Q6Y306

PR
Gene name
Abcc12 (Mrp9)
Protein name
ATP-binding cassette sub-family C member 12
Names
Multidrug resistance-associated protein 9
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:291923
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

421-498 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6Y306

Entry ID Method Resolution Chain Position Source
AF-Q6Y306-F1 Predicted AlphaFoldDB

No variants for Q6Y306

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6Y306

No associated diseases with Q6Y306

8 regional properties for Q6Y306

Type Name Position InterPro Accession
domain ABC transporter-like, ATP-binding domain 478 - 702 IPR003439-1
domain ABC transporter-like, ATP-binding domain 1127 - 1361 IPR003439-2
domain AAA+ ATPase domain 506 - 679 IPR003593-1
domain AAA+ ATPase domain 1153 - 1346 IPR003593-2
domain ABC transporter type 1, transmembrane domain 127 - 404 IPR011527-1
domain ABC transporter type 1, transmembrane domain 793 - 1089 IPR011527-2
conserved_site ABC transporter-like, conserved site 604 - 618 IPR017871-1
conserved_site ABC transporter-like, conserved site 1264 - 1278 IPR017871-2

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Localizes to the midpiece of the sperm tail
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

3 GO annotations of molecular function

Name Definition
ABC-type transporter activity Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase-coupled transmembrane transporter activity Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.

