Q6P5Z2
SS
Gene name |
PKN3 (PKNBETA) |
Protein name |
Serine/threonine-protein kinase N3 |
Names |
EC 2.7.11.13 , Protein kinase PKN-beta , Protein-kinase C-related kinase 3 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:29941 |
EC number |
2.7.11.13: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
Serine/threonine-protein kinase N1 (PKN1) is a PKC-related serine/threonine protein kinase involved in specific signal transduction responses such as regulation of intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion, and transcription regulation in cells. Its kinase activity is enhanced by fatty acids such as arachidonic acid or the small GTP-binding protein Rho. Residues 455-511 of PKN selectively inhibit the kinase activity of the catalytic fragment of PKN1. Arachidonic acid relieves the catalytic activity of wild-type PKN from autoinhibition by residues 455-511 of PKN.
Autoinhibitory domains (AIDs)
Target domain |
559-818 (Protein kinase domain) |
Relief mechanism |
Ligand binding, PTM |
Assay |
|
Accessory elements
701-724 (Activation loop from InterPro)
Target domain |
559-818 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
701-724 (Activation loop from InterPro)
Target domain |
559-818 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Yoshinaga C et al. (1999) "Mutational analysis of the regulatory mechanism of PKN: the regulatory region of PKN contains an arachidonic acid-sensitive autoinhibitory domain", Journal of biochemistry, 126, 475-84
- Huang X et al. (2003) "Crystal structure of an inactive Akt2 kinase domain", Structure (London, England : 1993), 11, 21-30
- Truebestein L et al. (2021) "Structure of autoinhibited Akt1 reveals mechanism of PIP(3)-mediated activation", Proceedings of the National Academy of Sciences of the United States of America, 118,
- Lučić I et al. (2018) "Conformational sampling of membranes by Akt controls its activation and inactivation", Proceedings of the National Academy of Sciences of the United States of America, 115, E3940-E3949
Autoinhibited structure
Activated structure
1 structures for Q6P5Z2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6P5Z2-F1 | Predicted | AlphaFoldDB |
758 variants for Q6P5Z2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
rs1451844152 CA375062473 |
2 | E>A | No |
ClinGen gnomAD |
|
|
rs1312564186 CA375062485 CA375062486 |
3 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
rs1045302696 CA200418175 |
4 | G>V | No |
ClinGen TOPMed |
|
|
rs908755167 CA200418181 |
5 | A>T | No |
ClinGen TOPMed |
|
|
CA375062503 rs1246200294 |
6 | P>Q | No |
ClinGen gnomAD |
|
|
rs375885408 CA5267151 COSM98953 |
11 | P>L | large_intestine stomach [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA5267150 rs375885408 |
11 | P>R | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1174420976 CA375062850 |
12 | S>I | No |
ClinGen gnomAD |
|
|
CA200420195 rs888286625 |
14 | W>* | No |
ClinGen TOPMed |
|
|
rs1242389011 CA375062878 |
14 | W>* | No |
ClinGen TOPMed |
|
|
CA375062895 rs771840775 |
15 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771840775 CA5267153 |
15 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375062892 rs771840775 |
15 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375062918 rs1218548994 |
16 | P>R | No |
ClinGen gnomAD |
|
|
CA375062914 rs1352574135 |
16 | P>S | No |
ClinGen gnomAD |
|
|
CA375062924 rs1443861780 |
17 | E>K | No |
ClinGen gnomAD |
|
|
CA5267155 rs760040215 |
18 | D>N | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 18 | D>Y | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1342506615 CA375062982 |
19 | E>D | No |
ClinGen TOPMed |
|
| TCGA novel | 22 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1221145809 CA375063044 |
22 | V>G | No |
ClinGen gnomAD |
|
|
rs1284710994 CA375063059 |
23 | I>T | No |
ClinGen gnomAD |
|
|
CA5267156 rs765945214 |
24 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1220318953 CA375063076 |
24 | R>H | No |
ClinGen gnomAD |
|
|
rs1220318953 CA375063081 |
24 | R>L | No |
ClinGen gnomAD |
|
|
CA5267158 rs373360025 |
25 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267157 rs369925350 |
25 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs765129851 CA5267159 |
26 | A>T | No |
ClinGen ExAC gnomAD |
|
|
COSM1220815 rs377752354 CA5267160 |
26 | A>V | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs1419753811 CA375063103 |
27 | I>V | No |
ClinGen TOPMed |
|
|
rs1478291312 CA375063155 |
32 | K>R | No |
ClinGen gnomAD |
|
|
CA375063167 rs1473548305 |
33 | I>T | No |
ClinGen TOPMed |
|
|
CA5267165 rs546780208 CA5267164 |
35 | E>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs144842292 CA200420269 CA5267166 |
36 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs144842292 CA5267167 |
36 | G>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA375063266 rs528959123 |
41 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267170 rs528959123 |
41 | R>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267171 rs528959123 |
41 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267169 rs560359660 |
41 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs746700545 COSM1220817 CA5267172 |
42 | R>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs770542091 CA5267173 |
42 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1021442463 CA200420292 |
43 | V>M | No |
ClinGen TOPMed gnomAD |
|
|
rs759037852 CA5267175 |
45 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs986815320 CA200420304 |
45 | T>I | No |
ClinGen Ensembl |
|
|
rs370013888 CA375063326 |
47 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs370013888 CA5267176 |
47 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267177 rs775416496 |
47 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs765133433 CA5267178 |
48 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375063332 rs765133433 |
48 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267179 rs763903613 |
48 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375063371 rs1476382208 |
51 | G>D | No |
ClinGen gnomAD |
|
|
rs1240280241 CA375063367 |
51 | G>S | No |
ClinGen gnomAD |
|
|
rs373024694 CA5267180 |
52 | H>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA200420370 rs999163892 |
54 | Q>R | No |
ClinGen TOPMed |
|
|
CA200420371 rs976416273 |
55 | Q>* | No |
ClinGen gnomAD |
|
|
CA375063446 rs1589475368 |
57 | L>R | No |
ClinGen Ensembl |
|
|
CA375063454 rs750509484 |
58 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs750509484 CA5267183 |
58 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267182 rs548837083 |
58 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1589475389 CA375063462 |
59 | S>A | No |
ClinGen Ensembl |
|
|
CA5267184 rs756163526 |
61 | N>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA200420398 rs756163526 |
61 | N>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs568799465 CA5267185 |
62 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA375063502 rs1266686337 COSM3847777 |
62 | R>H | breast [Cosmic] | No |
ClinGen cosmic curated TOPMed |
|
CA5267186 rs200996917 |
63 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267187 rs200996917 |
63 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267188 rs779402289 |
63 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1357404278 CA375063542 |
66 | Q>* | No |
ClinGen gnomAD |
|
|
CA375063573 rs1448592506 |
68 | H>R | No |
ClinGen gnomAD |
|
|
rs1282259066 CA375063569 |
68 | H>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs1209308773 CA375063583 |
69 | G>D | No |
ClinGen gnomAD |
|
|
rs748504331 CA5267189 |
69 | G>S | No |
ClinGen ExAC |
|
|
rs780763936 CA5267191 |
70 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA375063593 rs1185242066 |
71 | L>M | No |
ClinGen gnomAD |
|
|
rs1368686170 CA375063597 |
71 | L>R | No |
ClinGen gnomAD |
|
|
CA5267193 rs551707428 |
72 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267192 rs745322952 |
72 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375063607 rs1386501435 |
73 | E>D | No |
ClinGen gnomAD |
|
|
rs1345362001 CA375063618 |
75 | H>R | No |
ClinGen TOPMed |
|
|
rs1280812321 CA375063615 |
75 | H>Y | No |
ClinGen gnomAD |
|
|
CA375063623 rs768629700 |
