AiPD: Autoinhibited Protein Database

Q6ZMU5

Gene name	TRIM72
Protein name	Tripartite motif-containing protein 72
Names	Mitsugumin-53, Mg53
Species	Homo sapiens (Human)
KEGG Pathway	hsa:493829
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

269-345 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

269-345 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for Q6ZMU5

Entry ID	Method	Resolution	Chain	Position	Source
3KB5	X-ray	150 A	A	278-470	PDB
7XT2	X-ray	300 A	A/B	1-477	PDB
7Y4S	EM	350 A	A/B	1-477	PDB
AF-Q6ZMU5-F1	Predicted				AlphaFoldDB

477 variants for Q6ZMU5

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1428902806 CA395692770	3	A>T		No	ClinGen TOPMed gnomAD
rs941438425 CA395692794	4	A>E		No	ClinGen gnomAD
rs941438425 CA280625175	4	A>V		No	ClinGen gnomAD
rs1040297827 CA280625180	5	P>S		No	ClinGen TOPMed
CA395692849 rs772186103	6	G>R		No	ClinGen ExAC TOPMed gnomAD
CA8024645 rs772186103	6	G>S		No	ClinGen ExAC TOPMed gnomAD
CA8024646 rs775366554	7	L>P		No	ClinGen ExAC gnomAD
rs1306014013 CA395692918	9	H>L		No	ClinGen TOPMed
rs760852942 CA8024647	9	H>Q		No	ClinGen ExAC gnomAD
rs1277881435 CA395692961	11	E>*		No	ClinGen gnomAD
CA395693032 rs1440608019	13	S>P		No	ClinGen gnomAD
rs764074408 CA8024648	14	C>*		No	ClinGen ExAC gnomAD
rs1389658626 CA395693095	15	P>L		No	ClinGen TOPMed
rs1471942388 CA395693141	17	C>*		No	ClinGen gnomAD
CA395693199 rs1478601345	20	L>R		No	ClinGen TOPMed gnomAD
rs1400750879 CA395693226	22	D>N		No	ClinGen gnomAD
rs1412150352 CA395693257	23	A>P		No	ClinGen TOPMed gnomAD
rs1412150352 CA395693251	23	A>T		No	ClinGen TOPMed gnomAD
CA395693292 rs1370032300	24	P>L		No	ClinGen gnomAD
rs758057099 CA8024653	25	V>M		No	ClinGen ExAC TOPMed gnomAD
rs766066140 CA8024654	26	T>A		No	ClinGen ExAC gnomAD
CA395693361 rs1233770552	29	C>G		No	ClinGen gnomAD
CA395693363 rs1596935972	29	C>Y		No	ClinGen Ensembl
TCGA novel	30	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1216265557 CA395693390	31	H>N		No	ClinGen TOPMed gnomAD
CA395693458 rs1421441263	34	C>S		No	ClinGen TOPMed
CA8024657 rs754511013	35	R>C		No	ClinGen ExAC gnomAD
rs1482477323 CA395693487	35	R>H		No	ClinGen gnomAD
CA8024658 rs778219100	36	A>S		No	ClinGen ExAC gnomAD
TCGA novel	36	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1451796095 CA395693504	36	A>V		No	ClinGen gnomAD
rs1020005582 CA280625362	37	C>R		No	ClinGen TOPMed
rs757602634 CA8024660	37	C>S		No	ClinGen ExAC gnomAD
rs779211761 CA8024661	38	L>P		No	ClinGen ExAC gnomAD
rs746246758 CA8024662	40	R>S		No	ClinGen ExAC gnomAD
rs1325044807 CA395693607	42	A>T		No	ClinGen gnomAD
CA395693623 rs772128235	43	G>R		No	ClinGen ExAC gnomAD
CA8024663 rs772128235	43	G>W		No	ClinGen ExAC gnomAD
CA395693646 rs1366221016	44	E>A		No	ClinGen gnomAD
CA395693643 rs1165525481	44	E>K		No	ClinGen TOPMed gnomAD
rs1329151033 CA395693687	46	A>V		No	ClinGen gnomAD
CA8024665 rs747047326	48	D>G		No	ClinGen ExAC gnomAD
CA395693707 rs1298327069	48	D>H		No	ClinGen gnomAD
rs1356384611 CA395693886	57	Q>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8024668 rs776690440	58	A>T		No	ClinGen ExAC
CA395693927 rs1264755347	58	A>V		No	ClinGen TOPMed gnomAD
CA8024670 rs769631711	59	P>S		No	ClinGen ExAC gnomAD
rs769631711 CA395693936	59	P>T		No	ClinGen ExAC gnomAD
CA280625407 rs1017497201	60	T>K		No	ClinGen TOPMed gnomAD
TCGA novel	60	T>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395693994 rs1336233016	61	R>Q		No	ClinGen TOPMed
CA395694001 rs1369133305	62	P>S		No	ClinGen gnomAD
CA8024671 rs377300213	65	L>P		No	ClinGen ExAC TOPMed gnomAD
rs762825035 CA8024672	66	S>I		No	ClinGen ExAC gnomAD
CA395694158 rs1458658565	67	T>A		No	ClinGen gnomAD
CA280625431 rs979874959	69	L>M		No	ClinGen TOPMed gnomAD
rs1432848023 CA395694257	72	A>V		No	ClinGen TOPMed gnomAD
CA280625436 rs1032425121	73	R>H		No	ClinGen TOPMed gnomAD
CA395694274 rs1032425121	73	R>L		No	ClinGen TOPMed gnomAD
CA395694299 rs1263379428	75	V>E		No	ClinGen TOPMed gnomAD
CA395694338 rs1208912989	77	G>E		No	ClinGen gnomAD
CA280625438 rs958559598	77	G>W		No	ClinGen Ensembl
CA280625443 rs993164751	78	L>M		No	ClinGen TOPMed gnomAD
rs549168444 CA8024675	80	Q>L		No	ClinGen 1000Genomes ExAC gnomAD
