Q6XAT2

PR
Gene name
ERL2 (At5g07180, T28J14.120)
Protein name
LRR receptor-like serine/threonine-protein kinase ERL2
Names
Protein ERECTA-like kinase 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G07180
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

911-967 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q6XAT2

Entry ID Method Resolution Chain Position Source
5XKN X-ray 365 A A/B 30-575 PDB
AF-Q6XAT2-F1 Predicted AlphaFoldDB

61 variants for Q6XAT2

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_2233212_C_T 7 M>I No 1000Genomes
ENSVATH00610251 11 F>V No 1000Genomes
tmp_5_2233193_G_T 14 L>M No 1000Genomes
tmp_5_2233181_C_A 18 V>F No 1000Genomes
tmp_5_2233151_T_C 28 M>V No 1000Genomes
ENSVATH10625915 38 I>M No 1000Genomes
ENSVATH06934756 39 K>R No 1000Genomes
ENSVATH00610248 58 H>N No 1000Genomes
tmp_5_2232454_C_T 92 A>T No 1000Genomes
tmp_5_2232445_C_T 95 D>N No 1000Genomes
ENSVATH03033007 118 G>E No 1000Genomes
tmp_5_2232288_C_G 118 G>R No 1000Genomes
tmp_5_2232276_A_G 122 S>P No 1000Genomes
tmp_5_2232266_T_A 125 Y>F No 1000Genomes
tmp_5_2231681_G_C 206 T>S No 1000Genomes
tmp_5_2231669_G_A 210 S>F No 1000Genomes
tmp_5_2231666_G_T 211 P>H No 1000Genomes
ENSVATH06934744 213 M>V No 1000Genomes
ENSVATH06934742 218 G>S No 1000Genomes
tmp_5_2231486_T_A 242 S>C No 1000Genomes
ENSVATH10625734 276 L>F No 1000Genomes
ENSVATH13948175 349 V>M No 1000Genomes
ENSVATH06934728 375 L>V No 1000Genomes
ENSVATH03032980 380 I>V No 1000Genomes
tmp_5_2230429_C_A 400 V>L No 1000Genomes
tmp_5_2230284_C_G 419 S>T No 1000Genomes
tmp_5_2230130_A_C 440 S>A No 1000Genomes
ENSVATH00610224 454 D>V No 1000Genomes
ENSVATH00610220 472 L>V No 1000Genomes
tmp_5_2229921_C_T 481 S>N No 1000Genomes
tmp_5_2229654_T_C 517 H>R No 1000Genomes
tmp_5_2229456_A_C 550 F>V No 1000Genomes
ENSVATH00610216 554 S>A No 1000Genomes
ENSVATH00610216 554 S>P No 1000Genomes
tmp_5_2229148_A_C 600 C>G No 1000Genomes
tmp_5_2229145_T_A 601 M>L No 1000Genomes
tmp_5_2229144_A_G 601 M>T No 1000Genomes
tmp_5_2229079_G_T 623 P>T No 1000Genomes
ENSVATH00610208 652 D>N No 1000Genomes
ENSVATH06934702 657 I>V No 1000Genomes
ENSVATH06934701 659 Y>N No 1000Genomes
tmp_5_2228866_C_T 665 V>I No 1000Genomes
tmp_5_2228853_G_A 669 T>I No 1000Genomes
tmp_5_2228851_A_G 670 S>P No 1000Genomes
ENSVATH00610207 687 S>N No 1000Genomes
tmp_5_2228706_A_G 718 F>S No 1000Genomes
ENSVATH00610205 811 Y>S No 1000Genomes
ENSVATH10625640 828 R>C No 1000Genomes
ENSVATH10625639 835 I>L No 1000Genomes
tmp_5_2228193_C_A 858 L>F No 1000Genomes
ENSVATH13948112 908 P>A No 1000Genomes
ENSVATH06934696 922 P>L No 1000Genomes
ENSVATH00610202 924 P>S No 1000Genomes
tmp_5_2227915_G_C 926 P>A No 1000Genomes
tmp_5_2227914_G_A 926 P>L No 1000Genomes
ENSVATH00610200 942 R>C No 1000Genomes
tmp_5_2227824_A_C 956 V>G No 1000Genomes
tmp_5_2227825_C_T 956 V>I No 1000Genomes
tmp_5_2227816_G_C 959 R>G No 1000Genomes
ENSVATH00610199 964 K>N No 1000Genomes
tmp_5_2227800_T_C 964 K>R No 1000Genomes

No associated diseases with Q6XAT2

17 regional properties for Q6XAT2

Type Name Position InterPro Accession
domain Protein kinase domain 651 - 921 IPR000719
repeat Leucine-rich repeat 170 - 192 IPR001611-1
repeat Leucine-rich repeat 239 - 256 IPR001611-2
repeat Leucine-rich repeat 433 - 490 IPR001611-3
repeat Leucine-rich repeat, typical subtype 96 - 120 IPR003591-1
repeat Leucine-rich repeat, typical subtype 144 - 167 IPR003591-2
repeat Leucine-rich repeat, typical subtype 168 - 192 IPR003591-3
repeat Leucine-rich repeat, typical subtype 216 - 240 IPR003591-4
repeat Leucine-rich repeat, typical subtype 287 - 311 IPR003591-5
repeat Leucine-rich repeat, typical subtype 359 - 383 IPR003591-6
repeat Leucine-rich repeat, typical subtype 407 - 431 IPR003591-7
repeat Leucine-rich repeat, typical subtype 455 - 478 IPR003591-8
repeat Leucine-rich repeat, typical subtype 503 - 527 IPR003591-9
active_site Serine/threonine-protein kinase, active site 772 - 784 IPR008271
domain Leucine-rich repeat-containing N-terminal, plant-type 29 - 69 IPR013210
binding_site Protein kinase, ATP binding site 657 - 679 IPR017441
repeat Leucine rich repeat 4 145 - 181 IPR025875

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
receptor serine/threonine kinase binding Binding to a receptor that possesses protein serine/threonine kinase activity.