76 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768629700 CA5267196 |
76 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375063627 rs1336622465 |
77 | R>* | No |
ClinGen gnomAD |
|
|
rs767476875 CA5267197 |
77 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs200784357 CA5267198 |
81 | P>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA375063656 rs1229144498 |
82 | G>A | No |
ClinGen gnomAD |
|
|
rs534131407 CA5267200 |
82 | G>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA200420523 rs928356128 |
83 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs553989365 CA375063666 |
84 | G>A | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5267201 rs553989365 |
84 | G>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1205316562 CA375063664 CA375063663 |
84 | G>R | No |
ClinGen TOPMed gnomAD |
|
|
rs1179265618 CA375063677 |
86 | G>D | No |
ClinGen gnomAD |
|
|
rs1436801707 CA375063674 |
86 | G>S | No |
ClinGen gnomAD |
|
|
rs776514907 CA200420525 |
88 | A>T | No |
ClinGen gnomAD |
|
|
CA375063693 rs1472613975 |
89 | E>* | No |
ClinGen gnomAD |
|
|
rs1268664391 CA375063710 |
89 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
rs766751863 CA5267221 |
90 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA5267223 rs759749886 |
94 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs1430602919 CA375063744 |
95 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs1476562925 CA375063740 |
95 | P>S | No |
ClinGen gnomAD |
|
|
rs371312873 CA5267226 |
96 | R>P | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs371312873 CA5267225 |
96 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267224 rs557769856 |
96 | R>W | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267227 rs374331102 |
97 | P>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1384079895 CA375063755 |
98 | W>* | No |
ClinGen gnomAD |
|
|
rs755732035 CA5267229 |
98 | W>C | No |
ClinGen ExAC gnomAD |
|
|
CA375063761 rs540550803 |
99 | A>P | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5267230 rs540550803 |
99 | A>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5267231 rs748781527 |
99 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs748058657 CA5267234 |
101 | Q>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs778870556 CA5267233 |
101 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs772096063 CA5267235 |
102 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1159351495 CA375063785 |
103 | R>K | No |
ClinGen TOPMed |
|
|
CA200420827 rs924643573 |
104 | A>D | No |
ClinGen Ensembl |
|
|
CA200420818 rs1026480619 |
104 | A>S | No |
ClinGen TOPMed gnomAD |
|
|
rs147107905 CA5267238 |
105 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs141891943 CA5267237 |
105 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs372236370 CA200420848 |
106 | H>Y | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs1183411757 CA375063804 |
107 | L>I | No |
ClinGen TOPMed gnomAD |
|
|
CA375063806 rs1383601170 |
107 | L>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs1383601170 CA375063808 |
107 | L>R | No |
ClinGen TOPMed gnomAD |
|
|
rs777009643 CA5267239 |
108 | E>G | No |
ClinGen ExAC gnomAD |
|
|
CA5267242 rs776013610 |
111 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs116453286 CA5267241 |
111 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs150942621 CA5267243 |
112 | R>K | No |
ClinGen ESP ExAC gnomAD |
|
|
CA5267244 rs764701452 |
116 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375063865 rs1228539945 |
117 | E>K | No |
ClinGen gnomAD |
|
|
CA375063888 rs1314642092 |
120 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
CA5267245 rs751915793 |
121 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA200420881 rs889208385 |
124 | A>T | No |
ClinGen Ensembl |
|
|
CA5267247 rs765956426 |
124 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA375063915 rs1236089069 |
125 | E>K | No |
ClinGen gnomAD |
|
|
CA375063936 rs1564370010 |
127 | M>R | No |
ClinGen Ensembl |
|
|
rs754464265 CA5267249 |
128 | T>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375063943 rs754464265 |
128 | T>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs915565310 CA200420900 |
129 | H>R | No |
ClinGen TOPMed |
|
|
rs778265024 CA5267250 |
130 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267251 rs373887264 |
130 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs746744914 CA5267254 |
132 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA5267256 rs781521767 |
135 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA375063993 rs1411125236 |
136 | P>R | No |
ClinGen gnomAD |
|
|
CA375064001 rs1330340622 |
137 | K>N | No |
ClinGen gnomAD |
|
|
rs1450887974 CA375064019 |
138 | E>D | No |
ClinGen TOPMed gnomAD |
|
|
CA375064013 rs1194287170 |
138 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA gnomAD |
|
rs916819707 CA200421768 |
139 | R>K | No |
ClinGen gnomAD |
|
|
rs1364616021 CA375064030 |
140 | K>R | No |
ClinGen gnomAD |
|
|
rs1325017165 CA375064049 |
143 | A>G | No |
ClinGen gnomAD |
|
|
rs781108795 CA5267273 |
143 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1437816011 CA375064059 |
145 | A>D | No |
ClinGen TOPMed gnomAD |
|
|
CA375064056 rs1352067148 |
145 | A>T | No |
ClinGen gnomAD |
|
|
rs1437816011 CA375064061 |
145 | A>V | No |
ClinGen TOPMed gnomAD |
|
|
CA200421769 rs1045405946 |
147 | Q>* | No |
ClinGen Ensembl |
|
|
CA5267274 rs367820994 |
147 | Q>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs998583334 CA200421779 |
148 | M>I | No |
ClinGen TOPMed gnomAD |
|
|
CA375064091 rs371687806 |
150 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267276 rs371687806 |
150 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs772389099 CA5267275 |
150 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1424676728 CA375064101 |
152 | S>G | No |
ClinGen gnomAD |
|
|
rs749266685 CA5267277 |
152 | S>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1589477376 CA375064131 |
156 | V>G | No |
ClinGen Ensembl |
|
|
CA375064135 rs1292117366 |
157 | A>S | No |
ClinGen gnomAD |
|
|
rs571277935 CA5267279 |
160 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD |
|
rs1215004599 CA375064151 |
160 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
rs1466063606 CA375064155 |
161 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1189050315 CA375064172 |
163 | I>V | No |
ClinGen gnomAD |
|
|
rs368495780 CA5267280 |
165 | S>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA375064240 rs1406411254 |
169 | S>G | No |
ClinGen gnomAD |
|
|
rs772607204 CA5267281 |
169 | S>T | No |
ClinGen ExAC |
|
|
CA5267282 rs773562928 |
172 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA375064283 rs773562928 |
172 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs376672674 CA200422005 |
175 | G>E | No |
ClinGen ESP TOPMed |
|
|
CA5267300 rs114614395 |
176 | P>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
COSM3699449 rs56251280 VAR_042346 CA5267303 |
180 | A>E | large_intestine [Cosmic] | No |
ClinGen cosmic curated UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
CA5267302 rs774953118 |
180 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs56251280 CA375064422 |
180 | A>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5267305 rs773990798 |
182 | E>* | No |
ClinGen ExAC gnomAD |
|
|
rs1589477662 CA375064459 |
182 | E>G | No |
ClinGen Ensembl |
|
|
rs150075957 CA5267306 |
183 | L>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA375064497 rs1192178380 |
184 | Q>H | No |
ClinGen TOPMed |
|
|
rs1185824186 CA375064509 |
185 | H>R | No |
ClinGen gnomAD |
|
|
CA375064518 rs1260163894 |
186 | R>* | No |
ClinGen TOPMed |
|
|
CA5267307 rs767504978 |
186 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA200422060 rs368901119 |
187 | L>Q | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs564975981 CA5267309 |
189 | V>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA200422080 rs564975981 |
189 | V>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1589477746 CA375064626 |
192 | A>G | No |
ClinGen Ensembl |
|
|
rs753618170 CA5267311 |
194 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1157672202 CA375064689 |
196 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
