Q6T310
PR
Gene name |
RASL11A |
Protein name |
Ras-like protein family member 11A |
Names |
|
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:387496 |
EC number |
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6T310
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6T310-F1 | Predicted | AlphaFoldDB |
199 variants for Q6T310
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA387628077 rs1399405476 |
2 | R>Q | No |
ClinGen gnomAD |
|
|
rs866994045 CA247210613 |
2 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA247210617 rs376471623 |
3 | P>L | No |
ClinGen gnomAD |
|
|
CA387628083 rs376471623 |
3 | P>Q | No |
ClinGen gnomAD |
|
|
CA6925925 rs767983147 |
4 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA387628104 rs1286518090 |
6 | M>I | No |
ClinGen TOPMed |
|
|
rs1284351802 CA387628110 |
7 | S>Y | No |
ClinGen gnomAD |
|
|
rs1235486485 CA387628120 |
9 | H>D | No |
ClinGen gnomAD |
|
|
rs1235486485 CA387628121 |
9 | H>N | No |
ClinGen gnomAD |
|
|
CA387628124 rs1409491416 |
9 | H>R | No |
ClinGen TOPMed gnomAD |
|
|
CA6925926 rs778516573 |
10 | F>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs772682215 CA6925928 |
12 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA6925930 rs761092958 |
13 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA387628167 rs1421848904 |
16 | P>L | No |
ClinGen TOPMed |
|
|
CA387628166 rs1421848904 |
16 | P>R | No |
ClinGen TOPMed |
|
|
rs1486794056 CA387628171 |
17 | E>G | No |
ClinGen gnomAD |
|
|
CA6925932 rs201895282 |
17 | E>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA387628169 rs201895282 |
17 | E>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA6925933 rs200948138 |
18 | S>Y | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs765195600 CA6925934 |
20 | S>W | No |
ClinGen ExAC gnomAD |
|
|
rs1158235338 CA387628201 |
22 | Y>N | No |
ClinGen TOPMed |
|
|
CA247210690 rs752847538 |
26 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6925935 rs752847538 |
26 | K>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA387628237 rs1397807427 |
28 | I>L | No |
ClinGen gnomAD |
|
|
CA247210698 rs373973836 |
28 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
CA387628255 rs1228623625 |
30 | L>P | No |
ClinGen gnomAD |
|
|
rs1343521466 CA387628260 |
31 | A>V | No |
ClinGen gnomAD |
|
|
rs1018336408 CA247210702 |
32 | V>M | No |
ClinGen Ensembl |
|
|
rs867456249 CA247210707 |
35 | A>T | No |
ClinGen Ensembl |
|
|
CA6925940 rs780008956 |
35 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA247210712 rs1045521748 |
37 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
CA6925941 rs753500307 |
37 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA387628291 rs753500307 |
37 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1045521748 CA387628288 |
37 | R>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1356283354 CA387628294 |
38 | V>E | No |
ClinGen TOPMed |
|
|
rs906637448 CA387628293 CA247210733 |
38 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs866423127 CA247210739 |
41 | S>R | No |
ClinGen gnomAD |
|
|
CA247210743 rs866874258 |
42 | A>T | No |
ClinGen gnomAD |
|
|
CA387628343 CA247211179 rs775124920 |
43 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1566043761 CA387628351 |
45 | V>M | No |
ClinGen Ensembl |
|
|
rs746287530 CA6925968 |
47 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA6925971 rs749486551 |
51 | R>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA387628396 rs1460338135 |
52 | F>L | No |
ClinGen TOPMed |
|
|
CA387628401 rs1393222474 |
52 | F>L | No |
ClinGen gnomAD |
|
|
CA6925973 rs143135503 |
53 | I>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA6925974 rs760665024 |
56 | Y>D | No |
ClinGen ExAC gnomAD |
|
|
rs1039882304 CA247211206 |
57 | E>Q | No |