4 GO annotations of biological process

Name Definition
embryo sac development The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate.
plant ovule development The process whose specific outcome is the progression of the ovule over time, from its formation to the mature structure. The ovule is the structure in seed plants enclosing the female gametophyte, and is composed of the nucellus, one or two integuments, and the funiculus; it develops into the seed.
protein phosphorylation The process of introducing a phosphate group on to a protein.
stomatal complex morphogenesis The process in which the anatomical structures of the stomatal complex are generated and organized. The stomatal complex is the stomatal guard cells and their associated epidermal cells.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P09581 Csf1r Macrophage colony-stimulating factor 1 receptor Mus musculus (Mouse) SS
P21803 Fgfr2 Fibroblast growth factor receptor 2 Mus musculus (Mouse) SS
P16092 Fgfr1 Fibroblast growth factor receptor 1 Mus musculus (Mouse) SS
Q03142 Fgfr4 Fibroblast growth factor receptor 4 Mus musculus (Mouse) PR
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
Q00342 Flt3 Receptor-type tyrosine-protein kinase FLT3 Mus musculus (Mouse) SS
Q61006 Musk Muscle, skeletal receptor tyrosine-protein kinase Mus musculus (Mouse) SS
P55144 Tyro3 Tyrosine-protein kinase receptor TYRO3 Mus musculus (Mouse) SS
Q00993 Axl Tyrosine-protein kinase receptor UFO Mus musculus (Mouse) PR
Q60805 Mertk Tyrosine-protein kinase Mer Mus musculus (Mouse) SS
Q3UFB7 Ntrk1 High affinity nerve growth factor receptor Mus musculus (Mouse) SS
Q61851 Fgfr3 Fibroblast growth factor receptor 3 Mus musculus (Mouse) PR
C0LGT6 EFR LRR receptor-like serine/threonine-protein kinase EFR Arabidopsis thaliana (Mouse-ear cress) PR
C0LGE4 At1g12460 Probable LRR receptor-like serine/threonine-protein kinase At1g12460 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SHI4 RLP3 Receptor-like protein 3 Arabidopsis thaliana (Mouse-ear cress) SS
C0LGJ1 At1g74360 Probable LRR receptor-like serine/threonine-protein kinase At1g74360 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MRRIETMKGL FFCLGMVVFM LLGSVSPMNN EGKALMAIKA SFSNVANMLL DWDDVHNHDF
70 80 90 100 110 120
CSWRGVFCDN VSLNVVSLNL SNLNLGGEIS SALGDLMNLQ SIDLQGNKLG GQIPDEIGNC
130 140 150 160 170 180
VSLAYVDFST NLLFGDIPFS ISKLKQLEFL NLKNNQLTGP IPATLTQIPN LKTLDLARNQ
190 200 210 220 230 240
LTGEIPRLLY WNEVLQYLGL RGNMLTGTLS PDMCQLTGLW YFDVRGNNLT GTIPESIGNC
250 260 270 280 290 300
TSFEILDVSY NQITGVIPYN IGFLQVATLS LQGNKLTGRI PEVIGLMQAL AVLDLSDNEL
310 320 330 340 350 360
TGPIPPILGN LSFTGKLYLH GNKLTGQIPP ELGNMSRLSY LQLNDNELVG KIPPELGKLE
370 380 390 400 410 420
QLFELNLANN NLVGLIPSNI SSCAALNQFN VHGNFLSGAV PLEFRNLGSL TYLNLSSNSF
430 440 450 460 470 480
KGKIPAELGH IINLDTLDLS GNNFSGSIPL TLGDLEHLLI LNLSRNHLNG TLPAEFGNLR
490 500 510 520 530 540
SIQIIDVSFN FLAGVIPTEL GQLQNINSLI LNNNKIHGKI PDQLTNCFSL ANLNISFNNL
550 560 570 580 590 600
SGIIPPMKNF TRFSPASFFG NPFLCGNWVG SICGPSLPKS QVFTRVAVIC MVLGFITLIC
610 620 630 640 650 660
MIFIAVYKSK QQKPVLKGSS KQPEGSTKLV ILHMDMAIHT FDDIMRVTEN LDEKYIIGYG
670 680 690 700 710 720
ASSTVYKCTS KTSRPIAIKR IYNQYPSNFR EFETELETIG SIRHRNIVSL HGYALSPFGN
730 740 750 760 770 780
LLFYDYMENG SLWDLLHGPG KKVKLDWETR LKIAVGAAQG LAYLHHDCTP RIIHRDIKSS
790 800 810 820 830 840
NILLDGNFEA RLSDFGIAKS IPATKTYAST YVLGTIGYID PEYARTSRLN EKSDIYSFGI
850 860 870 880 890 900
VLLELLTGKK AVDNEANLHQ MILSKADDNT VMEAVDAEVS VTCMDSGHIK KTFQLALLCT
910 920 930 940 950 960
KRNPLERPTM QEVSRVLLSL VPSPPPKKLP SPAKVQEGEE RRESHSSDTT TPQWFVQFRE
DISKSSL