rs373356783 CA5267313 |
196 | G>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA5267315 rs758479945 |
197 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267316 rs778105324 |
197 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1352431866 CA375064740 |
199 | N>I | No |
ClinGen gnomAD |
|
|
CA375064757 rs1329341512 |
200 | V>E | No |
ClinGen TOPMed gnomAD |
|
|
CA375064752 rs140271016 |
200 | V>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs140271016 CA5267319 |
200 | V>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA375064772 rs1589477841 |
201 | V>G | No |
ClinGen Ensembl |
|
|
rs1169018240 CA375064851 |
206 | S>N | No |
ClinGen TOPMed |
|
|
rs560984157 CA5267322 |
207 | R>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267323 rs560984157 |
207 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267321 rs768409176 |
207 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375064875 rs1202612600 |
208 | R>G | No |
ClinGen gnomAD |
|
|
rs771642186 CA5267324 |
208 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267325 rs772648294 |
209 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375064896 rs772648294 |
209 | T>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267326 rs760631752 |
210 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
rs145492637 CA5267327 |
210 | Q>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA375064935 rs1457056464 |
211 | D>E | No |
ClinGen TOPMed |
|
|
rs138000368 CA5267328 |
212 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA200422190 rs754465307 |
212 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
rs1378604862 CA375064959 |
213 | K>E | No |
ClinGen gnomAD |
|
|
rs1378604862 CA375064957 |
213 | K>Q | No |
ClinGen gnomAD |
|
|
CA5267348 rs759292162 |
218 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA200380846 rs924199144 |
219 | Q>* | No |
ClinGen TOPMed |
|
|
CA200380848 rs935554283 |
223 | Q>* | No |
ClinGen Ensembl |
|
|
rs907786176 CA200380850 |
223 | Q>R | No |
ClinGen TOPMed |
|
|
CA375062731 rs1258225200 |
225 | S>P | No |
ClinGen TOPMed |
|
|
CA5267349 rs765041696 |
226 | S>F | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA375062741 rs1250298573 |
227 | Q>K | No |
ClinGen gnomAD |
|
|
rs1486296306 CA375062744 |
227 | Q>R | No |
ClinGen gnomAD |
|
|
CA5267350 rs752533632 |
233 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs939240747 CA200380859 |
233 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
CA375062819 rs752533632 |
233 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs763127314 CA5267351 |
234 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA375062879 rs1455581314 |
235 | A>V | No |
ClinGen gnomAD |
|
|
rs1589478341 CA375062889 |
236 | L>W | No |
ClinGen Ensembl |
|
|
CA375062907 rs1351687434 |
237 | E>* | No |
ClinGen TOPMed |
|
| TCGA novel | 237 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5267352 rs764287821 |
238 | Q>* | No |
ClinGen ExAC gnomAD |
|
|
CA200380876 rs992183941 |
239 | L>V | No |
ClinGen TOPMed |
|
|
rs1465403060 CA375062987 |
241 | E>Q | No |
ClinGen gnomAD |
|
|
CA5267354 rs757295652 |
243 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1287177848 CA375063086 |
245 | P>L | No |
ClinGen gnomAD |
|
|
rs1043826382 CA375063114 CA200380882 |
247 | H>Q | No |
ClinGen TOPMed gnomAD |
|
|
CA375063121 rs1270363868 |
248 | P>A | No |
ClinGen gnomAD |
|
|
rs756497660 CA5267357 |
250 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM295757 rs201793972 CA5267358 |
250 | R>H | large_intestine [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
rs1254467284 CA375064453 |
252 | R>K | No |
ClinGen gnomAD |
|
|
CA200380905 rs1038769989 |
253 | V>M | No |
ClinGen Ensembl |
|
|
CA5267359 rs200481836 |
254 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771744489 CA5267360 |
255 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA5267361 rs536513523 |
255 | R>Q | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA375064569 rs1418461555 |
257 | L>S | No |
ClinGen TOPMed |
|
|
CA375064589 rs776506971 |
258 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267364 rs776506971 |
258 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267362 rs746463444 |
258 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA375064612 rs1413696458 |
259 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA5267365 rs745785845 |
259 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs769758916 CA5267366 |
260 | A>P | No |
ClinGen ExAC gnomAD |
|
|
rs200867685 CA5267367 |
260 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1589478512 CA375064650 |
261 | V>G | No |
ClinGen Ensembl |
|
|
CA5267369 rs200583902 |
262 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 262 | P>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5267370 rs563299465 |
263 | G>E | No |
ClinGen ExAC gnomAD |
|
|
rs886364298 CA200380946 |
264 | Y>* | No |
ClinGen TOPMed gnomAD |
|
|
rs761911188 CA5267371 |
264 | Y>C | No |
ClinGen ExAC gnomAD |
|
|
CA5267372 rs767727865 |
265 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767727865 CA375064746 |
265 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1218943989 CA375064737 |
265 | P>S | No |
ClinGen gnomAD |
|
|
CA375064751 rs1211891574 |
266 | Q>K | No |
ClinGen gnomAD |
|
|
rs749294521 CA200380977 |
267 | P>L | No |
ClinGen Ensembl |
|
|
CA5267374 rs756685759 |
267 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375064822 rs1207467147 |
268 | S>L | No |
ClinGen gnomAD |
|
| TCGA novel | 271 | P>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs767051388 CA5267377 |
271 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs754199667 CA5267378 |
272 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 273 | K>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1427048875 CA375064953 |
274 | P>A | No |
ClinGen gnomAD |
|
|
rs746666401 CA200381034 |
276 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267381 rs746666401 |
276 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1323541659 CA375065044 |
279 | G>R | No |
ClinGen TOPMed |
|
|
rs776823760 CA5267420 |
280 | T>S | No |
ClinGen ExAC gnomAD |
|
|
CA5267422 rs377120914 |
284 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267423 rs141840709 |
284 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 287 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 290 | Q>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5267426 rs767087494 |
292 | L>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375065947 rs1234903288 |
292 | L>V | No |
ClinGen TOPMed |
|
|
CA5267427 rs750106502 |
293 | T>K | No |
ClinGen ExAC gnomAD |
|
|
rs1445834577 CA375065968 |
294 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
rs779409698 CA5267429 |
296 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1227728873 CA375066009 |
297 | G>R | No |
ClinGen gnomAD |
|
|
CA5267430 rs537996467 |
298 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs754859270 CA5267431 |
298 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1205568219 CA375066055 |
300 | P>S | No |
ClinGen gnomAD |
|
|
CA375066063 rs370572604 |
301 | A>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267434 rs370572604 |
301 | A>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM357443 rs370572604 CA5267433 |
301 | A>V | lung [Cosmic] | No |
ClinGen cosmic curated ESP ExAC TOPMed gnomAD |
|
CA200384984 rs891451595 |
302 | A>T | No |
ClinGen TOPMed |
|
|
rs1475793722 CA375066069 |
303 | A>T | No |
ClinGen gnomAD |
|
|
rs771323662 CA5267437 |
305 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs759716404 CA5267439 |
306 | S>N | No |
ClinGen ExAC gnomAD |
|
|
rs140830817 CA5267438 |
306 | S>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs759716404 CA375066107 |
306 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs1564374103 CA375066123 |
307 | S>R | No |
ClinGen Ensembl |
|
|
rs770137433 CA5267440 |
309 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs75008607 CA200385052 |
310 | E>A | No |
ClinGen Ensembl |
|
|
CA5267443 rs372991211 |
310 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA375066196 rs1564374128 |
311 | G>D | No |
ClinGen Ensembl |
|
|
rs1352724703 CA375066193 |
