExAC gnomAD
rs963842157 CA287566613	28	W>R		No	ClinGen TOPMed
rs1597487367 CA398009553	29	S>P		No	ClinGen Ensembl
rs1401710182 CA398009543	29	S>Y		No	ClinGen gnomAD
rs976246989 CA398009522	31	W>G		No	ClinGen Ensembl
CA287566609 rs976246989	31	W>R		No	ClinGen Ensembl
rs1597487352 CA398009477	32	Q>H		No	ClinGen Ensembl
CA398009471 rs1361063900	33	Q>*		No	ClinGen gnomAD
CA8376010 rs777259592	33	Q>H		No	ClinGen ExAC gnomAD
CA8376011 rs140252285	33	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs1597487321 CA398009421	35	M>K		No	ClinGen Ensembl
rs1489564596 CA398009426	35	M>V		No	ClinGen TOPMed
CA398009380 rs1216890370	36	L>F		No	ClinGen TOPMed
CA398009353 rs1474613429	37	F>L		No	ClinGen gnomAD
rs764510883 CA8376008	37	F>L		No	ClinGen ExAC gnomAD
CA398009265 rs1414958526	41	T>K		No	ClinGen gnomAD
CA8376007 rs147827381	42	A>T		No	ClinGen ESP ExAC gnomAD
CA398009246 rs1246521138	42	A>V		No	ClinGen TOPMed
rs756048695 CA287566585	43	F>L		No	ClinGen gnomAD
CA398009151 rs1263046136	46	M>K		No	ClinGen gnomAD
CA398009096 rs1567698767	48	K>R		No	ClinGen Ensembl
rs1567698756 CA398009088	49	D>N		No	ClinGen Ensembl
CA8376005 rs113942862	50	W>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA398009041 rs113942862	50	W>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8376006 rs113942862	50	W>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	52	Y>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA287566557 rs867941963	53	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1334284087 CA398008947	55	G>D		No	ClinGen gnomAD
CA8376003 rs759886367	57	Q>P		No	ClinGen ExAC gnomAD
CA8376002 rs773129544	60	C>F		No	ClinGen ExAC gnomAD
rs1382038213 CA398008769	61	Y>C		No	ClinGen TOPMed
rs769779807 CA8376001	61	Y>H		No	ClinGen ExAC gnomAD
CA398008626 rs1326197642	65	M>I		No	ClinGen gnomAD
rs1156694200 CA398008642	65	M>V		No	ClinGen gnomAD
rs1460641884 CA398008580	67	D>G		No	ClinGen gnomAD
rs112398711 CA8375998	68	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs200754656 CA287566530	69	Y>C		No	ClinGen gnomAD
rs758027784 CA8375996	72	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8375995 rs758027784	72	T>R		No	ClinGen ExAC TOPMed gnomAD
rs779247981 CA8375993	73	V>G		No	ClinGen ExAC gnomAD
rs1209418508 CA398006606	80	Q>E		No	ClinGen TOPMed
CA287566109 rs867693389	81	L>P		No	ClinGen Ensembl
CA8375981 rs768603708	81	L>V		No	ClinGen ExAC gnomAD
TCGA novel	82	S>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1174730947 CA398006506	83	M>I		No	ClinGen gnomAD
CA8375978 rs779606236	84	M>I		No	ClinGen ExAC TOPMed gnomAD
CA8375979 rs746973070	84	M>R		No	ClinGen ExAC gnomAD
CA398006454 rs1193403460	85	P>L		No	ClinGen TOPMed
rs771639419 CA8375977	85	P>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	87	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398006412 rs1430550229	87	R>I		No	ClinGen TOPMed
rs1438489688 CA398006382	88	A>P		No	ClinGen gnomAD
CA398006283 rs1597486478	92	P>T		No	ClinGen Ensembl
rs74532943 CA8375976	93	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1194119252 CA398006228	94	G>R		No	ClinGen gnomAD
rs936121292 CA287566084	95	V>F		No	ClinGen Ensembl
TCGA novel	96	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1375994133 CA398006122	98	A>E		No	ClinGen TOPMed
