AiPD: Autoinhibited Protein Database

Q6SZW1

Gene name	SARM1 (KIAA0524, SAMD2, SARM)
Protein name	NAD hydrolase SARM1 hydrolase SARM1)
Names	+, NADase SARM1, hSARM1, NADP(+, Sterile alpha and Armadillo repeat protein, Sterile alpha and TIR motif-containing protein 1, Sterile alpha motif domain-containing protein 2, MyD88-5, SAM domain-containing protein 2, Tir-1 homolog, HsTIR
Species	Homo sapiens (Human)
KEGG Pathway	hsa:23098
EC number	3.2.2.6: Hydrolyzing N-glycosyl compounds
Protein Class	SARM1 (PTHR22998)

Descriptions

Sterile alpha and Toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) regulates axon degeneration, functioning as a key player in the cellular processes involved in neurodegenerative diseases and nerve injury. The physical interaction between the autoinhibitory Armadillo/HEAT motif (ARM) and catalytic Toll/interleukin-1 receptor (TIR) domains blocks the NAD hydrolase activity of SARM1. The autoinhibited TIR domain is activated upon axon injury, activating its NAD+ hydrolase activity and enabling TIR-dependent neuronal destruction.

Autoinhibitory domains (AIDs)

Target domain	560-703 (TIR domain)
Relief mechanism	Others
Assay	Deletion assay, Mutagenesis experiment, Structural analysis

AID

50-409 (ARM domain)

Target domain

560-703 (TIR domain)

Relief mechanism

Others (Injury)

Assay

Deletion assay, Mutagenesis experiment, Structural analysis

Accessory elements

No accessory elements

References

Bratkowski M et al. (2020) "Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1", Cell reports, 32, 107999

Summers DW et al. (2016) "SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation", Proceedings of the National Academy of Sciences of the United States of America, 113, E6271-E6280

Sasaki Y et al. (2021) "Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection", Experimental neurology, 345, 113842

Bloom AJ et al. (2022) "Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients", Molecular neurodegeneration, 17, 1

Shen C et al. (2021) "Multiple domain interfaces mediate SARM1 autoinhibition", Proceedings of the National Academy of Sciences of the United States of America, 118,

Khazma T et al. (2022) "A duplex structure of SARM1 octamers stabilized by a new inhibitor", Cellular and molecular life sciences : CMLS, 80, 16

Autoinhibited structure

Activated structure

39 structures for Q6SZW1

Entry ID	Method	Resolution	Chain	Position	Source
6O0Q	X-ray	180 A	A/B	560-700	PDB
6O0R	X-ray	180 A	A/B	560-700	PDB
6O0S	X-ray	270 A	A/B/C/D/E/F/G/H	409-561	PDB
6O0T	X-ray	280 A	A/B/C/D/E/F/G/H	409-561	PDB
6O0U	X-ray	303 A	A/B	560-700	PDB
6O0V	X-ray	207 A	A/B/C/D	560-700	PDB
6O1B	X-ray	167 A	A	560-700	PDB
6QWV	X-ray	247 A	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P	387-548	PDB
6WPK	EM	330 A	A/B/C/D/E/F/G/H	49-724	PDB
6ZFX	EM	288 A	A/B/C/D/E/F/G/H	26-724	PDB
6ZG0	EM	770 A	A/B/C/D/E/F/G/H	26-724	PDB
6ZG1	EM	377 A	A/B/C/D/E/F/G/H	387-548	PDB
7ANW	EM	268 A	A/B/C/D/E/F/G/H	26-724	PDB
7CM5	EM	260 A	A/B/C/D/E/F/G/H	1-724	PDB
7CM6	EM	300 A	A/B/C/D/E/F/G/H	1-724	PDB
7CM7	EM	260 A	A/B/C/D/E/F/G/H	1-724	PDB
7DJT	EM	280 A	A/B/C/D/E/F/G/H	27-724	PDB
7KNQ	EM	340 A	A/B/C/D/E/F/G/H	1-724	PDB
7LD0	EM	310 A	A/B/C/D/E/F/G/H	28-724	PDB
7NAG	X-ray	172 A	A/B	560-700	PDB
7NAH	X-ray	179 A	A/B	560-700	PDB
7NAI	X-ray	174 A	A/B	560-700	PDB
7NAJ	X-ray	160 A	A/B	560-700	PDB
7NAK	EM	290 A	A/B/C/D/E/F/G/H	28-724	PDB
7NAL	EM	300 A	A/B/C/D/E/F/G/H	28-724	PDB
7QG0	EM	402 A	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P	26-724	PDB
8D0C	X-ray	209 A	A/B	558-700	PDB
8D0D	X-ray	196 A	A/B	558-700	PDB
8D0E	X-ray	188 A	A/B	558-700	PDB
8D0F	X-ray	174 A	A/B	558-700	PDB
8D0G	X-ray	199 A	A/B	558-700	PDB
8D0H	X-ray	237 A	A/B	558-700	PDB
8D0I	X-ray	200 A	A/B	558-700	PDB
8D0J	X-ray	194 A	A/B	558-700	PDB
8GNI	EM	374 A	A/B	1-724	PDB
8GNJ	EM	378 A	A/B	1-724	PDB
8GQ5	EM	270 A	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P	1-724	PDB
8P2L	EM	268 A	A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P	26-570	PDB
AF-Q6SZW1-F1	Predicted				AlphaFoldDB