311 | G>R | No |
ClinGen TOPMed |
|
|
CA5267447 rs144703543 |
314 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267446 rs144703543 |
314 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs201413988 CA5267445 |
314 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375066265 rs1409342809 |
315 | T>A | No |
ClinGen gnomAD |
|
|
CA375066277 rs1286366783 |
316 | K>T | No |
ClinGen TOPMed gnomAD |
|
|
rs753231218 CA5267449 |
319 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs534189894 CA5267450 |
321 | R>C | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5267451 rs370067044 |
321 | R>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267452 rs752705620 |
323 | R>* | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs758462075 CA5267453 |
323 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 324 | G>C | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA200385112 rs1014967827 |
324 | G>D | No |
ClinGen TOPMed |
|
|
CA5267456 rs140077098 |
325 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1440076307 CA375066474 |
326 | L>P | No |
ClinGen TOPMed gnomAD |
|
|
rs1440076307 CA375066473 |
326 | L>R | No |
ClinGen TOPMed gnomAD |
|
|
rs199826404 CA5267478 |
328 | S>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5267479 rs576187132 |
329 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267480 rs769138655 |
330 | V>A | No |
ClinGen ExAC gnomAD |
|
|
rs769138655 CA375068036 |
330 | V>G | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 330 | V>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA375068062 CA375068064 rs748472968 |
333 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs748472968 CA5267482 |
333 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1589485626 CA375068087 |
335 | K>T | No |
ClinGen Ensembl |
|
|
CA375068098 rs1388559897 |
336 | V>M | No |
ClinGen gnomAD |
|
|
CA200385314 rs72758841 |
337 | D>H | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
CA5267484 rs772510422 |
338 | N>D | No |
ClinGen ExAC gnomAD |
|
|
rs998268749 CA200385329 |
339 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs773500708 CA5267485 |
339 | R>H | No |
ClinGen ExAC gnomAD |
|
|
CA200385350 rs547402411 |
340 | V>I | No |
ClinGen gnomAD |
|
|
CA375068167 rs1265367962 |
341 | V>A | No |
ClinGen gnomAD |
|
|
CA5267486 rs759197568 |
341 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs764868009 CA5267487 |
344 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1208047616 CA375068246 |
345 | G>A | No |
ClinGen TOPMed |
|
|
CA200385370 rs55948654 |
346 | W>* | No |
ClinGen gnomAD |
|
|
rs762570387 CA5267490 |
346 | W>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267491 rs375779089 |
347 | G>E | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA375068321 rs1589485762 |
349 | V>G | No |
ClinGen Ensembl |
|
|
CA375068315 rs1276576592 |
349 | V>M | No |
ClinGen TOPMed |
|
|
rs150025953 CA375068344 |
351 | E>* | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs150025953 CA5267495 |
351 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1385659192 CA375068356 |
352 | Q>E | No |
ClinGen TOPMed |
|
|
CA375068362 rs145409935 |
352 | Q>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267496 rs145409935 |
352 | Q>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267498 rs774759313 |
353 | S>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375068379 rs774759313 |
353 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs780313147 CA5267497 |
353 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA375068407 rs1228666395 |
355 | D>G | No |
ClinGen gnomAD |
|
|
rs149211383 CA5267499 |
355 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267500 rs779345869 |
356 | Q>E | No |
ClinGen ExAC gnomAD |
|
|
rs1172384585 CA375068469 |
360 | I>L | No |
ClinGen TOPMed |
|
|
CA5267502 rs142070198 |
363 | E>D | No |
ClinGen ESP ExAC gnomAD |
|
|
CA200385470 rs1014853316 |
363 | E>K | No |
ClinGen TOPMed |
|
|
rs115678685 CA5267503 |
364 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA5267531 rs760414400 |
366 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs766142138 CA5267532 |
366 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267533 rs776452671 |
367 | E>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA200385662 rs976178792 |
368 | L>V | No |
ClinGen TOPMed |
|
| TCGA novel | 371 | G>V | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1241489859 CA375068698 |
371 | G>W | No |
ClinGen gnomAD |
|
|
rs1300466351 CA375068724 |
372 | V>I | No |
ClinGen TOPMed gnomAD |
|
|
rs1300466351 CA375068730 |
372 | V>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1386623302 CA375068777 |
373 | H>R | No |
ClinGen gnomAD |
|
|
CA375068819 rs1350332026 |
374 | W>* | No |
ClinGen gnomAD |
|
|
CA5267536 rs557099498 |
375 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs1047193647 CA200385679 |
375 | R>W | No |
ClinGen TOPMed |
|
|
rs1589486147 COSM4007063 CA375068871 |
376 | D>G | urinary_tract [Cosmic] | No |
ClinGen cosmic curated Ensembl |
|
rs758417384 CA5267537 |
377 | W>R | No |
ClinGen ExAC gnomAD |
|
|
CA375068916 rs886764421 |
378 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs764618362 CA375068924 |
378 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs764618362 CA5267538 |
378 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA200385694 rs886764421 |
378 | R>W | No |
ClinGen TOPMed gnomAD |
|
|
CA200385711 rs1048811555 |
380 | L>I | No |
ClinGen TOPMed gnomAD |
|
|
CA375069004 rs1589486193 |
381 | C>W | No |
ClinGen Ensembl |
|
|
rs781660120 CA5267542 |
383 | V>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs781660120 CA5267541 |
383 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1454455465 CA375069061 |
384 | A>D | No |
ClinGen gnomAD |
|
|
CA375069142 rs1167358788 |
388 | L>F | No |
ClinGen gnomAD |
|
|
CA5267543 rs543209721 |
394 | N>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1564374589 CA375069296 |
394 | N>S | No |
ClinGen Ensembl |
|
|
rs543209721 CA5267544 |
394 | N>Y | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1411206759 CA375069330 |
396 | C>* | No |
ClinGen gnomAD |
|
|
CA200385731 rs908923569 |
396 | C>Y | No |
ClinGen TOPMed |
|
|
CA5267545 rs747628085 |
397 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375069358 rs1355701001 |
398 | Q>* | No |
ClinGen gnomAD |
|
|
CA375069392 rs1324318558 |
400 | S>F | No |
ClinGen gnomAD |
|
|
rs1373408849 CA375069395 |
401 | L>F | No |
ClinGen gnomAD |
|
|
VAR_050565 rs12932 CA5267548 |
404 | V>L | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
CA5267549 rs770923878 |
405 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1589486304 CA375069490 |
409 | L>V | No |
ClinGen Ensembl |
|
|
CA5267551 rs759337171 |
411 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA5267552 rs765430335 |
412 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs766620262 CA5267579 |
414 | T>I | No |
ClinGen ExAC |
|
|
rs766620262 CA375069595 |
414 | T>N | No |
ClinGen ExAC |
|
|
rs1352344578 CA375069648 |
417 | D>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs757971551 CA5267581 |
418 | P>L | No |
ClinGen ExAC gnomAD |
|
|
rs1484396257 CA375069689 |
419 | V>F | No |
ClinGen gnomAD |
|
|
rs751000614 CA5267583 |
420 | I>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781055201 CA5267585 |
420 | I>T | No |
ClinGen ExAC gnomAD |
|
|
rs751000614 CA5267584 |
420 | I>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1486291972 CA375069730 |
422 | R>S | No |
ClinGen gnomAD |
|
|
rs745787517 CA5267586 |
423 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA200386221 COSM1460311 rs1030805889 |
423 | R>W | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs145344292 CA5267587 |
424 | P>H | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 424 | P>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1471382562 CA375069737 |
424 | P>S | No |
ClinGen gnomAD |
|
|
rs141019196 CA5267589 |
425 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs41275912 CA5267588 |
425 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA375069754 rs1375939033 |
427 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
CA375069759 rs1308683471 |
428 | R>T | No |
