Q6NZJ6
SS
Gene name |
Eif4g1 |
Protein name |
Eukaryotic translation initiation factor 4 gamma 1 |
Names |
eIF-4-gamma 1 , eIF-4G 1 , eIF-4G1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:208643 |
EC number |
|
Protein Class |
|
Descriptions
EIF4G is a probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. The eIF4E-binding site in eukaryotic initiation factor 4G (eIF4G) functions as an autoinhibitory domain to modulate its ability to stimulate eIF4A helicase activity. Binding of eIF4E counteracts this autoinhibition, enabling eIF4G to stimulate eIF4A helicase activity.
Autoinhibitory domains (AIDs)
Target domain |
686-1089 (eIF4A-binding domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NZJ6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NZJ6-F1 | Predicted | AlphaFoldDB |
78 variants for Q6NZJ6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3406788083 | 26 | G>V | No | EVA | |
| rs3406150448 | 28 | T>S | No | EVA | |
| rs237672896 | 35 | T>S | No | EVA | |
| rs3389387217 | 85 | P>A | No | EVA | |
| rs3389322949 | 87 | V>D | No | EVA | |
| rs3389413304 | 87 | V>L | No | EVA | |
| rs3389414686 | 88 | Y>F | No | EVA | |
| rs3389387166 | 104 | S>P | No | EVA | |
| rs3389401280 | 149 | A>V | No | EVA | |
| rs3389414727 | 164 | S>G | No | EVA | |
| rs3389403663 | 213 | P>S | No | EVA | |
| rs3508089888 | 247 | A>G | No | EVA | |
| rs3508087019 | 247 | A>T | No | EVA | |
| rs3508090742 | 248 | I>T | No | EVA | |
| rs3389407474 | 250 | G>V | No | EVA | |
| rs1134739190 | 251 | R>Q | No | EVA | |
| rs3508086942 | 252 | P>S | No | EVA | |
| rs1133198718 | 310 | S>L | No | EVA | |
| rs3389401023 | 313 | I>N | No | EVA | |
| rs3389417900 | 324 | S>F | No | EVA | |
| rs3406403081 | 331 | E>* | No | EVA | |
| rs3389355967 | 336 | V>I | No | EVA | |
| rs242328290 | 359 | A>S | No | EVA | |
| rs3389409820 | 362 | P>S | No | EVA | |
| rs247354483 | 364 | K>R | No | EVA | |
| rs3389423100 | 370 | P>S | No | EVA | |
| rs3389368006 | 432 | P>A | No | EVA | |
| rs215266436 | 447 | I>V | No | EVA | |
| rs251283225 | 451 | A>S | No | EVA | |
| rs251283225 | 451 | A>T | No | EVA | |
| rs3389377142 | 451 | A>V | No | EVA | |
| rs221592403 | 459 | T>N | No | EVA | |
| rs3389423143 | 479 | A>T | No | EVA | |
| rs3413048523 | 520 | R>Q | No | EVA | |
| rs3389404725 | 536 | D>N | No | EVA | |
| rs3389367954 | 544 | A>T | No | EVA | |
| rs3389407510 | 544 | A>V | No | EVA | |
| rs3405074848 | 547 | E>Q | No | EVA | |
| rs233857892 | 564 | G>A | No | EVA | |
| rs31416468 | 566 | M>T | No | EVA | |
| rs3389407528 | 631 | M>V | No | EVA | |
| rs3389324485 | 632 | Q>K | No | EVA | |
| rs3389355958 | 658 | P>H | No | EVA | |
| rs3389377132 | 668 | P>S | No | EVA | |
| rs45770361 | 673 | S>P | No | EVA | |
| rs3389423089 | 712 | P>L | No | EVA | |
| rs3389409874 | 754 | E>* | No | EVA | |
| rs3389367992 | 779 | M>I | No | EVA | |
| rs3389409815 | 816 | S>F | No | EVA | |
| rs3389398198 | 839 | V>E | No | EVA | |
| rs3389414724 | 861 | D>N | No | EVA | |
| rs3389409871 | 864 | V>A | No | EVA | |
| rs3389409806 | 868 | K>R | No | EVA | |
| rs3389409888 | 870 | K>I | No | EVA | |
| rs3389398247 | 875 | A>T | No | EVA | |
| rs47774653 | 892 | R>W | No | EVA | |
| rs3389367976 | 958 | R>P | No | EVA | |
| rs3406150445 | 966 | M>L | No | EVA | |
| rs13473261 | 994 | W>* | No | EVA | |
| rs3389414712 | 1015 | M>K | No | EVA | |
| rs3389404756 | 1118 | R>C | No | EVA | |
| rs3389387225 | 1121 | T>I | No | EVA | |
| rs242629180 | 1191 | E>D | No | EVA | |
| rs3389423075 | 1255 | H>P | No | EVA | |
| rs3389414732 | 1255 | H>Y | No | EVA | |
| rs3389408236 | 1268 | E>V | No | EVA | |
| rs3389417831 | 1269 | L>V | No | EVA | |
| rs3389409822 | 1285 | S>A | No | EVA | |
| rs3389423112 | 1289 | R>L | No | EVA | |
| rs3389356004 | 1306 | C>Y | No | EVA | |
