Q6PHZ2

SS
Gene name
Camk2d (Kiaa4163)
Protein name
Calcium/calmodulin-dependent protein kinase type II subunit delta
Names
CaM kinase II subunit delta, CaMK-II subunit delta
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:108058
EC number
2.7.11.17: Protein-serine/threonine kinases
Protein Class

Descriptions

CAMK2D is a Calcium/Calmodulin (CaM)-dependent kinase II (CaMKII) that plays as a molecular switch of cellular signalling by transmitting Ca2+ signals in human. The C-terminal helix bound to the substrate-binding site causes autoinhibited CaMKII.

Autoinhibitory domains (AIDs)

283-292 (Autoinhibitory domain) SS

Target domain

14-272 (Protein kinase domain)

Relief mechanism

Partner binding

Assay

Accessory elements

156-179 (Activation loop from InterPro)

Target domain

14-272 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

2 structures for Q6PHZ2

Entry ID Method Resolution Chain Position Source
6BAB X-ray 191 A A/B/C/D 3-301 PDB
AF-Q6PHZ2-F1 Predicted AlphaFoldDB

No variants for Q6PHZ2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6PHZ2

No associated diseases with Q6PHZ2

2 regional properties for Q6PHZ2

Type Name Position InterPro Accession
domain Longin domain 4 - 116 IPR010908
domain v-SNARE, coiled-coil homology domain 124 - 210 IPR042855

Functions

Description
EC Number 2.7.11.17 Protein-serine/threonine kinases
Subcellular Localization
  • Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side
  • Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

13 GO annotations of cellular component

Name Definition
axon initial segment Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
calcium- and calmodulin-dependent protein kinase complex An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intercalated disc A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
sarcoplasmic reticulum membrane The lipid bilayer surrounding the sarcoplasmic reticulum.
T-tubule Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.

13 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
calmodulin-dependent protein kinase activity Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate.
identical protein binding Binding to an identical protein or proteins.
nitric-oxide synthase binding Binding to nitric-oxide synthase.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
sodium channel inhibitor activity Binds to and stops, prevents, or reduces the activity of a sodium channel.
titin binding Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.
transmembrane transporter binding Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

32 GO annotations of biological process

Name Definition
calcium ion transport The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cardiac muscle cell contraction The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell.
cardiac muscle contraction Muscle contraction of cardiac muscle tissue.
cell growth involved in cardiac muscle cell development The growth of a cardiac muscle cell, where growth contributes to the progression of the cell over time from its initial formation to its mature state.
cellular potassium ion homeostasis Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
endoplasmic reticulum calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.
G1/S transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
negative regulation of sodium ion transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transport.
negative regulation of sodium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of cardiac muscle cell apoptotic process Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
positive regulation of cardiac muscle hypertrophy Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
positive regulation of DNA biosynthetic process Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.
positive regulation of ERK1 and ERK2 cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
positive regulation of G2/M transition of mitotic cell cycle Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
positive regulation of Rac protein signal transduction Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction.
positive regulation of smooth muscle cell migration Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.
positive regulation of vascular associated smooth muscle cell proliferation Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
regulation of cardiac muscle cell action potential Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
regulation of cell communication by electrical coupling Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.
regulation of cellular localization Any process that modulates the frequency, rate or extent of a process in which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
regulation of membrane depolarization Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.
regulation of protein localization to plasma membrane Any process that modulates the frequency, rate or extent of protein localization to plasma membrane.
regulation of relaxation of cardiac muscle Any process that modulates the frequency, rate or extent of relaxation of cardiac muscle.
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
regulation of sodium ion transport Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
relaxation of cardiac muscle The process in which the extent of cardiac muscle contraction is reduced.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.