CA398006131 rs1432768022	98	A>T		No	ClinGen TOPMed
CA398006114 rs1375994133	98	A>V		No	ClinGen TOPMed
rs577200043 CA8375974	99	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs778039881 CA8375972	105	I>V		No	ClinGen ExAC gnomAD
rs374998111 CA398005899	106	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA398005884 rs1214837928	107	N>T		No	ClinGen TOPMed
rs200210515 CA8375970	108	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768141366 CA8375969	110	E>*		No	ClinGen ExAC gnomAD
rs1309993804 CA398005773	113	L>P		No	ClinGen TOPMed
rs751708706 CA8375967	114	M>T		No	ClinGen ExAC TOPMed gnomAD
rs1486295017 CA398005748	115	S>G		No	ClinGen TOPMed
CA398005734 rs1243848826	115	S>R		No	ClinGen gnomAD
rs776460471 CA8375962	120	V>A		No	ClinGen ExAC gnomAD
rs1448514125 CA398005650	121	E>G		No	ClinGen gnomAD
rs1344326954 CA398005615	123	K>N		No	ClinGen TOPMed gnomAD
rs914975150 CA287566056	124	S>G		No	ClinGen TOPMed
CA8375961 rs760660430	126	N>K		No	ClinGen ExAC TOPMed gnomAD
rs775342859 CA8375959	128	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1430997998 CA398005553	129	V>G		No	ClinGen TOPMed
rs745334661 CA8375958	130	F>C		No	ClinGen ExAC gnomAD
CA8375957 rs745334661	130	F>S		No	ClinGen ExAC gnomAD
rs773883944 CA8375956	131	S>F		No	ClinGen ExAC
TCGA novel	131	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8375954 rs770541325	134	K>N		No	ClinGen ExAC TOPMed gnomAD
CA398005439 rs1316138309	137	Q>R		No	ClinGen gnomAD
rs1179824207 CA398005407	139	I>T		No	ClinGen gnomAD
rs1444149603 CA398005387	141	E>K		No	ClinGen TOPMed gnomAD
rs1444149603 CA398005385	141	E>Q		No	ClinGen TOPMed gnomAD
CA287566044 rs756070294	145	A>G		No	ClinGen TOPMed gnomAD
CA398005323 rs1442399976	145	A>P		No	ClinGen TOPMed
rs1287953178 CA398005309	146	K>E		No	ClinGen gnomAD
CA398005286 rs1224095992	147	E>A		No	ClinGen gnomAD
CA287566035 rs972780717	149	G>R		No	ClinGen Ensembl
CA398005208 rs1246367194	152	S>*		No	ClinGen gnomAD
rs548731615 CA8375951	154	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs145231451 CA8375950	154	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1414770468 CA398005158	156	Y>S		No	ClinGen gnomAD
rs529177884 CA8375949	157	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8375948 rs781744763	157	R>H		No	ClinGen ExAC TOPMed gnomAD
rs150010343 CA8375947	158	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs139656920 CA8375946	158	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200814100 CA8375945	159	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA398005128 rs1418599934	161	K>Q		No	ClinGen gnomAD
rs77907170 CA287566002	163	D>Y		No	ClinGen Ensembl
rs758637309 CA398005067	164	V>L		No	ClinGen ExAC TOPMed gnomAD
rs758637309 CA8375944	164	V>M		No	ClinGen ExAC TOPMed gnomAD
CA8375942 rs750681169	166	S>F		No	ClinGen ExAC TOPMed gnomAD
rs760332172 CA398004979 CA8375940	167	V>L		No	ClinGen ExAC gnomAD
CA398004936 rs1175470462	168	Q>R		No	ClinGen TOPMed
rs775287841 CA8375939	169	G>S		No	ClinGen ExAC gnomAD
CA398004869 rs1211222996	171	E>Q		No	ClinGen gnomAD
rs767404324 CA8375938	174	I>T		No	ClinGen ExAC gnomAD
rs759510949 CA8375937	177	T>I		No	ClinGen ExAC gnomAD
rs1240783854 CA398004669	178	H>Q		No	ClinGen TOPMed gnomAD
rs1354176898 CA398004675	178	H>R		No	ClinGen gnomAD