ClinGen Ensembl |
|
|
CA6925975 rs766458775 |
58 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs759430155 CA6925977 |
59 | N>K | No |
ClinGen ExAC gnomAD |
|
|
COSM1366156 rs372800147 CA6925976 |
59 | N>T | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA247211231 rs947457087 |
60 | T>I | No |
ClinGen Ensembl |
|
|
rs1409800105 CA387628478 |
63 | L>M | No |
ClinGen TOPMed |
|
|
CA6926002 rs751068692 |
63 | L>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6926004 rs541940275 |
66 | R>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA6926005 rs750876959 |
68 | V>G | No |
ClinGen ExAC gnomAD |
|
|
rs963275506 CA247211337 |
68 | V>I | No |
ClinGen Ensembl |
|
|
CA6926006 rs756611320 |
69 | Y>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 70 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs976376080 CA247211349 |
71 | E>D | No |
ClinGen Ensembl |
|
|
rs1593268140 CA387628539 |
73 | D>G | No |
ClinGen Ensembl |
|
|
rs1235873272 CA387628577 |
79 | I>V | No |
ClinGen gnomAD |
|
|
rs1283380941 CA387628585 |
80 | Q>* | No |
ClinGen gnomAD |
|
|
CA6926008 rs754293576 |
80 | Q>P | No |
ClinGen ExAC |
|
|
rs777701224 CA247211363 |
81 | D>Y | No |
ClinGen Ensembl |
|
|
CA387628602 rs1593268162 |
82 | T>N | No |
ClinGen Ensembl |
|
|
CA387628606 rs1215480270 |
83 | P>H | No |
ClinGen gnomAD |
|
|
rs1215480270 CA387628607 |
83 | P>R | No |
ClinGen gnomAD |
|
|
CA387628609 rs1238759617 |
84 | G>R | No |
ClinGen TOPMed |
|
|
COSM213728 rs748392058 CA6926011 |
85 | G>A | breast [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs748392058 CA6926012 |
85 | G>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs777742731 CA6926013 |
86 | V>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA387628657 rs1273410674 |
89 | Q>P | No |
ClinGen TOPMed |
|
| TCGA novel | 93 | P>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6926034 rs747101856 |
94 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
CA6926035 rs369518217 |
94 | Q>H | No |
ClinGen ESP ExAC gnomAD |
|
|
CA387628695 rs1231796151 |
95 | V>I | No |
ClinGen gnomAD |
|
|
rs780028614 CA6926036 |
96 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA387628706 rs1271513132 |
97 | D>N | No |
ClinGen gnomAD |
|
|
CA6926039 rs774165446 |
102 | C>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs560577318 CA387628746 |
103 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs560577318 CA6926040 |
103 | V>M | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA387628755 rs1258035411 |
104 | Q>R | No |
ClinGen gnomAD |
|
|
rs140404399 CA6926041 |
105 | W>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1593268777 CA387628767 |
106 | A>T | No |
ClinGen Ensembl |
|
|
CA6926044 rs760160690 |
107 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6926043 rs760160690 |
107 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 108 | G>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA387628813 rs1312635873 |
113 | Y>C | No |
ClinGen gnomAD |
|
| TCGA novel | 113 | Y>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs758618668 CA6926049 |
115 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1268888003 CA387628831 |
116 | T>A | No |
ClinGen gnomAD |
|
|
CA6926051 rs542993970 |
116 | T>I | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs374287525 CA6926052 |
117 | D>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 118 | Y>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA387628855 rs1275265087 |
119 | D>E | No |
ClinGen gnomAD |
|
|
CA6926053 rs781254090 |
122 | L>F | No |
ClinGen ExAC gnomAD |
|
|
CA6926055 rs201189276 |
124 | I>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM145851 rs778646573 CA6926056 |
125 | R>* | haematopoietic_and_lymphoid_tissue [Cosmic] | No |
ClinGen cosmic curated ExAC gnomAD |
|