ClinGen TOPMed |
|
| TCGA novel | 430 | E>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 430 | E>G | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5267591 COSM1220821 rs200958296 |
431 | R>C | large_intestine [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs200958296 CA200386227 |
431 | R>G | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1326821744 CA375069780 |
431 | R>P | No |
ClinGen gnomAD |
|
|
rs200958296 CA5267592 |
431 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 432 | I>M | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs372123292 CA375069789 |
433 | F>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs372123292 CA5267594 |
433 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1302229733 CA375069799 |
434 | S>C | No |
ClinGen TOPMed gnomAD |
|
|
CA200386247 rs961822730 |
434 | S>P | No |
ClinGen TOPMed |
|
|
rs1435935768 CA375069808 |
435 | K>N | No |
ClinGen TOPMed |
|
|
CA5267595 rs201340158 |
436 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs200438464 CA200386255 |
436 | R>H | No |
ClinGen 1000Genomes TOPMed |
|
|
CA200386257 rs200438464 |
436 | R>L | No |
ClinGen 1000Genomes TOPMed |
|
|
CA375069809 rs201340158 |
436 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs779228645 CA5267608 |
440 | D>H | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 444 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5267610 rs772489304 |
445 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375069883 rs1474050000 |
446 | Q>* | No |
ClinGen TOPMed |
|
|
rs771273797 CA5267613 |
447 | M>L | No |
ClinGen ExAC gnomAD |
|
|
CA5267614 rs777223035 |
447 | M>R | No |
ClinGen ExAC |
|
|
rs1011482820 CA200386399 |
449 | L>R | No |
ClinGen Ensembl |
|
|
CA5267616 rs73669966 |
450 | G>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs371936211 CA5267619 |
452 | A>E | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267617 rs775876601 |
452 | A>T | No |
ClinGen ExAC gnomAD |
|
|
rs371936211 CA5267618 |
452 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267621 rs139012351 |
454 | W>* | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA375069957 rs1589487219 |
455 | G>E | No |
ClinGen Ensembl |
|
|
RCV001196477 CA5267622 rs766188402 |
455 | G>W | No |
ClinGen ClinVar ExAC dbSNP gnomAD |
|
|
CA5267623 rs753836061 COSM1460312 |
456 | R>C | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
rs536918275 CA5267624 |
456 | R>H | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267627 rs373783574 |
458 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs778143168 CA5267628 |
459 | M>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375070070 rs1333136477 |
462 | L>P | No |
ClinGen gnomAD |
|
|
rs1485672035 CA375070119 |
464 | P>L | No |
ClinGen gnomAD |
|
|
rs1203415053 CA375070141 |
465 | C>F | No |
ClinGen TOPMed gnomAD |
|
| rs1216019307 | 465 | C>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs377599116 CA5267629 |
466 | S>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267632 rs370634438 COSM3327622 |
468 | P>L | central_nervous_system [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD |
|
CA5267631 rs370634438 |
468 | P>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA375070248 rs1415656661 |
469 | S>G | No |
ClinGen TOPMed gnomAD |
|
|
CA5267635 rs201364965 |
471 | I>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1362811690 CA375070333 |
472 | S>G | No |
ClinGen gnomAD |
|
|
CA375070344 rs1195205784 |
472 | S>N | No |
ClinGen TOPMed |
|
|
CA375070353 rs377311012 |
472 | S>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267637 rs772950783 |
473 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375070361 rs772950783 |
473 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs765891441 CA5267640 |
474 | P>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375070397 rs1214624572 |
474 | P>L | No |
ClinGen TOPMed |
|
|
CA5267639 rs765891441 |
474 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA200386564 rs765891441 |
474 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754952764 CA375070424 |
476 | G>* | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
| TCGA novel | 476 | G>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs754952764 CA5267641 |
476 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267644 rs775289389 |
479 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs752472485 CA5267643 |
479 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs969769129 CA200386630 |
480 | T>I | No |
ClinGen gnomAD |
|
|
rs1589487429 CA375070498 |
480 | T>P | No |
ClinGen Ensembl |
|
|
rs777806092 CA5267645 |
482 | T>A | No |
ClinGen ExAC gnomAD |
|
|
CA5267646 rs747228163 |
483 | T>A | No |
ClinGen ExAC gnomAD |
|
|
rs757457708 CA5267647 |
483 | T>I | No |
ClinGen ExAC gnomAD |
|
|
rs1589487460 CA375070587 |
484 | L>R | No |
ClinGen Ensembl |
|
|
rs200637064 COSM3847779 CA200386645 |
485 | R>* | Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs781332086 CA5267648 |
485 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
rs200435271 CA5267649 |
487 | A>P | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA375070694 rs1372616243 |
488 | S>F | No |
ClinGen TOPMed |
|
|
CA5267650 rs770230806 |
489 | D>A | No |
ClinGen ExAC gnomAD |
|
|
rs981474029 CA200386650 |
490 | P>L | No |
ClinGen Ensembl |
|
|
rs780546405 CA5267651 |
490 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1431883737 CA375070742 |
491 | A>T | No |
ClinGen gnomAD |
|
|
CA375071226 rs1211412830 |
496 | F>L | No |
ClinGen gnomAD |
|
|
rs548000293 CA5267684 |
498 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1185433021 CA375071322 |
501 | T>I | No |
ClinGen TOPMed gnomAD |
|
|
CA375071319 rs1185433021 |
501 | T>N | No |
ClinGen TOPMed gnomAD |
|
|
rs761519542 CA5267686 |
502 | P>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1701805 rs761519542 CA375071345 |
502 | P>L | skin [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA5267689 rs147486451 |
504 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA200387042 rs1016413869 |
505 | E>K | No |
ClinGen TOPMed |
|
| TCGA novel | 506 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5267690 rs536656541 |
508 | T>I | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
| TCGA novel | 508 | T>S | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5267692 rs202027236 |
509 | P>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1437214152 CA375071529 |
509 | P>H | No |
ClinGen gnomAD |
|
|
CA375071525 rs202027236 |
509 | P>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267691 rs202027236 |
509 | P>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs779291228 CA5267693 |
510 | P>Q | No |
ClinGen ExAC gnomAD |
|
|
CA200387069 rs868811810 |
514 | P>L | No |
ClinGen Ensembl |
|
|
rs778329029 CA5267696 |
515 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs56208848 CA5267697 |
515 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs56208848 CA375071631 |
515 | R>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA375071663 rs1274584259 |
517 | Y>H | No |
ClinGen gnomAD |
|
|
rs553100465 CA5267701 |
520 | Q>* | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5267700 rs553100465 |
520 | Q>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
| TCGA novel | 520 | Q>P | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA375071831 rs768574963 |
522 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs768574963 CA5267702 |
522 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767195662 CA5267705 |
525 | E>K | No |
ClinGen ExAC gnomAD |
|
| rs1317952953 | 528 | P>= | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs750891213 CA5267708 |
528 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs760882822 CA5267707 |
528 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267729 rs766441382 |
529 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375072256 rs766441382 |
529 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA200387242 rs376943562 |
529 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
rs150658893 CA375072402 |
532 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs765197601 CA5267731 |
532 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs150658893 CA5267730 |
