Q6T8E9
SS
Gene name |
CCNT1 |
Protein name |
Cyclin-T1 |
Names |
CycT1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:407194 |
EC number |
|
Protein Class |
|
Descriptions
Cyclin-T1 (CycT1) combines with cyclin-dependent kinase (Cdk9) and this complex is called positive transcription elongation factor B (P-TEFb). An intramolecular interaction between the N- and C-terminal regions of cyclin T1 sterically masks the TAR-binding surface, thereby blocking the P-TEFb?TAR interaction. Binding of Tat-SF1 to the CycT1 C-terminal region disrupts the intramolecular interaction in CycT1, stabilizes the P-TEFb-Tat-TAR complex, and stimulates HIV-1 transcription. The efficient interaction between P-TEFb and TAR RNA requires suppression of the autoinhibitory activity of the CycT1 C-terminal region.
Autoinhibitory domains (AIDs)
Target domain |
1-334 (N-terminal cyclin box) |
Relief mechanism |
PTM, Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6T8E9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6T8E9-F1 | Predicted | AlphaFoldDB |
85 variants for Q6T8E9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs467202272 | 49 | G>A | No | EVA | |
| rs467186736 | 129 | Q>E | No | EVA | |
| rs876600889 | 134 | V>A | No | EVA | |
| rs452762025 | 138 | S>T | No | EVA | |
| rs471391746 | 143 | T>P | No | EVA | |
| rs447548099 | 195 | V>E | No | EVA | |
| rs464381073 | 206 | K>N | No | EVA | |
| rs433059716 | 208 | S>P | No | EVA | |
| rs451991688 | 258 | W>S | No | EVA | |
| rs446304277 | 263 | A>P | No | EVA | |
| rs463055308 | 264 | D>H | No | EVA | |
| rs467340579 | 269 | A>G | No | EVA | |
| rs450429305 | 269 | A>T | No | EVA | |
| rs446468023 | 275 | D>N | No | EVA | |
| rs459155931 | 315 | P>T | No | EVA | |
| rs209763046 | 322 | S>N | No | EVA | |
| rs432121038 | 394 | R>L | No | EVA | |
| rs452441602 | 401 | L>W | No | EVA | |
| rs475732696 | 411 | M>R | No | EVA | |
| rs437875679 | 419 | Y>C | No | EVA | |
| rs454966174 | 425 | N>K | No | EVA | |
| rs474998672 | 435 | S>W | No | EVA | |
| rs719701738 | 450 | R>W | No | EVA | |
| rs439724818 | 451 | P>L | No | EVA | |
| rs462969381 | 452 | F>V | No | EVA | |
| rs483252550 | 456 | T>A | No | EVA | |
| rs481037165 | 461 | L>V | No | EVA | |
| rs446559197 | 464 | R>T | No | EVA | |
| rs466593310 | 473 | A>S | No | EVA | |
| rs432033935 | 474 | A>T | No | EVA | |
| rs445890497 | 476 | I>V | No | EVA | |
| rs451228191 | 482 | K>N | No | EVA | |
| rs469167622 | 485 | I>S | No | EVA | |
| rs454703328 | 489 | T>P | No | EVA | |
| rs468599458 | 490 | A>T | No | EVA | |
| rs433942714 | 492 | D>E | No | EVA | |
| rs454219332 | 493 | K>E | No | EVA | |
| rs470940487 | 493 | K>N | No | EVA | |
| rs439663525 | 495 | N>D | No | EVA | |
| rs476570964 | 495 | N>K | No | EVA | |
| rs456615845 | 495 | N>S | No | EVA | |
| rs462397033 | 497 | V>E | No | EVA | |
| rs481074868 | 499 | D>Y | No | EVA | |
| rs440027263 | 502 | T>K | No | EVA | |
| rs477145196 | 513 | T>I | No | EVA | |
| rs469179674 | 514 | H>R | No | EVA | |
| rs448389467 | 519 | H>Q | No | EVA | |
| rs468409519 | 526 | S>P | No | EVA | |
| rs433851468 | 528 | K>R | No | EVA | |
| rs454069670 | 529 | H>P | No | EVA | |
| rs133730852 | 530 | S>A | No | EVA | |
| rs433261066 | 531 | H>D | No | EVA | |
| rs442158132 | 532 | S>L | No | EVA | |
| rs476632150 | 532 | S>P | No | EVA | |
| rs455900380 | 534 | L>R | No | EVA | |
| rs800620900 | 535 | P>L | No | EVA | |
| rs441500252 | 536 | A>S | No | EVA | |
| rs460174689 | 556 | A>P | No | EVA | |
| rs476955271 | 559 | P>T | No | EVA | |
| rs439329520 | 561 | S>T | No | EVA | |
| rs462617189 | 564 | S>R | No | EVA | |
| rs448216450 | 567 | S>C | No | EVA | |
| rs468372149 | 572 | S>A | No | EVA | |
| rs478992358 | 574 | K>T | No | EVA | |
| rs447509274 | 584 | V>E | No | EVA | |
| rs447509274 | 584 | V>G | No | EVA | |
| rs717437959 | 589 | S>* | No | EVA | |
| rs135032279 | 589 | S>P | No | EVA | |
| rs136608799 | 592 | T>P | No | EVA | |
| rs433120772 | 598 | S>P | No | EVA | |
| rs450112992 | 598 | S>Y | No | EVA | |
| rs470146281 | 605 | F>L | No | EVA | |
| rs455912876 | 609 | P>T | No | EVA | |
| rs798893223 | 613 | Q>E | No | EVA | |
| rs435088111 | 613 | Q>H | No | EVA | |
| rs451976075 | 614 | L>V | No | EVA | |
| rs435185599 | 615 | P>T | No | EVA | |
