Q6NMA7

PR
Gene name
PLC9 (At3g47220, F13I12.270)
Protein name
Phosphoinositide phospholipase C 9
Names
Phosphoinositide phospholipase PLC9, AtPLC9, PI-PLC9
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G47220
EC number
3.1.4.11: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q6NMA7

Entry ID Method Resolution Chain Position Source
AF-Q6NMA7-F1 Predicted AlphaFoldDB

148 variants for Q6NMA7

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH02459389 3 N>I No 1000Genomes
ENSVATH02459390 4 L>V No 1000Genomes
ENSVATH02459391 11 K>N No 1000Genomes
ENSVATH00405050 17 G>D No 1000Genomes
ENSVATH14390575 18 R>H No 1000Genomes
ENSVATH00405051 20 P>R No 1000Genomes
tmp_3_17388188_A_G 24 R>G No 1000Genomes
ENSVATH02459392 26 K>Q No 1000Genomes
ENSVATH02459395 32 D>E No 1000Genomes
ENSVATH02459394 32 D>N No 1000Genomes
ENSVATH02459397 36 N>D No 1000Genomes
ENSVATH02459398 36 N>T No 1000Genomes
ENSVATH02459400 37 L>S No 1000Genomes
ENSVATH02459401 39 P>L No 1000Genomes
ENSVATH14390577 41 F>I No 1000Genomes
ENSVATH00405052 43 K>E No 1000Genomes
ENSVATH00405053 43 K>N No 1000Genomes
ENSVATH00405054 53 G>S No 1000Genomes
ENSVATH02459403 57 N>K No 1000Genomes
tmp_3_17388296_G_A 60 E>K No 1000Genomes
ENSVATH06257136 63 D>G No 1000Genomes
ENSVATH02459405 63 D>Y No 1000Genomes
ENSVATH02459407 64 R>K No 1000Genomes
ENSVATH02459408 64 R>S No 1000Genomes
ENSVATH02459409 67 K>E No 1000Genomes
tmp_3_17388320_A_G 68 S>G No 1000Genomes
ENSVATH02459410 71 C>S No 1000Genomes
ENSVATH15997904 71 C>W No 1000Genomes
ENSVATH02459411 71 C>Y No 1000Genomes
ENSVATH02459413 72 D>N No 1000Genomes
ENSVATH02459413 72 D>Y No 1000Genomes
ENSVATH02459414 74 L>F No 1000Genomes
ENSVATH06257137 77 R>L No 1000Genomes
ENSVATH12598910 84 L>F No 1000Genomes
ENSVATH00405055 85 P>R No 1000Genomes
tmp_3_17388376_C_G 86 H>Q No 1000Genomes
ENSVATH12598911 97 N>K No 1000Genomes
ENSVATH00405057 106 H>R No 1000Genomes
ENSVATH00405058 107 R>H No 1000Genomes
ENSVATH00405058 107 R>L No 1000Genomes
ENSVATH02459432 110 N>D No 1000Genomes
tmp_3_17388594_C_G 119 H>D No 1000Genomes
tmp_3_17388597_A_T 120 T>S No 1000Genomes
ENSVATH12598945 123 K>N No 1000Genomes
ENSVATH06257140 126 F>S No 1000Genomes
tmp_3_17388690_G_C 151 V>L No 1000Genomes
ENSVATH12598952 152 V>I No 1000Genomes
ENSVATH06257143 158 P>L No 1000Genomes
ENSVATH02459433 158 P>S No 1000Genomes
ENSVATH02459434 162 D>Y No 1000Genomes
ENSVATH02459435 165 C>S No 1000Genomes
ENSVATH02459437 169 K>N No 1000Genomes
ENSVATH02459441 172 F>I No 1000Genomes
ENSVATH12598982 186 K>N No 1000Genomes
ENSVATH02459442 187 Q>E No 1000Genomes
ENSVATH00405062 187 Q>H No 1000Genomes
ENSVATH02459442 187 Q>K No 1000Genomes
ENSVATH12599005 191 T>I No 1000Genomes
ENSVATH12599005 191 T>N No 1000Genomes
ENSVATH08145517 191 T>S No 1000Genomes
ENSVATH06257150 193 T>M No 1000Genomes
ENSVATH02459444 195 S>I No 1000Genomes
ENSVATH14390580 196 Y>F No 1000Genomes
ENSVATH06257153 214 V>A No 1000Genomes
tmp_3_17389072_G_A 223 G>S No 1000Genomes
ENSVATH02459454 224 D>G No 1000Genomes
ENSVATH02459453 224 D>N No 1000Genomes
ENSVATH02459456 228 H>D No 1000Genomes
ENSVATH02459457 229 E>* No 1000Genomes
tmp_3_17389091_A_C 229 E>A No 1000Genomes
ENSVATH08145524 229 E>D No 1000Genomes
ENSVATH08145526 233 Q>* No 1000Genomes
ENSVATH12599011 236 E>D No 1000Genomes
ENSVATH02459459 243 E>K No 1000Genomes
ENSVATH06257156 245 Q>R No 1000Genomes
ENSVATH06257157 246 N>K No 1000Genomes