674 variants for Q6SZW1

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs144613221 RCV001260208 CA8457913	501	Y>H	Amyotrophic lateral sclerosis [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs886052741 CA10639232 RCV000317240	666	Q>H	Congenital defect of folate absorption [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs782774927 CA8458037 RCV000371910	672	M>V	Congenital defect of folate absorption [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
RCV001127834 rs372946020 CA8458079	697	R>G	Congenital defect of folate absorption [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
CA8458097 RCV000399865 rs146812537	719	A>V	Congenital defect of folate absorption [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1490277771	1	M>?	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA398324643 rs868959696	3	L>M		No	ClinGen Ensembl
rs782586056 CA289096856	4	T>A		No	ClinGen ExAC gnomAD
rs1597813510 CA398324659	4	T>M		No	ClinGen Ensembl
CA398324706 rs1283643256	8	S>F		No	ClinGen TOPMed gnomAD
rs1224579416 CA398324710	9	A>P		No	ClinGen TOPMed gnomAD
CA398324726 rs1555584089	10	Y>C		No	ClinGen gnomAD
rs868954301 CA289096858	10	Y>H		No	ClinGen gnomAD
rs1555584091 CA398324772	13	C>W		No	ClinGen gnomAD
CA398324782 rs1555584092	14	R>H		No	ClinGen gnomAD
rs782640296 CA289096862	16	F>L		No	ClinGen ExAC
rs782269124 CA289096864	17	A>P		No	ClinGen ExAC TOPMed gnomAD
CA289096867 rs782351870	17	A>V		No	ClinGen ExAC gnomAD
rs1555584094 CA398324836	18	M>I		No	ClinGen gnomAD
CA398324829 rs1273249300	18	M>L		No	ClinGen TOPMed
CA398324832 rs1221492667	18	M>T		No	ClinGen TOPMed
rs782616436 CA289096872	20	G>C		No	ClinGen ExAC gnomAD
CA398324857 rs1555584099	20	G>D		No	ClinGen gnomAD
rs782616436 CA289096874	20	G>S		No	ClinGen ExAC gnomAD
rs782021842 CA289096886	21	P>Q		No	ClinGen ExAC gnomAD
rs1555584101 CA398324864	21	P>T		No	ClinGen gnomAD
CA398324876 rs782169698	22	R>G		No	ClinGen ExAC TOPMed gnomAD
CA398324882 rs782388206	22	R>L		No	ClinGen ExAC gnomAD
CA289096894 rs782388206	22	R>P		No	ClinGen ExAC gnomAD
CA398324880 rs782388206	22	R>Q		No	ClinGen ExAC gnomAD
CA289096889 rs782169698	22	R>W		No	ClinGen ExAC TOPMed gnomAD
CA658682948 rs7212814	23	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA398324889 rs7212814	23	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
VAR_061702 rs7212814 CA289096918	23	P>R		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs782100517 CA289096916	23	P>S		No	ClinGen ExAC gnomAD
rs782100517 CA398324885	23	P>T		No	ClinGen ExAC gnomAD
CA398324895 rs1555584107	24	G>C		No	ClinGen gnomAD
CA289096921 rs552929140	24	G>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1555584107 CA398324893	24	G>S		No	ClinGen gnomAD
rs782525192 CA289096927	25	A>S		No	ClinGen ExAC gnomAD
CA289096925 rs782525192	25	A>T		No	ClinGen ExAC gnomAD
CA289096930 rs781845348	26	E>*		No	ClinGen ExAC gnomAD
rs1555584112 CA398324933	26	E>D		No	ClinGen gnomAD
rs781845348 CA398324919	26	E>K		No	ClinGen ExAC gnomAD
CA398324963 rs1409753403	29	A>G		No	ClinGen TOPMed gnomAD
CA398324965 rs1409753403	29	A>V		No	ClinGen TOPMed gnomAD
CA398324974 rs1555584117	30	V>G		No	ClinGen gnomAD
CA289096938 rs957963171	30	V>M		No	ClinGen Ensembl
CA398324980 rs1555584120	31	P>S		No	ClinGen gnomAD
CA398324997 rs1170377798	32	G>A		No	ClinGen TOPMed
rs1555584121 CA398324989	32	G>R		No	ClinGen gnomAD
CA289096939 rs56951297	34	D>Y		No	ClinGen Ensembl
CA398325032 rs1480321233	35	G>E		No	ClinGen TOPMed
CA398325049 rs1430405423	37	G>S		No	ClinGen TOPMed gnomAD
CA398325059 rs1597813664	37	G>V		No	ClinGen Ensembl
CA289096941 rs988047470	39	T>M		No	ClinGen gnomAD
rs1567803580 CA398325073	39	T>S		No	ClinGen Ensembl
CA289096948 rs186729002	42	W>L		No	ClinGen 1000Genomes
CA289096944 rs913719958	42	W>R		No	ClinGen TOPMed
rs1487575967 CA398325146	44	A>G		No	ClinGen TOPMed
CA289096951 rs782593684	45	A>P		No	ClinGen ExAC TOPMed gnomAD
rs782593684 CA398325149	45	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1555584127 CA398325157	45	A>V		No	ClinGen gnomAD
CA398325176 rs1555584129	47	G>A		No	ClinGen gnomAD
rs868975302 CA919820300	49	G>R		No	ClinGen Ensembl
rs1276773183 CA2254276049	50	P>A		No	ClinGen TOPMed
rs1276773183 CA727731909	50	P>S		No	ClinGen TOPMed
rs782566300 CA2254276055	51	R>H		No	ClinGen ExAC TOPMed gnomAD
rs782566300 CA289096965	51	R>P		No	ClinGen ExAC TOPMed gnomAD
rs554949758 CA289096969	52	E>Q		No	ClinGen ExAC
rs538665060 CA289096974	54	S>L		No	ClinGen 1000Genomes
CA398325206 rs1322636333	55	P>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1283655216 CA398325209	56	G>R		No	ClinGen TOPMed
rs1225331114 CA398325223	57	A>S		No	ClinGen TOPMed
CA398325221 rs1225331114	57	A>T		No	ClinGen TOPMed
CA289096979 rs981850967	58	G>S		No	ClinGen Ensembl
rs1430832648 CA398325246	60	E>K		No	ClinGen TOPMed gnomAD
rs1430832648 CA398325248	60	E>Q		No	ClinGen TOPMed gnomAD
rs937668150 CA289096991	61	V>E		No	ClinGen TOPMed
rs1334350421 CA398325262	61	V>M		No	ClinGen TOPMed
CA289096994 rs781920108	62	Q>R		No	ClinGen ExAC gnomAD
CA398325367 rs1419459913	68	A>E		No	ClinGen TOPMed
rs2285408 CA289096996	68	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	68	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1476467173 CA398325383	70	P>A		No	ClinGen TOPMed gnomAD
rs888141305 CA289096997	70	P>R		No	ClinGen Ensembl
CA398325431 rs1183268152	73	Q>P		No	ClinGen TOPMed
CA398325440 rs1461926584	74	Q>*		No	ClinGen TOPMed
CA398325463 rs1555584155	75	A>D		No	ClinGen gnomAD
CA398325458 rs1265178102	75	A>S		No	ClinGen TOPMed
TCGA novel	75	A>T	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA398325556 rs1215073393	83	G>D		No	ClinGen TOPMed gnomAD
rs1555584159 CA398325562	84	G>S		No	ClinGen gnomAD
CA289097012 rs901335526	85	A>S		No	ClinGen TOPMed gnomAD
rs1312241107 CA398325580	86	R>Q		No	ClinGen TOPMed
CA289097015 rs998771132	87	A>T		No	ClinGen Ensembl
CA398325601 rs1555584160 CA398325599	88	V>L		No	ClinGen gnomAD
rs1460789682 CA398325627	91	G>D		No	ClinGen TOPMed
rs1460789682 CA398325630	91	G>V		No	ClinGen TOPMed
CA398325634 rs1171817944	92	L>V		No	ClinGen TOPMed
TCGA novel	94	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1183093159 CA398325666	94	E>G		No	ClinGen TOPMed
TCGA novel	94	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA398325726 rs1555584166	99	V>L		No	ClinGen gnomAD
rs1555584172 CA398325786	103	W>C		No	ClinGen gnomAD
CA398325778 rs1555584169	103	W>G		No	ClinGen gnomAD
rs782028902 CA289097017	103	W>L		No	ClinGen ExAC
CA398325825 rs1555584180	107	A>V		No	ClinGen gnomAD
rs1555584184 CA398325830	108	V>M		No	ClinGen gnomAD
rs782105063 CA289097030	109	G>C		No	ClinGen ExAC gnomAD
rs782798088 CA289097034	110	R>C		No	ClinGen ExAC gnomAD
