Q6NVG1
PR
Gene name |
Lpcat4 (Agpat7, Aytl3) |
Protein name |
Lysophospholipid acyltransferase LPCAT4 |
Names |
1-acylglycerol-3-phosphate O-acyltransferase 7, 1-AGP acyltransferase 7, 1-AGPAT 7, 1-acylglycerophosphocholine O-acyltransferase, 1-acylglycerophosphoserine O-acyltransferase, 1-alkenylglycerophosphoethanolamine O-acyltransferase, 1-alkylglycerophosphocholine O-acetyltransferase, Acyltransferase-like 3, Lysophosphatidylcholine acyltransferase 4, Lysophosphatidylethanolamine acyltransferase 2, Plasmalogen synthase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:99010 |
EC number |
2.3.1.23: Transferring groups other than amino-acyl groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NVG1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NVG1-F1 | Predicted | AlphaFoldDB |
18 variants for Q6NVG1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388578419 | 60 | L>I | No | EVA | |
| rs3413066165 | 82 | T>K | No | EVA | |
| rs3388568832 | 146 | V>I | No | EVA | |
| rs3388579937 | 166 | Q>* | No | EVA | |
| rs27463438 | 276 | L>P | No | EVA | |
| rs107616303 | 330 | A>G | No | EVA | |
| rs3391769623 | 338 | L>M | No | EVA | |
| rs3392077345 | 339 | S>P | No | EVA | |
| rs3388579971 | 375 | A>G | No | EVA | |
| rs3388572512 | 406 | E>K | No | EVA | |
| rs3388575482 | 411 | L>M | No | EVA | |
| rs3388579985 | 416 | F>I | No | EVA | |
| rs3388572055 | 473 | S>C | No | EVA | |
| rs3388579976 | 480 | G>C | No | EVA | |
| rs3388579935 | 483 | F>S | No | EVA | |
| rs3388572487 | 493 | P>T | No | EVA | |
| rs3388575463 | 504 | S>F | No | EVA | |
| rs3388576262 | 513 | N>K | No | EVA |
No associated diseases with Q6NVG1
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.1.23 | Transferring groups other than amino-acyl groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| 1-acylglycerophosphocholine O-acyltransferase activity | Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. |
| 1-acylglycerophosphoethanolamine O-acyltransferase activity | Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA. |
| 1-acylglycerophosphoserine O-acyltransferase activity | Catalysis of the reaction:a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA. |
| 1-alkenylglycerophosphoethanolamine O-acyltransferase activity | Catalysis of the reaction: 1-alkenylglycerophosphoethanolamine + acyl-CoA = 1-alkenyl-2-acyl-glycerophosphoethanolamine + CoA. |
| 1-alkylglycerophosphocholine O-acetyltransferase activity | Catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + CoA. |
| lysophospholipid acyltransferase activity | Catalysis of the transfer of acyl groups from an acyl-CoA to a lysophospholipid. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidylcholine acyl-chain remodeling | Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains. |
| phosphatidylethanolamine acyl-chain remodeling | Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains. |
| phosphatidylserine acyl-chain remodeling | Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains. |
| phospholipid biosynthetic process | The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. |
| phospholipid metabolic process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q8NF37 | LPCAT1 | Lysophosphatidylcholine acyltransferase 1 | Homo sapiens (Human) | PR |
| Q8C0N2 | Gpat3 | Glycerol-3-phosphate acyltransferase 3 | Mus musculus (Mouse) | PR |
| Q8K2C8 | Gpat4 | Glycerol-3-phosphate acyltransferase 4 | Mus musculus (Mouse) | PR |
| Q3TFD2 | Lpcat1 | Lysophosphatidylcholine acyltransferase 1 | Mus musculus (Mouse) | PR |
| Q1HAQ0 | Lpcat1 | Lysophosphatidylcholine acyltransferase 1 | Rattus norvegicus (Rat) | PR |
| Q8L7R3 | LPEAT1 | Lysophospholipid acyltransferase LPEAT1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8S8S2 | LPEAT2 | Lysophospholipid acyltransferase LPEAT2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q1LWG4 | lpcat1 | Lysophosphatidylcholine acyltransferase 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSQGSPGAWA | PLDPTSGSSA | SPNPFVHELH | LSGLQRVKFC | LLGVLLAPIR | VLLAFIVLFL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LWPFAWLQVA | GLTEEQLQEP | ITGWRKTVCH | NGVLGLSRLL | FFLLGFLRIR | VRGQRASRLE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| APVLVAAPHS | TFFDPIVLLP | CDLPKVVSRA | ENLSVPVIGA | LLRFNQAILV | SRHDPASRRR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVEEVRRRAT | SGGKWPQVLF | FPEGTCSNKK | ALLKFKPGAF | IAGVPVQPVL | IRYPNSLDTT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SWAWRGPGVL | KVLWLTASQP | CSIVDVEFLP | VYQPSLEESK | DPTLYANNVQ | RVMAQALGIP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ATECEFVGSL | PVIVVGQLKV | ALEPQLWELA | KVLQKAGLSP | GFVDMGAEPG | RSRMISQEAF |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AQQLQLSDPQ | TVAGAFSYFQ | QDAKGLVDFR | NVALALAALD | GGRSLEELTR | LAFELFAEEQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AEGSDRLLYK | DGFSTILHLL | LGSPRPAATT | LHAELCQPGC | SQGLSLCQFQ | NFSLHDPLYG |
| 490 | 500 | 510 | 520 | ||
| KLFSAYLRPP | HKPRSTSQIP | NASSPSSPTA | LANGTVQAPK | QKGD |