1 GO annotations of biological process

Name Definition
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

26 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P38735 VMR1 ABC transporter ATP-binding protein/permease VMR1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P0CE68 NFT1 ABC transporter NFT1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q8HXQ5 ABCC1 Multidrug resistance-associated protein 1 Bos taurus (Bovine) PR
Q2QLE5 CFTR Cystic fibrosis transmembrane conductance regulator Pan troglodytes (Chimpanzee) PR
P91660 Rh5 Probable multidrug resistance-associated protein lethal(2)03659 Drosophila melanogaster (Fruit fly) PR
P13569 CFTR Cystic fibrosis transmembrane conductance regulator Homo sapiens (Human) PR
O95255 ABCC6 ATP-binding cassette sub-family C member 6 Homo sapiens (Human) PR
O15438 ABCC3 ATP-binding cassette sub-family C member 3 Homo sapiens (Human) PR
Q92887 ABCC2 ATP-binding cassette sub-family C member 2 Homo sapiens (Human) SS
O15439 ABCC4 ATP-binding cassette sub-family C member 4 Homo sapiens (Human) PR
Q96J66 ABCC11 ATP-binding cassette sub-family C member 11 Homo sapiens (Human) PR
P33527 ABCC1 Multidrug resistance-associated protein 1 Homo sapiens (Human) PR
B2RX12 Abcc3 ATP-binding cassette sub-family C member 3 Mus musculus (Mouse) PR
Q8VI47 Abcc2 ATP-binding cassette sub-family C member 2 Mus musculus (Mouse) SS
P26361 Cftr Cystic fibrosis transmembrane conductance regulator Mus musculus (Mouse) PR
O35379 Abcc1 Multidrug resistance-associated protein 1 Mus musculus (Mouse) PR
Q80WJ6 Abcc12 ATP-binding cassette sub-family C member 12 Mus musculus (Mouse) PR
Q6PQZ2 CFTR Cystic fibrosis transmembrane conductance regulator Sus scrofa (Pig) PR
Q63120 Abcc2 ATP-binding cassette sub-family C member 2 Rattus norvegicus (Rat) EV
Q8CG09 Abcc1 Multidrug resistance-associated protein 1 Rattus norvegicus (Rat) PR
Q00553 CFTR Cystic fibrosis transmembrane conductance regulator Macaca mulatta (Rhesus macaque) PR
Q9SKX0 ABCC13 ABC transporter C family member 13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8H0 ABCC12 ABC transporter C family member 12 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C8G9 ABCC1 ABC transporter C family member 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VZZ4 ABCC6 ABC transporter C family member 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M1C7 ABCC9 ABC transporter C family member 9 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVGEDPYLIS DLDRRGRRRS FAERYDPSLK TMIPMRPYAR LAPNPVDDAG LLSFATFSWL
70 80 90 100 110 120
TPVMIRSYKH TLTVDTLPPL SPYDSSDVNA KRLQILWDEE IERVGPERAS LGRVVWKFQR
130 140 150 160 170 180
TRVLMDVVAN ILCIIMAALG PTVLIHQILQ HVTNISSGHI GISICLCLAL FATEFTKVLF
190 200 210 220 230 240
RALAWAINYR TAIRLKVALS TLIFKNLLSF KTLTHISAGE VLNVLSSDSY SLFEAALFCP
250 260 270 280 290 300
LPATIPILMV VCAVYAFFIL GSTALVGICV YLIFIPIQMF MAKLNSAFRR SAISVTDKRV
310 320 330 340 350 360
QTMNEFLTCI KLIKMYAWEK SFMNTIHDIR KREKKLLEKA GYVQSGNSAL APIVSTIAIV
370 380 390 400 410 420
STFTCHIFLK RTLTAPVAFS VIAMFNVMKF SIAILPFSVK AVAEASVSLR RMKKILVAKS
430 440 450 460 470 480
PPSYITQPED PDTILLLANA TLTWEQEINR KRGPSKTQDQ RRHVFKKQRA ELYSEQSLSD
490 500 510 520 530 540
QGVASPERQS GSPKSVLHNI SFVVRKGKVL GICGNVGSGK SSLISALLGQ MQLQKGVVAA
550 560 570 580 590 600
SGPLAYVSQQ AWIFHGNVRE NILFGEKYNH QRYQHTVHVC GLQKDLNSLP YGDLTEIGER
610 620 630 640 650 660
GVNLSGGQRQ RISLARAVYA NRQLYLLDDP LSAVDAHVGK HVFEECIKKT LKGKTVVLVT
670 680 690 700 710 720
HQLQFLESCD EVILLEDGEI CEKGTHKELM EERGRYAKLI HNLRGLQFKD PEHIYNVAMV
730 740 750 760 770 780
ETLKESQAQR DEDAVLASGD ERDEGKEPET EEFVDIKAPV HQLIQIESPQ EGIVTWKTYH
790 800 810 820 830 840
TYIKASGGYL VSFLVLCLFF LMMGSSAFST WWLGLWLDSG SQVICAPQSN ETACNVNQTL
850 860 870 880 890 900
QDTKHHMYQL VYIASMMSVL TFGIIKGFTF TNTTLMASSS LHNRVFNKIV SSPMSFFDTT
910 920 930 940 950 960
PTGRLMNRFS KDMDELDVRL PFHAENFLQQ FSMVVFILVI MAASFPVVLV VLAGLAILFF
970 980 990 1000 1010 1020
ILLRIFHRGV QELKQVENIS RSPWFSHITS SMQGLGVIHA YDKKDDCISK FKALNDENSS
1030 1040 1050 1060 1070 1080
HLLYFNCALR WFALRMDILM NIVTFVVALL VTLSFSSISA SSKGLSLSYI IQLSGLLQVC
1090 1100 1110 1120 1130 1140
VRTGTETQAK FTSAELMREY ISTCVPEHTQ SFKVGTCPKD WPSRGEITFK DYRMRYRDNT
1150 1160 1170 1180 1190 1200
PLVLDGLNLN IQSGQTVGIV GRTGSGKSSL GMALFRLVEP ASGTIFIDEV DICTVGLEEL
1210 1220 1230 1240 1250 1260
RTKLTMIPQD PVLFVGTVRY NLDPLGSHTD EMLWHVLERT FMRDTIMKLP EKLQAEVTEN
1270 1280 1290 1300 1310 1320
GENFSVGERQ LLCMARALLR NSKIILLDEA TASMDSKTDT LVQSTIKEAF KSCTVLTIAH
1330 1340 1350 1360
RLNTVLNCDL VLVMENGKVI EFDKPEVLAE KPDSAFAMLL AAEVGL