Q6SJ95
PR
Gene name |
Tbpl2 |
Protein name |
TATA box-binding protein-like 2 |
Names |
TBP-like 2, TATA box-binding protein-related factor 3, TBP-related factor 3 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:227606 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6SJ95
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6SJ95-F1 | Predicted | AlphaFoldDB |
16 variants for Q6SJ95
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388534803 | 11 | I>V | No | EVA | |
| rs3412988820 | 43 | H>L | No | EVA | |
| rs27219244 | 83 | N>S | No | EVA | |
| rs258783531 | 89 | T>I | No | EVA | |
| rs239205930 | 98 | S>N | No | EVA | |
| rs27219245 | 138 | H>D | No | EVA | |
| rs227972282 | 158 | A>S | No | EVA | |
| rs3388534902 | 159 | S>C | No | EVA | |
| rs3388532460 | 160 | M>L | No | EVA | |
| rs3388534290 | 161 | M>I | No | EVA | |
| rs3388532805 | 162 | P>S | No | EVA | |
| rs3388532792 | 168 | G>R | No | EVA | |
| rs27219247 | 173 | V>L | No | EVA | |
| rs3388533665 | 182 | T>I | No | EVA | |
| rs3388528165 | 298 | E>V | No | EVA | |
| rs3388534780 | 299 | L>F | No | EVA |
No associated diseases with Q6SJ95
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| female germ cell nucleus | The nucleus of the female germ cell, a reproductive cell in females. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| general transcription initiation factor activity | A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary. |
| RNA polymerase II general transcription initiation factor activity | A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription initiation | The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q02879 | TBP2 | TATA-box-binding protein 2 | Triticum aestivum (Wheat) | PR |
| P26356 | TBP1 | TATA-box-binding protein 1 | Triticum aestivum (Wheat) | PR |
| P13393 | SPT15 | TATA-box-binding protein | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| Q2HJ52 | TBP | TATA-box-binding protein | Bos taurus (Bovine) | PR |
| O13270 | TBP | TATA-box-binding protein | Gallus gallus (Chicken) | PR |
| A6H907 | TBPL2 | TATA box-binding protein-like 2 | Pan troglodytes (Chimpanzee) | PR |
| Q27896 | Trf | TBP-related factor | Drosophila melanogaster (Fruit fly) | PR |
| Q6SJ96 | TBPL2 | TATA box-binding protein-like 2 | Homo sapiens (Human) | PR |
| P20226 | TBP | TATA-box-binding protein | Homo sapiens (Human) | EV |
| P50158 | TBP1 | TATA-box-binding protein 1 | Zea mays (Maize) | PR |
| P50159 | TBP2 | TATA-box-binding protein 2 | Zea mays (Maize) | PR |
| P29037 | Tbp | TATA-box-binding protein | Mus musculus (Mouse) | PR |
| A6H909 | Tbpl2 | TATA box-binding protein-like 2 | Rattus norvegicus (Rat) | PR |
| Q8W0W4 | TBP2 | TATA-binding protein 2 | Oryza sativa subsp japonica (Rice) | PR |
| B2D6P4 | tlf-1 | TATA box-binding protein-like 1 | Caenorhabditis elegans | SS |
| O45211 | Tbp | TATA-box-binding protein | Bombyx mori (Silk moth) | PR |
| Q42808 | TBP1 | TATA-box-binding protein | Glycine max (Soybean) (Glycine hispida) | PR |
| P28148 | TBP2 | TATA-box-binding protein 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P28147 | TBP1 | TATA-box-binding protein 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q28DH2 | tbpl2 | TATA box-binding protein-like 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q28GG8 | tbp | TATA-box-binding protein | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q1JPY4 | tbpl2 | TATA box-binding protein-like 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q7SXL3 | tbp | TATA-box-binding protein | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVGSLIMEED | IYLDLFLDPY | TIQDDFPPAM | SQLFSPGVPL | DMHSLPSNPE | TVFHPHLGGV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KKASTDFSSV | DLSFLPDELT | QENRDQTVTG | NKLASEESCR | TRDRQSQLQL | PDEHGSELNL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NSNSSPDPQS | CLCFDDAHSN | QPSPETPNSN | ALPVALIASM | MPMNPVPGFS | GIVPQLQNVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| STANLACKLD | LRKIALNAKN | TEYNPKRFAA | VIMRIREPRT | TALIFSSGKV | VCTGAKSEEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SRLAARKYAR | VVQKLGFPVR | FFNFKIQNMV | GSCDVKFPIR | LEILALTHRQ | FSSSYEPELF |
| 310 | 320 | 330 | 340 | ||
| PGLIYKMVKP | QVVLLIFASG | KVVLTGAKER | SEIYEAFENM | YPILESFKKV |