39 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3MHJ9 CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta Bos taurus (Bovine) SS
Q2HJF7 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta Bos taurus (Bovine) SS
Q5ZKI0 CAMK2D Calcium/calmodulin-dependent protein kinase type II delta chain Gallus gallus (Chicken) SS
Q24210 CASK Peripheral plasma membrane protein CASK Drosophila melanogaster (Fruit fly) SS
Q00168 CaMKII Calcium/calmodulin-dependent protein kinase type II alpha chain Drosophila melanogaster (Fruit fly) SS
Q13555 CAMK2G Calcium/calmodulin-dependent protein kinase type II subunit gamma Homo sapiens (Human) EV
O14936 CASK Peripheral plasma membrane protein CASK Homo sapiens (Human) EV
Q13554 CAMK2B Calcium/calmodulin-dependent protein kinase type II subunit beta Homo sapiens (Human) EV
Q9UQM7 CAMK2A Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens (Human) EV
Q13557 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta Homo sapiens (Human) EV
O70589 Cask Peripheral plasma membrane protein CASK Mus musculus (Mouse) SS
P07934 Phkg1 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform Mus musculus (Mouse) SS
Q9DB30 Phkg2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform Mus musculus (Mouse) PR
P28652 Camk2b Calcium/calmodulin-dependent protein kinase type II subunit beta Mus musculus (Mouse) SS
P11798 Camk2a Calcium/calmodulin-dependent protein kinase type II subunit alpha Mus musculus (Mouse) PR
Q923T9 Camk2g Calcium/calmodulin-dependent protein kinase type II subunit gamma Mus musculus (Mouse) SS
Q8VCR8 Mylk2 Myosin light chain kinase 2, skeletal/cardiac muscle Mus musculus (Mouse) SS
Q3UIZ8 Mylk3 Myosin light chain kinase 3 Mus musculus (Mouse) SS
Q91YA2 Pskh1 Serine/threonine-protein kinase H1 Mus musculus (Mouse) SS
Q9QYK9 Pnck Calcium/calmodulin-dependent protein kinase type 1B Mus musculus (Mouse) PR
Q91VB2 Camk1g Calcium/calmodulin-dependent protein kinase type 1G Mus musculus (Mouse) SS
Q8BW96 Camk1d Calcium/calmodulin-dependent protein kinase type 1D Mus musculus (Mouse) SS
Q3UHL1 Camkv CaM kinase-like vesicle-associated protein Mus musculus (Mouse) SS
Q91YS8 Camk1 Calcium/calmodulin-dependent protein kinase type 1 Mus musculus (Mouse) SS
Q95266 CAMK2D Calcium/calmodulin-dependent protein kinase type II subunit delta Sus scrofa (Pig) SS
P11275 Camk2a Calcium/calmodulin-dependent protein kinase type II subunit alpha Rattus norvegicus (Rat) PR
P11730 Camk2g Calcium/calmodulin-dependent protein kinase type II subunit gamma Rattus norvegicus (Rat) SS
P15791 Camk2d Calcium/calmodulin-dependent protein kinase type II subunit delta Rattus norvegicus (Rat) SS
P54936 lin-2 Protein lin-2 Caenorhabditis elegans SS
O62305 unc-43 Calcium/calmodulin-dependent protein kinase type II Caenorhabditis elegans EV
Q9SSF8 CPK30 Calcium-dependent protein kinase 30 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M9V8 CPK10 Calcium-dependent protein kinase 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W4I7 CPK13 Calcium-dependent protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) PR
Q9SIQ7 CPK24 Calcium-dependent protein kinase 24 Arabidopsis thaliana (Mouse-ear cress) PR
P93759 GK-1 Calcium-dependent protein kinase 14 Arabidopsis thaliana (Mouse-ear cress) PR
Q6NLQ6 CPK32 Calcium-dependent protein kinase 32 Arabidopsis thaliana (Mouse-ear cress) PR
Q38873 CPK7 Calcium-dependent protein kinase 7 Arabidopsis thaliana (Mouse-ear cress) PR
Q6DEH3 camk2d1 Calcium/calmodulin-dependent protein kinase type II delta 1 chain Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q6DGS3 camk2d2 Calcium/calmodulin-dependent protein kinase type II delta 2 chain Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MASTTTCTRF TDEYQLFEEL GKGAFSVVRR CMKIPTGQEY AAKIINTKKL SARDHQKLER
70 80 90 100 110 120
EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIQQI
130 140 150 160 170 180
LESVNHCHLN GIVHRDLKPE NLLLASKSKG AAVKLADFGL AIEVQGDQQA WFGFAGTPGY
190 200 210 220 230 240
LSPEVLRKDP YGKPVDMWAC GVILYILLVG YPPFWDEDQH RLYQQIKAGA YDFPSPEWDT
250 260 270 280 290 300
VTPEAKDLIN KMLTINPAKR ITASEALKHP WICQRSTVAS MMHRQETVDC LKKFNARRKL
310 320 330 340 350 360
KGAILTTMLA TRNFSAAKSL LKKPDGVKES TESSNTTIED EDVKARKQEI IKVTEQLIEA
370 380 390 400 410 420
INNGDFEAYT KICDPGLTAF EPEALGNLVE GMDFHRFYFE NALSKSNKPI HTIILNPHVH
430 440 450 460 470 480
LVGDDAACIA YIRLTQYMDG SGMPKTMQSE ETRVWHRRDG KWQNVHFHRS GSPTVPIKPP
490
CIPNGKENFS GGTSLWQNI