Q6Q413
Gene name |
nf2b (nf2, NF2a, nf2a) |
Protein name |
NF2, moesin-ezrin-radixin-like |
Names |
MERLIN tumor suppressor b , Neurofibromin 2b , Merlin , Nf2a |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:405887 |
EC number |
|
Protein Class |
|
Descriptions
The tumor suppressor gene Nf2 encodes the protein 4.1, Ezrin, Radixin, Moesin (FERM) domain-containing protein Merlin. The tumor suppressor Merlin/NF2 functions upstream of the core Hippo pathway kinases Lats1/2 and Mst1/2, as well as the nuclear E3 ubiquitin ligase CRL4.
Merlin’s autoinhibitory tail physically blocks the Lats1/2-binding site on the Merlin FERM domain. Angiomotin binding releases this autoinhibition, promoting Merlin’s binding to Lats1/2, leading to activation of Hippo pathway kinases.
Autoinhibitory domains (AIDs)
Target domain |
14-304 (FERM domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for Q6Q413
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for Q6Q413
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6Q413 | |||||
No associated diseases with Q6Q413
6 regional properties for Q6Q413
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase S8/S53 domain | 192 - 474 | IPR000209 |
| domain | P domain | 490 - 628 | IPR002884 |
| active_site | Peptidase S8, subtilisin, His-active site | 240 - 250 | IPR022398 |
| active_site | Peptidase S8, subtilisin, Asp-active site | 197 - 208 | IPR023827 |
| domain | Peptidase S8, pro-domain | 42 - 116 | IPR032815 |
| domain | Kexin/furin catalytic domain | 159 - 447 | IPR034182 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| adherens junction | A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules. |
| apical part of cell | The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoskeleton | A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. |
| filopodium | Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin binding | Binding to monomeric or multimeric forms of actin, including actin filaments. |
| integrin binding | Binding to an integrin. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of cell population proliferation | Any process that stops, prevents or reduces the rate or extent of cell proliferation. |
| positive regulation of early endosome to late endosome transport | Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport. |
| positive regulation of protein localization to early endosome | Any process that activates or increases the frequency, rate or extent of protein localization to early endosome. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
| regulation of gliogenesis | Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia. |
| regulation of hippo signaling | Any process that modulates the frequency, rate or extent of hippo signaling. |
| regulation of organelle assembly | Any process that modulates the frequency, rate or extent of organelle assembly. |
21 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P31976 | EZR | Ezrin | Bos taurus (Bovine) | PR |
| Q2HJ49 | MSN | Moesin | Bos taurus (Bovine) | PR |
| Q32LP2 | RDX | Radixin | Bos taurus (Bovine) | SS |
| Q9PU45 | RDX | Radixin | Gallus gallus (Chicken) | PR |
| P46150 | Moe | Moesin/ezrin/radixin homolog 1 | Drosophila melanogaster (Fruit fly) | SS |
| Q24564 | Mer | Moesin/ezrin/radixin homolog 2 | Drosophila melanogaster (Fruit fly) | SS |
| Q3KP66 | INAVA | Innate immunity activator protein | Homo sapiens (Human) | PR |
| P15311 | EZR | Ezrin | Homo sapiens (Human) | EV |
| P26038 | MSN | Moesin | Homo sapiens (Human) | EV |
| P35240 | NF2 | Merlin | Homo sapiens (Human) | EV |
| P35241 | RDX | Radixin | Homo sapiens (Human) | SS |
| A2AD83 | Frmd7 | FERM domain-containing protein 7 | Mus musculus (Mouse) | PR |
| P26040 | Ezr | Ezrin | Mus musculus (Mouse) | SS |
| P26041 | Msn | Moesin | Mus musculus (Mouse) | SS |
| P26043 | Rdx | Radixin | Mus musculus (Mouse) | SS |
| P46662 | Nf2 | Merlin | Mus musculus (Mouse) | SS |
| P26042 | MSN | Moesin | Sus scrofa (Pig) | PR |
| P26044 | RDX | Radixin | Sus scrofa (Pig) | SS |
| Q63648 | Nf2 | Merlin | Rattus norvegicus (Rat) | SS |
| O35763 | Msn | Moesin | Rattus norvegicus (Rat) | SS |
| P31977 | Ezr | Ezrin | Rattus norvegicus (Rat) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSILGLKKKQ | PKTFKVKVST | MDAEMEFSCE | VKWKGKDLFD | LVCRTIGLRE | TWFFGLRYTV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KDTYAWLKPD | KRVLDQEVPK | DSPITFHFLA | KFFPEKVEDE | LVQEITQHLF | FLQVKKQILD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EEIFCSPEAS | VLLASYAVQA | KYGDYDPNFH | KPGFLAQDEL | LPKRVLMQYQ | MTPDMWEEKI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TAWYAEHRNI | TRDEAEMEYL | KIAQDLDMYG | VSYFSITQNK | RDTELLLGVD | AQGLHIYNPN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NKLSPNKSFP | WSGIRNISYS | EKEFTIKPLD | KKKEVFKFYS | SQLRVNKLIL | QLCIGNHDLF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MRRRKVDSIE | VQQMKAQAKE | EKARKKVERQ | ILAREKQMRE | EAERAKEEME | RRMFQLQDEA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RMANEALLRS | EETADLLAEK | AQIAEEEAKL | LAHKAAEAEQ | ERQRLEVTAL | KTKEEKRLME |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QKMREAEQLA | VKLVEQSERR | LKEADHLKQD | LNEAKDAERR | AKQKLLEITK | TTYPLIAAYS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NPPPPAGPES | PEMAIEMGNP | IQMDFKDSDM | KRLSMEIERE | RLEYMEKSKH | LQDQLKELKS |
| 550 | 560 | 570 | 580 | ||
| EIESLKLEEQ | QQAGVYNLRS | YAEPPFIPPS | NRNSAYMAQM | AFYEEV |