rs773828886 CA8375936	178	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1488933840 CA398004632	180	E>G		No	ClinGen gnomAD
rs1291654610 CA8375932	181	R>C		No	ClinGen TOPMed gnomAD
CA8375931 rs748834423	181	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1291654610 CA8375933	181	R>S		No	ClinGen TOPMed gnomAD
rs202118881 CA8375930	183	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs769507265 CA8375929	183	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA8375927 rs781717920	185	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA8375928 rs748418470	185	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs532592586 CA8375924	186	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
CA8375925 rs375843572	186	Y>C		No	ClinGen ESP ExAC gnomAD
rs755516124 CA398004462	186	Y>D		No	ClinGen ExAC TOPMed gnomAD
rs755516124 CA8375926	186	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs758347451 CA8375923	188	V>I		No	ClinGen ExAC gnomAD
CA8375922 rs750532025	189	H>R		No	ClinGen ExAC TOPMed gnomAD
CA8375920 rs757532574	193	L>F		No	ClinGen ExAC gnomAD
rs765330482 CA8375921	193	L>W		No	ClinGen ExAC gnomAD
rs752459776 CA8375919	194	F>S		No	ClinGen ExAC gnomAD
rs1597485967 CA398004174	196	I>V		No	ClinGen Ensembl
CA398004141 rs1319311056	197	L>R		No	ClinGen gnomAD
CA8375918 rs767349566	198	H>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	199	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs183150950 CA8375917	201	H>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751430907 CA8375916	202	L>P		No	ClinGen ExAC gnomAD
rs140199749 CA8375914	204	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs766351086 CA8375915	204	I>V		No	ClinGen ExAC TOPMed gnomAD
rs772806988 CA8375913	206	H>R		No	ClinGen ExAC TOPMed gnomAD
rs769297130 CA8375912	207	G>A		No	ClinGen ExAC
TCGA novel	207	G>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA398003871 rs866574986	207	G>R		No	ClinGen TOPMed gnomAD
CA287565912 rs866574986	207	G>S		No	ClinGen TOPMed gnomAD
rs1356312555 CA398003840	208	G>E		No	ClinGen gnomAD
CA8375911 rs761603524	208	G>R		No	ClinGen ExAC gnomAD
CA398003820 rs777118150	209	R>G		No	ClinGen ExAC TOPMed gnomAD
rs141572082 CA8375909	209	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777118150 CA8375910	209	R>W		No	ClinGen ExAC TOPMed gnomAD
CA398003797 rs1597485898	210	T>A		No	ClinGen Ensembl
CA398003769 rs1417293498	211	R>C		No	ClinGen gnomAD
CA8375908 rs146158158	211	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8375907 rs141614560	212	M>K	Variant assessed as Somatic; 0.0001386 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA398003753 rs1454508143	212	M>V		No	ClinGen gnomAD
CA398003685 rs1191322315	213	L>P		No	ClinGen gnomAD
CA398003628 rs1481342772	215	E>D		No	ClinGen gnomAD
rs1385656829 CA398003650	215	E>K		No	ClinGen Ensembl
rs372624800 CA8375903	218	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1273085675 CA398003482	220	Y>C		No	ClinGen gnomAD
rs754118331 CA8375901	221	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1443613523 CA398003454	221	G>R		No	ClinGen TOPMed
rs1597485824 CA398003401	223	V>I		No	ClinGen Ensembl
CA398003371 rs1416925821	224	T>A		No	ClinGen gnomAD
CA287565883 rs1051101261	227	V>G		No	ClinGen TOPMed