rs767071126 CA8024676	82	P>R		No	ClinGen ExAC gnomAD
CA395694462 rs1260557342	83	Q>L		No	ClinGen TOPMed
CA395694475 rs1423388645	84	G>S		No	ClinGen gnomAD
rs1425316077 CA395694525	86	C>Y		No	ClinGen gnomAD
CA395694543 rs1489115430	87	E>Q		No	ClinGen TOPMed
CA395694638 rs1567492479	90	L>V		No	ClinGen Ensembl
rs1357162624 CA395694732	92	P>L		No	ClinGen TOPMed
rs1473052320 CA395694780	94	S>I		No	ClinGen TOPMed gnomAD
rs779489515 CA8024679	95	I>M		No	ClinGen ExAC gnomAD
rs567360429 CA8024678	95	I>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1679044 rs567360429 CA280625495 COSM1679043	95	I>S	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs1245564849 CA395694802	95	I>V		No	ClinGen TOPMed
CA395694823 rs1455390231	96	Y>C		No	ClinGen gnomAD
rs780109162 CA8024682	97	C>*		No	ClinGen ExAC gnomAD
CA8024681 rs750705473	97	C>R		No	ClinGen ExAC TOPMed gnomAD
CA8024680 rs750705473	97	C>S		No	ClinGen ExAC TOPMed gnomAD
rs1361652864 CA395694874	98	E>G		No	ClinGen TOPMed
CA395694887 rs1394986685	99	Q>R		No	ClinGen gnomAD
CA8024683 rs747286617	101	R>G		No	ClinGen ExAC gnomAD
rs781493336 CA8024685	101	R>L		No	ClinGen ExAC gnomAD
rs747286617 CA8024684	101	R>S		No	ClinGen ExAC gnomAD
CA395694976 rs1228631787	102	A>V		No	ClinGen gnomAD
CA280625536 rs949548449	104	V>A		No	ClinGen TOPMed
rs769565638 CA8024687	104	V>M		No	ClinGen ExAC gnomAD
CA8024688 rs773228834	105	C>*		No	ClinGen ExAC TOPMed gnomAD
rs926893076 CA395695059	106	G>E		No	ClinGen TOPMed gnomAD
CA8024689 rs762622415	106	G>R		No	ClinGen ExAC gnomAD
CA280625570 rs926893076	106	G>V		No	ClinGen TOPMed gnomAD
CA395695076 rs1252788789	107	V>M		No	ClinGen gnomAD
rs941699631 CA280625580	109	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1181742784 CA395695215	110	S>L		No	ClinGen gnomAD
CA395695257 rs1471525096	112	G>A		No	ClinGen gnomAD
rs1037813604 CA280625617	112	G>R		No	ClinGen TOPMed gnomAD
rs1177930934 CA395695276	113	S>W		No	ClinGen TOPMed gnomAD
CA8024693 rs767161211	114	H>Q		No	ClinGen ExAC gnomAD
rs1221422076 CA395695317	115	R>C		No	ClinGen TOPMed
CA280625649 rs897493166	116	G>D		No	ClinGen TOPMed
CA8024694 rs752143235	117	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs760255630 CA8024696	118	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8024697 rs750980692	118	R>L		No	ClinGen ExAC TOPMed gnomAD
rs760255630 CA8024695	118	R>S		No	ClinGen ExAC TOPMed gnomAD
rs758668680 CA8024698	120	L>M		No	ClinGen ExAC gnomAD
rs766910598 CA8024699	121	P>T		No	ClinGen ExAC gnomAD
rs1596936306 CA395695484	122	A>D		No	ClinGen Ensembl
rs1311932071 CA395695593	125	A>T		No	ClinGen gnomAD
CA8024702 rs755188223	126	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA280625708 rs890264579	127	A>S		No	ClinGen TOPMed
rs890264579 CA395695642	127	A>T		No	ClinGen TOPMed
rs199876193 CA8024703	128	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA395695673 rs1352142797	128	R>H		No	ClinGen TOPMed
CA8024704 rs200603153	129	L>F		No	ClinGen ExAC TOPMed gnomAD
rs934135318 CA280625723	129	L>R		No	ClinGen TOPMed
rs1243621524 CA395698409	132	Q>*		No	ClinGen TOPMed gnomAD
TCGA novel	134	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs531394387 CA8024796	137	K>N		No	ClinGen 1000Genomes ExAC gnomAD
rs769061768 CA395698540	139	Q>*		No	ClinGen ExAC TOPMed gnomAD
rs769061768 CA8024797	139	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA8024798 rs776916600	140	L>V		No	ClinGen ExAC gnomAD
rs1485190692 CA395698576	141	Q>*		No	ClinGen gnomAD
CA395698582 rs1202658958	141	Q>R		No	ClinGen gnomAD
CA395698609 rs1441852379	143	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA8024800 rs748528190	144	C>F		No	ClinGen ExAC gnomAD
rs1186145703 CA395698639	144	C>R		No	ClinGen gnomAD
rs748528190 CA8024799	144	C>S		No	ClinGen ExAC gnomAD
rs1056294548 CA280628276	145	M>T		No	ClinGen gnomAD
rs773457022 CA8024801	146	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs201191466 CA8024802 COSM1737065 COSM1737064	146	R>H	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA280628278 rs773457022	146	R>S		No	ClinGen ExAC TOPMed gnomAD
rs774337718 CA8024804	149	K>N		No	ClinGen ExAC gnomAD
