Q6QLM7

SS
Gene name
Kif5a
Protein name
Kinesin heavy chain isoform 5A
Names
Kinesin heavy chain neuron-specific 1 , Neuronal kinesin heavy chain , NKHC
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:314906
EC number
Protein Class

Autoinhibited structure

Activated structure

3 structures for Q6QLM7

Entry ID Method Resolution Chain Position Source
2KIN X-ray 200 A B 252-351 PDB
3KIN X-ray 310 A B/D 256-372 PDB
AF-Q6QLM7-F1 Predicted AlphaFoldDB

No variants for Q6QLM7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6QLM7

No associated diseases with Q6QLM7

1 regional properties for Q6QLM7

Type Name Position InterPro Accession
domain Kinesin motor domain 7 - 335 IPR001752

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, perinuclear region
  • Cytoplasm, cytoskeleton
  • Perikaryon
  • Concentrated in the cell body of the neurons, particularly in the perinuclear region
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

15 GO annotations of cellular component

Name Definition
apical dendrite A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axon cytoplasm Any cytoplasm that is part of a axon.
central region of growth cone The center of the migrating motile tip of a growing nerve cell axon or dendrite.
ciliary rootlet A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
dendrite cytoplasm All of the contents of a dendrite, excluding the surrounding plasma membrane.
kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work.
microtubule Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
P-body A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction
kinesin binding Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
microtubule binding Binding to a microtubule, a filament composed of tubulin monomers.
microtubule motor activity A motor activity that generates movement along a microtubule, driven by ATP hydrolysis.
plus-end-directed microtubule motor activity A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis.
protein-containing complex binding Binding to a macromolecular complex.
scaffold protein binding Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.

15 GO annotations of biological process

Name Definition
anterograde axonal protein transport The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons.
anterograde dendritic transport of neurotransmitter receptor complex The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse.
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
cellular response to ethanol Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
cellular response to nerve growth factor stimulus A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
cerebral cortex development The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
hippocampus development The progression of the hippocampus over time from its initial formation until its mature state.
microtubule-based process Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
neuron development The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
response to rotenone Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rotenone stimulus.
retrograde neuronal dense core vesicle transport The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body.
synaptic vesicle transport The directed movement of synaptic vesicles.
thalamus development The process in which the thalamus changes over time, from its initial formation to its mature state.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P17210 Khc Kinesin heavy chain Drosophila melanogaster (Fruit fly) EV
P33176 KIF5B Kinesin-1 heavy chain Homo sapiens (Human) EV
O60282 KIF5C Kinesin heavy chain isoform 5C Homo sapiens (Human) EV
Q12840 KIF5A Kinesin heavy chain isoform 5A Homo sapiens (Human) EV
Q61768 Kif5b Kinesin-1 heavy chain Mus musculus (Mouse) EV
P28738 Kif5c Kinesin heavy chain isoform 5C Mus musculus (Mouse) SS
P33175 Kif5a Kinesin heavy chain isoform 5A Mus musculus (Mouse) SS
Q2PQA9 Kif5b Kinesin-1 heavy chain Rattus norvegicus (Rat) SS
Q7M6Z5 Kif27 Kinesin-like protein KIF27 Rattus norvegicus (Rat) SS
F1M5N7 Kif21b Kinesin-like protein KIF21B Rattus norvegicus (Rat) SS
Q9WV63 Kif2a Kinesin-like protein KIF2A Rattus norvegicus (Rat) PR
P34540 unc-116 Kinesin heavy chain Caenorhabditis elegans SS
Q9SV36 KINUC Kinesin-like protein KIN-UC Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAETNNECSI KVLCRFRPLN QAEILRGDKF IPIFQGDDSV IIGGKPYVFD RVFPPNTTQE
70 80 90 100 110 120
QVYHACAMQI VKDVLAGYNG TIFAYGQTSS GKTHTMEGKL HDPQLMGIIP RIARDIFNHI
130 140 150 160 170 180
YSMDENLEFH IKVSYFEIYL DKIRDLLDVT KTNLSVHEDK NRVPFVRGCT ERFVSSPEEI
190 200 210 220 230 240
LDVIDEGKSN RHVAVTNMNE HSSRSHSIFL INIKQENIET EQKLSGKLYL ADLAGSEKVS
250 260 270 280 290 300
KTGAEGAVLD EAKNINKSLS ALGNVISALA EGTKSYVPYR DSKMTRILQD SLGGNCRTTM
310 320 330 340 350 360
FICCSPSSYN DAETKSTLMF GQRAKTIKNT ASVNLELTAE QWKKKYEKEK EKTKAQKETI
370 380 390 400 410 420
AKLEAELSRW RNGENVPETE RLAGEDSALA AEICEETPVN DNSSIVVRIA PEERQKYEEE
430 440 450 460 470 480
IRRLYKQLDD KDDEINQQSQ LIEKLKQQML DQEELLVSTR GDNEKVQREL SHLQSENDAA
490 500 510 520 530 540
KEEVKEVLQA LEELAVNYDQ KSQEVEEKSQ QNQLLVDELS QKVATMLSLE SEPQRLQEVS
550 560 570 580 590 600
GHQRKRIAEV LNGLMKDLSE FSVIVGNGEI KLPVEISGAI EEEFTVARLY ISKIKSEVKS
610 620 630 640 650 660
VVKRCRQLEN LQVECHRKME VTGRELSSCQ LLISQHEAKI RSLTEYMQTV ELKKRHLEES
670 680 690 700 710 720
YDSLSDELAK LQAQETVHEV ALKDKEPDTQ DAEEVKKALE LQMENHREAH HRQLARLRDE
730 740 750 760 770 780
INEKQKTIDE LKDLDQKLQL ELEKLQADYE RLKNEENEKS AKLQELTFLY ERHEQSKQDL
790 800 810 820 830 840
KGLEETVARE LQTLHNLRKL FVQDVTTRVK KSAEMEPEDS GGIHSQKQKI SFLENNLEQL
850 860 870 880 890 900
TEVHKQLVRD NADLRCELPK LEKRLRATAE RVKALEGALK EAKEGAMKDK RRYQQEVDRI
910 920 930 940 950 960
KEAVRYKSSG KRGHSAQIAK PVRPGHYPAS SPTNPYGTRS PECISYTNNL FQNYQNLHLQ
970 980 990 1000 1010 1020
AAPSSTSDVY FASNGATSVA PLASYQKANT DNGNATDIND NRSDLPCGYE AEDPAKLFPL
HQETAAS