532 | R>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1240182668 CA375072509 |
533 | P>R | No |
ClinGen gnomAD |
|
|
CA375072561 rs1345166631 |
534 | H>R | No |
ClinGen gnomAD |
|
|
rs764714294 CA375072595 CA5267734 |
535 | M>I | No |
ClinGen ExAC TOPMed |
|
| TCGA novel | 535 | M>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1037767691 CA200387263 |
536 | E>G | No |
ClinGen Ensembl |
|
|
CA375072746 rs1368526050 |
539 | T>S | No |
ClinGen TOPMed |
|
|
CA5267735 rs751910390 |
540 | R>* | No |
ClinGen ExAC gnomAD |
|
|
rs757729788 CA5267736 |
540 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267738 rs182601722 |
541 | R>C | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267737 rs182601722 |
541 | R>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267739 rs754701201 |
542 | G>R | No |
ClinGen ExAC gnomAD |
|
|
CA5267741 rs747752598 |
543 | P>A | No |
ClinGen ExAC gnomAD |
|
|
CA375072846 rs747752598 |
543 | P>S | No |
ClinGen ExAC gnomAD |
|
|
rs1179289562 CA375073049 |
547 | A>T | No |
ClinGen gnomAD |
|
|
CA5267744 rs746757902 |
549 | P>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770109358 CA5267748 |
551 | R>M | No |
ClinGen ExAC gnomAD |
|
|
CA5267776 rs200442875 |
551 | R>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA200387679 rs56277381 |
552 | K>E | No |
ClinGen Ensembl |
|
|
rs1446547043 CA375073451 |
553 | P>L | No |
ClinGen gnomAD |
|
|
CA5267777 rs114084183 |
553 | P>T | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1190916290 CA375073455 |
554 | P>T | No |
ClinGen gnomAD |
|
|
rs368910557 CA375073475 |
555 | R>G | No |
ClinGen ExAC gnomAD |
|
|
CA5267779 rs369261081 |
555 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267778 rs368910557 |
555 | R>W | No |
ClinGen ExAC gnomAD |
|
|
rs763586720 CA5267780 |
556 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA5267781 rs751123891 |
560 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
COSM1220820 CA5267782 rs757126152 |
560 | R>H | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD |
|
CA375073625 rs757126152 |
560 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
COSM1496960 rs1382243468 CA375073725 |
564 | V>M | kidney [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1383604329 CA375073759 |
566 | G>V | No |
ClinGen gnomAD |
|
|
CA5267785 rs146680071 |
567 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs200554823 CA5267784 |
567 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1342951945 CA375073783 |
568 | G>E | No |
ClinGen TOPMed gnomAD |
|
|
CA5267806 rs779894977 |
575 | L>M | No |
ClinGen ExAC gnomAD |
|
|
CA5267808 rs755195981 CA375075195 |
577 | Q>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267807 rs749153614 |
577 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375075200 rs1210042757 |
578 | F>C | No |
ClinGen TOPMed gnomAD |
|
|
CA375075215 rs1254250726 |
580 | G>E | No |
ClinGen gnomAD |
|
|
rs779283647 CA5267809 |
581 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375075228 rs1249324628 |
582 | G>E | No |
ClinGen TOPMed gnomAD |
|
|
CA375075230 rs1404523423 |
583 | K>E | No |
ClinGen TOPMed |
|
|
CA5267811 rs528820099 |
583 | K>N | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1380355987 CA375075252 |
586 | A>T | No |
ClinGen TOPMed gnomAD |
|
|
CA200389117 rs982043108 |
587 | I>S | No |
ClinGen TOPMed |
|
|
rs1181439713 CA375075284 COSM1220818 |
590 | L>P | large_intestine [Cosmic] | No |
ClinGen cosmic curated gnomAD |
|
rs1184734160 CA375075325 |
593 | Q>* | No |
ClinGen TOPMed |
|
| TCGA novel | 595 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5267815 rs776918914 |
595 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs370437812 CA5267816 |
597 | S>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5267817 rs541998479 |
597 | S>T | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA375075391 rs1311798366 |
598 | R>Q | No |
ClinGen gnomAD |
|
|
CA5267818 rs140230260 |
598 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 600 | E>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA375075412 rs1443634612 |
600 | E>K | No |
ClinGen TOPMed |
|
|
CA200389880 rs896357885 |
603 | S>R | No |
ClinGen Ensembl |
|
|
rs1405172093 CA375075586 |
604 | L>V | No |
ClinGen gnomAD |
|
|
rs1218685598 CA375075609 |
606 | C>R | No |
ClinGen gnomAD |
|
|
rs549258373 CA5267844 COSM1137959 |
607 | E>K | kidney [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
rs1263180945 CA375075660 |
609 | R>Q | No |
ClinGen gnomAD |
|
|
rs759585265 CA5267845 |
609 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1020964055 CA200389888 |
613 | A>P | No |
ClinGen Ensembl |
|
|
CA375075735 rs1589490986 |
614 | V>G | No |
ClinGen Ensembl |
|
| TCGA novel | 615 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA200389889 rs968148279 |
617 | T>A | No |
ClinGen gnomAD |
|
|
rs752493287 CA5267847 |
618 | G>W | No |
ClinGen ExAC gnomAD |
|
|
rs77779228 CA200389890 |
619 | H>D | No |
ClinGen gnomAD |
|
|
rs758584175 CA5267848 |
619 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375075827 rs77779228 |
619 | H>Y | No |
ClinGen gnomAD |
|
|
rs1338348951 CA375076040 |
626 | L>F | No |
ClinGen gnomAD |
|
|
CA375076050 rs1589491056 |
626 | L>P | No |
ClinGen Ensembl |
|
|
rs1589491088 CA375076185 |
631 | T>P | No |
ClinGen Ensembl |
|
|
rs1589491100 CA375076209 |
632 | S>P | No |
ClinGen Ensembl |
|
|
CA375076536 rs1226236295 |
642 | V>M | No |
ClinGen gnomAD |
|
|
rs377160871 CA5267853 |
643 | P>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA200389899 rs954240422 |
644 | G>R | No |
ClinGen Ensembl |
|
|
CA5267854 rs770355723 |
651 | I>F | No |
ClinGen ExAC gnomAD |
|
|
CA375076830 rs780457846 |
652 | H>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267856 rs200678606 |
653 | E>K | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA375076871 rs1229588508 |
654 | D>N | No |
ClinGen gnomAD |
|
|
rs1283034598 CA375076915 |
655 | V>D | No |
ClinGen TOPMed gnomAD |
|
|
rs771689221 CA5267857 |
657 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375076986 rs1264325842 |
658 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs760185888 CA5267859 |
659 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA |
|
rs1007688598 CA200389921 |
660 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
CA5267861 rs776345506 |
660 | Q>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs56147168 CA5267862 |
661 | A>G | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5267863 rs765278398 |
662 | R>C | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs149051723 CA5267864 |
662 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs529311654 CA5267883 |
663 | F>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA5267884 COSM98954 rs763767828 |
664 | Y>C | stomach [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA5267886 rs762012967 |
665 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs767743873 CA5267887 |
667 | C>Y | No |
ClinGen ExAC gnomAD |
|
|
rs199899395 CA5267888 |
668 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267890 rs766861864 |
671 | G>A | No |
ClinGen ExAC gnomAD |
|
|
CA375078511 CA5267889 rs756219008 |
671 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755573862 CA5267893 |
677 | E>K | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed |
|
CA5267894 rs73625290 |
678 | K>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs748535515 CA5267895 |
679 | K>E | No |
ClinGen ExAC TOPMed gnomAD |
|
| rs747170999 | 679 | K>missing | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1432822771 CA375078777 |
684 | D>E | No |
ClinGen TOPMed |
|
|
CA375078875 rs1458941941 |
690 | L>R | No |
ClinGen gnomAD |
|
|
CA375078865 rs1366355286 |
690 | L>V | No |
ClinGen gnomAD |
|
|
CA5267929 rs773033212 |
696 | G>E | No |
ClinGen ExAC |
|
|
CA375079054 rs760793169 |
700 | I>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA200390655 rs554389616 |
702 | D>G | No |
ClinGen 1000Genomes |
|
|
rs896061143 CA200390665 |
706 | C>R | No |
ClinGen TOPMed |
|
|
rs1185233034 CA375079151 |
707 | K>R | No |
ClinGen TOPMed |
|
|
rs916861074 CA200390666 |
708 | E>D | No |
ClinGen TOPMed |
|
|
rs1247038247 CA375079160 |