rs1555584186 CA398325857	111	E>K		No	ClinGen gnomAD
CA398325879 rs1176943109	112	V>A		No	ClinGen TOPMed
CA289097054 rs1032963037	112	V>I		No	ClinGen TOPMed
rs1555584188 CA398325887	113	A>D		No	ClinGen gnomAD
rs575653548 CA289097059	113	A>T		No	ClinGen 1000Genomes
CA398325904 rs1479570257	114	Q>H		No	ClinGen TOPMed gnomAD
CA398325943 rs1232087262	117	C>*		No	ClinGen TOPMed
CA398325956 rs1567803748	118	D>E		No	ClinGen Ensembl
rs1205182747 CA398325948	118	D>H		No	ClinGen TOPMed
rs1309162546 CA398325975	120	I>F		No	ClinGen TOPMed
rs1289442893 CA398325994	121	R>L		No	ClinGen TOPMed
CA398325996 rs1244639440	122	L>F		No	ClinGen TOPMed
CA398326024 rs1555584195	124	G>S		No	ClinGen gnomAD
rs1359449112 CA398326073	127	D>E		No	ClinGen TOPMed gnomAD
rs1555584199 CA398326089	129	L>V		No	ClinGen gnomAD
rs1555584203 CA398326119	131	R>Q		No	ClinGen gnomAD
CA398326143 rs1373109175	133	L>Q		No	ClinGen TOPMed gnomAD
CA289097062 rs781961753	134	Q>R		No	ClinGen ExAC gnomAD
rs1299083444 CA398326179	136	P>Q		No	ClinGen TOPMed gnomAD
rs1299083444 CA398326180	136	P>R		No	ClinGen TOPMed gnomAD
rs1555584210 CA398326193	137	E>G		No	ClinGen gnomAD
CA398326203 rs1555584211	138	L>V		No	ClinGen gnomAD
rs1555584212 CA398326214	139	E>K		No	ClinGen gnomAD
rs1555584213 CA398326231	140	T>P		No	ClinGen gnomAD
TCGA novel	141	R>C	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA398326259 rs1555584215	142	V>A		No	ClinGen gnomAD
CA289097063 rs956063846	142	V>L		No	ClinGen gnomAD
CA398326271 rs370967865	143	Q>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs370967865 CA289097064	143	Q>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA289097070 rs970546135	145	A>G		No	ClinGen TOPMed gnomAD
CA398326295 rs970546135	145	A>V		No	ClinGen TOPMed gnomAD
TCGA novel	146	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs772299091 CA289097081	150	Q>H		No	ClinGen Ensembl
CA398326374 rs1387150811	152	L>V		No	ClinGen TOPMed gnomAD
TCGA novel	155	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs982371779 CA289097086	157	R>*		No	ClinGen TOPMed
CA398326435 rs1555584221	157	R>P		No	ClinGen gnomAD
CA398327523 rs538784770	159	R>H		No	ClinGen 1000Genomes ExAC gnomAD
rs538784770 CA289101837	159	R>P		No	ClinGen 1000Genomes ExAC gnomAD
CA398327526 rs1555585152	160	V>M		No	ClinGen gnomAD
rs1555585154 CA398327535	161	A>T		No	ClinGen gnomAD
TCGA novel	162	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs893364527 CA289101840	163	I>F		No	ClinGen Ensembl
rs1555585157 CA398327555	163	I>T		No	ClinGen gnomAD
rs893364527 CA289101839	163	I>V		No	ClinGen Ensembl
CA398327599 rs1332818278	166	G>A		No	ClinGen TOPMed gnomAD
rs1332818278 CA398327595	166	G>V		No	ClinGen TOPMed gnomAD
CA289101854 rs781834636	167	V>E		No	ClinGen ExAC gnomAD
rs1555585163 CA398327647	170	N>H		No	ClinGen gnomAD
rs1567806541 CA398327694	172	A>V		No	ClinGen Ensembl
rs1555585165 CA398327719	174	E>Q		No	ClinGen gnomAD
CA289101860 rs782715579	175	R>C		No	ClinGen ExAC gnomAD
CA398327780 rs1381539904	177	P>R		No	ClinGen TOPMed
CA398327791 rs1555585170	178	V>L		No	ClinGen gnomAD
rs781870467 CA289101878	179	E>D		No	ClinGen ExAC gnomAD
CA398327846 rs1597817905	181	A>G		No	ClinGen Ensembl
CA398327838 rs1467944039	181	A>P		No	ClinGen TOPMed gnomAD
rs1467944039 CA398327836	181	A>T		No	ClinGen TOPMed gnomAD
TCGA novel	181	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1020868292 CA289101883	182	R>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1555585173 CA398327851	182	R>W		No	ClinGen gnomAD
rs782468627 CA289101891	183	S>R		No	ClinGen ExAC
CA289101908 rs71373646	184	V>G		No	ClinGen 1000Genomes ESP ExAC
rs386796348 CA919820454	184	V>GS		No	ClinGen Ensembl
rs903386094 CA289101907	184	V>L		No	ClinGen TOPMed
CA289101910 rs71373647	185	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs71373647 CA727736854	185	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	186	G>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA398327924 rs1250029233	187	I>N		No	ClinGen TOPMed
rs1461091216 CA398327992	190	H>D		No	ClinGen TOPMed
rs782377042 CA289101926	190	H>R		No	ClinGen ExAC gnomAD
rs782093856 CA289101930	191	M>I		No	ClinGen ExAC gnomAD
rs782304632 CA289101931	192	F>L		No	ClinGen ExAC gnomAD
rs1555585182 CA398328081	193	K>R		No	ClinGen gnomAD
rs1555585185 CA398328138	195	S>L		No	ClinGen gnomAD
TCGA novel	196	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	197	E>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA398328204 rs1202333892	198	T>I		No	ClinGen TOPMed gnomAD
rs1002924966 CA289101940	199	C>F		No	ClinGen TOPMed gnomAD
CA398328218 rs1555585188	199	C>R		No	ClinGen gnomAD
rs1035779951 CA289101942	199	C>W		No	ClinGen TOPMed gnomAD
CA398328236 rs1555585189	200	Q>*		No	ClinGen gnomAD
rs138813409 CA289101954	201	R>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs555253295 CA289101962	202	L>R		No	ClinGen 1000Genomes ExAC gnomAD
CA289101965 rs140424050	203	V>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA398328342 rs1449823743	204	A>G		No	ClinGen TOPMed
rs1555585196 CA398328332	204	A>T		No	ClinGen gnomAD
TCGA novel	205	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA398328369 rs1555585199	206	G>S		No	ClinGen gnomAD
rs1555585201 CA398328427	209	D>G		No	ClinGen gnomAD
CA398328436 rs879956377	210	A>S		No	ClinGen Ensembl
CA398328453 rs1555585203	211	V>L		No	ClinGen gnomAD
CA398328484 rs1415779571	213	Y>C		No	ClinGen TOPMed
rs962931921 CA289101973	215	C>Y		No	ClinGen Ensembl
rs1555585206 CA398328552	216	R>C		No	ClinGen gnomAD
CA398328569 rs1555585207	217	R>C		No	ClinGen gnomAD
rs367907099 CA289101975	217	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371692238 CA289101978	218	T>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371692238 CA398328588	218	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA398328592 rs371692238	218	T>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA289101981 rs782546001	222	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1555585214 CA398328657	224	R>S		No	ClinGen gnomAD
rs1555585216 CA398328688	225	H>P		No	ClinGen gnomAD
rs951218681 CA289101988	226	C>R		No	ClinGen Ensembl
rs1555585220 CA398328724	227	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1555585223 CA398328775	231	G>D		No	ClinGen gnomAD
CA398328786 rs1204171820	232	N>S		No	ClinGen TOPMed gnomAD
rs1555585227 CA398328825	234	A>S		No	ClinGen gnomAD
rs1555585227 CA398328817	234	A>T		No	ClinGen gnomAD
CA289101992 rs782269035	234	A>V		No	ClinGen ExAC gnomAD
CA398328862 rs986488733	236	H>Q		No	ClinGen TOPMed gnomAD
CA289102000 rs782357936	237	G>W		No	ClinGen ExAC gnomAD
rs782567398 CA398328892	238	G>A	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs782567398 CA398328890	238	G>D		No	ClinGen ExAC TOPMed gnomAD