TCGA novel	151	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149024766 CA8024806	151	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8024807 rs752489122	153	V>G		No	ClinGen ExAC
CA395698818 rs1394911284	153	V>M		No	ClinGen gnomAD
CA280628319 rs939740670	156	H>R		No	ClinGen TOPMed
rs553295367 CA8024809	159	V>G		No	ClinGen ExAC gnomAD
rs756003981 CA8024808	159	V>L		No	ClinGen ExAC TOPMed gnomAD
CA395698964 rs1596939640	161	V>G		No	ClinGen Ensembl
rs1424530652 CA395698951	161	V>M		No	ClinGen TOPMed
rs756793233 CA280628508	163	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs759681780 CA8024824	164	T>I		No	ClinGen ExAC TOPMed gnomAD
rs143098996 CA8024825	165	V>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1460787138 CA395699050	165	V>M		No	ClinGen TOPMed
CA8024826 rs374969194	166	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA8024828 rs201331213	166	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA395699075 rs201331213	166	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8024827 rs374969194	166	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA8024830 rs761306791	167	Q>H		No	ClinGen ExAC gnomAD
CA8024829 rs753537137	167	Q>L		No	ClinGen ExAC gnomAD
CA395699125 rs1191595581	169	R>Q		No	ClinGen gnomAD
CA8024832 COSM1230418 rs148214926 COSM1230419	169	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed
TCGA novel	171	A>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8024834 COSM1179768 COSM1179769 rs757959915	172	V>M	prostate [Cosmic]	No	ClinGen cosmic curated ExAC
CA280628571 rs939072859	173	G>A		No	ClinGen TOPMed
rs939072859 CA395699173	173	G>E		No	ClinGen TOPMed
CA395699182 rs756462500	174	E>*		No	ClinGen ExAC TOPMed gnomAD
CA8024837 rs756462500	174	E>K		No	ClinGen ExAC TOPMed gnomAD
COSM557727 CA8024839 COSM557726 rs749674647	177	G>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs771007987 CA8024840	180	R>G		No	ClinGen ExAC TOPMed gnomAD
rs745904502 CA8024842	180	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs771007987 CA8024841	180	R>W		No	ClinGen ExAC TOPMed gnomAD
CA395699348 rs1596939838	181	V>G		No	ClinGen Ensembl
rs775555008 CA8024844	181	V>L		No	ClinGen ExAC TOPMed gnomAD
CA395699342 rs775555008	181	V>M		No	ClinGen ExAC TOPMed gnomAD
CA395699412 rs1567494055	184	A>P		No	ClinGen Ensembl
rs1596939849 CA395699426	185	A>P		No	ClinGen Ensembl
CA395699435 rs1596939854	185	A>V		No	ClinGen Ensembl
rs768721119 CA8024846	186	L>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA395699473 rs761692670	188	G>A		No	ClinGen ExAC TOPMed gnomAD
rs761692670 CA8024848	188	G>D		No	ClinGen ExAC TOPMed gnomAD
CA8024847 rs776233456	188	G>S		No	ClinGen ExAC gnomAD
CA8024849 rs115885262 RCV000955511	192	R>C		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA395699545 rs115885262	192	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs191800804 CA8024851	192	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA8024850 rs115885262	192	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA395699588 rs1166804246	193	E>D		No	ClinGen TOPMed
rs756675094 CA8024854	193	E>K		No	ClinGen ExAC gnomAD
rs778233584 CA8024855	194	A>V		No	ClinGen ExAC gnomAD
CA280628670 rs117857886	195	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA395699610 rs1431783321	195	E>Q		No	ClinGen TOPMed
rs757603858 CA8024857	196	R>C		No	ClinGen ExAC TOPMed gnomAD
rs745643982 CA280628671	196	R>H		No	ClinGen TOPMed gnomAD
rs555872534 CA8024858	197	V>I		No	ClinGen 1000Genomes ExAC gnomAD
rs200796476 CA8024860	198	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8024861 rs144116136	198	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs200796476 CA8024859	198	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs768760420 CA8024863	199	G>D		No	ClinGen ExAC gnomAD
CA280628688 rs74575362	200	E>G		No	ClinGen Ensembl
rs776598239 CA8024864	203	V>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA395699781 rs1596939972	203	V>G		No	ClinGen Ensembl
CA395699773 rs776598239	203	V>I		No	ClinGen ExAC gnomAD
CA8024867 rs769578887	204	A>P		No	ClinGen ExAC TOPMed gnomAD
CA8024866 rs769578887	204	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs766005593 CA8024869	206	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8024870 rs766005593	206	R>G		No	ClinGen ExAC TOPMed gnomAD
