Q6RFL5

PR
Gene name
BSX
Protein name
Brain-specific homeobox protein homolog
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:395183
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

47-233 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6RFL5

Entry ID Method Resolution Chain Position Source
AF-Q6RFL5-F1 Predicted AlphaFoldDB

6 variants for Q6RFL5

Variant ID(s) Position Change Description Diseaes Association Provenance
rs731801338 16 R>Q No Ensembl
rs737844440 63 A>T No Ensembl
rs740020069 73 L>P No Ensembl
rs731079669 190 E>Q No Ensembl
rs738670884 193 L>P No Ensembl
rs739355673 200 E>A No Ensembl

No associated diseases with Q6RFL5

4 regional properties for Q6RFL5

Type Name Position InterPro Accession
domain Homeobox domain 110 - 174 IPR001356
conserved_site Homeobox, conserved site 145 - 168 IPR017970
domain Homeobox domain, metazoa 134 - 145 IPR020479-1
domain Homeobox domain, metazoa 149 - 168 IPR020479-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

2 GO annotations of biological process

Name Definition
brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P50577 DLX5 Homeobox protein DLX-5 Gallus gallus (Chicken) PR
Q3C1V8 BSX Brain-specific homeobox protein homolog Homo sapiens (Human) PR
Q9HBU1 BARX1 Homeobox protein BarH-like 1 Homo sapiens (Human) PR
Q9UMQ3 BARX2 Homeobox protein BarH-like 2 Homo sapiens (Human) PR
Q810B3 Bsx Brain-specific homeobox protein homolog Mus musculus (Mouse) PR
Q9ER42 Barx1 Homeobox protein BarH-like 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MNLNFTSPVH PVPAPRPTSF FIEDILLHKP KPLREVPPEH FAGSLASRVP LLDYGYPLMP
70 80 90 100 110 120
APALLAPHPH PALHKPEHHH HHPYFLTTSG VPVPALFPHH AHAELPGKHC RRRKARTVFS
130 140 150 160 170 180
DSQLSGLEKR FEIQRYLSTP ERVELATALS LSETQVKTWF QNRRMKHKKQ LRKSQDDPIH
190 200 210 220 230
EENREQSSPE PELPEPAAAE PRKGPPGPFL LQDPEDEVDI LEEGDILAAP HRL