Q6R005
Gene name |
dlg4 |
Protein name |
Disks large homolog 4 |
Names |
Postsynaptic density protein 95 , PSD-95 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:405796 |
EC number |
|
Protein Class |
|
Descriptions
Autoinhibitory domains (AIDs)
Target domain |
593-779 (GK domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Target domain |
593-779 (GK domain) |
Relief mechanism |
Partner binding, Others |
Assay |
|
Accessory elements
No accessory elements
References
- Qian Y et al. (2006) "Interdomain interactions in the tumor suppressor discs large regulate binding to the synaptic protein GukHolder", The Journal of biological chemistry, 281, 35757-63
- McGee AW et al. (1999) "Identification of an intramolecular interaction between the SH3 and guanylate kinase domains of PSD-95", The Journal of biological chemistry, 274, 17431-6
- Brenman JE et al. (1998) "Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A", The Journal of neuroscience : the official journal of the Society for Neuroscience, 18, 8805-13
Autoinhibited structure
Activated structure
1 structures for Q6R005
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6R005-F1 | Predicted | AlphaFoldDB |
No variants for Q6R005
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6R005 | |||||
No associated diseases with Q6R005
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| basolateral plasma membrane | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| neuron projection | A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| postsynaptic density | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. |
| postsynaptic density membrane | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| kinase binding | Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group. |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| AMPA glutamate receptor clustering | The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane. |
| cell-cell adhesion | The attachment of one cell to another cell via adhesion molecules. |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| embryo development | The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. |
| establishment or maintenance of epithelial cell apical/basal polarity | Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell. |
| postsynaptic neurotransmitter receptor diffusion trapping | The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization. |
| synapse organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P31007 | dlg1 | Disks large 1 tumor suppressor protein | Drosophila melanogaster (Fruit fly) | EV |
| Q12959 | DLG1 | Disks large homolog 1 | Homo sapiens (Human) | SS |
| Q92796 | DLG3 | Disks large homolog 3 | Homo sapiens (Human) | SS |
| Q15700 | DLG2 | Disks large homolog 2 | Homo sapiens (Human) | SS |
| Q9BXL7 | CARD11 | Caspase recruitment domain-containing protein 11 | Homo sapiens (Human) | EV |
| P78352 | DLG4 | Disks large homolog 4 | Homo sapiens (Human) | SS |
| Q811D0 | Dlg1 | Disks large homolog 1 | Mus musculus (Mouse) | SS |
| Q8CIS0 | Card11 | Caspase recruitment domain-containing protein 11 | Mus musculus (Mouse) | SS |
| P70175 | Dlg3 | Disks large homolog 3 | Mus musculus (Mouse) | SS |
| Q99KF0 | Card14 | Caspase recruitment domain-containing protein 14 | Mus musculus (Mouse) | PR |
| Q91XM9 | Dlg2 | Disks large homolog 2 | Mus musculus (Mouse) | SS |
| Q62108 | Dlg4 | Disks large homolog 4 | Mus musculus (Mouse) | SS |
| Q62936 | Dlg3 | Disks large homolog 3 | Rattus norvegicus (Rat) | SS |
| Q63622 | Dlg2 | Disks large homolog 2 | Rattus norvegicus (Rat) | EV |
| Q62696 | Dlg1 | Disks large homolog 1 | Rattus norvegicus (Rat) | SS |
| P31016 | Dlg4 | Disks large homolog 4 | Rattus norvegicus (Rat) | SS |
| G5ECY0 | dlg-1 | Disks large homolog 1 | Caenorhabditis elegans | SS |
| Q28C55 | dlg1 | Disks large homolog 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q5PYH5 | dlg1l | Discs large homolog 1-like protein | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5PYH7 | dlg2 | Disks large homolog 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPLKREDTER | ALQAMEACQS | AGDEGFRTRA | ERLLTIFQSD | LFQALLDIQE | FYELTVFENQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TAGRALTPGL | KYRYHDEETP | PLQHSPAHLS | TGKSAEMLHL | GDSGHAPIDG | IHAYTPQMHV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPAKPVLLPS | GHAPYYATST | LMNGMDGDVE | YEEITLERGN | SGLGFSIAGG | TDNPHIGDDP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SIFITKIIPG | GAAAQDGRLR | VNDSILFVND | VDVREVTHSF | AVEALKEAGP | IVRLYVLRHK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSAEKITELK | LIKGPKGLGF | SIAGGVGNQH | VPGDNSIYVT | KIIEGGAAHK | DGRLQIGDKI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LAVNNMYLEE | VMHEDAVAAL | KNTGDVVFLR | VAKTLHQHHH | QDAYNPPDIT | SSYSPHMDMS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DYPQALSPSS | PRRYSPIPKG | LFLDDDISRE | PRRVVIHRGS | TGLGFNIVGG | EDGEGIFISF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ILAGGAADLS | GELRKGDQIL | SVNGVDLRHA | THEQAAAALK | NAGQTVTIIT | QYRPEEYSRF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EAKIHDLREQ | LMNSSLVSAA | ASLRSGKRSF | FIRALFDYDK | TADGGFLSQA | VSFRFGDVLQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VFDCSDEEWW | QAGKLAPHGE | LEETGYIPSK | RRVERKEWSR | LKTRGREPVS | GRSDYIVSYE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TVTQSEVHYA | RPVIILGPSK | DRVNDDLLSE | FPDKFGSCVP | HTTRPKREYE | MDGRDYHFVS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SREQMEKDIQ | SHRFIEAGQY | NSHLYGTSVQ | SVRQVAEQQG | KHCILDVSAN | AVRRLQAAQL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| YPIAIFIRPS | SLQNVLNISK | RLTEEQARRA | LDRAVKLEQD | FIECFSAIVE | GESFEEIYHH |
| 790 | 800 | ||||
| VKSVIEEQSG | PYIWIPARER | L |