Q6PDQ2
PR
Gene name |
Chd4 |
Protein name |
Chromodomain-helicase-DNA-binding protein 4 |
Names |
CHD-4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:107932 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6PDQ2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6PDQ2-F1 | Predicted | AlphaFoldDB |
92 variants for Q6PDQ2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs47403044 | 22 | A>S | No | EVA | |
| rs3388863586 | 72 | K>* | No | EVA | |
| rs3388823666 | 86 | V>E | No | EVA | |
| rs3388860911 | 152 | G>R | No | EVA | |
| rs3388863564 | 153 | M>I | No | EVA | |
| rs3388857211 | 154 | E>* | No | EVA | |
| rs3388857186 | 168 | L>P | No | EVA | |
| rs3388855237 | 207 | T>I | No | EVA | |
| rs3388858340 | 225 | A>S | No | EVA | |
| rs3388857221 | 244 | P>S | No | EVA | |
| rs3397312560 | 246 | V>G | No | EVA | |
| rs3388859596 | 258 | G>S | No | EVA | |
| rs3388857269 | 269 | G>D | No | EVA | |
| rs3388850420 | 270 | S>N | No | EVA | |
| rs3388859668 | 346 | K>T | No | EVA | |
| rs3397171504 | 349 | E>K | No | EVA | |
| rs3388862417 | 377 | L>V | No | EVA | |
| rs3388866766 | 379 | D>N | No | EVA | |
| rs3388850485 | 390 | L>V | No | EVA | |
| rs3388823663 | 405 | P>L | No | EVA | |
| rs3397248251 | 428 | E>A | No | EVA | |
| rs3396523456 | 428 | E>Q | No | EVA | |
| rs3388845372 | 457 | C>Y | No | EVA | |
| rs3397336646 | 464 | Y>C | No | EVA | |
| rs3397379088 | 465 | H>N | No | EVA | |
| rs3388823660 | 508 | S>Y | No | EVA | |
| rs3388854285 | 528 | L>M | No | EVA | |
| rs3388823655 | 580 | D>N | No | EVA | |
| rs3388855161 | 609 | G>E | No | EVA | |
| rs3388836827 | 626 | D>E | No | EVA | |
| rs3388850498 | 628 | K>R | No | EVA | |
| rs3388850494 | 660 | F>I | No | EVA | |
| rs3388863176 | 679 | G>D | No | EVA | |
| rs3388861977 | 749 | G>R | No | EVA | |
| rs3388836833 | 757 | F>I | No | EVA | |
| rs3397248220 | 767 | S>P | No | EVA | |
| rs3388836832 | 778 | S>Y | No | EVA | |
| rs3388841933 | 780 | I>F | No | EVA | |
| rs3396918001 | 796 | V>L | No | EVA | |
| rs3388863158 | 957 | K>E | No | EVA | |
| rs3388857202 | 989 | A>T | No | EVA | |
| rs3388836831 | 1034 | D>V | No | EVA | |
| rs3388862455 | 1087 | E>V | No | EVA | |
| rs3388854320 | 1161 | K>M | No | EVA | |
| rs3388855156 | 1179 | Q>H | No | EVA | |
| rs3388841956 | 1180 | V>M | No | EVA | |
| rs3388859619 | 1185 | M>L | No | EVA | |
| rs3397471366 | 1225 | T>P | No | EVA | |
| rs3397248248 | 1226 | D>E | No | EVA | |
| rs3388823628 | 1261 | T>I | No | EVA | |
| rs3388852012 | 1271 | S>C | No | EVA | |
| rs3397309130 | 1315 | Y>N | No | EVA | |
| rs3396524563 | 1316 | E>V | No | EVA | |
| rs3397322198 | 1317 | Q>P | No | EVA | |
| rs3388858401 | 1367 | D>G | No | EVA | |
| rs3397373248 | 1387 | N>D | No | EVA | |
| rs3396524529 | 1388 | D>E | No | EVA | |
| rs3397248218 | 1391 | K>E | No | EVA | |
| rs3388857227 | 1414 | R>Q | No | EVA | |
| rs3388841930 | 1417 | F>S | No | EVA | |
| rs3388845412 | 1432 | F>L | No | EVA | |
| rs3388858425 | 1433 | T>P | No | EVA | |
| rs3388841907 | 1439 | R>I | No | EVA | |
| rs3388857196 | 1502 | F>C | No | EVA | |
| rs13463121 | 1579 | T>S | No | EVA | |
| rs3388861989 | 1586 | E>V | No | EVA | |
| rs108857492 | 1590 | P>L | No | EVA | |
| rs30618367 | 1593 | P>S | No | EVA | |
| rs30618367 | 1593 | P>T | No | EVA | |
| rs579699204 | 1597 | T>P | No | EVA | |
| rs1135381637 | 1599 | P>T | No | EVA | |
| rs582217170 | 1605 | P>S | No | EVA | |
| rs235167786 | 1638 | A>P | No | EVA | |
| rs3388854343 | 1648 | E>A | No | EVA | |
| rs3388854343 | 1648 | E>G | No | EVA | |
| rs251765102 | 1674 | D>E | No | EVA | |
| rs223866560 | 1676 | M>T | No | EVA | |