tmp_3_17389144_A_C 247 K>Q No 1000Genomes
ENSVATH02459460 257 K>E No 1000Genomes
tmp_3_17389191_A_T 262 K>N No 1000Genomes
ENSVATH12599012 262 K>Q No 1000Genomes
ENSVATH02459461 263 A>D No 1000Genomes
ENSVATH02459462 264 V>D No 1000Genomes
ENSVATH06257159 271 E>K No 1000Genomes
ENSVATH02459463 273 Q>R No 1000Genomes
tmp_3_17389227_G_T 274 E>D No 1000Genomes
ENSVATH02459464 274 E>Q No 1000Genomes
ENSVATH02459465 275 G>E No 1000Genomes
ENSVATH02459466 276 S>L No 1000Genomes
ENSVATH02459467 278 D>N No 1000Genomes
ENSVATH02459467 278 D>Y No 1000Genomes
ENSVATH02459468 279 K>M No 1000Genomes
ENSVATH00405064 279 K>Q No 1000Genomes
ENSVATH06257160 283 S>C No 1000Genomes
ENSVATH06257161 284 V>I No 1000Genomes
tmp_3_17389279_C_G 292 P>A No 1000Genomes
ENSVATH00405066 293 R>K No 1000Genomes
ENSVATH00405067 309 W>L No 1000Genomes
ENSVATH02459477 321 K>R No 1000Genomes
ENSVATH12599065 322 F>L No 1000Genomes
tmp_3_17389494_G_A 324 R>Q No 1000Genomes
ENSVATH12599066 329 K>R No 1000Genomes
ENSVATH06257167 334 S>R No 1000Genomes
ENSVATH02459478 335 N>K No 1000Genomes
ENSVATH02459479 336 P>A No 1000Genomes
ENSVATH00405069 350 M>L No 1000Genomes
ENSVATH02459495 357 D>E No 1000Genomes
ENSVATH06257172 358 D>E No 1000Genomes
tmp_3_17389770_G_A 363 W>* No 1000Genomes
tmp_3_17389801_G_T 374 G>W No 1000Genomes
ENSVATH00405074 387 A>E No 1000Genomes
ENSVATH00405074 387 A>V No 1000Genomes
ENSVATH02459496 388 G>S No 1000Genomes
tmp_3_17389844_G_T 388 G>V No 1000Genomes
ENSVATH06257174 391 G>E No 1000Genomes
ENSVATH02459497 396 T>P No 1000Genomes
ENSVATH02459499 397 E>G No 1000Genomes
ENSVATH02459498 397 E>K No 1000Genomes
tmp_3_17389880_T_A 400 V>E No 1000Genomes
tmp_3_17389895_T_C 405 L>S No 1000Genomes
ENSVATH08145535 421 K>E No 1000Genomes
ENSVATH12599109 421 K>T No 1000Genomes
tmp_3_17390029_G_A 424 G>S No 1000Genomes
ENSVATH08145537 426 L>R No 1000Genomes
ENSVATH08145539 428 K>R No 1000Genomes
ENSVATH08145539 428 K>T No 1000Genomes
ENSVATH06257180 432 Y>F No 1000Genomes
ENSVATH06257183 442 H>N No 1000Genomes
tmp_3_17390182_G_C 445 K>N No 1000Genomes
ENSVATH02459511 447 M>T No 1000Genomes
ENSVATH02459513 451 V>G No 1000Genomes
ENSVATH02459512 451 V>M No 1000Genomes
tmp_3_17390204_A_C 453 N>H No 1000Genomes
ENSVATH14390632 454 N>K No 1000Genomes
ENSVATH02459515 457 K>T No 1000Genomes
tmp_3_17390228_G_A 461 G>R No 1000Genomes
tmp_3_17390250_T_A 468 L>* No 1000Genomes
ENSVATH02459518 485 V>I No 1000Genomes
ENSVATH08145550 486 S>L No 1000Genomes
ENSVATH14390633 487 T>I No 1000Genomes
ENSVATH02459520 488 P>A No 1000Genomes
ENSVATH02459523 490 Y>* No 1000Genomes
ENSVATH02459521 490 Y>D No 1000Genomes
ENSVATH02459522 490 Y>S No 1000Genomes
tmp_3_17390333_T_A 496 C>S No 1000Genomes
tmp_3_17390340_C_G 498 P>R No 1000Genomes
ENSVATH02459526 504 E>Q No 1000Genomes
ENSVATH00405080 515 R>G No 1000Genomes
ENSVATH02459529 520 S>R No 1000Genomes

No associated diseases with Q6NMA7

3 regional properties for Q6NMA7

Type Name Position InterPro Accession
domain C2 domain 386 - 513 IPR000008
domain Phosphatidylinositol-specific phospholipase C, X domain 107 - 253 IPR000909
domain Phospholipase C, phosphatidylinositol-specific, Y domain 267 - 385 IPR001711

Functions

Description
EC Number 3.1.4.11 Phosphoric diester hydrolases
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
phosphatidylinositol phospholipase C activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).