CA6926057 rs747958383 |
125 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1476636858 CA387628905 |
127 | L>R | No |
ClinGen TOPMed |
|
|
rs771742330 CA6926058 |
128 | Y>* | No |
ClinGen ExAC gnomAD |
|
|
CA387628916 rs1193166788 |
129 | Q>R | No |
ClinGen TOPMed |
|
|
rs1187737559 CA387628939 |
132 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
CA387628938 rs1187737559 |
132 | R>P | No |
ClinGen TOPMed gnomAD |
|
|
CA387628937 rs1187737559 |
132 | R>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA6926059 rs772681195 |
132 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746675559 CA6926060 |
133 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1215133510 CA387628942 |
133 | K>R | No |
ClinGen TOPMed |
|
|
rs1349759986 CA387628952 |
134 | V>A | No |
ClinGen gnomAD |
|
|
CA387628955 rs1593268841 |
135 | H>Y | No |
ClinGen Ensembl |
|
|
rs1173814097 CA387628964 |
136 | P>H | No |
ClinGen gnomAD |
|
|
rs1332248605 CA387628961 |
136 | P>T | No |
ClinGen TOPMed |
|
|
CA6926061 rs199902599 |
139 | K>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs200560214 CA247212296 |
141 | P>A | No |
ClinGen 1000Genomes |
|
|
CA387629019 rs1271998914 |
145 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs751665444 CA6926068 |
147 | N>K | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 148 | K>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA6926069 rs762127373 |
149 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1350362208 CA387629057 |
150 | D>E | No |
ClinGen gnomAD |
|
| TCGA novel | 150 | D>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA387629064 rs1221884222 |
151 | L>R | No |
ClinGen gnomAD |
|
| TCGA novel | 153 | H>Q | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA387629085 rs1283352566 |
154 | A>V | No |
ClinGen gnomAD |
|
|
CA6926072 rs368660825 |
155 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA6926070 rs767537468 |
155 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs778877684 CA6926073 |
156 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA387629104 rs1453218753 |
158 | Q>* | No |
ClinGen TOPMed gnomAD |
|
|
CA387629111 rs1193758312 |
159 | T>A | No |
ClinGen TOPMed gnomAD |
|
|
rs752692361 CA6926074 |
160 | Q>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA387629127 rs1593268911 |
161 | D>G | No |
ClinGen Ensembl |
|
|
rs372256338 CA6926076 |
162 | G>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs770753534 CA6926078 |
163 | I>V | No |
ClinGen ExAC gnomAD |
|
|
CA387629144 rs1455108163 |
164 | Q>* | No |
ClinGen TOPMed |
|
|
rs201547230 CA247212375 |
164 | Q>H | No |
ClinGen 1000Genomes |
|
| TCGA novel | 166 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs780814903 CA6926079 |
167 | N>S | No |
ClinGen ExAC gnomAD |
|
|
CA6926080 rs188163286 |
168 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA387629178 rs1593268954 |
169 | L>R | No |
ClinGen Ensembl |
|
|
rs199943435 CA6926081 |
170 | G>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6926083 rs763520981 |
171 | S>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA387629191 rs1351037901 |
171 | S>R | No |
ClinGen gnomAD |
|
|
CA387629204 rs1206698430 |
173 | F>L | No |
ClinGen gnomAD |
|
|
CA6926084 rs768863856 |
178 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768863856 CA387629236 |
178 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1227516359 CA387629238 |
179 | S>G | No |
ClinGen TOPMed |
|
|
rs774803111 CA387629244 |
179 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6926087 COSM946413 rs200613411 |
183 | E>K | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs750488212 CA6926088 |
184 | D>H | No |
ClinGen ExAC gnomAD |
|
|
rs750488212 CA6926089 |
184 | D>N | No |
ClinGen ExAC gnomAD |
|
|
rs1364034141 CA387629286 |