| rs3388857201 | 1677 | L>F | No | EVA | |
| rs261921828 | 1685 | D>E | No | EVA | |
| rs3388863625 | 1688 | D>N | No | EVA | |
| rs222786350 | 1695 | S>I | No | EVA | |
| rs3388859679 | 1702 | N>K | No | EVA | |
| rs3397379072 | 1711 | L>* | No | EVA | |
| rs3388863614 | 1728 | T>I | No | EVA | |
| rs3388858335 | 1739 | W>* | No | EVA | |
| rs3388866744 | 1880 | R>L | No | EVA | |
| rs3388863567 | 1882 | P>L | No | EVA | |
| rs3388858375 | 1884 | V>L | No | EVA | |
| rs3388863173 | 1885 | A>T | No | EVA | |
| rs3388862432 | 1890 | M>I | No | EVA | |
| rs3388823686 | 1890 | M>V | No | EVA | |
| rs3388823678 | 1895 | I>T | No | EVA |
No associated diseases with Q6PDQ2
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| chromatin | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. |
| chromosome, telomeric region | The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| NuRD complex | An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| protein-DNA complex | A macromolecular complex containing both protein and DNA molecules. |
| RNA polymerase II transcription regulator complex | A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. |
12 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| ATP-dependent chromatin remodeler activity | An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. |
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
| DNA-binding transcription factor binding | Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| histone deacetylase binding | Binding to histone deacetylase. |
| metal ion binding | Binding to a metal ion. |
| RNA polymerase II-specific DNA-binding transcription factor binding | Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. |
| transcription coregulator binding | Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin remodeling | A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. |
| histone deacetylation | The modification of histones by removal of acetyl groups. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of cell fate specification | Any process that mediates the adoption of a specific fate by a cell. |
| regulation of stem cell differentiation | Any process that modulates the frequency, rate or extent of stem cell differentiation. |
| terminal button organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a terminal button. A terminal button is the terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| O16102 | Chd3 | Chromodomain-helicase-DNA-binding protein 3 | Drosophila melanogaster (Fruit fly) | PR |
| Q12873 | CHD3 | Chromodomain-helicase-DNA-binding protein 3 | Homo sapiens (Human) | PR |
| Q8TDI0 | CHD5 | Chromodomain-helicase-DNA-binding protein 5 | Homo sapiens (Human) | PR |
| Q14839 | CHD4 | Chromodomain-helicase-DNA-binding protein 4 | Homo sapiens (Human) | PR |
| A2A8L1 | Chd5 | Chromodomain-helicase-DNA-binding protein 5 | Mus musculus (Mouse) | PR |
| P40201 | Chd1 | Chromodomain-helicase-DNA-binding protein 1 | Mus musculus (Mouse) | PR |
| D3ZD32 | Chd5 | Chromodomain-helicase-DNA-binding protein 5 | Rattus norvegicus (Rat) | PR |
| Q22516 | chd-3 | Chromodomain-helicase-DNA-binding protein 3 homolog | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASGLGSPSP | CSAGSEEEDM | DALLNNSLPP | PHPENEEDPD | EDLSEAETPK | LKKKKKPKKP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RDPKIPKSKR | QKKELGDSSG | EGPEFVEEEE | EVALRSDSEG | SDYTPGKKKK | KKLGPKKEKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SKSKRKEEEE | EEDEDDDSKE | PKSSAQLLED | WGMEDIDHVF | SEEDYRTLTN | YKAFSQFVRP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LIAAKNPKIA | VSKMMMVLGA | KWREFSTNNP | FKGSSGASVA | AAAAAAVAVV | ESMVTATEVA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PPPPPVEVPI | RKAKTKEGKG | PNARRKPKGS | PRVPDAKKPK | PKKVAPLKIK | LGGFGSKRKR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SSSEDDDLDV | ESDFDDASIN | SYSVSDGSTS | RSSRSRKKLR | TAKKKKKGEE | EVTAVDGYET |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DHQDYCEVCQ | QGGEIILCDT | CPRAYHMVCL | DPDMEKAPEG | KWSCPHCEKE | GIQWEAKEDN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SEGEEILEEV | GGDPEEEDDH | HMEFCRVCKD | GGELLCCDTC | PSSYHIHCLN | PPLPEIPNGE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| WLCPRCTCPA | LKGKVQKILI | WKWGQPPSPT | PVPRPPDADP | NTPSPKPLEG | RPERQFFVKW |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QGMSYWHCSW | VSELQLELHC | QVMFRNYQRK | NDMDEPPSGD | FGGDEEKSRK | RKNKDPKFAE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| MEERFYRYGI | KPEWMMIHRI | LNHSVDKKGH | VHYLIKWRDL | PYDQASWESE | DVEIQDYDLF |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KQSYWNHREL | MRGEEGRPGK | KLKKVKLRKL | ERPPETPTVD | PTVKYERQPE | YLDATGGTLH |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PYQMEGLNWL | RFSWAQGTDT | ILADEMGLGK | TVQTAVFLYS | LYKEGHSKGP | FLVSAPLSTI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| INWEREFEMW | APDMYVVTYV | GDKDSRAIIR | ENEFSFEDNA | IRGGKKASRM | KKEASVKFHV |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LLTSYELITI | DMAILGSIDW | ACLIVDEAHR | LKNNQSKFFR | VLNGYSLQHK | LLLTGTPLQN |
| 910 | 920 | 930 | 940 | 950 | 960 |
| NLEELFHLLN | FLTPERFHNL | EGFLEEFADI | AKEDQIKKLH | DMLGPHMLRR | LKADVFKNMP |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SKTELIVRVE | LSPMQKKYYK | YILTRNFEAL | NARGGGNQVS | LLNVVMDLKK | CCNHPYLFPV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| AAMEAPKMPN | GMYDGSALIR | ASGKLLLLQK | MLKNLKEGGH | RVLIFSQMTK | MLDLLEDFLE |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| HEGYKYERID | GGITGNMRQE | AIDRFNAPGA | QQFCFLLSTR | AGGLGINLAT | ADTVIIYDSD |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| WNPHNDIQAF | SRAHRIGQNK | KVMIYRFVTR | ASVEERITQV | AKKKMMLTHL | VVRPGLGSKT |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| GSMSKQELDD | ILKFGTEELF | KDEATDGGGD | NKEGEDSSVI | HYDDKAIERL | LDRNQDETED |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| TELQGMNEYL | SSFKVAQYVV | REEEMGEEEE | VEREIIKQEE | SVDPDYWEKL | LRHHYEQQQE |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| DLARNLGKGK | RIRKQVNYND | GSQEDRDWQD | DQSDNQSDYS | VASEEGDEDF | DERSEAPRRP |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| SRKGLRNDKD | KPLPPLLARV | GGNIEVLGFN | ARQRKAFLNA | IMRYGMPPQD | AFTTQWLVRD |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| LRGKSEKEFK | AYVSLFMRHL | CEPGADGAET | FADGVPREGL | SRQHVLTRIG | VMSLIRKKVQ |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| EFEHVNGRWS | MPELAEVEEN | KKMSQPGSPS | PKTPTPSTPG | DTQPNTPAPV | PPAEDGIKIE |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| ENSLKEEEST | EGEKEVKSTA | PEATVECAQP | PAPAPATAPA | TATAPEDDKA | PAEPPEGEEK |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| VEKAEVKERT | EEPMETEAKG | TTEVEKVEEK | SAVDLTPIVV | EDKEEKKEEE | EKKDVMLQNG |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| ETPKDLSDEK | QKKNSKQRFM | FNIADGGFTE | LHSLWQNEER | AATVTKKTYE | IWHRRHDYWL |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| LAGIINHGYA | RWQDIQNDPR | YAILNEPFKG | EMNRGNFLEI | KNKFLARRFK | LLEQALVIEE |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| QLRRAAYLNM | SEDPSHPSMA | LNTRFAEVEC | LAESHQHLSK | ESMAGNKPAN | AVLHKVLKQL |
| 1870 | 1880 | 1890 | 1900 | 1910 | |
| EELLSDMKAD | VTRLPATIAR | IPPVAVRLQM | SERNILSRLA | NRAPEPPPQQ | VAQQQ |