rs754709657 CA8375899	228	I>N		No	ClinGen ExAC TOPMed gnomAD
CA398003218 rs754709657	228	I>S		No	ClinGen ExAC TOPMed gnomAD
rs754709657 CA398003222	228	I>T		No	ClinGen ExAC TOPMed gnomAD
CA398003211 rs1478331725	229	V>I		No	ClinGen TOPMed gnomAD
rs1441550071 CA398003160	230	L>F		No	ClinGen TOPMed gnomAD
CA398003157 rs1597485778	231	Y>H		No	ClinGen Ensembl
rs1194105921 CA398003123	232	L>V		No	ClinGen TOPMed
CA398003099 rs1314575467	233	T>N		No	ClinGen gnomAD
CA398003061 rs1268829699	235	C>G		No	ClinGen TOPMed gnomAD
rs764856131 CA8375894	235	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs763201056 CA287565860	236	K>N		No	ClinGen TOPMed
rs761548690 CA8375893	237	Q>*		No	ClinGen ExAC gnomAD
CA398002962 rs1197824297	237	Q>H		No	ClinGen TOPMed gnomAD
CA8375891 rs768439968	239	H>Q		No	ClinGen ExAC gnomAD
CA8375892 rs776359776	239	H>Y		No	ClinGen ExAC gnomAD
CA398002877 rs1250252413	240	Q>*		No	ClinGen gnomAD
CA398002849 rs1213592655	241	K>Q		No	ClinGen gnomAD
rs761074372 CA8375890	243	P>S		No	ClinGen ExAC TOPMed gnomAD
CA287565843 rs902426363	245	P>S		No	ClinGen TOPMed
rs201158245 CA8375889	246	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs772428238 CA398002651	247	R>K		No	ClinGen ExAC gnomAD
CA8375888 rs772428238	247	R>T		No	ClinGen ExAC gnomAD
rs1307907887 CA398002638	248	G>D		No	ClinGen gnomAD
rs1474240197 CA398002645	248	G>R		No	ClinGen TOPMed
rs778845341 CA8375886	254	M>L		No	ClinGen ExAC TOPMed gnomAD
CA287565820 rs778845341	254	M>V		No	ClinGen ExAC TOPMed gnomAD
CA8375885 rs750795064	257	K>E		No	ClinGen ExAC TOPMed gnomAD
CA8375884 rs749382995	258	D>E		No	ClinGen ExAC gnomAD
rs375748384 CA8375883	259	I>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA398002378 rs1416822284	260	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1188017684 CA398002324	262	T>A		No	ClinGen gnomAD
CA287565809 rs921205943	263	C>Y		No	ClinGen Ensembl
CA398002273 rs1475842780	264	Q>*		No	ClinGen gnomAD
CA398002243 rs1257419071	265	V>A		No	ClinGen TOPMed gnomAD
CA398002244 rs1257419071	265	V>G		No	ClinGen TOPMed gnomAD
CA8375882 rs756358359	266	E>K		No	ClinGen ExAC
rs751278391 CA8375881	269	D>G		No	ClinGen ExAC gnomAD
CA8375880 rs779945991	270	M>L		No	ClinGen ExAC gnomAD
rs367917105 CA287565800	271	Q>*		No	ClinGen ESP TOPMed gnomAD
CA287565798 rs990940847	271	Q>P		No	ClinGen TOPMed
CA8375879 rs758251408	273	S>G		No	ClinGen ExAC gnomAD
rs750438696 CA8375878	273	S>I		No	ClinGen ExAC TOPMed gnomAD
rs147982380 CA8375877	273	S>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8375875 rs151266248	275	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA398002018 rs151266248	275	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA398001995 rs1354801908	276	G>R		No	ClinGen gnomAD
CA398001950 rs1310411929	277	E>D		No	ClinGen gnomAD
rs981790559 CA287565772	278	F>L		No	ClinGen TOPMed
rs758288730 CA287565770	279	K>E		No	ClinGen Ensembl
CA398001909 rs1362348085	279	K>R		No	ClinGen gnomAD
rs111373953 CA287565766	280	F>S		No	ClinGen Ensembl
rs1486623464 CA398001809	283	Y>D		No	ClinGen TOPMed
CA8375872 rs760446051	284	Y>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1396180462 CA398001710	286	D>N		No	ClinGen TOPMed gnomAD
rs143478082 CA8375871	288	S>L		No	ClinGen ESP ExAC gnomAD
