Q6PH18

PR
Gene name
nr2f1b
Protein name
Nuclear receptor subfamily 2 group F member 1-B
Names
COUP transcription factor 1-B, COUP-TFalpha-B
Species
Danio rerio (Zebrafish) (Brachydanio rerio)
KEGG Pathway
dre:393564
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6PH18

Entry ID Method Resolution Chain Position Source
AF-Q6PH18-F1 Predicted AlphaFoldDB

No variants for Q6PH18

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6PH18

No associated diseases with Q6PH18

4 regional properties for Q6PH18

Type Name Position InterPro Accession
domain Protein kinase domain 119 - 403 IPR000719
active_site Serine/threonine-protein kinase, active site 240 - 252 IPR008271
binding_site Protein kinase, ATP binding site 125 - 149 IPR017441
domain Glycogen synthase kinase 3, catalytic domain 114 - 406 IPR039192

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
nuclear receptor activity A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytoplasm, which leads to its tranlocation to the nucleus.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
zinc ion binding Binding to a zinc ion (Zn).

9 GO annotations of biological process

Name Definition
anatomical structure development The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
angioblast cell migration The orderly movement of angioblasts, cells involved in blood vessel morphogenesis.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
cranial skeletal system development The process whose specific outcome is the progression of a cranial skeletal system over time, from its formation to the mature structure. The cranial skeletal system is the skeletal subdivision of the head, and includes the skull (cranium plus mandible), pharyngeal and/or hyoid apparatus.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
vasculature development The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
venous blood vessel development The progression of the venous blood vessel over time from its initial formation to the mature structure. Venous blood vessels carry blood back to the heart after the capillary bed.

28 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9TTR7 NR2F2 COUP transcription factor 2 Bos taurus (Bovine) PR
O18971 PPARG Peroxisome proliferator-activated receptor gamma Bos taurus (Bovine) PR
Q90733 NR2F2 COUP transcription factor 2 Gallus gallus (Chicken) PR
P68306 THRB Thyroid hormone receptor beta Gallus gallus (Chicken) PR
A7X8B3 PGR Progesterone receptor Pan troglodytes (Chimpanzee) SS
P37231 PPARG Peroxisome proliferator-activated receptor gamma Homo sapiens (Human) PR
P10588 NR2F6 Nuclear receptor subfamily 2 group F member 6 Homo sapiens (Human) PR
P06401 PGR Progesterone receptor Homo sapiens (Human) EV
O75469 NR1I2 Nuclear receptor subfamily 1 group I member 2 Homo sapiens (Human) PR
P24468 NR2F2 COUP transcription factor 2 Homo sapiens (Human) PR
P49116 NR2C2 Nuclear receptor subfamily 2 group C member 2 Homo sapiens (Human) PR
P10589 NR2F1 COUP transcription factor 1 Homo sapiens (Human) PR
P35396 Ppard Peroxisome proliferator-activated receptor delta Mus musculus (Mouse) PR
P43136 Nr2f6 Nuclear receptor subfamily 2 group F member 6 Mus musculus (Mouse) PR
P43135 Nr2f2 COUP transcription factor 2 Mus musculus (Mouse) PR
Q00175 Pgr Progesterone receptor Mus musculus (Mouse) SS
Q9Z0Y9 Nr1h3 Oxysterols receptor LXR-alpha Mus musculus (Mouse) PR
O62807 PPARG Peroxisome proliferator-activated receptor gamma Sus scrofa (Pig) PR
O09018 Nr2f2 COUP transcription factor 2 Rattus norvegicus (Rat) PR
Q63449 Pgr Progesterone receptor Rattus norvegicus (Rat) SS
Q8SQ01 NR1I2 Nuclear receptor subfamily 1 group I member 2 Macaca mulatta (Rhesus macaque) PR
G5EFF5 daf-12 Nuclear hormone receptor family member daf-12 Caenorhabditis elegans PR
O45460 nhr-54 Nuclear hormone receptor family member nhr-54 Caenorhabditis elegans PR
Q20765 nhr-7 Nuclear hormone receptor family member nhr-7 Caenorhabditis elegans PR
Q21006 nhr-34 Nuclear hormone receptor family member nhr-34 Caenorhabditis elegans PR
O17928 nhr-52 Nuclear hormone receptor family member nhr-52 Caenorhabditis elegans PR
Q21878 nhr-1 Nuclear hormone receptor family member nhr-1 Caenorhabditis elegans PR
O18141 nhr-79 Nuclear hormone receptor family member nhr-79 Caenorhabditis elegans PR
10 20 30 40 50 60
MAMVVSAWRD PQEELAAVDD QSAAGREHLQ HRHSPKSAEE KAQIAAQNQQ HVECVVCGDK
70 80 90 100 110 120
SSGKHYGQFT CEGCKSFFKR SVRRNLSYTC RANRNCPVDQ HHRNQCQYCR LKKCLKVGMR
130 140 150 160 170 180
REAVQRGRMP PNQPNPSHYA LTNGDHLNGQ CYLSGYISLL LRAEPYPASR YGNQCMQSGN
190 200 210 220 230 240
IMGIENICEL AARLLFSAVE WARNIPFFPD LQITDQVSLL RLTWSELFVL NAAQSSMPLH
250 260 270 280 290 300
VAPLLAAAGL HASPMSADRV VAFMDHIRFF QEQVEKLKAL QVDSAEYSCA KAIVLFTSDA
310 320 330 340 350 360
CGLSDIPHIE GLQEKSQCAL EEYVRSQYPN QPTRFGKLLL RLPALRMVSS SVIEQLFFVR
370 380
LVGKTPIETL IRDMLLSGSS FNWPYMPIQ