Q6R2V0

SS
Gene name
WNK1
Protein name
Serine/threonine-protein kinase WNK1
Names
Species
Sus scrofa (Pig)
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

WNK family protein kinases are large enzymes that contain the catalytic lysine in a unique position compared with all other protein kinases. Rat WNK1 (Q9JIH7) contains an autoinhibitory region C-terminal to the catalytic kinase domain.

Autoinhibitory domains (AIDs)

512-535 (Autoinhibitory region) SS

Target domain

221-479 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

365-386 (Activation loop from InterPro)

Target domain

219-477 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6R2V0

Entry ID Method Resolution Chain Position Source
AF-Q6R2V0-F1 Predicted AlphaFoldDB

No variants for Q6R2V0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6R2V0

No associated diseases with Q6R2V0

14 regional properties for Q6R2V0

Type Name Position InterPro Accession
domain Protein kinase domain 508 - 785 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 509 - 776 IPR001245
domain Immunoglobulin subtype 2 45 - 114 IPR003598-1
domain Immunoglobulin subtype 2 141 - 200 IPR003598-2
domain Immunoglobulin subtype 39 - 126 IPR003599-1
domain Immunoglobulin subtype 135 - 212 IPR003599-2
domain Fibronectin type III 215 - 310 IPR003961-1
domain Fibronectin type III 313 - 406 IPR003961-2
domain Immunoglobulin-like domain 26 - 118 IPR007110-1
domain Immunoglobulin-like domain 129 - 209 IPR007110-2
active_site Tyrosine-protein kinase, active site 641 - 653 IPR008266
domain Immunoglobulin I-set 38 - 122 IPR013098
binding_site Protein kinase, ATP binding site 514 - 540 IPR017441
domain Tyrosine-protein kinase, catalytic domain 508 - 776 IPR020635

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Cytoplasm, cytoskeleton, spindle
  • Mediates formation and localizes to cytoplasmic membraneless compartment in response to hyperosmotic stress
  • Also localizes to the nucleus
  • Localizes to the mitotic spindle during mitosis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
chloride channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a chloride channel.
phosphatase binding Binding to a phosphatase.
potassium channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a potassium channel.
protein kinase inhibitor activity Binds to and stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

6 GO annotations of biological process

Name Definition
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
ion homeostasis Any process involved in the maintenance of an internal steady state of ions within an organism or cell.
negative regulation of sodium ion transport Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
positive regulation of potassium ion import across plasma membrane Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane.
positive regulation of sodium ion transmembrane transporter activity Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity.
protein phosphorylation The process of introducing a phosphate group on to a protein.