CA287565755 rs950390219	290	K>M		No	ClinGen TOPMed
rs149282797 CA8375870	290	K>N		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	290	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs988888282 CA287565754	292	I>T		No	ClinGen TOPMed
TCGA novel	292	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs956149002 CA287565751	295	R>Q		No	ClinGen TOPMed gnomAD
CA8375869 rs376563729	295	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs774862673 CA8375868	296	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA398001358 rs1186266649	299	T>I		No	ClinGen gnomAD
rs771450923 CA8375867	301	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs78738842 CA8375866	302	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs773319655 CA398001277	305	V>L		No	ClinGen ExAC gnomAD
rs773319655 CA8375865	305	V>M		No	ClinGen ExAC gnomAD
rs1229454413 CA398001263	306	V>F		No	ClinGen gnomAD
CA398001255 rs1000225855	307	S>G	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA398001247 rs1320455530	307	S>R		No	ClinGen TOPMed
CA287565736 rs1000225855	307	S>R		No	ClinGen gnomAD
rs202097875 CA398001245	308	V>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA8375863 rs202097875	308	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA398001223 rs1326085061	311	D>G		No	ClinGen gnomAD
rs748458086 CA8375862	313	F>L		No	ClinGen ExAC gnomAD
rs1387892948 CA398001197	315	I>F		No	ClinGen gnomAD
CA398001198 rs1387892948	315	I>V		No	ClinGen gnomAD
rs758141650 CA8375860	317	G>D		No	ClinGen ExAC gnomAD
CA398001174 rs1440199724	318	T>I		No	ClinGen TOPMed
rs1017120283 CA287565723	319	P>T		No	ClinGen TOPMed
CA8375857 rs200739857	328	V>I	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA287565711 rs1037194460	329	E>Q		No	ClinGen Ensembl
CA287565705 rs888219013	331	T>I		No	ClinGen Ensembl
rs1206680589 CA398001077	333	Q>E		No	ClinGen TOPMed
rs753371224 CA287565701	333	Q>H		No	ClinGen ExAC gnomAD
CA398001068 rs1479669949	334	V>A		No	ClinGen TOPMed gnomAD
CA8375854 rs763746973	334	V>F		No	ClinGen ExAC gnomAD
CA8375853 rs755817432	335	V>I		No	ClinGen ExAC TOPMed gnomAD
rs752461446 CA8375852	336	H>R		No	ClinGen ExAC gnomAD
rs1191166427 CA398001060	336	H>Y		No	ClinGen TOPMed
TCGA novel	337	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1480956567 CA398001054	337	E>K		No	ClinGen gnomAD
rs767081244 CA8375851	338	L>F		No	ClinGen ExAC gnomAD
CA398001046 rs767081244	338	L>I		No	ClinGen ExAC gnomAD
rs759895729 CA8375850	339	N>H		No	ClinGen ExAC gnomAD
CA8375849 rs142255132	339	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs902542000 CA287565681	340	E>G		No	ClinGen TOPMed gnomAD
CA287565676 rs932340403	341	L>F		No	ClinGen Ensembl
CA398001020 rs1328969956	342	W>R		No	ClinGen gnomAD
rs545744148 CA287565673	342	W>S		No	ClinGen Ensembl
CA287565665 rs112847423	344	D>G		No	ClinGen Ensembl
CA8375847 rs763497325	344	D>N		No	ClinGen ExAC gnomAD
CA287565668 rs763497325	344	D>Y		No	ClinGen ExAC gnomAD
CA8375846 rs773264231	346	K>N		No	ClinGen ExAC gnomAD
rs771665356 CA8375845	347	I>T		No	ClinGen ExAC TOPMed gnomAD
rs976706665 CA287565645	348	V>I		No	ClinGen TOPMed gnomAD
CA398000985 rs976706665	348	V>L		No	ClinGen TOPMed gnomAD
rs943987709 CA287565642	349	S>F		No	ClinGen TOPMed
CA8375844 rs748177181	350	G>D		No	ClinGen ExAC gnomAD
