Q6NVF0
PR
Gene name |
Ocrl |
Protein name |
Inositol polyphosphate 5-phosphatase OCRL |
Names |
Inositol polyphosphate 5-phosphatase OCRL-1, Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:320634 |
EC number |
3.1.3.36: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6NVF0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6NVF0-F1 | Predicted | AlphaFoldDB |
45 variants for Q6NVF0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs227153522 | 29 | V>I | No | EVA | |
| rs3410246432 | 43 | I>F | No | EVA | |
| rs3410146838 | 53 | Q>* | No | EVA | |
| rs30130935 | 85 | R>Q | No | EVA | |
| rs864266630 | 95 | H>D | No | EVA | |
| rs227418537 | 124 | P>L | No | EVA | |
| rs3389465159 | 138 | T>N | No | EVA | |
| rs3410471773 | 198 | Q>R | No | EVA | |
| rs3389552107 | 222 | I>V | No | EVA | |
| rs3409722980 | 227 | T>A | No | EVA | |
| rs3409992979 | 228 | K>L | No | EVA | |
| rs3389465149 | 263 | C>S | No | EVA | |
| rs3389514138 | 294 | Q>L | No | EVA | |
| rs3389551350 | 309 | K>R | No | EVA | |
| rs3410247158 | 349 | G>W | No | EVA | |
| rs216476492 | 397 | T>I | No | EVA | |
| rs216476492 | 397 | T>S | No | EVA | |
| rs247876485 | 404 | T>A | No | EVA | |
| rs3389573265 | 449 | F>V | No | EVA | |
| rs257816732 | 473 | V>I | No | EVA | |
| rs3389514092 | 486 | D>Y | No | EVA | |
| rs3389465177 | 488 | S>T | No | EVA | |
| rs3389465142 | 504 | G>* | No | EVA | |
| rs3389568612 | 506 | N>I | No | EVA | |
| rs3389556536 | 517 | E>K | No | EVA | |
| rs3389507166 | 536 | V>A | No | EVA | |
| rs3389573279 | 574 | E>* | No | EVA | |
| rs3389573232 | 577 | K>* | No | EVA | |
| rs3389559208 | 673 | N>I | No | EVA | |
| rs3389551374 | 713 | E>D | No | EVA | |
| rs30137468 | 743 | H>Y | No | EVA | |
| rs248646866 | 760 | M>L | No | EVA | |
| rs3410306069 | 798 | P>A | No | EVA | |
| rs3410217831 | 810 | C>HEQSQDIADTAHNR* | No | EVA | |
| rs3389568579 | 826 | Q>L | No | EVA | |
| rs30133537 | 843 | R>H | No | EVA | |
| rs3389514071 | 874 | L>I | No | EVA | |
| rs30134379 | 876 | T>A | No | EVA | |
| rs30134382 | 885 | H>R | No | EVA | |
| rs3409340011 | 895 | L>V | No | EVA | |
| rs3410471760 | 896 | G>A | No | EVA | |
| rs3410353665 | 896 | G>R | No | EVA | |
| rs3408969810 | 897 | N>K | No | EVA | |
| rs3409723034 | 898 | E>Q | No | EVA | |
| rs3410105812 | 901 | D>Q | No | EVA |
No associated diseases with Q6NVF0
7 regional properties for Q6NVF0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Rho GTPase-activating protein domain | 720 - 900 | IPR000198 |
| domain | Inositol polyphosphate-related phosphatase | 237 - 538 | IPR000300 |
| domain | Endonuclease/exonuclease/phosphatase | 244 - 523 | IPR005135 |
| domain | Inositol polyphosphate 5-phosphatase, clathrin binding domain | 19 - 117 | IPR031995 |
| domain | OCRL1, PH domain | 11 - 115 | IPR037787 |
| domain | OCRL1/INPP5B, INPP5c domain | 239 - 532 | IPR037793 |
| domain | Inositol polyphosphate 5-phosphatase OCRL, RhoGAP | 667 - 895 | IPR047078 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.36 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| clathrin-coated pit | A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes. |
| clathrin-coated vesicle | A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| early endosome | A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways. |
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| phagocytic vesicle membrane | The lipid bilayer surrounding a phagocytic vesicle. |
| photoreceptor outer segment | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
8 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTPase activator activity | Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. |