CA395699853 rs780638717	206	R>H		No	ClinGen ExAC TOPMed gnomAD
CA8024871 rs780638717	206	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8024874 rs572271373	207	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA8024873 rs369542040	207	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	208	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs750748445 CA8024876	210	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1182145743 CA395700029	211	S>N		No	ClinGen gnomAD
rs1371274198 CA395700063	212	L>R		No	ClinGen TOPMed
rs780399664 CA8024878	214	S>A		No	ClinGen ExAC gnomAD
rs1312295541 CA719951218	215	Y>*		No	ClinGen TOPMed
CA8024882 rs781011212	220	R>Q		No	ClinGen ExAC gnomAD
CA8024881 rs374279718	220	R>W		No	ClinGen ESP ExAC TOPMed
rs748055741 CA8024883	221	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA8024884 rs769618706	222	M>I		No	ClinGen ExAC gnomAD
rs1469998012 CA395700418	222	M>R		No	ClinGen TOPMed
CA395700411 rs1596940076	222	M>V		No	ClinGen Ensembl
CA395700461 rs1596940090	223	E>G		No	ClinGen Ensembl
CA395700451 rs1361024396	223	E>K		No	ClinGen gnomAD
rs773120703 CA8024885	224	K>M		No	ClinGen ExAC gnomAD
CA395700547 rs1596940102	225	V>G		No	ClinGen Ensembl
rs1410185144 CA395700518	225	V>L		No	ClinGen TOPMed
CA280628799 rs867053659	227	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA8024886 rs749063759	229	V>G		No	ClinGen ExAC
CA395700635 rs1312538377	229	V>M		No	ClinGen gnomAD
rs139612395 CA8024888	230	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs139612395 CA8024887	230	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8024891 rs200975523	231	D>E		No	ClinGen ExAC gnomAD
CA8024890 rs766996531	231	D>N		No	ClinGen ExAC
CA8024893 rs201571350	233	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA395700795 rs201571350	233	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs939123654 CA280628855	233	P>S		No	ClinGen Ensembl
rs1567494182 CA395700898	237	F>C		No	ClinGen Ensembl
rs758802409 CA8024895	237	F>L		No	ClinGen ExAC gnomAD
rs766735832 CA395700926	239	M>L		No	ClinGen ExAC gnomAD
CA395700937 rs1210944047	239	M>T		No	ClinGen TOPMed gnomAD
CA8024896 rs766735832	239	M>V		No	ClinGen ExAC gnomAD
rs1037370861 CA280630007	241	Y>C		No	ClinGen gnomAD
rs1409209161 CA395702128	245	T>A		No	ClinGen gnomAD
rs1326631528 CA395702140	245	T>I		No	ClinGen gnomAD
TCGA novel	246	S>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA280630061 rs142710131	247	R>K		No	ClinGen ESP TOPMed gnomAD
CA280630051 rs900140660	247	R>W		No	ClinGen gnomAD
rs1314377489 CA395702565	249	Q>R		No	ClinGen gnomAD
TCGA novel	250	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8024945 rs779776298	253	A>S		No	ClinGen ExAC TOPMed gnomAD
rs368945748 CA8024947	254	E>D		No	ClinGen ESP ExAC TOPMed
CA395702673 rs1458727559	254	E>K		No	ClinGen TOPMed
CA8024948 rs754536847	256	P>A		No	ClinGen ExAC gnomAD
TCGA novel	257	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780912615 CA8024949	257	P>L		No	ClinGen ExAC TOPMed gnomAD
CA8024950 rs780912615	257	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA8024951 rs780912615	257	P>R		No	ClinGen ExAC TOPMed gnomAD
rs911724963 CA280631388	258	P>H		No	ClinGen TOPMed
CA8024952 rs774961699	258	P>S		No	ClinGen ExAC TOPMed gnomAD
CA280631387 rs774961699	258	P>T		No	ClinGen ExAC TOPMed gnomAD
CA395702791 rs1485483447	259	A>D		No	ClinGen gnomAD
CA8024955 COSM185258 rs775787122 COSM185259	259	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
COSM970165 rs1185990761 COSM970166 CA395702822	260	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA8024956 rs151006683	260	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA395702848 rs764288374	262	D>N		No	ClinGen ExAC gnomAD
CA8024957 rs764288374	262	D>Y		No	ClinGen ExAC gnomAD
rs1488672638 CA395702961	267	I>V		No	ClinGen TOPMed
CA395703003 rs1451062037	268	I>V		No	ClinGen gnomAD
rs1250715432 CA395703087	269	S>L		No	ClinGen TOPMed
CA8024959 rs562867534	270	D>E		No	ClinGen 1000Genomes ExAC gnomAD
CA395703106 rs1375479846	270	D>Y		No	ClinGen gnomAD
rs1310636468 CA395703135	271	D>N		No	ClinGen gnomAD
rs750277758 CA8024961	272	F>L		No	ClinGen ExAC gnomAD