rs1567696925 CA398000975	350	G>S		No	ClinGen Ensembl
rs1597485163 CA398000948	352	Y>S		No	ClinGen Ensembl
rs1597485160 CA398000928	353	H>P		No	ClinGen Ensembl
CA287565632 rs750193657	359	G>C		No	ClinGen Ensembl
rs1385892506 CA398000809	359	G>V		No	ClinGen TOPMed
TCGA novel	360	S>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1597485128 CA398000784	361	L>R		No	ClinGen Ensembl
CA8375842 rs768786477	365	S>N		No	ClinGen ExAC TOPMed gnomAD
rs745637619 CA8375841	366	R>C		No	ClinGen ExAC TOPMed gnomAD
rs759136505 CA8375840	366	R>H		No	ClinGen ExAC TOPMed gnomAD
rs1419680337 CA398000684	367	D>G		No	ClinGen gnomAD
rs1249772120 CA398000592	370	N>H		No	ClinGen gnomAD
rs147631824 CA8375838	371	M>T		No	ClinGen ESP ExAC TOPMed
CA8375839 rs770970522	371	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1313924020 CA398000511	372	I>M		No	ClinGen gnomAD
rs777417222 CA8375837	372	I>V		No	ClinGen ExAC TOPMed gnomAD
CA398000500 rs1261129600	373	S>C		No	ClinGen TOPMed
CA398000492 rs1280833762	373	S>N		No	ClinGen gnomAD
rs1597485057 CA398000474	374	T>P		No	ClinGen Ensembl
rs752170419 CA8375836 CA8375835	375	W>C		No	ClinGen ExAC TOPMed gnomAD
rs537566827 CA8375834	377	Q>*		No	ClinGen 1000Genomes ExAC gnomAD
rs1390340148 CA398000384	377	Q>R		No	ClinGen gnomAD
rs1280871855 CA398000341	379	N>K		No	ClinGen gnomAD
rs1373943076 CA398000349	379	N>S		No	ClinGen TOPMed gnomAD
CA8375833 rs774047599	380	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs1597485008 CA398000289	382	C>*		No	ClinGen Ensembl
CA8375832 rs573376561	382	C>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8375831 rs371945971	386	K>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1250367743 CA398000192	388	L>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8375829 rs368681596	389	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs140909751 CA8375828	389	R>Q		No	ClinGen ESP ExAC gnomAD
rs1364787249 CA398000151	390	F>L		No	ClinGen TOPMed
CA398000118 rs1414248701	391	M>T		No	ClinGen TOPMed gnomAD
rs374292457 CA8375827	392	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1160474335 CA398000043	393	M>I		No	ClinGen gnomAD
rs201810530 CA8375826	394	V>M		No	ClinGen ExAC TOPMed gnomAD
CA287565576 rs1023603571	396	N>K		No	ClinGen Ensembl
rs1461979221 CA397999960	396	N>S		No	ClinGen TOPMed
rs928929295 CA287565571	397	Q>E		No	ClinGen TOPMed gnomAD
rs1014499135 CA287565569	398	A>G		No	ClinGen gnomAD
rs768894255 CA397999845	399	F>L		No	ClinGen ExAC TOPMed gnomAD
CA397999823 rs1307418040	400	D>G		No	ClinGen TOPMed
rs760858667 CA8375824	400	D>N		No	ClinGen ExAC TOPMed gnomAD
CA8375823 rs774276819	401	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8375821 rs749100434	405	Q>R		No	ClinGen ExAC gnomAD
CA397999616 rs777796649	407	P>S		No	ClinGen ExAC TOPMed gnomAD
rs777796649 CA8375820	407	P>T		No	ClinGen ExAC TOPMed gnomAD
CA397999589 rs1349472621	408	F>S		No	ClinGen gnomAD
CA8375819 rs151038855	409	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA397999564 rs1234586797	410	A>T		No	ClinGen gnomAD
CA8375818 rs747663095	411	M>V		No	ClinGen ExAC TOPMed gnomAD
CA8375816 rs754643990	414	Y>C		No	ClinGen ExAC TOPMed gnomAD
CA8375817 rs780614838	414	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA397999269 rs1320669838	421	Y>H		No	ClinGen gnomAD
