Q6NWJ4
Gene name |
dnajc2 (zgc:85671) |
Protein name |
DnaJ homolog subfamily C member 2 |
Names |
|
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:403080 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NWJ4
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NWJ4-F1 | Predicted | AlphaFoldDB |
No variants for Q6NWJ4
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6NWJ4 | |||||
No associated diseases with Q6NWJ4
6 regional properties for Q6NWJ4
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | SANT/Myb domain | 446 - 505 | IPR001005-1 |
| domain | SANT/Myb domain | 545 - 601 | IPR001005-2 |
| domain | DnaJ domain | 84 - 158 | IPR001623 |
| domain | SANT domain | 548 - 603 | IPR017884 |
| domain | Myb domain | 552 - 603 | IPR017930 |
| domain | Ribosome-associated complex head domain | 336 - 423 | IPR032003 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| chromatin binding | Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. |
| histone binding | Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. |
| Hsp70 protein binding | Binding to a Hsp70 protein, heat shock proteins around 70kDa in size. |
| ribosome binding | Binding to a ribosome. |
| ubiquitin modification-dependent histone binding | Binding to a histone protein in which a residue has been modified by ubiquitination. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| 'de novo' cotranslational protein folding | The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated. |
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| positive regulation of DNA-templated transcription | Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of translational fidelity | Any process that modulates the ability of the translational apparatus to interpret the genetic code. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32527 | ZUO1 | Zuotin | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| Q99543 | DNAJC2 | DnaJ homolog subfamily C member 2 | Homo sapiens (Human) | PR |
| P54103 | Dnajc2 | DnaJ homolog subfamily C member 2 | Mus musculus (Mouse) | PR |
| Q7TQ20 | Dnajc2 | DnaJ homolog subfamily C member 2 | Rattus norvegicus (Rat) | PR |
| P34454 | F54F2.9 | Uncharacterized protein F54F2.9 | Caenorhabditis elegans | PR |
| F4KGY6 | RVE1 | Protein REVEILLE 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| F4K5X6 | RVE2 | Protein REVEILLE 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLTEALEGQL | TVVYNTVAAS | VQVQVEPVGR | WFEAFLKRRN | RNVSASFQEL | EEEEELSEEE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EDEELQLEEY | PMLKTLDPKD | WKNQDHYAVL | GLAHVRYKAT | QKQIKAAHKA | MVLKHHPDKR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KAAGEQIVEG | DNDYFTCITK | AIEILSDPVK | RRAFDSVDPT | FDNAVPTKAE | GKENFFEVFA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PVFERNARWS | VKKHFPSLGT | MESSFEDVDN | FYSFWYNFDS | WREFSYLDEE | EKEKAECRDE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RRWIEKQNRA | SRAQRKKEEM | NRIRTLVDTA | YNADPRIKKF | KEEEKARKES | EKKAKVEAKK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| REQEEKERAR | QQQEEAARLL | KEQQEEAARQ | AAQQAKKEKE | AQKKAIKKER | QKLRMTCKSQ |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NYFTDNEADS | VRMMEEVEKL | CDRLELISLQ | TLNEALSAGN | KEQSKAALEK | QVQEVNMQLQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KEKDAELQAQ | QAARGSEHSS | AAGGQNNRGW | SEEDLQLLIK | AVNLFPAGTN | ARWEVIANYM |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NQHSSSGVRR | TAKDVINKAK | TLQKLDPHQK | DEINRKAFEK | FKKEHSAVPP | TVDNAMPSER |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FDAVGADSNA | AAWTTEEQKL | LEQALKTYPV | STAERWERIS | EAVPGRSKKD | CMKRYKELVE |
| 610 | |||||
| MIKAKKAAQE | QVAAKNKK |