CA395703229 rs1306975214	274	F>L		No	ClinGen gnomAD
CA280631468 rs868381885	275	Q>*		No	ClinGen Ensembl
CA280631473 rs1045551590	280	M>V		No	ClinGen Ensembl
rs1236013003 CA395703450 CA395703452	281	F>L		No	ClinGen TOPMed gnomAD
rs1320107533 CA395703436	281	F>S		No	ClinGen TOPMed
rs140739096 CA8024963	282	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA280631481 rs887056269	282	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA280631486 rs939947094	285	M>I		No	ClinGen Ensembl
CA280631513 rs1038375589	287	A>T		No	ClinGen gnomAD
rs1156785619 CA395704692	287	A>V		No	ClinGen TOPMed
CA395704743 rs1471150496	290	E>K		No	ClinGen TOPMed
rs773204133 CA8024980	291	L>P		No	ClinGen ExAC TOPMed gnomAD
CA8024982 rs150087468	292	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs534421116 CA395704895	295	P>A		No	ClinGen 1000Genomes ExAC gnomAD
CA395704914 rs1371759585	295	P>L		No	ClinGen gnomAD
CA8024984 rs534421116	295	P>T		No	ClinGen 1000Genomes ExAC gnomAD
rs754784371 CA8024985	296	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA395704984 rs1394365990	296	S>R		No	ClinGen TOPMed gnomAD
rs767302913 CA8024987	297	S>F		No	ClinGen ExAC
rs1596943327 CA395705037	299	H>P		No	ClinGen Ensembl
CA395705109 rs755691030	300	P>L		No	ClinGen ExAC gnomAD
CA8024989 rs755691030	300	P>R		No	ClinGen ExAC gnomAD
rs752343664 CA8024988	300	P>S		No	ClinGen ExAC gnomAD
TCGA novel	305	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395705351 rs1273526288	306	S>C		No	ClinGen gnomAD
TCGA novel	306	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs866681890 CA280632702	308	G>S		No	ClinGen Ensembl
rs758879061 CA8024993	309	R>C		No	ClinGen ExAC gnomAD
rs368859412 CA280632709	309	R>H		No	ClinGen gnomAD
rs758879061 CA8024994	309	R>S		No	ClinGen ExAC gnomAD
rs1019552922 CA280632712	310	R>G		No	ClinGen gnomAD
rs1185637569 CA395705456	310	R>H		No	ClinGen gnomAD
CA395705442 rs1019552922	310	R>S		No	ClinGen gnomAD
rs1284100831 CA395705467	311	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA395705476 rs1195696274	312	E>Q		No	ClinGen gnomAD
rs141229511 CA8024996	313	C>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs1166136120 CA395705555	314	S>*		No	ClinGen gnomAD
rs1166136120 CA395705565	314	S>W		No	ClinGen gnomAD
rs773058167 CA280632745	315	E>Q		No	ClinGen gnomAD
CA8024999 rs571127764	319	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA8025000 rs773218230	320	P>L		No	ClinGen ExAC gnomAD
CA395705741 rs1287383801	321	A>T		No	ClinGen TOPMed gnomAD
rs1003218502 CA280632792	321	A>V		No	ClinGen TOPMed gnomAD
CA395705779 rs1354517530	322	G>E	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA395705766 rs1293682315 CA395705764	322	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1354517530 CA395705785	322	G>V		No	ClinGen gnomAD
CA280632810 rs112486041	323	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA280632824 rs936743874	324	D>E		No	ClinGen gnomAD
CA280632846 rs989532506	326	R>S		No	ClinGen Ensembl
COSM225042 CA395705949 COSM225041 rs1317028548	327	Q>*	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs763062275 CA395705971	329	D>N		No	ClinGen ExAC TOPMed gnomAD
rs763062275 CA8025001	329	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs375401025 CA8025004	331	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	331	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8025003 rs774300796	331	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	333	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs199815688 CA8025007 CA8025006	335	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	336	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA280632878 rs369457250	337	H>Q		No	ClinGen ESP gnomAD
rs1400584459 CA395706260	337	H>Y		No	ClinGen gnomAD
rs201970764 CA280632879	338	Q>E		No	ClinGen 1000Genomes gnomAD
CA8025008 rs763780493	339	Q>L		No	ClinGen ExAC TOPMed gnomAD
CA395706422 rs1442714325	341	S>Y		No	ClinGen gnomAD
rs1373999972 CA395706484	344	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA395706483 rs1373999972	344	E>Q		No	ClinGen gnomAD
rs1223108582 CA395706522	345	H>R		No	ClinGen gnomAD
CA395706574 rs1306467317	347	W>R		No	ClinGen gnomAD
CA280632911 rs1046980046	348	E>A		No	ClinGen Ensembl