rs782567398 CA289102005	238	G>V		No	ClinGen ExAC TOPMed gnomAD
rs1555585236 CA398328904	239	Q>R		No	ClinGen gnomAD
rs1449836804 CA398328915	240	A>E	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1555585238 CA398328913	240	A>T		No	ClinGen gnomAD
rs1333588274 CA398328920	241	V>M		No	ClinGen TOPMed gnomAD
rs1307877515 CA398328954	242	Q>P		No	ClinGen TOPMed
CA398328960 rs1567806732	243	R>G		No	ClinGen Ensembl
CA289102010 rs576847785	244	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1301838832 CA398328985	245	M>L		No	ClinGen TOPMed
CA398329005 rs1555585240	246	V>A		No	ClinGen gnomAD
rs544008809 CA289102013	249	R>C		No	ClinGen 1000Genomes
rs1555585243 CA398329036	250	A>T		No	ClinGen gnomAD
rs374789573 CA398329055	252	E>*		No	ClinGen ESP TOPMed gnomAD
CA289102018 rs374789573	252	E>K		No	ClinGen ESP TOPMed gnomAD
rs1555585245 CA398329071	253	W>*		No	ClinGen gnomAD
rs368596957 CA289102032	256	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1555585248 CA398329088	256	P>S		No	ClinGen gnomAD
CA398329164 rs782385813	263	D>E		No	ClinGen ExAC gnomAD
CA398329155 rs1555585250	263	D>N		No	ClinGen gnomAD
CA398329163 rs1555585251	263	D>V		No	ClinGen gnomAD
CA289102055 rs782106258	264	E>V		No	ClinGen ExAC
rs782706352 CA289102060	265	L>M		No	ClinGen ExAC gnomAD
CA289102068 rs781946234	266	L>I		No	ClinGen ExAC
CA289102085 rs11652384	267	R>P		No	ClinGen 1000Genomes ESP ExAC gnomAD
CA398329202 rs11652384	267	R>Q		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs70956802 CA919820460	267	R>S		No	ClinGen Ensembl
rs11658194 CA289102077	267	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1555585260 CA398329208	268	L>M		No	ClinGen gnomAD
CA289102089 rs781855136	269	H>D		No	ClinGen ExAC gnomAD
rs781855136 CA289102087	269	H>N		No	ClinGen ExAC gnomAD
rs782733803 CA289102094	269	H>P		No	ClinGen ExAC
CA289102104 rs781788541	269	H>Q		No	ClinGen ExAC gnomAD
rs1555585262 CA398329227	270	A>D		No	ClinGen gnomAD
rs782453628 CA289102116	270	A>S		No	ClinGen ExAC gnomAD
CA289102112 rs782453628	270	A>T		No	ClinGen ExAC gnomAD
rs782488618 CA289102133	273	A>S		No	ClinGen ExAC TOPMed gnomAD
CA398329254 rs782488618	273	A>T		No	ClinGen ExAC TOPMed gnomAD
rs376587698 CA398329277	275	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA289102143 rs782203639	275	A>T		No	ClinGen ExAC gnomAD
rs376587698 CA289102151	275	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1555585268 CA398329301	278	A>T		No	ClinGen gnomAD
CA398329306 rs1348171410	278	A>V		No	ClinGen TOPMed
CA398329330 rs1555585271	280	N>K		No	ClinGen gnomAD
rs782411598 CA289102161	280	N>S		No	ClinGen ExAC gnomAD
rs1555585272 CA398329334	281	K>E		No	ClinGen gnomAD
rs782032148 CA289102162	281	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1555585275 CA398329355	282	E>D		No	ClinGen gnomAD
CA398329359 rs1555585276	283	V>M		No	ClinGen gnomAD
rs782115117 CA289102167	284	E>D		No	ClinGen ExAC TOPMed gnomAD
CA398329380 rs782772441	285	R>C		No	ClinGen ExAC TOPMed gnomAD
CA398329379 rs782772441	285	R>G		No	ClinGen ExAC TOPMed gnomAD
CA398329384 rs1555585278	285	R>L		No	ClinGen gnomAD
CA289102170 rs782772441	285	R>S		No	ClinGen ExAC TOPMed gnomAD
CA289102176 rs782047905	286	E>Q		No	ClinGen ExAC gnomAD
rs1555585286 CA398329404	287	V>A		No	ClinGen gnomAD
TCGA novel rs1042000746 CA398329400	287	V>L	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA ClinGen TOPMed
CA289102183 rs1042000746	287	V>M		No	ClinGen TOPMed
CA289102188 rs782711704	288	E>K		No	ClinGen ExAC
CA398329421 rs1555585288	289	R>C		No	ClinGen gnomAD
rs781886204 CA289102193	289	R>H		No	ClinGen ExAC TOPMed gnomAD
CA289102196 rs781886204	289	R>L		No	ClinGen ExAC TOPMed gnomAD
CA398329424 rs781886204	289	R>P		No	ClinGen ExAC TOPMed gnomAD
rs782769243 CA289102199	290	S>L		No	ClinGen ExAC TOPMed gnomAD
CA289102198 rs782769243	290	S>W		No	ClinGen ExAC TOPMed gnomAD
CA398329434 rs1567806862	291	G>S		No	ClinGen Ensembl
rs1555585295 CA398329456	293	L>P		No	ClinGen gnomAD
rs372349604 CA289102200	294	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs372349604 CA398329465	294	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1555585297 CA398329472	295	L>F		No	ClinGen gnomAD
rs1555585299 CA398329478	296	V>M		No	ClinGen gnomAD
rs1555585300 CA398329491	297	E>A		No	ClinGen gnomAD
rs1555585302 CA398329499	298	P>S		No	ClinGen gnomAD
rs782606059 CA289102213	301	A>S		No	ClinGen ExAC TOPMed gnomAD
rs782186429 CA289102218	304	D>E		No	ClinGen ExAC gnomAD
CA289102223 rs1013028737	306	G>V		No	ClinGen TOPMed
rs1016678586 CA398329588	307	R>H		No	ClinGen TOPMed gnomAD
CA398329587 rs1016678586	307	R>L		No	ClinGen TOPMed gnomAD
rs1016678586 CA289102224	307	R>P		No	ClinGen TOPMed gnomAD
CA289102226 rs963416117	308	F>L		No	ClinGen Ensembl
rs1555585311 CA398329602	309	A>T		No	ClinGen gnomAD
CA289102230 rs995788726	309	A>V		No	ClinGen TOPMed
rs782675051 CA289102232	310	R>C		No	ClinGen ExAC gnomAD
CA289102234 rs369186722	310	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1555585312 CA398329624	311	C>Y		No	ClinGen gnomAD
rs782661360 CA289102242	313	V>A		No	ClinGen ExAC TOPMed gnomAD
CA398329640 rs1597818355	313	V>M		No	ClinGen Ensembl
rs951188002 CA289102244	315	A>T		No	ClinGen TOPMed gnomAD
CA289102249 rs782211561	316	S>G		No	ClinGen ExAC gnomAD
rs782362670 CA289102257	316	S>R		No	ClinGen ExAC gnomAD
CA398329694 rs1277127878	318	T>A		No	ClinGen TOPMed gnomAD
rs1555585316 CA398329700	318	T>I		No	ClinGen gnomAD
TCGA novel	320	Q>*	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs1567806942 CA398329740	322	R>G		No	ClinGen Ensembl
rs782422254 CA8457790	322	R>L		No	ClinGen ExAC gnomAD
CA398329744 rs1429193575	323	G>R		No	ClinGen TOPMed gnomAD
rs1555585318 CA398329761	324	P>L		No	ClinGen gnomAD
rs868921475 CA398329756	324	P>T		No	ClinGen Ensembl
rs868944204 CA398329767	325	D>Y		No	ClinGen Ensembl
rs1555585320 CA398329782	326	D>A		No	ClinGen gnomAD
rs868955276 CA398329780	326	D>Y		No	ClinGen Ensembl
rs868924014 CA398329811	328	Q>H		No	ClinGen Ensembl
rs782715279 CA8457793	329	R>C		No	ClinGen ExAC gnomAD
rs868933164 CA398329819	329	R>L		No	ClinGen gnomAD
CA398329812 rs782715279	329	R>S		No	ClinGen ExAC gnomAD
CA398329821 rs868991872	330	L>F		No	ClinGen gnomAD
CA398329825 rs868991872	330	L>I		No	ClinGen gnomAD
rs1404173387 CA398329828	330	L>R		No	ClinGen TOPMed
rs1555585331 CA398329837	331	V>E		No	ClinGen gnomAD
CA398329833 rs1413711851	331	V>L		No	ClinGen TOPMed
rs140811640 CA8457794	332	P>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140811640 CA398329844	332	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs868935674 CA398329842	332	P>S		No	ClinGen Ensembl
