Q6ZEZ5

PR
Gene name
NEK3
Protein name
Serine/threonine-protein kinase Nek3
Names
NimA-related protein kinase 3, OsNek3
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4342542
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

229-554 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

146-168 (Activation loop from InterPro)

Target domain

4-258 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6ZEZ5

Entry ID Method Resolution Chain Position Source
AF-Q6ZEZ5-F1 Predicted AlphaFoldDB

No variants for Q6ZEZ5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6ZEZ5

No associated diseases with Q6ZEZ5

3 regional properties for Q6ZEZ5

Type Name Position InterPro Accession
domain Protein kinase domain 4 - 258 IPR000719
active_site Serine/threonine-protein kinase, active site 125 - 137 IPR008271
binding_site Protein kinase, ATP binding site 10 - 33 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

1 GO annotations of biological process

Name Definition
protein phosphorylation The process of introducing a phosphate group on to a protein.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P22209 KIN3 Serine/threonine-protein kinase KIN3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q6P3R8 NEK5 Serine/threonine-protein kinase Nek5 Homo sapiens (Human) PR
Q8NE28 STKLD1 Serine/threonine kinase-like domain-containing protein STKLD1 Homo sapiens (Human) PR
P51957 NEK4 Serine/threonine-protein kinase Nek4 Homo sapiens (Human) PR
P51955 NEK2 Serine/threonine-protein kinase Nek2 Homo sapiens (Human) EV
Q8K1R7 Nek9 Serine/threonine-protein kinase Nek9 Mus musculus (Mouse) SS
Q7TSC3 Nek5 Serine/threonine-protein kinase Nek5 Mus musculus (Mouse) PR
O35942 Nek2 Serine/threonine-protein kinase Nek2 Mus musculus (Mouse) PR
Q10GB1 NEK1 Serine/threonine-protein kinase Nek1 Oryza sativa subsp japonica (Rice) PR
Q19469 sad-1 Serine/threonine kinase SAD-1 Caenorhabditis elegans SS
Q9LT35 NEK6 Serine/threonine-protein kinase Nek6 Arabidopsis thaliana (Mouse-ear cress) PR
Q8RXT4 NEK4 Serine/threonine-protein kinase Nek4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SLI2 NEK1 Serine/threonine-protein kinase Nek1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MEQYEVLEQI GKGSFGSALL VRHKVEKKRY VLKKIRLARQ TDRCRRSAHQ EMELIAKVRN
70 80 90 100 110 120
PYIVEYKDSW VEKGCYVCIV IGYCEGGDMS EAIKKANSNY FSEERLCMWL VQLLMALDYL
130 140 150 160 170 180
HVNHILHRDV KCSNIFLTKD QNIRLGDFGL AKVLTSDDLT SSVVGTPSYM CPELLADIPY
190 200 210 220 230 240
GSKSDIWSLG CCLYEMTALK PAFKAFDMQT LINKISKSVL APLPTIYSGA FRGLIKSMLR
250 260 270 280 290 300
KSPDHRPSAA ELLKHPHLQP FVLELQLKSS PARNLFPDTN KASCSDDENN WKAKYSKSHS
310 320 330 340 350 360
FKVDRIVKVD KVAANNGHPS STGTAKDYQE LLKQPMDELL GQLTEKVVDE VIHGNHSRVT
370 380 390 400 410 420
KSPAPTPRRA SSTPRIRLEP SKTFHARAAE TPPSKCSLER ASQPTRRAST PVNMLQTPEK
430 440 450 460 470 480
RQGADILTRL KSPDVSVNSP RIDRIAEFPI PSFDDEQLHP TTKLKLYPPS ITDQSITKDK
490 500 510 520 530 540
CTFQVLRSDS SKNHTGDSSD PSILGTDSNP LITSSSDWMK QRRFDTTSYR QRAEALEGLL
550 560 570 580
EFSAQLLQQE RFEELGILLK PFGPGKASPR ETAIWLSKSF KGTGL