Q6P730

PR
Gene name
Dab2ip
Protein name
Disabled homolog 2-interacting protein
Names
DAB2-interacting protein, ASK-interacting protein 1, AIP-1, DIP1/2, DOC-2/DAB2 interactive protein
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:192126
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

624-839 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P730

Entry ID Method Resolution Chain Position Source
AF-Q6P730-F1 Predicted AlphaFoldDB

No variants for Q6P730

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q6P730

No associated diseases with Q6P730

4 regional properties for Q6P730

Type Name Position InterPro Accession
domain C2 domain 1 - 120 IPR000008
domain Ras GTPase-activating domain 127 - 464 IPR001936
domain Disabled homolog 2-interacting protein, C-terminal domain 453 - 966 IPR021887
conserved_site Ras GTPase-activating protein, conserved site 326 - 340 IPR023152

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell membrane ; Peripheral membrane protein
  • Membrane
  • Cell projection, dendrite
  • Localized in soma and dendrites of Purkinje cells as well as in scattered cell bodies in the molecular layer of the cerebellum
  • Colocalizes with TIRAP at the plasma membrane
  • Colocalizes with ARF6 at the plasma membrane and endocytic vesicles
  • Translocates from the plasma membrane to the cytoplasm in response to TNF-alpha
  • Phosphatidylinositol 4-phosphate (PtdIns4P) binding is essential for plasma membrane localization (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

11 GO annotations of cellular component

Name Definition
AIP1-IRE1 complex A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein).
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
cerebellar mossy fiber An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons a mossy-looking appearance in Golgi stained preparations.
climbing fiber The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
neuronal cell body membrane The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
parallel fiber A parallel fiber results from the bifurcation of a cerebellar granule cell axon in the molecular layer into two diametrically opposed branches, that are oriented parallel to the long axis of the folium.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

20 GO annotations of molecular function

Name Definition
14-3-3 protein binding Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
death receptor binding Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD).
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
identical protein binding Binding to an identical protein or proteins.
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
mitogen-activated protein kinase kinase binding Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase.
mitogen-activated protein kinase kinase kinase binding Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase.
phosphatidylinositol 3-kinase binding Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.
phosphatidylinositol 3-kinase regulatory subunit binding Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.
phosphatidylinositol-3-phosphate binding Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
phosphatidylinositol-4-phosphate binding Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein N-terminus binding Binding to a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
protein phosphatase 2A binding Binding to protein phosphatase 2A.
protein serine/threonine kinase activator activity Binds to and increases the activity of a protein serine/threonine kinase.
protein-containing complex binding Binding to a macromolecular complex.
SH3 domain binding Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
signaling adaptor activity The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.
vascular endothelial growth factor receptor 2 binding Binding to a vascular endothelial growth factor receptor 2.