CA395706589 rs1303628124	348	E>K		No	ClinGen TOPMed gnomAD
rs1372224005 CA395706616	349	V>M		No	ClinGen gnomAD
rs1349344355 CA395706706	350	D>N		No	ClinGen gnomAD
CA280632912 rs765642505	351	V>F		No	ClinGen gnomAD
CA395706731 rs765642505	351	V>I		No	ClinGen gnomAD
rs1207089367 CA395706796	353	D>G		No	ClinGen gnomAD
rs752003573 CA8025013	353	D>Y		No	ClinGen ExAC gnomAD
rs1353657027 CA395706870	355	P>L		No	ClinGen TOPMed
CA8025014 rs755338073	356	R>C		No	ClinGen ExAC gnomAD
rs781600735 CA8025015	356	R>H		No	ClinGen ExAC gnomAD
CA395706890 rs781600735	356	R>L		No	ClinGen ExAC gnomAD
rs1254783583 CA395706969	359	L>M		No	ClinGen gnomAD
rs1339491076 CA395707033	361	V>E		No	ClinGen TOPMed
rs1397026037 CA395707019	361	V>M		No	ClinGen TOPMed gnomAD
CA395707050 rs1567495928	362	I>T		No	ClinGen Ensembl
CA8025018 rs778019966	363	A>S		No	ClinGen ExAC TOPMed gnomAD
CA395707109 rs1330679793	365	E>K		No	ClinGen TOPMed gnomAD
rs1196879675 CA395707137	366	A>P		No	ClinGen gnomAD
CA280632958 rs908054101	366	A>V		No	ClinGen TOPMed
CA280632982 rs896786892	367	P>L		No	ClinGen TOPMed gnomAD
CA280632981 rs1036695116	367	P>S		No	ClinGen TOPMed gnomAD
rs749353531 CA280632985	368	R>C		No	ClinGen ExAC TOPMed gnomAD
CA395707189 rs1234344465	368	R>P		No	ClinGen gnomAD
COSM4129021 CA8025019 rs749353531 COSM4129020	368	R>S	thyroid [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA395707243 rs1302301016	370	G>E		No	ClinGen gnomAD
CA395707239 rs1456479883	370	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA395707284 rs1342476792	371	R>C		No	ClinGen gnomAD
CA395707290 rs1215892505	371	R>H		No	ClinGen gnomAD
rs760372032 CA395707323	373	H>N		No	ClinGen ExAC TOPMed gnomAD
rs760372032 CA8025020	373	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA8025021 rs774438318	374	A>G		No	ClinGen ExAC TOPMed gnomAD
CA395707342 rs1197371146	374	A>S		No	ClinGen gnomAD
CA395707359 rs774438318	374	A>V		No	ClinGen ExAC TOPMed gnomAD
CA280633028 rs889516572	375	V>A		No	ClinGen TOPMed gnomAD
TCGA novel	378	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395707423 rs1316696566	378	Q>L		No	ClinGen TOPMed
CA8025022 rs770390611	379	G>A		No	ClinGen ExAC TOPMed gnomAD
CA395707596 rs1384246333	385	L>V		No	ClinGen Ensembl
rs922138735 CA280633036	386	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA395707667 rs1420037120	388	G>D		No	ClinGen gnomAD
CA395707658 rs1274090807	388	G>S		No	ClinGen TOPMed
rs565529736 CA280633039	390	I>S		No	ClinGen Ensembl
rs1409152342 CA395707775	392	E>A		No	ClinGen TOPMed gnomAD
rs1441494900 CA395707882	395	V>A		No	ClinGen gnomAD
CA395707876 rs1446168459	395	V>L		No	ClinGen TOPMed
TCGA novel	395	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395707885 rs1328791124	396	E>K		No	ClinGen TOPMed gnomAD
CA395707887 rs1328791124	396	E>Q		No	ClinGen TOPMed gnomAD
CA395707943 rs1054155250	398	K>R		No	ClinGen TOPMed gnomAD
CA280633043 rs1054155250	398	K>T		No	ClinGen TOPMed gnomAD
rs1217157136 CA395707995	399	E>D		No	ClinGen gnomAD
rs1339179097 CA395707986	399	E>G		No	ClinGen gnomAD
CA395708033 rs1336153790	400	P>Q		No	ClinGen gnomAD
rs760488562 CA8025025	400	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1319773067 CA395708062	401	R>L		No	ClinGen Ensembl
rs1448803842 CA395708064	402	A>T		No	ClinGen TOPMed gnomAD
rs1194249329 CA395708113	404	R>C		No	ClinGen gnomAD
rs1241713679 CA395708223	406	P>S		No	ClinGen gnomAD
rs1191267964 CA395708253	407	E>*		No	ClinGen gnomAD
TCGA novel	407	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395708268 rs1462524687	408	R>G		No	ClinGen TOPMed gnomAD
TCGA novel	408	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395708295 rs1419672259	409	R>W		No	ClinGen gnomAD
rs1326178389 CA395708337	411	T>A		No	ClinGen TOPMed gnomAD
CA8025029 rs753481207	412	R>C		No	ClinGen ExAC gnomAD
rs1326474252 CA395708393	412	R>L		No	ClinGen Ensembl
CA8025030 rs761241218	413	I>L		No	ClinGen ExAC gnomAD
rs1401903150 CA395708426	414	G>C		No	ClinGen gnomAD
rs1393209259 CA395708428	414	G>D		No	ClinGen TOPMed gnomAD
TCGA novel	414	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1397706801 CA395708476	416	Y>F		No	ClinGen gnomAD
