Q6Z2Z4

PR
Gene name
Os02g0146600 (LOC_Os02g05330, OJ1008_C03.10, OsJ_05367)
Protein name
Eukaryotic initiation factor 4A-3
Names
eIF-4A-3, ATP-dependent RNA helicase eIF4A-3, DEAD-box ATP-dependent RNA helicase 23, eIF4A-2
Species
Oryza sativa subsp japonica (Rice)
KEGG Pathway
osa:4328286
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-67 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6Z2Z4

Entry ID Method Resolution Chain Position Source
AF-Q6Z2Z4-F1 Predicted AlphaFoldDB

No variants for Q6Z2Z4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6Z2Z4

No associated diseases with Q6Z2Z4

5 regional properties for Q6Z2Z4

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 188 - 196 IPR000629
domain Helicase, C-terminal 253 - 414 IPR001650
domain DEAD/DEAH box helicase domain 66 - 227 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 60 - 257 IPR014001
domain RNA helicase, DEAD-box type, Q motif 41 - 69 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Localizes to the nucleus when interacting with DRM2
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

1 GO annotations of biological process

Name Definition
cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

23 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41378 Eukaryotic initiation factor 4A Triticum aestivum (Wheat) PR
P10081 TIF2 ATP-dependent RNA helicase eIF4A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3SZ54 EIF4A1 Eukaryotic initiation factor 4A-I Bos taurus (Bovine) PR
Q3SZ65 EIF4A2 Eukaryotic initiation factor 4A-II Bos taurus (Bovine) PR
Q8JFP1 EIF4A2 Eukaryotic initiation factor 4A-II Gallus gallus (Chicken) PR
A5A6N4 EIF4A1 Eukaryotic initiation factor 4A-I Pan troglodytes (Chimpanzee) PR
Q14240 EIF4A2 Eukaryotic initiation factor 4A-II Homo sapiens (Human) PR
P60842 EIF4A1 Eukaryotic initiation factor 4A-I Homo sapiens (Human) PR
Q41741 Eukaryotic initiation factor 4A Zea mays (Maize) PR
P60843 Eif4a1 Eukaryotic initiation factor 4A-I Mus musculus (Mouse) PR
P10630 Eif4a2 Eukaryotic initiation factor 4A-II Mus musculus (Mouse) PR
Q5RKI1 Eif4a2 Eukaryotic initiation factor 4A-II Rattus norvegicus (Rat) PR
P35683 Os06g0701100 Eukaryotic initiation factor 4A-1 Oryza sativa subsp japonica (Rice) PR
Q7Y183 RH10 DEAD-box ATP-dependent RNA helicase 10 Oryza sativa subsp japonica (Rice) PR
Q5K5B6 Os07g0647900 DEAD-box ATP-dependent RNA helicase 57 Oryza sativa subsp japonica (Rice) PR
Q0DBS1 Os06g0535100 Putative DEAD-box ATP-dependent RNA helicase 51 Oryza sativa subsp japonica (Rice) PR
Q0D622 Os07g0517000 DEAD-box ATP-dependent RNA helicase 32 Oryza sativa subsp japonica (Rice) PR
Q8L4E9 Os07g0633500 DEAD-box ATP-dependent RNA helicase 36 Oryza sativa subsp japonica (Rice) PR
P27639 inf-1 Eukaryotic initiation factor 4A Caenorhabditis elegans PR
Q9CAI7 TIF4A-3 Eukaryotic initiation factor 4A-3 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E9C3 RH58 DEAD-box ATP-dependent RNA helicase 58, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
P41377 TIF4A-2 Eukaryotic initiation factor 4A-2 Arabidopsis thaliana (Mouse-ear cress) PR
P41376 EIF4A1 Eukaryotic initiation factor 4A-1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAGMAPEGSQ FDAKHYDSKM QELLHQGDNE EFFTSYDEVF ESFDDMGLQE NLLRGIYAYG
70 80 90 100 110 120
FEKPSAIQQR GIVPFCKGLD VIQQAQSGTG KTATFCSGIL QQLDYGLVEC QSLVLAPTRE
130 140 150 160 170 180
LAQQIEKVMR ALGDYLGVKV HACVGGTSVR EDQRILASGV HVVVGTPGRV FDMLRRQSLR
190 200 210 220 230 240
PDHIKMFVLD EADEMLSRGF KDQIYDIFQL LPPKIQVGVF SATMPPEALE ITRKFMNKPV
250 260 270 280 290 300
RILVKRDELT LEGIKQFYVN VEKEDWKLDT LCDLYETLAI TQSVIFVNTR RKVDWLTDKM
310 320 330 340 350 360
RSRDHTVSAT HGDMDQNTRD IIMREFRSGS SRVLITTDLL ARGIDVQQVS LVINYDLPTQ
370 380 390 400 410
PENYLHRIGR SGRFGRKGVA INFVTRDDER MLFDIQRFYN VTIEELPANV ADLL