4 GO annotations of biological process

Name Definition
calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.
heat acclimation Any process that increases heat tolerance of an organism in response to high temperatures.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.

43 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32383 PLC1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P08487 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Bos taurus (Bovine) EV SS
P10895 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Bos taurus (Bovine) SS
Q1RML2 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Bos taurus (Bovine) PR
P10894 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Bos taurus (Bovine) SS
Q2VRL0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Gallus gallus (Chicken) PR
P19174 PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Homo sapiens (Human) EV
Q8N3E9 PLCD3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Homo sapiens (Human) SS
P16885 PLCG2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Homo sapiens (Human) SS
Q15111 PLCL1 Inactive phospholipase C-like protein 1 Homo sapiens (Human) PR
Q9UPR0 PLCL2 Inactive phospholipase C-like protein 2 Homo sapiens (Human) PR
Q86YW0 PLCZ1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Homo sapiens (Human) PR
P51178 PLCD1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Homo sapiens (Human) EV
Q9BRC7 PLCD4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 Homo sapiens (Human) SS
Q00722 PLCB2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Homo sapiens (Human) EV
Q01970 PLCB3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Homo sapiens (Human) EV
Q9NQ66 PLCB1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Homo sapiens (Human) EV
Q9P212 PLCE1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Homo sapiens (Human) SS
Q15147 PLCB4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 Homo sapiens (Human) PR
Q8K2J0 Plcd3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 Mus musculus (Mouse) PR
Q8K394 Plcl2 Inactive phospholipase C-like protein 2 Mus musculus (Mouse) PR
Q8K4S1 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Mus musculus (Mouse) SS
Q8R3B1 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Mus musculus (Mouse) SS
P51432 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Mus musculus (Mouse) SS
Q62077 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Mus musculus (Mouse) SS
A3KGF7 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Mus musculus (Mouse) PR
Q9Z1B3 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Mus musculus (Mouse) SS
Q7YRU3 PLCZ 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 Sus scrofa (Pig) PR
P10686 Plcg1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Rattus norvegicus (Rat) EV
P24135 Plcg2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Rattus norvegicus (Rat) SS
O89040 Plcb2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 Rattus norvegicus (Rat) PR
P10688 Plcd1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 Rattus norvegicus (Rat) SS
P10687 Plcb1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Rattus norvegicus (Rat) SS
Q99P84 Plce1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 Rattus norvegicus (Rat) EV
Q99JE6 Plcb3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Rattus norvegicus (Rat) SS
G5EBH0 egl-8 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 Caenorhabditis elegans SS
Q39032 PLC1 Phosphoinositide phospholipase C 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q56W08 PLC3 Phosphoinositide phospholipase C 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q8GV43 PLC6 Phosphoinositide phospholipase C 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C2 PLC5 Phosphoinositide phospholipase C 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9STZ3 PLC8 Phosphoinositide phospholipase C 8 Arabidopsis thaliana (Mouse-ear cress) PR
Q944C1 PLC4 Phosphoinositide phospholipase C 4 Arabidopsis thaliana (Mouse-ear cress) PR
A5D6R3 plcd3a 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MVNLRKKFEM KQANQPGRVP NYFRNKYHGY DDDMPNLLPT FIKLLDTEKD EDGAGLNAAE
70 80 90 100 110 120
QIDRELKSRK CDILKFRNLT ILELPHLNEF LFSTELNPPI SDQVRHRDMN APLSHYFIHT
130 140 150 160 170 180
SLKSYFTGNN VFGRLYSIEP IIDALKQGVR VVELDLLPFG KDGICVRPKW NFEKPLELQE
190 200 210 220 230 240
CLDAIKQHAF TPTRSYPVII TIKDSLKPDL QSKVTQMIDQ TFGDMVYHED PQQSLEEFPS
250 260 270 280 290 300
PAELQNKILI SRRPPTKLLY AKAVENGVEL EIQEGSTDKN YQSVVGFHAV EPRGMLQKAL
310 320 330 340 350 360
TDDVQQPGWY ERDVISFTQN KFLRTRPKKR NLLSNPPYKP QRAWMHGAQM IALSRQDDKE
370 380 390 400 410 420
KLWLMQGMFR ANGGCGYVKK PNFLLNAGSS GVFYPTENPV VVKTLKVKIY MGDGWIVDFK
430 440 450 460 470 480
KRIGRLSKPD LYVRISIAGV PHDEKIMNTT VKNNEWKPTW GEEFTFPLTY PDLALISFEV
490 500 510 520 530
YDYEVSTPDY FCGQTCLPVS ELIEGIRAVP LYDERGKACS STMLLTRFKW S