CA8025032 rs749928208	417	L>M		No	ClinGen ExAC TOPMed gnomAD
rs868424182 CA280633123	417	L>P		No	ClinGen Ensembl
CA280633134 rs866527463	418	S>R		No	ClinGen Ensembl
CA395708543 rs1239264378	420	G>A		No	ClinGen TOPMed
rs767985630 CA8025034	420	G>R		No	ClinGen ExAC TOPMed gnomAD
rs753097453 CA8025036	421	D>E		No	ClinGen ExAC TOPMed gnomAD
CA395708559 rs1352988351	421	D>G		No	ClinGen gnomAD
CA395708572 rs777875525	422	G>C		No	ClinGen ExAC TOPMed gnomAD
rs777875525 CA8025037	422	G>S		No	ClinGen ExAC TOPMed gnomAD
rs757419145 CA8025039	423	V>F		No	ClinGen ExAC TOPMed gnomAD
CA395708590 rs757419145	423	V>I		No	ClinGen ExAC TOPMed gnomAD
CA8025040 rs779193788	424	L>F		No	ClinGen ExAC TOPMed gnomAD
CA280633185 rs779193788	424	L>I		No	ClinGen ExAC TOPMed gnomAD
rs779193788 CA8025041	424	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1475407963 CA395708629	425	S>A		No	ClinGen gnomAD
CA280633199 rs372751574	425	S>F		No	ClinGen ESP TOPMed
rs372751574 CA280633195	425	S>Y		No	ClinGen ESP TOPMed
rs1438452095 CA395708643	426	F>L		No	ClinGen TOPMed
CA8025043 rs373379714	427	Y>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1470153983 CA395708687	428	D>E		No	ClinGen TOPMed
TCGA novel	428	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395708702 rs1158672388	429	A>D		No	ClinGen TOPMed gnomAD
CA395708752 rs1417501127	431	D>E		No	ClinGen TOPMed gnomAD
CA395708720 rs1567496211	431	D>N		No	ClinGen Ensembl
rs1314317870 CA395708764	432	A>D		No	ClinGen gnomAD
rs1314317870 CA395708774	432	A>V		No	ClinGen gnomAD
CA395708785 rs1395781107	433	D>N		No	ClinGen gnomAD
CA8025044 rs775530190	434	A>P		No	ClinGen ExAC gnomAD
rs775530190 CA395708811	434	A>T		No	ClinGen ExAC gnomAD
TCGA novel	436	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA395708855 rs1281267789	437	P>L		No	ClinGen TOPMed gnomAD
CA8025047 rs776184212	437	P>S		No	ClinGen ExAC TOPMed gnomAD
CA395708960 rs1376279067	442	H>R		No	ClinGen TOPMed
CA395708966 rs1253768290	443	E>K		No	ClinGen TOPMed gnomAD
CA8025049 rs540011147	444	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs763394921 CA280633280	444	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs763394921 CA280633281	444	R>L		No	ClinGen TOPMed gnomAD
rs1437272238 CA395709032	447	R>W		No	ClinGen gnomAD
CA280633308 rs774706835	449	V>M		No	ClinGen gnomAD
CA395709094 rs1257736020	451	P>L		No	ClinGen TOPMed
rs1399010832 CA395709124	453	F>V		No	ClinGen gnomAD
CA8025053 rs768038436	454	D>N		No	ClinGen ExAC gnomAD
rs1374811767 CA395709162	455	V>M		No	ClinGen gnomAD
rs865851823 CA280633389	456	C>*		No	ClinGen gnomAD
CA395709199 rs865851823	456	C>W		No	ClinGen gnomAD
CA8025055 rs756443702	457	W>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs756443702 CA395709211	457	W>C		No	ClinGen ExAC gnomAD
CA395709208 rs1347465972	457	W>S		No	ClinGen TOPMed gnomAD
rs764589997 CA8025056	458	H>N		No	ClinGen ExAC
rs1254046163 CA395709223	458	H>R		No	ClinGen gnomAD
rs1196380044 CA395709262	460	K>E		No	ClinGen gnomAD
rs1237461682 CA395709294	461	G>S		No	ClinGen gnomAD
rs1456108372 CA395709350	464	A>P		No	ClinGen gnomAD
rs866967489 CA280633398	464	A>V		No	ClinGen Ensembl
CA8025057 rs754140169	465	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA395709377 rs1253042363	465	Q>L		No	ClinGen gnomAD
CA280633401 rs889577918	466	P>L		No	ClinGen gnomAD
CA395709432 rs1263643847	469	L>F		No	ClinGen gnomAD
CA8025058 rs532226963	469	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA8025060 rs544541955	470	V>L		No	ClinGen 1000Genomes ExAC gnomAD
CA395709450 rs544541955	470	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA8025061 rs758502754	471	G>C		No	ClinGen ExAC TOPMed gnomAD
rs758502754 CA280633485	471	G>R		No	ClinGen ExAC TOPMed gnomAD
rs758502754 CA280633480	471	G>S		No	ClinGen ExAC TOPMed gnomAD
CA8025063 rs746896769	473	E>D		No	ClinGen ExAC gnomAD
rs1326666235 CA395709488	473	E>G		No	ClinGen gnomAD
rs1289982121 CA395709500	474	G>D		No	ClinGen TOPMed
CA395709506 rs1297992366	475	A>S		No	ClinGen gnomAD
rs1257140829 CA395709524	476	E>G		No	ClinGen gnomAD
CA395709542 rs1462536894	477	A>D		No	ClinGen TOPMed
rs1316026147 CA395709565	478	A>C		No	ClinGen gnomAD
rs1567496394 CA395709550	478	A>R		No	ClinGen Ensembl