65 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
cell motility involved in cerebral cortex radial glia guided migration The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration.
cellular response to epidermal growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
cellular response to interleukin-1 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
cellular response to vascular endothelial growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
extrinsic apoptotic signaling pathway via death domain receptors The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
I-kappaB phosphorylation The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
layer formation in cerebral cortex The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.
negative regulation of angiogenesis Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
negative regulation of cell growth Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of cell population proliferation Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of endothelial cell migration Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
negative regulation of epidermal growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
negative regulation of epithelial cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration.
negative regulation of epithelial cell proliferation Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation.
negative regulation of epithelial to mesenchymal transition Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
negative regulation of ERK1 and ERK2 cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
negative regulation of fibroblast proliferation Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.
negative regulation of G0 to G1 transition A cell cycle process that stops, prevents, or reduces the rate or extent of the transition from the G0 quiescent state to the G1 phase.
negative regulation of GTPase activity Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
negative regulation of I-kappaB kinase/NF-kappaB signaling Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
negative regulation of MAP kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
negative regulation of NF-kappaB transcription factor activity Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
negative regulation of phosphatidylinositol 3-kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity.
negative regulation of phosphatidylinositol 3-kinase signaling Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
negative regulation of protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.
negative regulation of protein phosphorylation Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
negative regulation of protein serine/threonine kinase activity Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
negative regulation of Ras protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Ras protein signal transduction.
negative regulation of toll-like receptor 4 signaling pathway Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
negative regulation of vascular endothelial growth factor receptor signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
negative regulation of vascular endothelial growth factor signaling pathway Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor signaling pathway.
neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
positive regulation of apoptotic process Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
positive regulation of apoptotic signaling pathway Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
positive regulation of dendrite development Any process that activates or increases the frequency, rate or extent of dendrite development.
positive regulation of epithelial cell proliferation Any process that activates or increases the rate or extent of epithelial cell proliferation.
positive regulation of JNK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
positive regulation of JUN kinase activity Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
positive regulation of MAPK cascade Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
positive regulation of neuron migration Any process that activates or increases the frequency, rate or extent of neuron migration.
positive regulation of neuron projection development Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
positive regulation of proteasomal protein catabolic process Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
positive regulation of protein catabolic process Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
positive regulation of protein serine/threonine kinase activity Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
positive regulation of protein-containing complex assembly Any process that activates or increases the frequency, rate or extent of protein complex assembly.
positive regulation of synapse maturation Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
reelin-mediated signaling pathway The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of I-kappaB kinase/NF-kappaB signaling Any process that modulates I-kappaB kinase/NF-kappaB signaling.
regulation of p38MAPK cascade Any process that modulates the frequency, rate or extent of p38MAPK cascade.
regulation of protein-containing complex assembly Any process that modulates the frequency, rate or extent of protein complex assembly.
response to unfolded protein Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
tube formation Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.
vascular endothelial growth factor receptor-2 signaling pathway The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-2 (VEGFR-2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q86YV0 RASAL3 RAS protein activator like-3 Homo sapiens (Human) PR
Q5VWQ8 DAB2IP Disabled homolog 2-interacting protein Homo sapiens (Human) PR
Q3UHC7 Dab2ip Disabled homolog 2-interacting protein Mus musculus (Mouse) PR
10 20 30 40 50 60
MENLRRAVHP NKDNSRRVEH ILKLWVIEAK DLPAKKKYLC ELCLDDVLYA RTTGKLKTDN
70 80 90 100 110 120
VFWGEHFEFH NLPPLRTVTV HLYRETDKKK KKERNSYLGL VSLPAASVAG RQFVEKWYPV
130 140 150 160 170 180
VTPNPKGGKG PGPMIRIKAR YQTITILPME MYKEFAEHIT NHYLGLCAAL EPILSAKTKE
190 200 210 220 230 240
EMASALVHIL QSTGKVKDFL TDLMMSEVDR CGDNEHLIFR ENTLATKAIE EYLKLVGQKY
250 260 270 280 290 300
LQDALGEFIK ALYESDENCE VDPSKCSAAD LPEHQGNLKM CCELAFCKII NSYCVFPREL
310 320 330 340 350 360
KEVFASWRQE CSSRGRPDIS ERLISASLFL RFLCPAIMSP SLFNLLQEYP DDRTARTLTL
370 380 390 400 410 420
IAKVTQNLAN FAKFGSKEEY MSFMNQFLEH EWTNMQRFLL EISNPETLSN TAGFEGYIDL
430 440 450 460 470 480
GRELSSLHSL LWEAVSQLDQ SIVSKLGPLP RILRDVHTAL STPGSGQLPG TNDLASTPGS
490 500 510 520 530 540
GSSSVSAGLQ KMVIENDLSG LIDFTRLPSP TPENKDLFFV TRSSGVQPSP ARSSSYSEAN
550 560 570 580 590 600
EPDLQMANGS KSLSMVDLQD ARTLDGEAGS PVGPEALPAD GQVPATQLVA GWPARAAPVS
610 620 630 640 650 660
LAGLATVRRA VPTPTTPGTS EGAPGRPQLL APLSFQNPVY QMAAGLPLSP RGLGDSGSEG
670 680 690 700 710 720
HSSLSSHSNS EELAAAAKLG SFSTAAEELA RRPGELARRQ MSLTEKGGQP TVPRQNSAGP
730 740 750 760 770 780
QRRIDQPPPP PPPPPPAPRG RTPPTMLSTL QYPRPSSGTL ASASPDWAGP GTRLRQQSSS
790 800 810 820 830 840
SKGDSPELKP RALHKQGPSP VSPNALDRTA AWLLTMNAQL LEDEGLGPDP PHRDRLRSKE
850 860 870 880 890 900
ELSQAEKDLA VLQDKLRIST KKLEEYETLF KCQEETTQKL VLEYQARLEE GEERLRRQQE
910 920 930 940 950 960
DKDVQMKGII SRLMSVEEEL KKDHAEMQAA VDSKQKIIDA QEKRIASLDA ANARLMSALT
970 980 990
QLKERYSMRA RNGVSPTNPT KLQITENGEF RNSSNC