708 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
rs1358274477 CA375080639 |
709 | G>V | No |
ClinGen TOPMed |
|
|
CA5267959 rs763877661 |
710 | I>MGLQA* | No |
ClinGen ExAC |
|
|
CA5267961 rs534305857 |
711 | G>D | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA375080667 rs1186132951 |
711 | G>S | No |
ClinGen Ensembl |
|
|
CA5267963 rs147008776 |
712 | F>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
COSM48680 CA5267964 rs758262540 |
713 | G>R | lung [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
CA375080814 rs1399850962 |
714 | D>H | No |
ClinGen gnomAD |
|
|
CA200391358 rs1017240248 |
715 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
rs1017240248 COSM1496959 CA200391359 |
715 | R>Q | kidney Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
rs777715456 CA5267965 |
715 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375080883 rs1188811801 |
716 | T>S | No |
ClinGen TOPMed |
|
|
CA5267966 rs368665975 |
718 | T>I | No |
ClinGen ESP ExAC gnomAD |
|
|
CA375081098 rs1313667805 |
722 | T>S | No |
ClinGen gnomAD |
|
|
CA5267968 rs780888710 |
723 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1223910354 CA375081115 |
723 | P>S | No |
ClinGen gnomAD |
|
|
CA375081215 rs1294866196 |
726 | L>M | No |
ClinGen gnomAD |
|
|
CA5267970 rs574368046 |
728 | P>S | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs1191114928 CA375081297 |
729 | E>K | No |
ClinGen TOPMed gnomAD |
|
|
CA375081356 rs1589495993 |
730 | V>G | No |
ClinGen Ensembl |
|
|
rs759466266 CA5267972 |
730 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1293332362 CA375081385 |
732 | T>A | No |
ClinGen TOPMed |
|
|
rs769246611 CA5267973 |
733 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
CA200391391 rs971466728 |
736 | Y>N | No |
ClinGen Ensembl |
|
|
rs377598367 CA5267974 |
737 | T>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA200391399 rs762279700 |
738 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375081538 rs1291657624 |
738 | R>Q | No |
ClinGen gnomAD |
|
|
CA5267975 rs762279700 |
738 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267978 rs759128835 |
740 | V>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267977 rs773519002 |
740 | V>M | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 744 | G>R | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5267980 rs752159330 |
745 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5267981 rs757921582 |
746 | G>V | No |
ClinGen ExAC gnomAD |
|
|
CA5267983 rs751482393 |
748 | L>M | No |
ClinGen ExAC gnomAD |
|
|
CA375081819 rs1264151007 |
748 | L>P | No |
ClinGen gnomAD |
|
|
CA375081932 rs1200829540 |
750 | Y>C | No |
ClinGen gnomAD |
|
|
CA5267987 rs750200385 |
751 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs1589496139 CA375082077 |
754 | V>G | No |
ClinGen Ensembl |
|
|
CA375082142 rs1589496158 |
756 | E>G | No |
ClinGen Ensembl |
|
|
CA200391527 rs962206838 |
757 | C>* | No |
ClinGen TOPMed |
|
|
rs750203427 CA5268011 |
758 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA5268013 rs780047761 |
762 | D>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5268014 rs754085315 |
765 | E>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375082721 rs1279581779 |
765 | E>K | No |
ClinGen TOPMed |
|
|
rs1318760301 CA375082824 |
766 | E>D | No |
ClinGen gnomAD |
|
|
CA375082956 rs1304285762 |
769 | D>E | No |
ClinGen gnomAD |
|
|
rs1445326185 CA375082919 |
769 | D>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1445326185 CA375082917 |
769 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA5268017 rs139077812 |
772 | V>I | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs143005041 CA5268019 |
773 | N>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs143005041 CA5268018 |
773 | N>T | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs1407569119 CA375083082 |
774 | M>V | No |
ClinGen TOPMed gnomAD |
|
|
rs373607826 CA5268020 |
775 | D>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA375083165 rs1208281885 |
776 | A>D | No |
ClinGen gnomAD |
|
|
rs777045732 CA5268022 |
776 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1038296106 CA200391631 |
778 | Y>F | No |
ClinGen Ensembl |
|
|
CA375083248 rs1461777521 |
778 | Y>N | No |
ClinGen gnomAD |
|
|
CA5268025 rs201467569 |
780 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs760938513 CA5268027 |
783 | S>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5268026 rs760938513 |
783 | S>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5268029 rs760738676 |
784 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375083557 rs1343850284 |
786 | G>V | No |
ClinGen TOPMed |
|
|
rs1178073472 CA375083574 |
787 | L>P | No |
ClinGen gnomAD |
|
|
CA375083595 rs1406389931 |
788 | E>G | No |
ClinGen TOPMed gnomAD |
|
|
CA5268031 rs753746649 |
789 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA375084119 rs1449762224 |
798 | P>L | No |
ClinGen TOPMed gnomAD |
|
|
CA375084140 rs1269313661 |
799 | E>G | No |
ClinGen gnomAD |
|
|
CA200391891 rs1045650856 |
799 | E>K | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA200391892 rs867731638 |
800 | K>E | No |
ClinGen Ensembl |
|
|
rs138407169 CA5268059 |
801 | R>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5268058 rs138407169 |
801 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA375084199 rs1297760574 |
801 | R>H | No |
ClinGen TOPMed |
|
|
rs747755433 CA5268062 |
803 | G>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1031769231 CA200391920 |
805 | G>D | No |
ClinGen TOPMed gnomAD |
|
|
CA5268065 rs376529565 |
808 | D>A | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs371913170 CA200391932 |
809 | A>T | No |
ClinGen ESP TOPMed gnomAD |
|
|
CA5268068 rs759554821 |
810 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375084524 rs1228478880 |
816 | P>S | No |
ClinGen gnomAD |
|
|
rs764933214 CA5268069 |
817 | F>C | No |
ClinGen ExAC gnomAD |
|
| TCGA novel | 821 | T>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5268093 rs774536921 |
822 | N>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1157627124 CA375084728 |
824 | Q>E | No |
ClinGen gnomAD |
|
|
CA200392020 rs976322050 |
824 | Q>R | No |
ClinGen Ensembl |
|
| TCGA novel | 827 | L>I | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs750578660 CA5268096 |
828 | A>D | No |
ClinGen ExAC gnomAD |
|
|
rs767580528 CA5268095 |
828 | A>T | Variant assessed as Somatic; 4.743e-05 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs1454614362 CA375084836 |
829 | R>C | No |
ClinGen gnomAD |
|
|
CA5268097 rs761034678 |
829 | R>H | No |
ClinGen ExAC gnomAD |
|
|
rs1276721705 CA375084888 |
831 | I>L | No |
ClinGen gnomAD |
|
|
CA200392039 rs982404130 |
833 | P>S | No |
ClinGen Ensembl |
|
|
CA5268100 rs754115435 |
834 | P>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs754115435 CA5268099 |
834 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1389594776 CA375085025 |
834 | P>S | No |
ClinGen gnomAD |
|
|
CA5268101 rs779458392 |
835 | F>V | No |
ClinGen ExAC gnomAD |
|
|
CA375085046 rs1442256864 |
835 | F>Y | No |
ClinGen TOPMed |
|
|
rs757025045 CA5268103 |
836 | V>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs757025045 CA5268104 |
836 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs745388425 CA5268105 |
837 | P>H | No |
ClinGen ExAC gnomAD |
|
|
rs190481477 CA200392062 |
838 | T>N | No |
ClinGen 1000Genomes |
|
|
CA375085149 rs1256852734 |
839 | L>M | No |
ClinGen gnomAD |
|
|
rs1033579987 CA200392081 |
840 | C>Y | No |
ClinGen TOPMed gnomAD |
|
|
CA5268109 rs553161560 |
843 | A>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA375085409 rs1589497642 |
844 | D>A | No |
ClinGen Ensembl |
|
| TCGA novel | 844 | D>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1589497657 CA375085446 |
846 | R>C | No |
ClinGen Ensembl |
|
|
rs1396634738 CA375085450 |
846 | R>H | No |
ClinGen TOPMed |
|
|
CA5268111 rs762010790 |
850 | G>D | No |
ClinGen ExAC gnomAD |
|
|
CA5268113 rs146395892 |
851 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs146395892 CA375085607 |
851 | E>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA5268114 rs201035165 |
856 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs777161734 CA5268116 |