rs1555585335 CA398329888	336	S>C		No	ClinGen gnomAD
rs375690432 CA8457795	337	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA398329906 rs1246926309	338	R>C		No	ClinGen TOPMed
CA398329916 rs1555585343	339	L>S		No	ClinGen gnomAD
CA289102342 rs781854217	340	E>K		No	ClinGen TOPMed gnomAD
rs373458416 CA8457797	341	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs373458416 CA8457796	341	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs571589599 CA398329980 CA8457799	345	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8457800 rs781882550	346	A>S		No	ClinGen ExAC TOPMed gnomAD
CA398329988 rs781882550	346	A>T		No	ClinGen ExAC TOPMed gnomAD
CA289102354 rs530896320	348	Y>C		No	ClinGen TOPMed gnomAD
CA398330025 rs1597818474	349	L>H		No	ClinGen Ensembl
TCGA novel	350	C>R	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	351	A>V	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1437344796 CA398330078	353	A>V		No	ClinGen TOPMed
rs1555585348 CA398330079	354	A>T		No	ClinGen gnomAD
rs782487571 CA8457803	355	I>M		No	ClinGen ExAC TOPMed gnomAD
CA398330120 rs1359546788	357	S>N		No	ClinGen TOPMed gnomAD
rs1555585352 CA398330132	358	L>R		No	ClinGen gnomAD
rs1427817559 CA398330150	360	G>D		No	ClinGen TOPMed
rs539040757 CA8457804	360	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA398330165 rs1555585357	361	K>N		No	ClinGen gnomAD
TCGA novel	362	T>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA8457805 rs550771122	363	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1555585623 CA398330912	364	V>M		No	ClinGen gnomAD
CA8457816 rs782804317	366	S>G		No	ClinGen ExAC TOPMed gnomAD
CA398330937 rs1555585624	366	S>R		No	ClinGen gnomAD
rs1157622143 CA398330954	368	I>V		No	ClinGen TOPMed
CA398330983 rs1408893846	371	I>F		No	ClinGen TOPMed
CA398330988 rs1179014253	371	I>M		No	ClinGen TOPMed
rs782437027 CA8457821	375	K>T		No	ClinGen ExAC TOPMed gnomAD
CA8457822 rs539545773	376	R>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs782642684 CA8457825	378	V>A		No	ClinGen ExAC gnomAD
rs782506925 CA8457824	378	V>F		No	ClinGen ExAC
CA398331050 rs1555585631	381	S>C		No	ClinGen gnomAD
rs782215392 CA8457826	383	N>D		No	ClinGen ExAC gnomAD
rs1567807787 CA398331069	383	N>K		No	ClinGen Ensembl
CA289103521 rs782213378	384	G>S		No	ClinGen Ensembl
rs147409181 CA8457827	385	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA398331122 rs1236874116	388	A>V		No	ClinGen TOPMed gnomAD
CA398331167 rs782190284	393	A>P		No	ClinGen ExAC TOPMed gnomAD
rs782190284 CA8457830	393	A>T		No	ClinGen ExAC TOPMed gnomAD
CA398331171 rs1555585637	393	A>V		No	ClinGen gnomAD
rs369804438 CA8457833	395	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs369804438 CA398331178	395	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1555585639 CA398331207	397	L>P		No	ClinGen gnomAD
CA398331218 rs1224966697	398	G>D		No	ClinGen TOPMed
rs1567807811 CA398331211	398	G>S		No	ClinGen Ensembl
rs375645219 CA8457836	399	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs782706244 CA398331287	403	R>P		No	ClinGen ExAC TOPMed gnomAD
CA8457837 rs782706244	403	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA289103653 rs927078089	405	I>T		No	ClinGen Ensembl
rs782747899 CA8457840	407	P>L		No	ClinGen ExAC
CA8457839 rs782155689	407	P>T		No	ClinGen ExAC gnomAD
rs113535815 CA398331355	408	S>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs113535815 CA8457841	408	S>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA398331364 rs1555585643	409	V>M		No	ClinGen gnomAD
TCGA novel	411	S>A	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs782463409 CA8457842	411	S>G		No	ClinGen ExAC TOPMed gnomAD
CA398331415 rs1346323012	412	W>R		No	ClinGen TOPMed
rs1555585649 CA398331469	414	E>K		No	ClinGen Ensembl
rs1452683355 CA398331521	415	A>V		No	ClinGen TOPMed
rs147156050 CA8457844	416	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs781788842 CA8457845	417	V>F		No	ClinGen ExAC gnomAD
CA398331573 rs1194545365	418	Q>H		No	ClinGen TOPMed gnomAD
CA289103665 rs907646354	418	Q>L		No	ClinGen Ensembl
CA8457846 rs782453427	419	T>R		No	ClinGen ExAC gnomAD
rs782670194 CA8457847	420	W>R		No	ClinGen ExAC gnomAD
rs1597819667 CA398331613	422	Q>E		No	ClinGen Ensembl
rs1597819673 CA398331616	422	Q>P		No	ClinGen Ensembl
rs782294365 CA8457848	423	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1555585653 CA398331645	424	I>V		No	ClinGen gnomAD
rs1555585655 CA398331664	425	G>C		No	ClinGen gnomAD
rs782642144 CA398331666	425	G>D		No	ClinGen ExAC gnomAD
rs1555585655 CA398331662	425	G>S		No	ClinGen gnomAD
rs782642144 CA8457850	425	G>V		No	ClinGen ExAC gnomAD
rs1555585658 CA398331687	426	F>L		No	ClinGen gnomAD
CA8457854 rs781927743	430	C>*		No	ClinGen ExAC TOPMed gnomAD
rs782366602 CA8457852	430	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs1555585662 CA398331758	431	E>G		No	ClinGen gnomAD
rs137938585 CA8457855	431	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs137938585 CA8457856	431	E>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1302026991 CA398331775	432	S>N		No	ClinGen TOPMed gnomAD
rs782121648 CA8457857	433	F>S		No	ClinGen ExAC TOPMed gnomAD
rs1555585664 CA398331791	434	R>W		No	ClinGen gnomAD
rs782384126 CA8457873	435	E>K		No	ClinGen ExAC gnomAD
rs1157884248 CA398331881	435	E>V		No	ClinGen TOPMed gnomAD
CA398331896 rs1555585731	436	Q>L		No	ClinGen gnomAD
CA8457874 rs782585352	439	D>H		No	ClinGen ExAC gnomAD
rs1470215238 CA398331942	440	G>C		No	ClinGen TOPMed gnomAD
rs1555585736 CA398331956	441	D>N		No	ClinGen gnomAD
rs782304965 CA8457876	445	R>W		No	ClinGen ExAC gnomAD
rs1191400920 CA398332079	447	T>K		No	ClinGen TOPMed gnomAD
rs1555585741 CA398332087	448	E>A		No	ClinGen gnomAD
rs374600669 CA289103937	449	E>K		No	ClinGen ESP TOPMed gnomAD
rs1254087263 CA398332137	450	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA398332167 rs1224262889	451	L>V		No	ClinGen TOPMed
rs539075656 CA289103940	452	Q>*		No	ClinGen 1000Genomes gnomAD
TCGA novel	454	D>Y	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs781938186 CA289103946	455	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1284219030 CA398332277	455	L>R		No	ClinGen TOPMed gnomAD
rs140340827 CA8457878	456	G>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA398332310 rs1356011215	457	M>R		No	ClinGen TOPMed
CA398332434 rs1597819967	462	T>P		No	ClinGen Ensembl
rs868944042 CA398332461	463	R>G		No	ClinGen gnomAD
CA398332464 rs868978881	463	R>H		No	ClinGen Ensembl
CA398332455 rs868944042	463	R>S		No	ClinGen gnomAD
CA398332502 rs1276762560	464	K>N		No	ClinGen TOPMed
rs781991419 CA8457880	464	K>R		No	ClinGen ExAC TOPMed gnomAD
CA398332513 rs1438380057	465	R>K		No	ClinGen TOPMed