| rs3389367927 | 1342 | E>D | No | EVA | |
| rs3406810084 | 1350 | E>V | No | EVA | |
| rs251863834 | 1357 | E>D | No | EVA | |
| rs214445582 | 1394 | M>T | No | EVA | |
| rs3552086809 | 1397 | R>Q | No | EVA | |
| rs3406403084 | 1438 | L>I | No | EVA | |
| rs226732776 | 1461 | F>S | No | EVA | |
| rs3389356008 | 1570 | A>T | No | EVA |
No associated diseases with Q6NZJ6
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic stress granule | A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| eukaryotic translation initiation factor 4F complex | The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| postsynapse | The part of a synapse that is part of the post-synaptic cell. |
| ribosome | An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| eukaryotic initiation factor 4E binding | Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. |
| identical protein binding | Binding to an identical protein or proteins. |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
19 GO annotations of biological process
| Name | Definition |
|---|---|
| behavioral fear response | An acute behavioral change resulting from a perceived external threat. |
| cellular response to nutrient levels | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients. |
| energy homeostasis | Any process involved in the balance between food intake (energy input) and energy expenditure. |
| lung development | The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax. |
| miRNA-mediated gene silencing by inhibition of translation | An RNA interference pathway in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs. |
| negative regulation of autophagy | Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. |
| negative regulation of peptidyl-threonine phosphorylation | Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| positive regulation of cell growth | Any process that activates or increases the frequency, rate, extent or direction of cell growth. |
| positive regulation of eukaryotic translation initiation factor 4F complex assembly | Any process that activates or increases the frequency, rate or extent of eukaryotic translation initiation factor 4F complex assembly. |
| positive regulation of G1/S transition of mitotic cell cycle | Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. |
| positive regulation of neuron differentiation | Any process that activates or increases the frequency, rate or extent of neuron differentiation. |
| positive regulation of peptidyl-serine phosphorylation | Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine. |
| positive regulation of protein localization to cell periphery | Any process that activates or increases the frequency, rate or extent of protein localization to cell periphery. |
| positive regulation of translation in response to endoplasmic reticulum stress | Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress. |
| regulation of presynapse assembly | Any process that modulates the frequency, rate or extent of presynapse assembly. |
| regulation of translational initiation | Any process that modulates the frequency, rate or extent of translational initiation. |
| response to ethanol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
| translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q41583 | Eukaryotic translation initiation factor isoform 4G-2 | Triticum aestivum (Wheat) | PR | |
| Q95L46 | EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2 | Bos taurus (Bovine) | PR |
| Q9H074 | PAIP1 | Polyadenylate-binding protein-interacting protein 1 | Homo sapiens (Human) | PR |
| P78344 | EIF4G2 | Eukaryotic translation initiation factor 4 gamma 2 | Homo sapiens (Human) | PR |
| O43432 | EIF4G3 | Eukaryotic translation initiation factor 4 gamma 3 | Homo sapiens (Human) | EV |
