Q6P5E6

SS
Gene name
Gga2 (Kiaa1080)
Protein name
ADP-ribosylation factor-binding protein GGA2
Names
Gamma-adaptin-related protein 2, Golgi-localized, gamma ear-containing, ARF-binding protein 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:74105
EC number
Protein Class

Descriptions

The cytosolic adaptors GGA1-3 mediate sorting of transmembrane proteins. GGA1 contains an autoinhibitory region that is activated by the phosphorylation of a serine positioned three residues upstream of the DXXLL motif. Autoinhibition is achieved by the interaction between DXXLL site and the VHS domain in CGGA1, and the phosphoserine upstream of the DXXLL motif facilitates this interaction.

Autoinhibitory domains (AIDs)

358-365 (Autoinhibitory site in hinge region) SS

Target domain

27-166 (VHS domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6P5E6

Entry ID Method Resolution Chain Position Source
AF-Q6P5E6-F1 Predicted AlphaFoldDB

4 variants for Q6P5E6

Variant ID(s) Position Change Description Diseaes Association Provenance
rs254363067 18 S>A No Ensembl
rs13466284 228 E>G No Ensembl
rs254899883 390 P>L No Ensembl
rs13466285 499 P>A No Ensembl

No associated diseases with Q6P5E6

5 regional properties for Q6P5E6

Type Name Position InterPro Accession
domain VHS domain 27 - 166 IPR002014
domain GAT domain 190 - 318 IPR004152
domain Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain 471 - 595 IPR008152
domain Gamma-adaptin ear (GAE) domain 474 - 595 IPR008153
domain N-terminal extension of GAT domain 190 - 226 IPR041198

Functions

Description
EC Number
Subcellular Localization
  • Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein
  • Endosome membrane ; Peripheral membrane protein
  • Early endosome membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
clathrin-coated vesicle A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
early endosome membrane The lipid bilayer surrounding an early endosome.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
trans-Golgi network The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.

3 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
small GTPase binding Binding to a small monomeric GTPase.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

3 GO annotations of biological process

Name Definition
Golgi to plasma membrane protein transport The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
protein localization to cell surface A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9UJY5 GGA1 ADP-ribosylation factor-binding protein GGA1 Homo sapiens (Human) EV
Q9UJY4 GGA2 ADP-ribosylation factor-binding protein GGA2 Homo sapiens (Human) SS
Q9NZ52 GGA3 ADP-ribosylation factor-binding protein GGA3 Homo sapiens (Human) EV
Q8BMI3 Gga3 ADP-ribosylation factor-binding protein GGA3 Mus musculus (Mouse) SS
Q8R0H9 Gga1 ADP-ribosylation factor-binding protein GGA1 Mus musculus (Mouse) SS
10 20 30 40 50 60
MAATAVAAGT GSPAGTESAE GGPGAAAALE LWLNKATDPS MAEQDWSAIQ KFCEQVNTDP
70 80 90 100 110 120
SGPTHAPWLL AHKIQSPQEK EALYALTVLE ICMNHCGEKF HSEVAKFRFL NELIKVLSPK
130 140 150 160 170 180
YLGAWATEKV KGRVIEILFS WTVWFPEDIK IRDAYQMLKK QGIIKQDPKL PMDKILPPPS
190 200 210 220 230 240
PWPKSIFDAD EEKSKLLTRL LKSNHPEDLQ AANRLIKNLV KEEQEKSEKV SRRVSAVEEV
250 260 270 280 290 300
RSHVRVLREM LSMYRRPGHA LPDQQALQVV YERCEKLRPT LFRLASDTTD DDDALAEILQ
310 320 330 340 350 360
ANDLLTQGVR LYKQVVEGRV SAGNAVPAAV GAIPAPRAFP NPEPCGLNCP LIDLETPSLL
370 380 390 400 410 420
HQDLAALGIN DVPTRNQVVI PSCCNDKKQP GAITLMGGGI QSLSADRNLL DLFSPQPSPG
430 440 450 460 470 480
LNYVPQKSIP KEVPPGTKAS PGWSWEAGPL ASSTASQNTP LAHVFVPLES VKPSSLPPIV
490 500 510 520 530 540
VYDRNGFRIL LHFSQTGAPG HPDVKVLLLT MMSTATQPVW DVMFQVAVPK SMRVKLQPAS
550 560 570 580 590 600
SSKLPAFSPL MPPAVISQTL LLDNPHKEPI RLRYKLTFNQ GGQPFSEVGE VKDFPDLAVL
STA