| inositol phosphate phosphatase activity | Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. |
| inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| inositol-1,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. |
| inositol-polyphosphate 5-phosphatase activity | Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. |
| phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity | Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-3,4-bisphosphate + phosphate. |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. |
| small GTPase binding | Binding to a small monomeric GTPase. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cilium assembly | The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole. |
| in utero embryonic development | The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus. |
| inositol phosphate dephosphorylation | The process of removing a phosphate group from any mono- or polyphosphorylated inositol. |
| phosphatidylinositol dephosphorylation | The process of removing one or more phosphate groups from a phosphatidylinositol. |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9NRR6 | INPP5E | Phosphatidylinositol polyphosphate 5-phosphatase type IV | Homo sapiens (Human) | PR |
| Q92835 | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | Homo sapiens (Human) | PR |
| P32019 | INPP5B | Type II inositol 1,4,5-trisphosphate 5-phosphatase | Homo sapiens (Human) | PR |
| Q9ES52 | Inpp5d | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | Mus musculus (Mouse) | PR |
| Q8K337 | Inpp5b | Type II inositol 1,4,5-trisphosphate 5-phosphatase | Mus musculus (Mouse) | PR |
| P97573 | Inpp5d | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEPRLPIGAQ | PLAMVAGLEM | KGPLREPCVL | TLARRNGQYE | LIIQLHGKEQ | HVQDIIPINS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HFRCVQEAEE | TLLIDIASNS | GCKIRVQGDW | TRERHFEIPD | EERCLKFLSE | VLEAQEAQSQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLVPEQKDSS | SWYQKLDTMD | KPAYSGLLGF | EDNFSSLDLD | KKMNTQNPRS | GSHREPPPPP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SSSTRMLSRE | KEASNKEQPK | VTNTMRKLFV | PNTQTGQREG | LIKHILTKRE | KEYVNIQSFR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FFVGTWNVNG | QSPDSSLEPW | LDCDPNPPDI | YCIGFQELDL | STEAFFYFES | VKEQEWSLAV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ERGLPSKAKY | RKVQLVRLVG | MMLLIFARKD | QCQYIRDVAT | ETTGTGIMGK | MGNKGGVAVR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FVFHNTTFCI | VNSHLAAHVE | EFERRNQDYK | DICARMTFSV | PNQTVPQVNI | MKHDVVIWLG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DLNYRLCMPD | ASEVKSLINK | NELHKLLKFD | QLNIQRTQKK | AFADFNEGEI | NFVPTYKYDS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| KTDRWDSSGK | CRVPAWCDRI | LWRGINVNQL | HYRSHMELKT | SDHKPVSALF | HIGVKVVDER |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RYRKVFEDIV | RIMDRMENDF | LPSLELSRRE | FFFENVKFRQ | LQKEKFQISN | NGQVPCHFSF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IPKLNDSQYC | KPWLRAEPFE | GYLEPNETLD | ISLDVYVSKD | SVTILNSGED | KIEDILVLHL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DRGKDYFLTI | GGNYLPSCFG | TSLEALCRMK | RPIREVPVTK | LIDLEEDSYL | EKEKSLLQMV |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PLDEGTSERP | LQVPKEIWLL | VDHLFKYACH | QEDLFQTPGM | QEELQQIIDC | LDTSIPETIP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GNNHSVAEAL | LIFLEALPEP | VICYELYQRC | LDSAHDPRIC | KQVISQLPRC | HRNVFRYLMA |
| 850 | 860 | 870 | 880 | 890 | |
| FLRELLKFSD | YNNINTNMIA | TLFSSLLLRP | PPNLMTRQTP | NDRQHAIQFL | LVFLLGNEED |