CA398332602 rs1210258116	465	R>S		No	ClinGen TOPMed gnomAD
rs1348632392 CA398332605	466	F>I		No	ClinGen TOPMed
rs1281018438 CA398332626 CA398332630	466	F>L		No	ClinGen TOPMed gnomAD
CA398332777 rs1555585800	472	E>K		No	ClinGen gnomAD
rs1213001324 CA398332822	473	L>I		No	ClinGen TOPMed
rs1597820055 CA398332872	474	K>Q		No	ClinGen Ensembl
CA398332908 rs782150304	475	T>I		No	ClinGen ExAC gnomAD
CA8457901 rs782150304	475	T>N		No	ClinGen ExAC gnomAD
rs1597820059 CA398332895	475	T>P		No	ClinGen Ensembl
rs782771413 CA8457902	476	F>L		No	ClinGen ExAC TOPMed gnomAD
rs1555585804 CA398332953	478	N>S		No	ClinGen gnomAD
CA398332946 rs1555585804	478	N>T		No	ClinGen gnomAD
CA398332977 rs1342310307	479	Y>N		No	ClinGen TOPMed
CA8457904 rs142415096	480	S>A		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	480	S>L	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
rs142415096 CA398333002	480	S>P		No	ClinGen 1000Genomes ExAC gnomAD
rs782741116 CA8457905	481	T>M		No	ClinGen ExAC TOPMed gnomAD
CA8457906 rs377210302	483	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA398333128 rs1555585809	484	R>C		No	ClinGen gnomAD
rs1555585813 CA398333134	484	R>L		No	ClinGen gnomAD
CA398333145 rs1359186464	485	S>T		No	ClinGen TOPMed
CA8457910 rs782228906	488	A>E		No	ClinGen ExAC TOPMed gnomAD
rs782782701 CA8457908	488	A>T		No	ClinGen ExAC gnomAD
CA8457909 rs782228906	488	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1555585819 CA398333292	490	W>G		No	ClinGen gnomAD
CA398333399 rs1597820115	495	D>A		No	ClinGen Ensembl
TCGA novel	496	P>Q	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA8457912 rs553007455	497	R>C		No	ClinGen 1000Genomes ExAC gnomAD
rs1002226271 CA289104178	498	F>S		No	ClinGen Ensembl
rs1171845687 CA398333437	499	R>C		No	ClinGen TOPMed
rs1555585828 CA398333446	500	Q>R		No	ClinGen gnomAD
CA8457915 rs782207189	501	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA8457914 rs782575737	501	Y>F		No	ClinGen ExAC gnomAD
CA398333469 rs782421919	502	T>A		No	ClinGen ExAC TOPMed gnomAD
CA8457916 rs782421919	502	T>P		No	ClinGen ExAC TOPMed gnomAD
CA398333498 rs1239250316	503	Y>*		No	ClinGen TOPMed gnomAD
rs1567808174 CA625381453	503	Y>*		No	ClinGen Ensembl
rs1555585833 CA398333495	503	Y>C		No	ClinGen gnomAD
rs545884324 CA8457917	503	Y>H		No	ClinGen 1000Genomes ExAC
rs782252720 CA8457918	505	L>P		No	ClinGen ExAC gnomAD
CA398333527 rs1202773157	506	V>F		No	ClinGen TOPMed gnomAD
CA398333523 rs1202773157	506	V>I		No	ClinGen TOPMed gnomAD
rs1202773157 CA398333525	506	V>L		No	ClinGen TOPMed gnomAD
CA398333554 rs746874324	507	S>I		No	ClinGen gnomAD
CA289104194 rs746874324	507	S>N		No	ClinGen gnomAD
CA398333551 rs746874324	507	S>T		No	ClinGen gnomAD
rs781957379 CA8457921	509	G>R		No	ClinGen ExAC gnomAD
CA8457920 rs781957379	509	G>S		No	ClinGen ExAC gnomAD
rs1307126718 CA398333598	509	G>V		No	ClinGen TOPMed
CA398333664 rs782714304	512	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8457922 rs782714304	512	R>G		No	ClinGen ExAC TOPMed gnomAD
CA8457923 rs782017916	512	R>H		No	ClinGen ExAC gnomAD
rs1555585847 CA398333704	514	L>R		No	ClinGen gnomAD
rs564566352 CA398333729	515	L>Q		No	ClinGen 1000Genomes
rs564566352 CA8457924	515	L>R		No	ClinGen 1000Genomes
rs371603376 CA289104225	517	R>H		No	ClinGen ESP TOPMed gnomAD
rs1014673627 CA289104227	518	V>A		No	ClinGen Ensembl
rs782106973 CA289104226	518	V>L		No	ClinGen Ensembl
CA289104231 rs961862651	520	E>V		No	ClinGen Ensembl
TCGA novel	525	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs1555585865 CA398333954	526	D>A		No	ClinGen gnomAD
rs782773588 CA8457928	527	C>G		No	ClinGen ExAC gnomAD
CA8457927 rs782773588	527	C>R		No	ClinGen ExAC gnomAD
CA8457929 rs782485432	528	G>R		No	ClinGen ExAC TOPMed gnomAD
CA398334038 rs1467530936	530	H>N		No	ClinGen TOPMed
rs1416108150 CA398334045	530	H>P		No	ClinGen TOPMed
CA398334055 rs1164877359	530	H>Q		No	ClinGen TOPMed
CA398334072 rs1555585870	531	L>Q		No	ClinGen gnomAD
rs1555585871 CA398334081	532	G>R		No	ClinGen gnomAD
rs1555585872 CA398334113	534	H>D		No	ClinGen gnomAD
rs781799621 CA398334141	535	R>C		No	ClinGen ExAC TOPMed gnomAD
rs781799621 CA8457931	535	R>S		No	ClinGen ExAC TOPMed gnomAD
rs868946115 CA398334164	536	A>T		No	ClinGen gnomAD
CA398334185 rs868958911	537	R>G		No	ClinGen TOPMed gnomAD
rs868958911 CA398334181	537	R>S		No	ClinGen TOPMed gnomAD
CA398334207 rs1555585876	538	I>L		No	ClinGen gnomAD
rs1458964014 CA398334219	538	I>T		No	ClinGen TOPMed gnomAD
CA398334282 rs1567808273	541	A>G		No	ClinGen Ensembl
rs1314696437 CA398334313	543	R>I		No	ClinGen TOPMed gnomAD
CA398334306 rs1314696437	543	R>K		No	ClinGen TOPMed gnomAD
rs914716164 CA289106314	545	M>I		No	ClinGen Ensembl
rs1555586319 CA398334847	545	M>L		No	ClinGen gnomAD
CA398334857 rs1476513870	545	M>T		No	ClinGen TOPMed
CA398334899 rs1555586323	547	H>Q		No	ClinGen gnomAD
rs1241475032 CA398334927	549	P>L		No	ClinGen TOPMed gnomAD
rs924706333 CA289106321	552	C>G		No	ClinGen gnomAD
CA398335007 rs1205471928	554	G>V		No	ClinGen TOPMed
CA398335063 rs1555586335	557	P>R		No	ClinGen gnomAD
CA398335055 rs1555586333	557	P>S		No	ClinGen gnomAD
CA289106326 rs938798379	558	S>R		No	ClinGen TOPMed gnomAD
CA398335096 rs1271687605	560	D>N		No	ClinGen TOPMed gnomAD
CA398335146 rs1214585553	563	D>G		No	ClinGen TOPMed gnomAD
CA398335138 rs1555586339	563	D>N		No	ClinGen gnomAD
rs1555586342 CA398335199	566	I>F		No	ClinGen gnomAD
rs1555586343 CA398335208	566	I>T		No	ClinGen gnomAD
rs1597821662 CA398335253	568	Y>S		No	ClinGen Ensembl
CA8457952 rs571724138	569	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8457953 rs781817572	569	R>H		No	ClinGen ExAC gnomAD
CA8457954 rs539229444	570	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1555586346 CA398335271	570	R>W		No	ClinGen gnomAD
rs150052156 CA398335292	571	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8457956 rs781797528	572	S>P		No	ClinGen ExAC gnomAD
CA398335311 rs1555586353	573	G>R		No	ClinGen gnomAD
rs1555586354 CA398335334	575	Q>R		No	ClinGen gnomAD
rs1555586356 CA398335355	577	A>T		No	ClinGen gnomAD
rs1555586358 CA398335370	577	A>V		No	ClinGen gnomAD
rs1339337421 CA398335378	578	S>G		No	ClinGen TOPMed gnomAD
CA398335384 rs1044973636	578	S>N		No	ClinGen TOPMed gnomAD
CA289106363 rs1044973636	578	S>T		No	ClinGen TOPMed gnomAD
CA289106433 rs111581438	580	L>Q		No	ClinGen gnomAD
CA8457976 rs782648839	585	Q>*		No	ClinGen ExAC gnomAD
rs1425539248 CA398335641	587	H>L		No	ClinGen TOPMed
rs1425539248 CA398335640	587	H>R		No	ClinGen TOPMed
CA8457977 rs781829395	588	G>D		No	ClinGen ExAC gnomAD
CA8457978 rs782491086	590	S>I		No	ClinGen ExAC gnomAD
CA8457980 rs782196205	593	I>T		No	ClinGen ExAC TOPMed gnomAD
rs782407924 CA8457981	594	D>E		No	ClinGen ExAC
