Q6P9R2

PR
Gene name
Oxsr1
Protein name
Serine/threonine-protein kinase OSR1
Names
Oxidative stress-responsive 1 protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:108737
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

267-527 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

163-191 (Activation loop from InterPro)

Target domain

17-291 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q6P9R2

Entry ID Method Resolution Chain Position Source
AF-Q6P9R2-F1 Predicted AlphaFoldDB

31 variants for Q6P9R2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389082561 56 S>R No EVA
rs3400172383 77 S>Y No EVA
rs3400196323 78 Y>* No EVA
rs3400534594 79 Y>D No EVA
rs3389087284 90 L>I No EVA
rs3389074752 109 A>S No EVA
rs3389077619 138 H>P No EVA
rs3389081183 152 I>V No EVA
rs3389090871 159 S>T No EVA
rs3389090864 204 Y>C No EVA
rs3389087313 213 F>L No EVA
rs3400196301 261 G>A No EVA
rs3389077562 269 S>L No EVA
rs3389091719 271 C>S No EVA
rs3399645639 301 Q>* No EVA
rs3389060898 311 I>N No EVA
rs3389049569 321 V>I No EVA
rs3389074708 346 E>K No EVA
rs3389068878 349 E>K No EVA
rs3389077537 360 P>H No EVA
rs236012427 368 S>N No EVA
rs585287900 373 A>S No EVA
rs3389086010 375 A>T No EVA
rs223116630 390 A>V No EVA
rs227124595 420 A>V No EVA
rs3389049624 456 P>H No EVA
rs3389026724 458 R>G No EVA
rs3389077586 474 V>A No EVA
rs3389057458 486 L>M No EVA
rs3389082627 488 K>M No EVA
rs3389090842 498 S>Y No EVA

No associated diseases with Q6P9R2

1 regional properties for Q6P9R2

Type Name Position InterPro Accession
conserved_site Vinculin, conserved site 183 - 203 IPR000633

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

6 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.
magnesium ion binding Binding to a magnesium (Mg) ion.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

15 GO annotations of biological process

Name Definition
cellular hypotonic response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.
cellular response to chemokine Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus.
chemokine (C-C motif) ligand 21 signaling pathway The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
chemokine (C-X-C motif) ligand 12 signaling pathway The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of potassium ion transmembrane transport Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transport.
negative regulation of potassium ion transmembrane transporter activity Any process that stops, prevents or reduces the frequency, rate or extent of potassium ion transmembrane transporter activity.
osmosensory signaling pathway The series of molecular signals initiated in response to osmotic change.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
positive regulation of T cell chemotaxis Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein phosphorylation The process of introducing a phosphate group on to a protein.
response to oxidative stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

20 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9C0K7 STRADB STE20-related kinase adapter protein beta Homo sapiens (Human) PR
Q7RTN6 STRADA STE20-related kinase adapter protein alpha Homo sapiens (Human) PR
Q9UEW8 STK39 STE20/SPS1-related proline-alanine-rich protein kinase Homo sapiens (Human) PR
O95747 OXSR1 Serine/threonine-protein kinase OSR1 Homo sapiens (Human) PR
Q8K4T3 Stradb STE20-related kinase adapter protein beta Mus musculus (Mouse) PR
Q3UUJ4 Strada STE20-related kinase adapter protein alpha Mus musculus (Mouse) PR
Q9Z1W9 Stk39 STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus (Mouse) PR
O54988 Slk STE20-like serine/threonine-protein kinase Mus musculus (Mouse) PR
O55098 Stk10 Serine/threonine-protein kinase 10 Mus musculus (Mouse) PR
P70218 Map4k1 Mitogen-activated protein kinase kinase kinase kinase 1 Mus musculus (Mouse) PR
Q61161 Map4k2 Mitogen-activated protein kinase kinase kinase kinase 2 Mus musculus (Mouse) SS
Q99JP0 Map4k3 Mitogen-activated protein kinase kinase kinase kinase 3 Mus musculus (Mouse) SS
Q99JT2 Stk26 Serine/threonine-protein kinase 26 Mus musculus (Mouse) PR
Q99KH8 Stk24 Serine/threonine-protein kinase 24 Mus musculus (Mouse) PR
Q9Z2W1 Stk25 Serine/threonine-protein kinase 25 Mus musculus (Mouse) PR
Q8BPM2 Map4k5 Mitogen-activated protein kinase kinase kinase kinase 5 Mus musculus (Mouse) PR
Q863I2 OXSR1 Serine/threonine-protein kinase OSR1 Sus scrofa (Pig) PR
Q7TNZ6 Strada STE20-related kinase adapter protein alpha Rattus norvegicus (Rat) PR
O88506 Stk39 STE20/SPS1-related proline-alanine-rich protein kinase Rattus norvegicus (Rat) PR
O23304 BLUS1 Serine/threonine-protein kinase BLUS1 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK ERVAIKRINL EKCQTSMDEL
70 80 90 100 110 120
LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV LDIIKHIVAK GEHKSGVLDE
130 140 150 160 170 180
PTIATILREV LEGLEYLHKN GQIHRDVKAG NILLGEDGSV QIADFGVSAF LATGGDITRN
190 200 210 220 230 240
KVRKTFVGTP CWMAPEVMEQ VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL
250 260 270 280 290 300
QNDPPSLETG VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL
310 320 330 340 350 360
QEKILQRAPT ISERSKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG RAAISQLRSP
370 380 390 400 410 420
RVKDSLSSSE LFAAAEPMGT LLQVPEQISA HLPQPAGQMP TQPAQVSLLP PAEPAKPAQA
430 440 450 460 470 480
QSSGERSQET KIPISLVLRL RNSKKELNDI RFEFTPGRDT AEGVSQELIS AGLVDGRDLV
490 500 510 520
IVAANLQKIV EEPQSNRSVT FKLASGVEGS DIPDDGKLIG FAQLSIS