16 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96J92 WNK4 Serine/threonine-protein kinase WNK4 Homo sapiens (Human) SS
Q9Y3S1 WNK2 Serine/threonine-protein kinase WNK2 Homo sapiens (Human) SS
Q9BYP7 WNK3 Serine/threonine-protein kinase WNK3 Homo sapiens (Human) SS
Q9H4A3 WNK1 Serine/threonine-protein kinase WNK1 Homo sapiens (Human) SS
Q3UH66 Wnk2 Serine/threonine-protein kinase WNK2 Mus musculus (Mouse) SS
Q80UE6 Wnk4 Serine/threonine-protein kinase WNK4 Mus musculus (Mouse) SS
Q80XP9 Wnk3 Serine/threonine-protein kinase WNK3 Mus musculus (Mouse) SS
P83741 Wnk1 Serine/threonine-protein kinase WNK1 Mus musculus (Mouse) SS
Q7TPK6 Wnk4 Serine/threonine-protein kinase WNK4 Rattus norvegicus (Rat) SS
Q9JIH7 Wnk1 Serine/threonine-protein kinase WNK1 Rattus norvegicus (Rat) EV
X5M5N0 wnk-1 Serine/threonine-protein kinase WNK Caenorhabditis elegans SS
Q8RXE5 WNK10 Probable serine/threonine-protein kinase WNK10 Arabidopsis thaliana (Mouse-ear cress) PR
Q944Q0 WNK8 Serine/threonine-protein kinase WNK8 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LVL5 WNK4 Probable serine/threonine-protein kinase WNK4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STK6 WNK3 Probable serine/threonine-protein kinase WNK3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8LST2 WNK7 Probable serine/threonine-protein kinase WNK7 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSGGGADQQS SPPGSLFLSP PAPAPKNGSS SDSSVGEKLG AAAADAGAGR TEEYRRRRHT
70 80 90 100 110 120
MDKDSRGAAA TTTTEHRFFR RSVICDSNAT ALELPGLPLP LPQPGAAAVA QQRSPPEPHR
130 140 150 160 170 180
EETLTPAVAH VAQQPPAAAT PGEPAAAVPA AASAPGSASR DRQVAQPSQA GSKEEPPSAR
190 200 210 220 230 240
SGSGGGSAKE PQEERSQQQD DIEELETKAV GMSNDGRFLK FDIEIGRGSF KTVYKGLDTE
250 260 270 280 290 300
TTVEVAWCEL QDRKLTKSER QRFKEEAEML KGLQHPNIVR FYDSWESTVK GKKCIVLVTE
310 320 330 340 350 360
LMTSGTLKTY LKRFKVMKIK VLRSWCRQIL KGLQFLHTRT PPIIHRDLKC DNIFITGPTG
370 380 390 400 410 420
SVKIGDLGLA TLKRASFAKS VIGTPEFMAP EMYEEKYDES VDVYAFGMCM LEMATSEYPY
430 440 450 460 470 480
SECQNAAQIY RRVTSGVKPA SFDKVAIPEV KEIIEGCIRQ NKDERYSIKD LLNHAFFQEE
490 500 510 520 530 540
TGVRVELAEE DDGEKIAIKL WLRIEDIKKL KGKYKDNEAI EFSFDLERDV PEDVAQEMVE
550 560 570 580 590 600
SGYVCEGDHK TMAKAIKDRV SLIKRKREQR QLVREEQEKR KQEESSLKQQ GEQQSSASQA
610 620 630 640 650 660
GILQPSSAST GLPAAATTSA SVSTQVEPEE PEADQHQQLQ YQQPSISVLS DGTVDSGQGS
670 680 690 700 710 720
SVFTESRVSS QQTVSYGSQH EQAHSTCTLP GHTASVVQAQ AQPHGGYPPS SMAQGQSQGQ
730 740 750 760 770 780
PSSSSLTGIP SSQPVQHSQQ QQGVQQTAPS QQTVQYSLPQ TSAPSEPTTA QPASQPQPPQ