CA8375815 rs751277260	422	S>C		No	ClinGen ExAC gnomAD
CA397999165 rs1485511425	423	S>L		No	ClinGen TOPMed
rs758699863 CA8375813	424	N>D		No	ClinGen ExAC gnomAD
rs142866034 CA8375812	424	N>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA8375811 rs139649633	426	P>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA287565534 rs201056616	427	R>P		No	ClinGen ExAC TOPMed
rs201056616 CA8375809	427	R>Q		No	ClinGen ExAC TOPMed
rs146840169 CA8375810	427	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1471698994 CA397998988	428	E>D		No	ClinGen gnomAD
CA8375808 rs764138898	430	V>M		No	ClinGen ExAC gnomAD
rs1179319137 CA397998917	431	A>G		No	ClinGen gnomAD
rs775788058 CA8375806	432	T>N		No	ClinGen ExAC gnomAD
rs1446676966 CA397998866	434	Q>*		No	ClinGen Ensembl
CA8375805 rs370752	435	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs370752 CA8375804 VAR_051087	435	T>M		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA397998775 rs73975831	436	E>D		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1274376853 CA397998752	437	E>V		No	ClinGen TOPMed gnomAD
rs372971807 CA8375801	438	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA397998720 rs1272358287	439	L>P		No	ClinGen gnomAD
rs1364754388 CA397998628	443	E>D		No	ClinGen gnomAD
rs1431919153 CA397998646	443	E>Q		No	ClinGen gnomAD
rs776197626 CA8375800	445	Q>R		No	ClinGen ExAC gnomAD
rs1443231077 CA397998547	447	E>*		No	ClinGen TOPMed gnomAD
TCGA novel	450	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767980792 CA8375799	451	W>*		No	ClinGen ExAC TOPMed gnomAD
rs767980792 CA397998443	451	W>C		No	ClinGen ExAC TOPMed gnomAD
rs1275903383 CA397998431	452	I>N		No	ClinGen TOPMed
rs746533236 CA8375798	452	I>V		No	ClinGen ExAC TOPMed gnomAD
CA8375797 rs113460836	454	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758080918 CA8375796	454	Q>P		No	ClinGen ExAC gnomAD
CA397998351 rs1209130155	456	E>*		No	ClinGen TOPMed
rs139030411 CA8375795	457	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA8375794 rs779199209	458	A>P		No	ClinGen ExAC gnomAD
rs1483690297 CA397998301	458	A>V		No	ClinGen TOPMed
CA397998284 rs757773499	459	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1387942331 CA397998296	459	E>Q		No	ClinGen gnomAD
CA8375792 rs754370952	460	I>T		No	ClinGen ExAC gnomAD
CA8375791 rs764667550	462	A>P		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	464	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA397998204 rs1430318768	464	R>T		No	ClinGen TOPMed
CA8375790 rs150731532	465	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA8375789 rs752848441	466	D>Y	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA287565486 rs1002023600	467	M>I		No	ClinGen TOPMed
CA8375788 rs767815732	467	M>T		No	ClinGen ExAC TOPMed gnomAD
CA8375787 rs759884250	468	D>H		No	ClinGen ExAC gnomAD
CA397998069 rs1295702184	469	D>E		No	ClinGen gnomAD
CA8375785 rs550164818	469	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA397998012 rs1398168362 CA397998011	471	M>I		No	ClinGen gnomAD
CA397998028 rs1429584727	471	M>L		No	ClinGen TOPMed
CA8375784 rs761669861	471	M>T		No	ClinGen ExAC gnomAD
CA287565472 rs796357980	472	D>G		No	ClinGen gnomAD
CA8375783 rs776371749	472	D>Y		No	ClinGen ExAC gnomAD