185 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs768439243 CA6926091 |
186 | C>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1161863189 CA387629289 |
186 | C>R | No |
ClinGen gnomAD |
|
|
rs149364268 CA247212432 |
186 | C>S | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA387629313 rs1326642298 |
189 | F>S | No |
ClinGen gnomAD |
|
|
rs1396863355 CA387629319 |
190 | Q>* | No |
ClinGen gnomAD |
|
|
CA387629328 rs1336613671 |
191 | H>R | No |
ClinGen gnomAD |
|
|
CA6926093 rs568883094 |
191 | H>Y | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 192 | L>F | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA387629344 rs1240886980 |
193 | C>* | No |
ClinGen gnomAD |
|
|
rs777406090 CA6926094 |
195 | E>V | No |
ClinGen ExAC gnomAD |
|
|
CA6926096 rs144256456 |
197 | S>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1233895952 CA387629369 |
197 | S>N | No |
ClinGen gnomAD |
|
|
CA387629373 rs1334916138 |
197 | S>R | No |
ClinGen TOPMed gnomAD |
|
|
CA6926097 rs781051894 |
200 | H>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs749691801 CA6926099 |
201 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs557790038 CA6926100 |
203 | S>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA6926102 rs749709336 |
203 | S>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 205 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA387629436 rs1255916493 |
207 | R>G | No |
ClinGen gnomAD |
|
|
CA6926104 rs769256003 |
208 | R>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6926105 rs774550299 |
209 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs376593196 CA6926106 |
210 | S>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs148550452 CA6926107 |
212 | I>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs760917496 CA6926109 |
213 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA247212520 rs766316979 |
214 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs766316979 CA6926110 |
214 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA387629478 rs1052031923 |
214 | R>W | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs776817624 CA6926111 |
216 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6926112 rs762765599 COSM946414 |
216 | R>H | endometrium [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
| TCGA novel | 219 | N>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs751389244 CA387629510 |
220 | M>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6926115 rs757063622 |
220 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA6926114 rs751389244 |
220 | M>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1341020715 CA387629521 |
221 | Q>R | No |
ClinGen gnomAD |
|
|
rs1279162562 CA387629529 |
222 | D>G | No |
ClinGen gnomAD |
|
|
CA387629526 rs1208359387 |
222 | D>Y | No |
ClinGen gnomAD |
|
|
CA6926117 rs750056223 |
223 | L>V | No |
ClinGen ExAC gnomAD |
|
|
CA6926118 rs755854689 COSM95156 |
226 | R>C | breast [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs1427315607 CA387629554 COSM1677567 |
226 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated TOPMed gnomAD |
|
CA387629556 rs1427315607 |
226 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs779410170 CA6926119 |
228 | K>M | No |
ClinGen ExAC |
|
|
rs1373785951 CA387629582 |
230 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
CA6926120 rs748871171 |
230 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA6926121 rs755424756 |
234 | K>R | No |
ClinGen ExAC gnomAD |
|
|
rs748657138 CA6926123 |
238 | P>H | No |
ClinGen ExAC gnomAD |
|
|
CA6926122 rs779416210 |
238 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1381635866 CA387629644 |
240 | A>V | No |
ClinGen gnomAD |
|
|
CA387629645 rs373964981 |
241 | L>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA387629650 rs1231453491 CA387629651 |