| Q04637 | EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1 | Homo sapiens (Human) | EV |
| Q8VE62 | Paip1 | Polyadenylate-binding protein-interacting protein 1 | Mus musculus (Mouse) | PR |
| Q62448 | Eif4g2 | Eukaryotic translation initiation factor 4 gamma 2 | Mus musculus (Mouse) | PR |
| Q80XI3 | Eif4g3 | Eukaryotic translation initiation factor 4 gamma 3 | Mus musculus (Mouse) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNKAPQPTGP | PPARSPGLPQ | PAFPPGQTAP | VVFSTPQATQ | MNTPSQPRQG | GFRSLQHFYP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SRAQPPSSAA | SRVQSAAPAR | PGPAPHVYPA | GSQVMMIPSQ | ISYSASQGAY | YIPGQGRSTY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VVPTQQYPVQ | PGAPGFYPGA | SPTEFGTYAG | AYYPAQGVQQ | FPASVAPAPV | LMNQPPQIAP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KRERKTIRIR | DPNQGGKDIT | EEIMSGARTA | STPTPPQTGG | SLEPQPNGES | PQVAVIIRPD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DRSQGAAIGG | RPGLPGPEHS | PGTESQPSSP | SPTPSPPPIL | EPGSESNLGV | LSIPGDTMTT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GMIPMSVEES | TPISCETGEP | YCLSPEPTLA | EPILEVEVTL | SKPIPESEFS | SSPLQVSTAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VPHKVETHEP | NGVIPSEDLE | PEVESSTEPA | PPPLSPCASE | SLVPIAPTAQ | PEELLNGAPS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PPAVDLSPVS | EPEEQAKKVS | SAALASILSP | APPVAPSDTS | PAQEEEMEED | DDDEEGGEAE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SEKGGEDVPL | DSTPVPAQLS | QNLEVAAATQ | VAVSVPKRRR | KIKELNKKEA | VGDLLDAFKE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VDPAVPEVEN | QPPTGSNPSP | ESEGSMVPTQ | PEETEETWDS | KEDKIHNAEN | IQPGEQKYEY |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KSDQWKPLNL | EEKKRYDREF | LLGFQFIFAS | MQKPEGLPHI | TDVVLDKANK | TPLRQLDPSR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LPGINCGPDF | TPSFANLGRP | ALSNRGPPRG | GPGGELPRGP | AGLGPRRSQQ | GPRKETRKII |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SSVIMTEDIK | LNKAEKAWKP | SSKRTAADKD | RGEEDADGSK | TQDLFRRVRS | ILNKLTPQMF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QQLMKQVTQL | AIDTEERLKG | VIDLIFEKAI | SEPNFSVAYA | NMCRCLMALK | VPTTEKPTVT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VNFRKLLLNR | CQKEFEKDKD | DDEVFEKKQK | EMDEAATAEE | RGRLKEELEE | ARDIARRRSL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GNIKFIGELF | KLKMLTEAIM | HDCVVKLLKN | HDEESLECLC | RLLTTIGKDL | DFAKAKPRMD |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| QYFNQMEKII | KEKKTSSRIR | FMLQDVLDLR | QSNWVPRRGD | QGPKTIDQIH | KEAEMEEHRE |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| HIKVQQLMAK | GSDKRRGGPP | GPPINRGLPL | VDDGGWNTVP | ISKGSRPIDT | SRLTKITKPG |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| SIDSNNQLFA | PGGRLSWGKG | SSGGSGAKPS | DTASEATRPA | TLNRFSALQQ | TLPAENTDNR |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| RVVQRSSLSR | ERGEKAGDRG | DRLERSERGG | DRGDRLDRAR | TPATKRSFSK | EVEERSRERP |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SQPEGLRKAA | SLTEDRGRDP | VKREATLPPV | SPPKAALSVD | EVEKKSKAII | EEYLHLNDMK |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| EAVQCVQELA | SPSLLFIFVR | LGIESTLERS | TIAREHMGRL | LHQLLCAGHL | STAQYYQGLY |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| ETLELAEDME | IDIPHVWLYL | AELITPILQE | DGVPMGELFR | EITKPLRPMG | KATSLLLEIL |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| GLLCKSMGPK | KVGMLWREAG | LSWREFLAEG | QDVGSFVAEK | KVEYTLGEES | EAPGQRTLAF |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| EELRRQLEKL | LKDGGSNQRV | FDWIDANLNE | QQIASNTLVR | ALMTTVCYSA | IIFETPLRVD |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| VQVLKVRARL | LQKYLCDEQK | ELQALYALQA | LVVTLEQPAN | LLRMFFDALY | DEDVVKEDAF |
| 1570 | 1580 | 1590 | |||
| YSWESSKDPA | EQQGKGVALK | SVTAFFNWLR | EAEDEESDHN |