TCGA novel	475	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369239851 CA8375778	477	A>V		No	ClinGen ESP ExAC gnomAD
CA397997788 rs1428895953	481	S>R		No	ClinGen TOPMed gnomAD
rs138757521 CA8375777	482	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs138757521 CA287565457	482	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA397997710 rs1454495155	484	Q>H		No	ClinGen gnomAD
rs1282923745 CA397997730	484	Q>K		No	ClinGen TOPMed
rs1424016531 CA397997689	485	G>E		No	ClinGen gnomAD
CA8375775 rs745581478	488	G>A		No	ClinGen ExAC gnomAD
rs941706912 CA287565449	488	G>S		No	ClinGen TOPMed gnomAD
CA397997638 rs745581478	488	G>V		No	ClinGen ExAC gnomAD
rs748078189 CA8375774	489	L>F		No	ClinGen ExAC TOPMed gnomAD
CA287565444 rs748078189	489	L>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	490	L>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with Q6ZNG9

2 regional properties for Q6ZNG9

Type	Name	Position	InterPro Accession
domain	Integrase, catalytic core	247 - 415	IPR001584
domain	Krueppel-associated box	42 - 75	IPR001909

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

No GO annotations of cellular component

Name	Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name	Definition
nucleic acid binding	Binding to a nucleic acid.

2 GO annotations of biological process

Name	Definition
DNA integration	The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
regulation of DNA-templated transcription	Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

12 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
A4FUB7	GIN1	Gypsy retrotransposon integrase-like protein 1	Bos taurus (Bovine)	PR
Q9P2P1	NYNRIN	Protein NYNRIN	Homo sapiens (Human)	PR
Q9UN19	DAPP1	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide	Homo sapiens (Human)	PR
Q6R2W3	ZBED9	SCAN domain-containing protein 3	Homo sapiens (Human)	PR
P0CF97	FAM200B	Protein FAM200B	Homo sapiens (Human)	PR
Q9QXT1	Dapp1	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide	Mus musculus (Mouse)	PR
Q94KB1	MLO14	MLO-like protein 14	Arabidopsis thaliana (Mouse-ear cress)	PR
O80580	MLO15	MLO-like protein 15	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SMP1	XTH11	Probable xyloglucan endotransglucosylase/hydrolase protein 11	Arabidopsis thaliana (Mouse-ear cress)	PR
O49621	MLO1	MLO-like protein 1	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FK75	At5g45670	GDSL esterase/lipase At5g45670	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FI00	MLO11	MLO-like protein 11	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MPSFLVPSLV	SSPVLLKLLF	SPGPKTIWSL	WQQPMLFQEA	TAFENMTKDW	NYLEGSQKDC
70	80	90	100	110	120
YRDTMLDSYE	NTVPQGSFLQ	LSMMPQRAGN	DPPGVSNASE	MEMEISNMRE	KFLMSVTKLV
130	140	150	160	170	180
ESKSYNSKVF	SKEKYFQTIK	EVKEAKEKGK	KSSRDYRRAA	KYDVISVQGT	EKLIEATHGE
190	200	210	220	230	240
RDRIRYYVHK	EELFDILHDT	HLSIGHGGRT	RMLKELQGKY	GNVTKEVIVL	YLTLCKQCHQ
250	260	270	280	290	300
KNPVPKRGLA	PKPMTFKDID	STCQVEILDM	QSSADGEFKF	ILYYQDHSTK	FIILRPLRTK
310	320	330	340	350	360
QAHEVVSVLL	DIFTILGTPS	VLDSDSGVEF	TNQVVHELNE	LWPDLKIVSG	KYHPGQSQGS
370	380	390	400	410	420
LEGASRDVKN	MISTWMQSNH	SCHWAKGLRF	MQMVRNQAFD	VSLQQSPFEA	MFGYKAKFGL
430	440	450	460	470	480
YSSNLPRETV	ATLQTEEELE	IAEEQLENSL	WIRQEERAEI	GADRSDMDDD	MDPTPEASEP
490
STSQGTSGLL	CW