Q6PBN5
Gene name |
aup1 |
Protein name |
Lipid droplet-regulating VLDL assembly factor AUP1 |
Names |
Ancient ubiquitous protein 1 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:324654 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6PBN5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6PBN5-F1 | Predicted | AlphaFoldDB |
No variants for Q6PBN5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6PBN5 | |||||
No associated diseases with Q6PBN5
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| Hrd1p ubiquitin ligase ERAD-L complex | A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. |
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lipid droplet | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ubiquitin binding | Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. |
| ubiquitin-protein transferase activator activity | Binds to and increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| ER-associated misfolded protein catabolic process | The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. |
| lipid droplet formation | A process that results in the assembly, arrangement of constituent parts of a lipid droplet. |
| lipid droplet organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle. |
| protein localization to lipid droplet | A process in which a protein is transported to, or maintained in, a location on or within a lipid droplet. |
| ubiquitin-dependent ERAD pathway | The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome. |
10 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A3FPG8 | GPAT4 | Glycerol-3-phosphate acyltransferase 4 | Bos taurus (Bovine) | PR |
| Q5ZLL8 | GPAT3 | Glycerol-3-phosphate acyltransferase 3 | Gallus gallus (Chicken) | PR |
| Q8NF37 | LPCAT1 | Lysophosphatidylcholine acyltransferase 1 | Homo sapiens (Human) | PR |
| Q86UL3 | GPAT4 | Glycerol-3-phosphate acyltransferase 4 | Homo sapiens (Human) | PR |
| Q9Y679 | AUP1 | Lipid droplet-regulating VLDL assembly factor AUP1 | Homo sapiens (Human) | PR |
| Q8C0N2 | Gpat3 | Glycerol-3-phosphate acyltransferase 3 | Mus musculus (Mouse) | PR |
| Q8K2C8 | Gpat4 | Glycerol-3-phosphate acyltransferase 4 | Mus musculus (Mouse) | PR |
| Q8S8S2 | LPEAT2 | Lysophospholipid acyltransferase LPEAT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SHJ5 | GPAT1 | Glycerol-3-phosphate acyltransferase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| A3KGT9 | agpat9l | Glycerol-3-phosphate acyltransferase 3-like | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| METRGIEQMF | DFQRLPNDRF | ILLLLLLYAP | VGFCLMLLRI | FIGVHVFLVS | CALPDSIVRR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FIVRIMCSVL | GLHVQQNSPR | LRDKTTRLYV | CNHVTHFDHN | IINLLTSCNT | PLLEGPVGFL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CWARGFMELG | QGVGSRTELT | ETLHRYCSSP | DTLPLLLFPE | EDTTNGRTGL | LKFSSWPFSV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SDSIQPVALL | VKRPFIAVST | PESSWLTELL | WTFFVPFTVY | HVRWLPPLSK | EDGETHQEFA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SKVQGLLATE | LGVISTQITK | ADKAEHIKRK | RHSAPQTAHS | NLGARPRTVA | QGFLGTSVGA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EDSRIARLAQ | QVKEVLPDVP | VSVITRDLLQ | TNCVDTTITN | LLERTDQFNS | EAAMTMPSGP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GKAAASSTPS | AMVSSPNLKP | AAKSFGRSPI | DRHMSLQERK | EALYEYARRR | YIEKHGLNKE |
| DDL |