CA398335829 rs1567809132	595	V>A		No	ClinGen Ensembl
CA398335826 rs1567809132	595	V>E		No	ClinGen Ensembl
rs1555586405 CA398335809	595	V>M		No	ClinGen gnomAD
CA398335836 rs1555586409	596	E>Q		No	ClinGen gnomAD
rs977609076 CA398335917	601	G>C		No	ClinGen TOPMed
rs977609076 CA289106480	601	G>S		No	ClinGen TOPMed
CA8457983 rs35201495 CA398335938	602	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs782398426 CA8457985	604	E>K		No	ClinGen ExAC TOPMed gnomAD
CA8457986 rs782398426	604	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA8457987 rs782047820	605	D>N	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1490414328 CA398336046	608	I>L		No	ClinGen TOPMed
rs1555586416 CA398336100	611	V>I	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs782008489 CA8457989	612	M>T		No	ClinGen ExAC TOPMed gnomAD
CA8457988 rs782321764	612	M>V		No	ClinGen ExAC gnomAD
CA398336133 rs1555586419	613	G>D		No	ClinGen gnomAD
CA8457990 rs782159743	615	R>C		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	615	R>G	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA8457991 rs782753946	615	R>H		No	ClinGen ExAC TOPMed gnomAD
rs782753946 CA398336164	615	R>L		No	ClinGen ExAC TOPMed gnomAD
CA398336166 rs1225970496	616	N>D		No	ClinGen TOPMed
TCGA novel	619	L>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
rs782001345 CA398336235	620	V>L		No	ClinGen ExAC TOPMed gnomAD
rs782001345 CA8457992	620	V>M		No	ClinGen ExAC TOPMed gnomAD
CA8457993 rs782083292	621	L>P		No	ClinGen ExAC
CA8457995 rs141324431	624	G>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA8457996 rs782456355	624	G>E		No	ClinGen ExAC gnomAD
CA398336314 rs1555586428	625	A>S		No	ClinGen gnomAD
CA8457997 rs368394015	626	L>P		No	ClinGen ESP ExAC gnomAD
rs1555586431 CA398336373	629	C>R		No	ClinGen gnomAD
CA8457998 rs781906310	630	M>V		No	ClinGen ExAC TOPMed gnomAD
rs948740126 CA289106514	635	C>R		No	ClinGen TOPMed gnomAD
CA398336496 rs1555586432	635	C>Y		No	ClinGen gnomAD
rs1451417529 CA398336542	637	D>Y		No	ClinGen TOPMed
CA398336571 rs1555586435	638	W>*		No	ClinGen TOPMed
CA8458000 rs782648225	639	V>G		No	ClinGen ExAC gnomAD
rs1037697118 CA289106518	639	V>M		No	ClinGen Ensembl
rs782225790 CA8458001	640	H>Y		No	ClinGen ExAC gnomAD
CA398336629 rs1344370780	641	K>N		No	ClinGen TOPMed gnomAD
rs1224037543 CA398338141	643	I>T		No	ClinGen TOPMed
CA289110934 rs781916448	644	V>M		No	ClinGen Ensembl
CA8458020 rs782676389	646	A>S		No	ClinGen ExAC TOPMed gnomAD
CA398338181 rs1555587719	647	L>S		No	ClinGen gnomAD
CA398338191 rs1555587723	648	S>N		No	ClinGen gnomAD
rs1273506942 CA398338206	649	C>*		No	ClinGen TOPMed gnomAD
rs1273506942 CA398338205	649	C>W		No	ClinGen TOPMed gnomAD
CA289110943 rs782196355	650	G>D	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA8458021 rs557710063	650	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1555587730 CA398338224	651	K>R		No	ClinGen gnomAD
rs782525385 CA8458022	653	I>T		No	ClinGen ExAC TOPMed gnomAD
CA8458025 rs782308805	654	V>E		No	ClinGen ExAC gnomAD
rs782225125 CA398338275	654	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8458024 rs782225125	654	V>M		No	ClinGen ExAC TOPMed gnomAD
rs776939252 CA8458026	655	P>S	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1555587744 CA398338339	657	I>T		No	ClinGen gnomAD
rs558864070 CA289110956	657	I>V		No	ClinGen gnomAD
rs1555587747 CA398338369	659	G>S		No	ClinGen gnomAD
rs782282998 CA398338424	660	F>L		No	ClinGen ExAC TOPMed gnomAD
CA398338438 rs1555587753	661	E>G		No	ClinGen gnomAD
rs782423138 CA398338428	661	E>K		No	ClinGen ExAC gnomAD
rs782423138 CA8458028	661	E>Q		No	ClinGen ExAC gnomAD
rs1175888767 CA398338487	663	P>R		No	ClinGen TOPMed
CA8458030 rs543954200	664	E>K		No	ClinGen ExAC TOPMed gnomAD
CA8458033 rs781912512	667	V>D		No	ClinGen ExAC TOPMed gnomAD
rs781912512 CA8458032	667	V>G		No	ClinGen ExAC TOPMed gnomAD
rs782348595 CA8458031	667	V>I		No	ClinGen ExAC gnomAD
rs781898499 CA8458035	668	L>P		No	ClinGen ExAC gnomAD
CA289110972 rs908381158	670	E>D		No	ClinGen Ensembl
CA398338581 rs1555587796	670	E>K		No	ClinGen gnomAD
CA398338640 rs1555587800	672	M>I		No	ClinGen gnomAD
rs782478303 CA8458039	675	V>A		No	ClinGen ExAC gnomAD
CA8458038 rs781822674	675	V>M		No	ClinGen ExAC TOPMed gnomAD
CA8458042 rs781794589	680	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	682	K>S	Variant assessed as Somatic; HIGH impact. [NCI-TCGA]	No	NCI-TCGA
CA398339032 rs1597826462	684	S>A		No	ClinGen Ensembl
CA8458072 rs782256561	684	S>F		No	ClinGen ExAC TOPMed gnomAD
rs782341481 CA8458074	685	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs1460394367 CA398339062	686	E>K	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA8458075 rs564769984	687	Y>H		No	ClinGen 1000Genomes ExAC gnomAD
CA8458076 rs782331635	693	E>D		No	ClinGen ExAC TOPMed gnomAD
CA398339453 rs1555587908	695	I>V		No	ClinGen gnomAD
rs782022324 CA8458078	696	I>F		No	ClinGen ExAC gnomAD
rs782022324 CA398339480	696	I>V		No	ClinGen ExAC gnomAD
CA8458080 rs372946020	697	R>C	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA8458081 rs544071937	697	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1162552426 CA398339550	698	F>L		No	ClinGen TOPMed
CA398339592 rs1555587925	700	Q>E		No	ClinGen gnomAD
CA398339614 rs1555587927	700	Q>P		No	ClinGen gnomAD
rs782530413 CA8458084	701	G>S		No	ClinGen ExAC gnomAD
CA8458086 rs781850558	702	R>C		No	ClinGen ExAC TOPMed gnomAD
rs782507505 CA8458087	702	R>H		No	ClinGen ExAC gnomAD
rs782222454 CA8458089	704	S>A		No	ClinGen ExAC gnomAD
TCGA novel	704	S>F	Variant assessed as Somatic; MODERATE impact. [NCI-TCGA]	No	NCI-TCGA
CA8458091 rs782584686	705	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs782438923 CA8458090	705	R>W		No	ClinGen ExAC TOPMed gnomAD
CA398339726 rs1567812372	706	D>H		No	ClinGen Ensembl
rs1027658221 CA289111151	706	D>V		No	ClinGen Ensembl
rs1555587945 CA398339909	713	T>A		No	ClinGen gnomAD
rs1207011384 CA398339957	714	S>R		No	ClinGen TOPMed
CA398339924 rs1555587947	714	S>R		No	ClinGen gnomAD
CA398339989 rs1291233051	716	E>K		No	ClinGen TOPMed
CA398340022 rs1246989287	717	G>C		No	ClinGen TOPMed
CA8458096 rs368545564	718	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA398340039 rs1304934966	719	A>T		No	ClinGen TOPMed
rs782058846 CA8458098	720	P>S		No	ClinGen ExAC
rs965225607 CA289111160	721	M>L		No	ClinGen Ensembl
rs1372480719 CA398340115	722	G>C		No	ClinGen TOPMed
rs1298702390 CA398340124	722	G>V		No	ClinGen TOPMed gnomAD
CA289111172 rs61456782	723	P>S		No	ClinGen Ensembl
rs567632194 CA398340159	724	T>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs567632194 CA8458099	724	T>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with Q6SZW1