242 | G>R | No |
ClinGen gnomAD |
No associated diseases with Q6T310
1 regional properties for Q6T310
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Small GTP-binding protein domain | 16 - 140 | IPR005225 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.5.2 | Acting on GTP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein activity | A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). |
| GTP binding | Binding to GTP, guanosine triphosphate. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of transcription by RNA polymerase I | Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase I. |
34 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P08642 | HRAS | GTPase HRas | Gallus gallus (Chicken) | SS |
| P11233 | RALA | Ras-related protein Ral-A | Homo sapiens (Human) | PR |
| P01116 | KRAS | GTPase KRas | Homo sapiens (Human) | EV |
| P62070 | RRAS2 | Ras-related protein R-Ras2 | Homo sapiens (Human) | PR |
| Q8IYK8 | REM2 | GTP-binding protein REM 2 | Homo sapiens (Human) | PR |
| P11234 | RALB | Ras-related protein Ral-B | Homo sapiens (Human) | PR |
| P55040 | GEM | GTP-binding protein GEM | Homo sapiens (Human) | PR |
| Q99578 | RIT2 | GTP-binding protein Rit2 | Homo sapiens (Human) | PR |
| Q6IQ22 | RAB12 | Ras-related protein Rab-12 | Homo sapiens (Human) | PR |
| Q9BU20 | CPLANE2 | Ciliogenesis and planar polarity effector 2 | Homo sapiens (Human) | PR |
| Q96HU8 | DIRAS2 | GTP-binding protein Di-Ras2 | Homo sapiens (Human) | PR |
| P01112 | HRAS | GTPase HRas | Homo sapiens (Human) | SS |
| Q9JIW9 | Ralb | Ras-related protein Ral-B | Mus musculus (Mouse) | PR |
| Q61411 | Hras | GTPase HRas | Mus musculus (Mouse) | SS |
| P32883 | Kras | GTPase KRas | Mus musculus (Mouse) | SS |
| O08989 | Mras | Ras-related protein M-Ras | Mus musculus (Mouse) | PR |
| Q5PR73 | Diras2 | GTP-binding protein Di-Ras2 | Mus musculus (Mouse) | PR |
| Q91Z61 | Diras1 | GTP-binding protein Di-Ras1 | Mus musculus (Mouse) | PR |
| P62071 | Rras2 | Ras-related protein R-Ras2 | Mus musculus (Mouse) | PR |
| P35283 | Rab12 | Ras-related protein Rab-12 | Mus musculus (Mouse) | PR |
| Q08AT1 | Rasl12 | Ras-like protein family member 12 | Mus musculus (Mouse) | PR |
| A2A825 | Cplane2 | Ciliogenesis and planar polarity effector 2 | Mus musculus (Mouse) | PR |
| P55041 | Gem | GTP-binding protein GEM | Mus musculus (Mouse) | PR |
| P70425 | Rit2 | GTP-binding protein Rit2 | Mus musculus (Mouse) | PR |
| Q8VEL9 | Rem2 | GTP-binding protein REM 2 | Mus musculus (Mouse) | PR |
| P36860 | Ralb | Ras-related protein Ral-B | Rattus norvegicus (Rat) | PR |
| P08644 | Kras | GTPase KRas | Rattus norvegicus (Rat) | SS |
| Q9WTY2 | Rem2 | GTP-binding protein REM 2 | Rattus norvegicus (Rat) | PR |
| P20171 | Hras | GTPase HRas | Rattus norvegicus (Rat) | SS |
| Q5BJQ5 | Rit2 | GTP-binding protein Rit2 | Rattus norvegicus (Rat) | PR |
| P97538 | Mras | Ras-related protein M-Ras | Rattus norvegicus (Rat) | PR |
| B7ZTR0 | cplane2 | Ciliogenesis and planar polarity effector 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| P79737 | nras | GTPase NRas | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| A1DZY4 | zgc:110179 | Ras-like protein family member 11A-like | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRPLSMSGHF | LLAPIPESSS | DYLLPKDIKL | AVLGAGRVGK | SAMIVRFLTK | RFIGDYEPNT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GKLYSRLVYV | EGDQLSLQIQ | DTPGGVQIQD | SLPQVVDSLS | KCVQWAEGFL | LVYSITDYDS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YLSIRPLYQH | IRKVHPDSKA | PVIIVGNKGD | LLHARQVQTQ | DGIQLANELG | SLFLEISTSE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NYEDVCDVFQ | HLCKEVSKMH | GLSGERRRAS | IIPRPRSPNM | QDLKRRFKQA | LSPKVKAPSA |
| LG |