No associated diseases with Q6ZMU5

2 regional properties for Q6ZMU5

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	12 - 291	IPR000719
active_site	Serine/threonine-protein kinase, active site	129 - 141	IPR008271

Functions

		Description
EC Number
Subcellular Localization	Cell membrane, sarcolemma Cytoplasmic vesicle membrane	Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle membrane	The lipid bilayer surrounding a cytoplasmic vesicle.
sarcolemma	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.

5 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
phosphatidylserine binding	Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.
ubiquitin conjugating enzyme binding	Binding to a ubiquitin conjugating enzyme, any of the E2 proteins.
ubiquitin protein ligase activity	Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
zinc ion binding	Binding to a zinc ion (Zn).

10 GO annotations of biological process

Name	Definition
exocytosis	A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell.
muscle organ development	The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
muscle system process	A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
negative regulation of insulin receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
negative regulation of insulin-like growth factor receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.
negative regulation of myotube differentiation	Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
plasma membrane repair	The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.
proteasome-mediated ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein homooligomerization	The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
protein ubiquitination	The process in which one or more ubiquitin groups are added to a protein.

49 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5E9G4	TRIM10	Tripartite motif-containing protein 10	Bos taurus (Bovine)	PR
Q2T9Z0	TRIM17	E3 ubiquitin-protein ligase TRIM17	Bos taurus (Bovine)	PR
E1BJS7	TRIM71	E3 ubiquitin-protein ligase TRIM71	Bos taurus (Bovine)	PR
Q7YRV4	TRIM21	E3 ubiquitin-protein ligase TRIM21	Bos taurus (Bovine)	PR
Q1PRL4	TRIM71	E3 ubiquitin-protein ligase TRIM71	Gallus gallus (Chicken)	PR
Q7YR32	TRIM10	Tripartite motif-containing protein 10	Pan troglodytes (Chimpanzee)	PR
Q9BTV5	FSD1	Fibronectin type III and SPRY domain-containing protein 1	Homo sapiens (Human)	PR
Q9UJV3	MID2	Probable E3 ubiquitin-protein ligase MID2	Homo sapiens (Human)	PR
P29590	PML	Protein PML	Homo sapiens (Human)	PR
Q9NQ86	TRIM36	E3 ubiquitin-protein ligase TRIM36	Homo sapiens (Human)	PR
Q86UV6	TRIM74	Tripartite motif-containing protein 74	Homo sapiens (Human)	PR
Q2Q1W2	TRIM71	E3 ubiquitin-protein ligase TRIM71	Homo sapiens (Human)	PR
Q9BXM9	FSD1L	FSD1-like protein	Homo sapiens (Human)	PR
Q9H2S5	RNF39	RING finger protein 39	Homo sapiens (Human)	PR
Q86UV7	TRIM73	Tripartite motif-containing protein 73	Homo sapiens (Human)	PR
Q86XT4	TRIM50	E3 ubiquitin-protein ligase TRIM50	Homo sapiens (Human)	PR
Q9UPQ4	TRIM35	E3 ubiquitin-protein ligase TRIM35	Homo sapiens (Human)	PR
Q9BZY9	TRIM31	E3 ubiquitin-protein ligase TRIM31	Homo sapiens (Human)	PR
Q9C029	TRIM7	E3 ubiquitin-protein ligase TRIM7	Homo sapiens (Human)	PR
O15553	MEFV	Pyrin	Homo sapiens (Human)	SS
A6NCK2	TRIM43B	Tripartite motif-containing protein 43B	Homo sapiens (Human)	PR
Q8N9V2	TRIML1	Probable E3 ubiquitin-protein ligase TRIML1	Homo sapiens (Human)	PR
P19474	TRIM21	E3 ubiquitin-protein ligase TRIM21	Homo sapiens (Human)	PR
Q14142	TRIM14	Tripartite motif-containing protein 14	Homo sapiens (Human)	PR
A6NK02	TRIM75	Tripartite motif-containing protein 75	Homo sapiens (Human)	PR
Q5EBN2	TRIM61	Putative tripartite motif-containing protein 61	Homo sapiens (Human)	PR
Q9WUH5	Trim10	Tripartite motif-containing protein 10	Mus musculus (Mouse)	PR
Q8BZT2	Sh3rf2	E3 ubiquitin-protein ligase SH3RF2	Mus musculus (Mouse)	PR
Q7TPM3	Trim17	E3 ubiquitin-protein ligase TRIM17	Mus musculus (Mouse)	PR
Q60953	Pml	Protein PML	Mus musculus (Mouse)	PR
Q9JJ26	Mefv	Pyrin	Mus musculus (Mouse)	SS
Q99PQ1	Trim12a	Tripartite motif-containing protein 12A	Mus musculus (Mouse)	PR
Q61510	Trim25	E3 ubiquitin/ISG15 ligase TRIM25	Mus musculus (Mouse)	PR
Q810I2	Trim50	E3 ubiquitin-protein ligase TRIM50	Mus musculus (Mouse)	PR
Q1PSW8	Trim71	E3 ubiquitin-protein ligase TRIM71	Mus musculus (Mouse)	PR
Q3TL54	Trim43a	Tripartite motif-containing protein 43A	Mus musculus (Mouse)	PR
P86449	Trim43c	Tripartite motif-containing protein 43C	Mus musculus (Mouse)	PR
Q1XH17	Trim72	Tripartite motif-containing protein 72	Mus musculus (Mouse)	PR
O77666	TRIM26	Tripartite motif-containing protein 26	Sus scrofa (Pig)	PR
O19085	TRIM10	Tripartite motif-containing protein 10	Sus scrofa (Pig)	PR
Q865W2	TRIM50	E3 ubiquitin-protein ligase TRIM50	Sus scrofa (Pig)	PR
Q920M2	Rnf39	RING finger protein 39	Rattus norvegicus (Rat)	PR
Q9JJ25	Mefv	Pyrin	Rattus norvegicus (Rat)	SS
Q810I1	Trim50	E3 ubiquitin-protein ligase TRIM50	Rattus norvegicus (Rat)	PR
D3ZVM4	Trim71	E3 ubiquitin-protein ligase TRIM71	Rattus norvegicus (Rat)	PR
A0JPQ4	Trim72	Tripartite motif-containing protein 72	Rattus norvegicus (Rat)	PR
F6QEU4	trim71	E3 ubiquitin-protein ligase TRIM71	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q640S6	trim72	Tripartite motif-containing protein 72	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
E7FAM5	trim71	E3 ubiquitin-protein ligase TRIM71	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSAAPGLLHQ	ELSCPLCLQL	FDAPVTAECG	HSFCRACLGR	VAGEPAADGT	VLCPCCQAPT
70	80	90	100	110	120
RPQALSTNLQ	LARLVEGLAQ	VPQGHCEEHL	DPLSIYCEQD	RALVCGVCAS	LGSHRGHRLL
130	140	150	160	170	180
PAAEAHARLK	TQLPQQKLQL	QEACMRKEKS	VAVLEHQLVE	VEETVRQFRG	AVGEQLGKMR
190	200	210	220	230	240
VFLAALEGSL	DREAERVRGE	AGVALRRELG	SLNSYLEQLR	QMEKVLEEVA	DKPQTEFLMK
250	260	270	280	290	300
YCLVTSRLQK	ILAESPPPAR	LDIQLPIISD	DFKFQVWRKM	FRALMPALEE	LTFDPSSAHP
310	320	330	340	350	360
SLVVSSSGRR	VECSEQKAPP	AGEDPRQFDK	AVAVVAHQQL	SEGEHYWEVD	VGDKPRWALG
370	380	390	400	410	420
VIAAEAPRRG	RLHAVPSQGL	WLLGLREGKI	LEAHVEAKEP	RALRSPERRP	TRIGLYLSFG
430	440	450	460	470
DGVLSFYDAS	DADALVPLFA	FHERLPRPVY	PFFDVCWHDK	GKNAQPLLLV	GPEGAEA