862 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA375085973 rs777161734 |
862 | P>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1347227899 CA375085992 |
864 | P>S | No |
ClinGen gnomAD |
|
|
rs1223740645 CA375086036 |
865 | H>Y | No |
ClinGen gnomAD |
|
| TCGA novel | 866 | S>missing | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA5268118 rs765680291 |
866 | S>N | No |
ClinGen ExAC gnomAD |
|
|
CA375086175 rs1206031482 |
868 | L>P | No |
ClinGen gnomAD |
|
|
rs756902558 CA5268120 |
869 | T>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1589497804 CA375086235 |
870 | A>V | No |
ClinGen Ensembl |
|
|
CA5268122 rs752180593 |
871 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5268123 rs373837557 |
871 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA375086291 rs1481663664 |
873 | Q>E | No |
ClinGen gnomAD |
|
|
CA375086350 rs1174765476 |
874 | A>T | No |
ClinGen gnomAD |
|
| TCGA novel | 875 | A>T | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA375086494 rs778625869 |
877 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA5268127 rs778625869 |
877 | R>Q | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA5268126 rs754968087 |
877 | R>W | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
rs139733366 CA5268129 |
880 | D>N | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs747232770 CA5268131 |
881 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA200392189 rs771037041 |
885 | R>* | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
CA5268132 rs771037041 |
885 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs574891762 CA5268133 |
885 | R>L | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
rs574891762 CA5268134 |
885 | R>Q | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA5268135 rs544051828 |
888 | E>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1251311511 CA375086978 |
889 | P>S | No |
ClinGen TOPMed |
No associated diseases with Q6P5Z2
5 regional properties for Q6P5Z2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 249 - 500 | IPR000719 |
| active_site | Serine/threonine-protein kinase, active site | 364 - 376 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 255 - 278 | IPR017441 |
| domain | p21 activated kinase binding domain | 72 - 117 | IPR033923 |
| domain | p21-activated kinase 2, catalytic domain | 229 - 524 | IPR035064 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.13 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| perinuclear region of cytoplasm | Cytoplasm situated near, or occurring around, the nucleus. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| diacylglycerol-dependent serine/threonine kinase activity | Catalysis of the reaction |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
| small GTPase binding | Binding to a small monomeric GTPase. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| epithelial cell migration | The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
40 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P24583 | PKC1 | Protein kinase C-like 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| A1A4I4 | PKN1 | Serine/threonine-protein kinase N1 | Bos taurus (Bovine) | SS |
| P83099 | Pkcdelta | Putative protein kinase C delta type homolog | Drosophila melanogaster (Fruit fly) | PR |
| A1Z7T0 | Pkn | Serine/threonine-protein kinase N | Drosophila melanogaster (Fruit fly) | SS |
| Q96LW2 | RSKR | Ribosomal protein S6 kinase-related protein | Homo sapiens (Human) | PR |
| Q02156 | PRKCE | Protein kinase C epsilon type | Homo sapiens (Human) | SS |
| O15530 | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens (Human) | EV |
| Q05513 | PRKCZ | Protein kinase C zeta type | Homo sapiens (Human) | SS |
| P41743 | PRKCI | Protein kinase C iota type | Homo sapiens (Human) | EV |
| Q16512 | PKN1 | Serine/threonine-protein kinase N1 | Homo sapiens (Human) | EV |
| Q16513 | PKN2 | Serine/threonine-protein kinase N2 | Homo sapiens (Human) | EV |
| P24723 | PRKCH | Protein kinase C eta type | Homo sapiens (Human) | SS |
| Q04759 | PRKCQ | Protein kinase C theta type | Homo sapiens (Human) | PR |
| Q05655 | PRKCD | Protein kinase C delta type | Homo sapiens (Human) | SS |
| P17252 | PRKCA | Protein kinase C alpha type | Homo sapiens (Human) | EV |
| P05129 | PRKCG | Protein kinase C gamma type | Homo sapiens (Human) | SS |
| P05771 | PRKCB | Protein kinase C beta type | Homo sapiens (Human) | SS |
| P31751 | AKT2 | RAC-beta serine/threonine-protein kinase | Homo sapiens (Human) | EV SS |
| P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase | Homo sapiens (Human) | EV |
| Q9Y243 | AKT3 | RAC-gamma serine/threonine-protein kinase | Homo sapiens (Human) | SS |
| Q96BR1 | SGK3 | Serine/threonine-protein kinase Sgk3 | Homo sapiens (Human) | SS |
| Q9HBY8 | SGK2 | Serine/threonine-protein kinase Sgk2 | Homo sapiens (Human) | SS |
| O00141 | SGK1 | Serine/threonine-protein kinase Sgk1 | Homo sapiens (Human) | PR |
| Q15208 | STK38 | Serine/threonine-protein kinase 38 | Homo sapiens (Human) | EV |
| Q9Y2H1 | STK38L | Serine/threonine-protein kinase 38-like | Homo sapiens (Human) | EV |
| Q6A1A2 | PDPK2P | Putative 3-phosphoinositide-dependent protein kinase 2 | Homo sapiens (Human) | PR |
| P23298 | Prkch | Protein kinase C eta type | Mus musculus (Mouse) | PR |
| Q02111 | Prkcq | Protein kinase C theta type | Mus musculus (Mouse) | PR |
| P16054 | Prkce | Protein kinase C epsilon type | Mus musculus (Mouse) | PR |
| P28867 | Prkcd | Protein kinase C delta type | Mus musculus (Mouse) | PR |
| P70268 | Pkn1 | Serine/threonine-protein kinase N1 | Mus musculus (Mouse) | SS |
| Q8BWW9 | Pkn2 | Serine/threonine-protein kinase N2 | Mus musculus (Mouse) | SS |
| Q8K045 | Pkn3 | Serine/threonine-protein kinase N3 | Mus musculus (Mouse) | SS |
| Q63433 | Pkn1 | Serine/threonine-protein kinase N1 | Rattus norvegicus (Rat) | SS |
| Q64617 | Prkch | Protein kinase C eta type | Rattus norvegicus (Rat) | PR |
| P09216 | Prkce | Protein kinase C epsilon type | Rattus norvegicus (Rat) | PR |
| P09215 | Prkcd | Protein kinase C delta type | Rattus norvegicus (Rat) | PR |
| O08874 | Pkn2 | Serine/threonine-protein kinase N2 | Rattus norvegicus (Rat) | SS |
| P34722 | tpa-1 | Protein kinase C-like 1 | Caenorhabditis elegans | PR |
| A7MBL8 | pkn2 | Serine/threonine-protein kinase N2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEEGAPRQPG | PSQWPPEDEK | EVIRRAIQKE | LKIKEGVENL | RRVATDRRHL | GHVQQLLRSS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NRRLEQLHGE | LRELHARILL | PGPGPGPAEP | VASGPRPWAE | QLRARHLEAL | RRQLHVELKV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KQGAENMTHT | CASGTPKERK | LLAAAQQMLR | DSQLKVALLR | MKISSLEASG | SPEPGPELLA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EELQHRLHVE | AAVAEGAKNV | VKLLSSRRTQ | DRKALAEAQA | QLQESSQKLD | LLRLALEQLL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EQLPPAHPLR | SRVTRELRAA | VPGYPQPSGT | PVKPTALTGT | LQVRLLGCEQ | LLTAVPGRSP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AAALASSPSE | GWLRTKAKHQ | RGRGELASEV | LAVLKVDNRV | VGQTGWGQVA | EQSWDQTFVI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PLERARELEI | GVHWRDWRQL | CGVAFLRLED | FLDNACHQLS | LSLVPQGLLF | AQVTFCDPVI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ERRPRLQRQE | RIFSKRRGQD | FLRASQMNLG | MAAWGRLVMN | LLPPCSSPST | ISPPKGCPRT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PTTLREASDP | ATPSNFLPKK | TPLGEEMTPP | PKPPRLYLPQ | EPTSEETPRT | KRPHMEPRTR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RGPSPPASPT | RKPPRLQDFR | CLAVLGRGHF | GKVLLVQFKG | TGKYYAIKAL | KKQEVLSRDE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IESLYCEKRI | LEAVGCTGHP | FLLSLLACFQ | TSSHACFVTE | FVPGGDLMMQ | IHEDVFPEPQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ARFYVACVVL | GLQFLHEKKI | IYRDLKLDNL | LLDAQGFLKI | ADFGLCKEGI | GFGDRTSTFC |
| 730 | 740 | 750 | 760 | 770 | 780 |
| GTPEFLAPEV | LTQEAYTRAV | DWWGLGVLLY | EMLVGECPFP | GDTEEEVFDC | IVNMDAPYPG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FLSVQGLEFI | QKLLQKCPEK | RLGAGEQDAE | EIKVQPFFRT | TNWQALLART | IQPPFVPTLC |
| 850 | 860 | 870 | 880 | ||
| GPADLRYFEG | EFTGLPPALT | PPAPHSLLTA | RQQAAFRDFD | FVSERFLEP |