Q6QNF3

SS
Gene name
PDGFRB (PDGFR, PDGFR1)
Protein name
Platelet-derived growth factor receptor beta
Names
PDGF-R-beta , PDGFR-beta , EC 2.7.10.1 , Beta platelet-derived growth factor receptor , Beta-type platelet-derived growth factor receptor , CD140 antigen-like family member B , Platelet-derived growth factor receptor 1 , PDGFR-1 , CD antigen CD140b
Species
Canis lupus familiaris (Dog) (Canis familiaris)
KEGG Pathway
cfa:442985
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

PDGF receptor-β (PDGFRβ) is one of the members of the PDGF receptor family of RTKs. Members of the PDGF receptor family share strong sequence similarity throughout the juxtamembrane region, which contains two Tyr autophosphorylation sites in a YφY motif. Deletions and missense mutations in the juxtamembrane region of PDGF receptor family members would be predicted to disrupt the interactions that stabilize the autoinhibitory conformation of the juxtamembrane region. Also, the C-terminal tail of PDGFRβ is required to stabilize the inactive conformation in the absence of ligand.

Autoinhibitory domains (AIDs)

525-562 (Juxtamembrane region) SS

Target domain

600-962 (Protein kinase domain)

Relief mechanism

Ligand binding

Assay

1058-1074 (C-terminal tail) SS

Target domain

600-962 (Protein kinase domain)

Relief mechanism

Ligand binding

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6QNF3

Entry ID Method Resolution Chain Position Source
AF-Q6QNF3-F1 Predicted AlphaFoldDB

No variants for Q6QNF3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6QNF3

No associated diseases with Q6QNF3

16 regional properties for Q6QNF3

Type Name Position InterPro Accession
domain C2 domain 1579 - 1695 IPR000008
domain Dbl homology (DH) domain 1237 - 1423 IPR000219
domain EH domain 14 - 108 IPR000261-1
domain EH domain 214 - 310 IPR000261-2
conserved_site Guanine-nucleotide dissociation stimulator, CDC24, conserved site 1371 - 1396 IPR001331
domain SH3 domain 740 - 806 IPR001452-1
domain SH3 domain 913 - 971 IPR001452-2
domain SH3 domain 1002 - 1060 IPR001452-3
domain SH3 domain 1074 - 1138 IPR001452-4
domain SH3 domain 1155 - 1214 IPR001452-5
domain Pleckstrin homology domain 1440 - 1593 IPR001849
domain EF-hand domain 53 - 88 IPR002048-1
domain EF-hand domain 254 - 289 IPR002048-2
binding_site EF-Hand 1, calcium-binding site 66 - 78 IPR018247-1
binding_site EF-Hand 1, calcium-binding site 267 - 279 IPR018247-2
domain Intersectin-1, AP2 binding region 803 - 917 IPR032140

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Cytoplasmic vesicle
  • Lysosome lumen
  • After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
lysosomal lumen The volume enclosed within the lysosomal membrane.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
platelet-derived growth factor beta-receptor activity Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity.
platelet-derived growth factor binding Binding to platelet-derived growth factor.

17 GO annotations of biological process

Name Definition
cell chemotaxis The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
cell migration involved in coronary angiogenesis The orderly movement of a cell from one site to another that will contribute to the formation of new blood vessels in the heart from pre-existing blood vessels.
cell migration involved in vasculogenesis The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.
peptidyl-tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
phosphatidylinositol metabolic process The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
platelet-derived growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
positive regulation of calcium-mediated signaling Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
positive regulation of phospholipase C activity Any process that increases the rate of phospholipase C activity.
positive regulation of phosphoprotein phosphatase activity Any process that activates or increases the activity of a phosphoprotein phosphatase.
positive regulation of smooth muscle cell migration Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
positive regulation of smooth muscle cell proliferation Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
retina vasculature development in camera-type eye The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q75ZY9 MET Hepatocyte growth factor receptor Canis lupus familiaris (Dog) (Canis familiaris) PR
O97799 KIT Mast/stem cell growth factor receptor Kit Canis lupus familiaris (Dog) (Canis familiaris) PR
P09619 PDGFRB Platelet-derived growth factor receptor beta Homo sapiens (Human) EV
P05622 Pdgfrb Platelet-derived growth factor receptor beta Mus musculus (Mouse) SS
Q05030 Pdgfrb Platelet-derived growth factor receptor beta Rattus norvegicus (Rat) SS
Q8RWW0 ALE2 Receptor-like serine/threonine-protein kinase ALE2 Arabidopsis thaliana (Mouse-ear cress) PR
P93050 BSH Probable LRR receptor-like serine/threonine-protein kinase RKF3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LDQ3 CRK34 Cysteine-rich receptor-like protein kinase 34 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MQVPGTMPAP VLKGQALWLP LLLMLSPQAS GGLVITPPGP ELVLNISSTF VLTCSGPAPV
70 80 90 100 110 120
VWERLSQEPL QKMARTQDGT FSSTLTLTNV TGLDTGEYFC TYKGSHGLEP DGRKRLYIFV
130 140 150 160 170 180
PDPTMGFLPV DPEELFIFLT EITEITIPCR VTDPRLVVTL HEKKVDIPLP IPYDHQRGFS
190 200 210 220 230 240
GTFEDKTYVC KTTIGDKEVD SEAYYVYSLQ VSSINVSVNA VQTVVRQGEN ITIMCIVTGN
250 260 270 280 290 300
EVVNFEWTYP RMESGRLVEP VTDFLFNVPS HIRSILHIPS AELGDSGTYI CNVSESVNDH
310 320 330 340 350 360
RDEKSINVTV VESGYVRLLG ELDAVQFAEL HRSRALQVVF EAYPPPTVVW FKDNRTLGDS
370 380 390 400 410 420
SAGEIALSTR NVSETRYVSE LTLVRVKVAE AGYYTMRAFH EDAEAQLSFQ LQVNVPVRVL
430 440 450 460 470 480
ELSESHPASG EQTVRCRGRG MPQPHLTWST CSDLKRCPRE LPPTPLGNSS EEESQLETNV
490 500 510 520 530 540
TYWPEDQEFE VVSTLRLRRV DQPLSVRCTL HNLLGHDMQE VTVVPHSLPF KVVVISAILA
550 560 570 580 590 600
LVVLTIISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD STWELPRDQL
610 620 630 640 650 660
VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP
670 680 690 700 710 720
HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQLCSDKRRP PSAELYSNAL
730 740 750 760 770 780
PAGLPLPSHV SLPGESDGGY MDMSKDESVD YVPMLDMKGG VKYADIESSS YMAPYDNYVP
790 800 810 820 830 840
TAPERTCRAT LINESPVLSY TDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV
850 860 870 880 890 900
KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG
910 920 930 940 950 960
GTPYPELPMN EQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFEIRPP FSQLVLLLER
970 980 990 1000 1010 1020
LLGEGYKKKY QQVDEEFLRS DHPAVLRSQA RLPGFPGLRS PLDTSSVLYT AVQPNEGDND
1030 1040 1050 1060 1070 1080
YIIPLPDPKP EVADGPLESS PSLASSTLNE VNTSSTISCD SPLEPQEEPE PEPEPQPEPQ
1090 1100
VVPEPPLDSS CPGPRAEAED SFL