| rs470603632 | 620 | D>E | No | EVA | |
| rs439189927 | 631 | C>Y | No | EVA | |
| rs448809241 | 668 | L>P | No | EVA | |
| rs462529552 | 674 | V>I | No | EVA | |
| rs378858628 | 677 | T>I | No | EVA | |
| rs476332235 | 685 | V>L | No | EVA | |
| rs441701417 | 693 | N>H | No | EVA | |
| rs461931967 | 708 | K>N | No | EVA |
No associated diseases with Q6T8E9
9 regional properties for Q6T8E9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ubiquitin-like domain | 1 - 73 | IPR000626 |
| domain | IBR domain | 313 - 377 | IPR002867-1 |
| domain | IBR domain | 401 - 457 | IPR002867-2 |
| domain | RING/Ubox-like zinc-binding domain | 228 - 318 | IPR041170 |
| domain | Parkin, RING/Ubox like zinc-binding domain | 145 - 217 | IPR041565 |
| domain | TRIAD supradomain | 234 - 465 | IPR044066 |
| domain | E3 ubiquitin-protein ligase parkin, BRcat domain | 301 - 381 | IPR047534 |
| domain | E3 ubiquitin-protein ligase parkin, RING finger, HC subclass | 236 - 294 | IPR047535 |
| domain | E3 ubiquitin-protein ligase parkin, Rcat domain | 409 - 463 | IPR047536 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cyclin/CDK positive transcription elongation factor complex | A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P-TEFb complex | A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 7SK snRNA binding | Binding to a 7SK small nuclear RNA (7SK snRNA). |
| cyclin-dependent protein serine/threonine kinase activator activity | Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. |
| molecular condensate scaffold activity | Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| positive regulation of DNA-templated transcription, elongation | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. |
| positive regulation of transcription elongation by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZCK5 | CCNC | Cyclin-C | Bos taurus (Bovine) | PR |
| Q3ZBL9 | CCNH | Cyclin-H | Bos taurus (Bovine) | PR |
| Q8HXN7 | CCNT1 | Cyclin-T1 | Pan troglodytes (Chimpanzee) | SS |
| Q9XT26 | CCNT1 | Cyclin-T1 | Equus caballus (Horse) | SS |
| O75909 | CCNK | Cyclin-K | Homo sapiens (Human) | PR |
| Q8N1B3 | CCNQ | Cyclin-Q | Homo sapiens (Human) | PR |
| O60563 | CCNT1 | Cyclin-T1 | Homo sapiens (Human) | EV |
| O88874 | Ccnk | Cyclin-K | Mus musculus (Mouse) | PR |
| Q9QWV9 | Ccnt1 | Cyclin-T1 | Mus musculus (Mouse) | SS |
| Q2QQS5 | CYCT1-1 | Cyclin-T1-4 | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z7H3 | CYCT1_2 | Cyclin-T1-2 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAC5 | CYCT1-3 | Cyclin-T1-3 | Oryza sativa subsp japonica (Rice) | PR |
| Q8GYM6 | CYCT1-4 | Cyclin-T1-4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q503D6 | ccnq | Cyclin-Q | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEGERKNNNK | RWYFTREQLE | NSPSRRFGLD | PDKELSNRQQ | AANLLQDMGQ | RLNVSQLTIN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TAIVYMHRFY | MIQSFTQFHR | NSVAPAALFL | AAKVEEQPKK | LEHVIKVAHT | CLHPQESLPD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TRSEAYLQQV | QDLVILESII | LQTLGFELTI | DHPHTHVVKC | TQLVRASKDL | AQTSYFMATN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SLHLTTFSLQ | YTPPVVACVC | IHLACKWSNW | EIPVSTDGKH | WWEYVDATVT | LELLDELTHE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLQILEKTPN | RLKRIWNWRA | WQADRKTKAD | DRGADENSSE | QTILNMISQS | SSDTTIAGLM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SMSASSTTSA | VPSLPATEDS | KSNLSNVEML | SSERWLSSHP | PFKVEPAQGY | RKSENLALVG |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ADHSLQQDGS | NAFVSQKQNS | KSVPSAKVSL | KEYRAKHAEE | LAAQKRQLEN | MEANVKSQYA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YAAQNLLSHH | DSHSSVILKM | PIEGSENPER | PFLEKTDKTA | LKMRIPMTGG | DKAASIKPEE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IKMRIKVHTA | ADKHNSVDDS | VTKNREHKEK | HKTHPSNHHH | HHNHHSHKHS | HSQLPAGTGN |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KRLGDPKHSS | QTSTLAHKPY | SLSSSFSSSS | SSRKRPLPEE | TGGVAYDHST | KTAKSAKSSS |
| 610 | 620 | 630 | 640 | 650 | 660 |
| INFSFPPLPT | MAQLPGHSSD | TSGLHFSQPS | CKTRVPHMKL | DKSSTGANSH | NTPQTTDYQD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TVNMLNSLLN | AQGVQPTQPP | AFEYVHSYGE | YMNPRAGGMS | SRSGNTDKPR | PPPLPSEPPP |
| PLPPLPK |