No regional properties for Q6SZW1

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q6SZW1

Functions

		Description
EC Number	3.2.2.6	Hydrolyzing N-glycosyl compounds
Subcellular Localization	Cytoplasm Cell projection, axon Cell projection, dendrite Synapse Mitochondrion	Associated with microtubules
PANTHER Family	PTHR22998	SARM1
PANTHER Subfamily	PTHR22998:SF1	NAD(+) HYDROLASE SARM1
PANTHER Protein Class	scaffold/adaptor protein
PANTHER Pathway Category	No pathway information available

8 GO annotations of cellular component

Name	Definition
axon	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
mitochondrial outer membrane	The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
mitochondrion	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

5 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.
NAD(P)+ nucleosidase activity	Catalysis of the reaction
NAD+ nucleosidase activity	Catalysis of the reaction
NAD+ nucleotidase, cyclic ADP-ribose generating	Catalysis of the reaction
signaling adaptor activity	The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.

12 GO annotations of biological process

Name	Definition
cell differentiation	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
NAD catabolic process	The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH.
negative regulation of MyD88-independent toll-like receptor signaling pathway	Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway.
nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
protein localization to mitochondrion	A process in which a protein is transported to, or maintained in, a location within the mitochondrion.
regulation of dendrite morphogenesis	Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
regulation of neuron apoptotic process	Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.
regulation of neuron death	Any process that modulates the frequency, rate or extent of neuron death.
response to axon injury	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus.
response to glucose	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q6IDD9	Sarm	NAD	Drosophila melanogaster (Fruit fly)	SS
Q6PDS3	Sarm1	NAD	Mus musculus (Mouse)	SS
I3L5V6	SARM1	NAD	Sus scrofa (Pig)	SS
D3ZUM2	Sarm1	NAD	Rattus norvegicus (Rat)	SS
F1QWA8	sarm1	NAD	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MVLTLLLSAY	KLCRFFAMSG	PRPGAERLAV	PGPDGGGGTG	PWWAAGGRGP	REVSPGAGTE
70	80	90	100	110	120
VQDALERALP	ELQQALSALK	QAGGARAVGA	GLAEVFQLVE	EAWLLPAVGR	EVAQGLCDAI
130	140	150	160	170	180
RLDGGLDLLL	RLLQAPELET	RVQAARLLEQ	ILVAENRDRV	ARIGLGVILN	LAKEREPVEL
190	200	210	220	230	240
ARSVAGILEH	MFKHSEETCQ	RLVAAGGLDA	VLYWCRRTDP	ALLRHCALAL	GNCALHGGQA
250	260	270	280	290	300
VQRRMVEKRA	AEWLFPLAFS	KEDELLRLHA	CLAVAVLATN	KEVEREVERS	GTLALVEPLV
310	320	330	340	350	360
ASLDPGRFAR	CLVDASDTSQ	GRGPDDLQRL	VPLLDSNRLE	AQCIGAFYLC	AEAAIKSLQG
370	380	390	400	410	420
KTKVFSDIGA	IQSLKRLVSY	STNGTKSALA	KRALRLLGEE	VPRPILPSVP	SWKEAEVQTW
430	440	450	460	470	480
LQQIGFSKYC	ESFREQQVDG	DLLLRLTEEE	LQTDLGMKSG	ITRKRFFREL	TELKTFANYS
490	500	510	520	530	540
TCDRSNLADW	LGSLDPRFRQ	YTYGLVSCGL	DRSLLHRVSE	QQLLEDCGIH	LGVHRARILT
550	560	570	580	590	600
AAREMLHSPL	PCTGGKPSGD	TPDVFISYRR	NSGSQLASLL	KVHLQLHGFS	VFIDVEKLEA
610	620	630	640	650	660
GKFEDKLIQS	VMGARNFVLV	LSPGALDKCM	QDHDCKDWVH	KEIVTALSCG	KNIVPIIDGF
670	680	690	700	710	720
EWPEPQVLPE	DMQAVLTFNG	IKWSHEYQEA	TIEKIIRFLQ	GRSSRDSSAG	SDTSLEGAAP

MGPT