Q6P9Q4

SS
Gene name
Fhod1 (Fhos1)
Protein name
FH1/FH2 domain-containing protein 1
Names
Formin homolog overexpressed in spleen 1, FHOS, Formin homology 2 domain-containing protein 1
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:234686
EC number
Protein Class

Descriptions

Formin-family proteins, in the active state, form actinbased structures such as stress fibres. Formin homology domain protein 1 (Fhod1) is a major endothelial formin. In a study with human FHOD1, FHOD1 was normally autoinhibited by intramolecular interaction between the N-terminal domain and C-terminal DAD domain. Since other formin proteins contain a GBD domain at N-terminus, Fhod1 may also contain a GBD domain and this GBD domain may interact with the DAD domain.

Autoinhibitory domains (AIDs)

1085-1166 (DAD domain) SS

Target domain

648-1100 (FH2 domains)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P9Q4

Entry ID Method Resolution Chain Position Source
AF-Q6P9Q4-F1 Predicted AlphaFoldDB

6 variants for Q6P9Q4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs227935141 378 V>G No Ensembl
rs219405860 427 T>I No Ensembl
rs864294456 498 R>G No Ensembl
rs30902758 725 V>I No Ensembl
rs30901926 936 C>Y No Ensembl
rs212112347 1124 P>S No Ensembl

No associated diseases with Q6P9Q4

13 regional properties for Q6P9Q4

Type Name Position InterPro Accession
domain Bromo adjacent homology (BAH) domain 2650 - 2787 IPR001025
domain SET domain 2135 - 2257 IPR001214
domain Bromodomain 2431 - 2541 IPR001487
domain Zinc finger, PHD-type 2576 - 2618 IPR001965
domain Post-SET domain 2259 - 2275 IPR003616
domain AWS domain 2081 - 2133 IPR006560
conserved_site AT hook, DNA-binding motif 823 - 835 IPR017956-1
conserved_site AT hook, DNA-binding motif 885 - 897 IPR017956-2
conserved_site AT hook, DNA-binding motif 1345 - 1357 IPR017956-3
conserved_site AT hook, DNA-binding motif 1843 - 1855 IPR017956-4
conserved_site Zinc finger, PHD-type, conserved site 2577 - 2617 IPR019786
domain ASH1-like, PHD finger 2575 - 2617 IPR043319
domain ASH1-like, Bromodomain 2432 - 2537 IPR043320

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cytoplasm, cytosol
  • Cytoplasm, cytoskeleton
  • Cell projection, bleb
  • Predominantly cytoplasmic
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
bleb A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. [GOC:mtg_apoptosis, PMID:12083798, PMID:16624291, Wikipedia:Bleb_(cell_biology)]
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intercalated disc A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
stress fiber A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.

4 GO annotations of molecular function

Name Definition
actin filament binding Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
identical protein binding Binding to an identical protein or proteins.
protein domain specific binding Binding to a specific domain of a protein.
protein self-association Binding to a domain within the same polypeptide.

7 GO annotations of biological process

Name Definition
actin filament network formation The assembly of a network of actin filaments; actin filaments on different axes and with differing orientations are crosslinked together to form a mesh of filaments.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
establishment of centrosome localization The directed movement of the centrosome to a specific location.
nuclear migration The directed movement of the nucleus to a specific location within a cell.
positive regulation of stress fiber assembly Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of stress fiber assembly Any process that modulates the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q2V2M9 FHOD3 FH1/FH2 domain-containing protein 3 Homo sapiens (Human) SS
Q9Y613 FHOD1 FH1/FH2 domain-containing protein 1 Homo sapiens (Human) EV
Q76LL6 Fhod3 FH1/FH2 domain-containing protein 3 Mus musculus (Mouse) SS
10 20 30 40 50 60
MAGEEERGDG DPVSVVTVRV QYLEDTDPFA CANFPEPRRA PTCSLDGALP LSAQIPALHR
70 80 90 100 110 120
LLGAPLKLED CALQVSPSGY YLDPELSLEE QREMLEGFYE EISKGRKPTL ILRTQLSVRV
130 140 150 160 170 180
NAILEKLYGS SGPELRRSLF SLKQIFQEDK DLVPEFVHSE GLSCLIRVGA AADHNYQSYI
190 200 210 220 230 240
LRALGQLMLF VDGMLGVVAH SETVQWLYTL CASLSRLVVK TALKLLLVFV EYSENNAPLF
250 260 270 280 290 300
IQAVNAVASA TGTLPWANLV SILEEKNGAD AELLVYTVTL INKTLAALPD QDSFYDVTDA
310 320 330 340 350 360
LEQQGMEALV QRFLGTAGTD VDLRTQLTLY ESALRLEDGD MEEAAAAAAA GGRRERRKPS
370 380 390 400 410 420
SEEGKRSRRS LEGGGCPVRA PEPGSTGSAS PVGSTPSTGS APPTNPAFSS TGPASGLLRT
430 440 450 460 470 480
SVNLFPTISV GPSVDSSCER SVYKARFLEN VAAAETEKQA ALAQGRAETL AGATVDDTDG
490 500 510 520 530 540
SSGTRELWDS PEPASAPRTP QSPVSRILLR TQRSLEPEPK KPVSPPSPKA EPIQEPPTCV
550 560 570 580 590 600
PKLCIGDLDF SDLGEDEDQD TLNVESVEAG KASPFLSSLS PSLSGGPPPP PPPPPPITGS
610 620 630 640 650 660
CPPPPPPPLP PPATGSCPPP PPPPPPPIIG SCPPPPPLAA PFTHSALDGP RHPTKRKTVK
670 680 690 700 710 720
LFWRELKLTG GPGCSRSRFG PCPTLWASLE PVSVDTARLE HLFESRAKDV LPTKKAGEGR
730 740 750 760 770 780
RTMTVVLDPK RSNAINIGLT TLPPVHVIKA ALLNFDEFAV SKDGIEKLLT MMPTEEERQK
790 800 810 820 830 840
IEEAQLANPD VPLGPAENFL MTLASIGGLA ARLQLWAFKL DYESMEREIA EPLFDLKVGM
850 860 870 880 890 900
EQLVHNATFR CILATLLAVG NFLNGSQSSG FELSYLEKVS EVKDTVRRQS LLYHLCSLVL
910 920 930 940 950 960
QTRPDSSDLY SEIPALTRCA KVDFEQLTEN LGQLECRSQA AEDSLRSLAK HELSPALRAR
970 980 990 1000 1010 1020
LTHFLAQCTR RVAMLRVVHR RVCNRFHAFL LYLGYTPQAA RDVRIMQFCH TLREFALEYR
1030 1040 1050 1060 1070 1080
TCRERVLQQQ QKRATYRERN KTRGRMITET EKFSGVAGEA PNNLSVPVAV GSGPGQGDTD
1090 1100 1110 1120 1130 1140
NHASMKSLLT SRPEDATHSR RSRGMVQSSS PVSHTAVGPS AASPEETAAS GLPTDTSDEI
1150 1160 1170 1180 1190
MDLLVQSVTK SGPRALAARE RKRSRGNRKS LRRTLKSGLG DDLVQALGLS KAPGLEV