790 800 810 820 830 840
VLPPVSAGKQ LPVSQPVPTI QGEPQISVAT QPSVVPVHSG AHFLPVGQPL PPSLLPQYPV
850 860 870 880 890 900
SQVPSAPHVS AAQPGFSPLP VTAAAGVNQP LLTLASSAAA AAVPGGSTVV PSQLPTLLQP
910 920 930 940 950 960
VTQLPSQAHP QLLQTAVQSM GIPANLGQTA EAPLPSGDVL YQGFPPRLPP QYPGDSNIAP
970 980 990 1000 1010 1020
SSSVASVCIP STVLSPPRPT EALAAPGYFP TVVQSYAESN LLVPVGSIGG QIQVSQPAVS
1030 1040 1050 1060 1070 1080
LAQAPTTSSQ QAALESTQGV SQVAPPEPVP AAPPQPTQPT TLVSSIDRSA HSDVASGMSD
1090 1100 1110 1120 1130 1140
GNENVPSSSG RHEGRTIKRH YRKSVRSRSR HEKTSRPKLR ILNVSNKGDR VVECQLETHN
1150 1160 1170 1180 1190 1200
RKMVTFKFDL DGDNPEEIAT IMVNNDFILA IEREAFVDQV REIIEKADEM LSEDVSVEPE
1210 1220 1230 1240 1250 1260
GDQGLENLQG KDDYGFSGSQ KLEGEFKQPI PASSMPQQIA GLPTSSLTQV VHSAGRRFIV
1270 1280 1290 1300 1310 1320
SPVPESRLRE SKVFTSEISD TVAASTSPGT GMNLSHSASS LSLQQAFSEL RRAQMTEGPS
1330 1340 1350 1360 1370 1380
TAPPHFSHTG PTFPVVPPSM SSIAGAAATP SVSVPATSCP FSDISTSVTP SEVTASTEKG
1390 1400 1410 1420 1430 1440
IAGVATCTGV ISSSGLTVPP ASDSPILSSV VSSITVPVAV SVSTTSLSVQ APTPGSIVSN
1450 1460 1470 1480 1490 1500
TGTFPSISVA MTSASAVSST AAPGAKPPPV SSQQVSGSTA GITTLASVPT TAPAPSVASQ
1510 1520 1530 1540 1550 1560
PSLSLSSSTS APTLAETIVV SAHSLDKASH SSTAGLALSL PASSSSASPA AGVSSSVSQP
1570 1580 1590 1600 1610 1620
GVAHPLVIPS AVASIPVLSQ AGPTCAPLLP QVPGIPPLVQ PAASVPAVQQ TLVHSQPQPA
1630 1640 1650 1660 1670 1680
LLPNQPHTHC PEMDADAQPR APGIDDIKTL EEKLRSLFSE HSSSGTQHAS VSLETSLVVE
1690 1700 1710 1720 1730 1740
TTVTPGIPTT AVAPGKLMTS TTSTCLPPTS LPLGTTGLSI LPVVTPGQVS TPVSTIPAVK
1750 1760 1770 1780 1790 1800
PGTAPSKPPS TKPPVLPLGT ELPAGTPPSE QLPPFPGPSL MQAQQPLEDL DAQLRRTLSP
1810 1820 1830 1840 1850 1860
ETVVLTSTVG PVSVVAPTAA VEAGAQLQKD VSQVTEGPIP APTSGTGVFQ MGRFQVSVAM
1870 1880 1890 1900 1910 1920
DDTQKEGKNK SEDVKSVHFE SSTSESSVLS SSSPESTLVK PEPNGTAIRG ISSDMPDSAH
1930 1940 1950 1960 1970 1980
KTSASEAKSE AGQPTKVGRF QVTTTADKVG RFSVSRTEDA IAEAKKEGPV ASPPFMDLEH
1990 2000 2010 2020 2030 2040
SILPAVIPKK EKPELSEPSH LNGPSSDLEA AFLSRDGDDG SGSPHSPPQL CSKSLPIQSL
2050 2060 2070 2080 2090 2100
SQSLSNSFNS SYMSSDNESD IEDEDLKLEL RRLREKHLKE IQDLQSRQKH EIESLYTRLG
2110 2120 2130 2140 2150 2160
KAPPAVIIPA AAPLAGRRRR PTKSKGSKSS RSSSLGNKSP GPAGNLSGQS TATVLHPQQT
2170 2180 2190 2200 2210 2220
LPAPGNIPET GQNQLLQPLK PSPSSDNLYS AFTSDGAISV PSLSAPGQGT SSTNTVGGTV
2230 2240 2250 2260 2270 2280
SSQAAQAQPP TMTSSRKGTF TDDLHKLVDN WARDAMNLSG RRGSKGHMSY EGPGMARKFS
2290 2300 2310 2320 2330 2340
APGQLCISMT SNLGGSAPIS AASATSLGHF TKSMCPPQQY GFPAPPFGTQ WSGTGGPAPQ
2350 2360 2370
PLSQFQPVGT ASLQNFNISN LQKSISNPPG SNLRTT